GREMLIN Database
Q9HPY2 - Uncharacterized protein
UniProt: Q9HPY2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 432 (348)
Sequences: 8523 (6619)
Seq/√Len: 354.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
254_A263_V4.2001.00
136_D141_A4.0361.00
31_L34_E3.8131.00
131_R148_V3.4531.00
134_T141_A3.3731.00
250_A263_V3.1371.00
226_E230_A3.0121.00
234_D237_A2.9371.00
226_E229_S2.8751.00
389_Y417_H2.7591.00
155_F192_A2.6441.00
157_G233_V2.4131.00
28_A39_A2.4011.00
189_E427_R2.3891.00
330_D334_D2.3881.00
94_D97_Q2.3641.00
240_V253_I2.3641.00
417_H421_D2.2971.00
191_I427_R2.2851.00
105_D108_V2.2571.00
385_R421_D2.2351.00
135_V223_A2.1931.00
362_P388_F2.1431.00
239_F262_G2.1101.00
243_H266_L2.1071.00
239_F426_V1.9961.00
333_L339_A1.9941.00
236_D261_A1.9691.00
133_V144_G1.9501.00
55_A60_E1.9471.00
87_S103_V1.9431.00
135_V144_G1.9421.00
225_D259_G1.9351.00
282_L285_F1.9211.00
144_G223_A1.9181.00
39_A42_D1.8851.00
29_A54_D1.8461.00
147_A187_A1.8381.00
224_L238_L1.8291.00
375_W382_E1.8251.00
213_D216_V1.7551.00
221_V260_V1.7541.00
206_A210_H1.7451.00
340_L343_S1.7451.00
146_L194_L1.7221.00
328_W331_S1.7081.00
228_A233_V1.7041.00
189_E423_A1.6911.00
210_H213_D1.6831.00
159_V220_A1.6701.00
254_A348_V1.6371.00
26_T39_A1.6251.00
344_I368_H1.6221.00
271_G367_M1.6151.00
61_E64_Y1.5971.00
254_A346_A1.5701.00
251_P265_S1.5671.00
194_L227_L1.5521.00
371_L375_W1.5501.00
135_V196_Y1.5401.00
144_G194_L1.5381.00
212_L216_V1.5351.00
264_V426_V1.5321.00
157_G194_L1.5131.00
225_D229_S1.5081.00
30_A37_R1.5051.00
199_R219_D1.5021.00
30_A35_T1.4971.00
71_G74_A1.4951.00
420_R424_E1.4511.00
185_G423_A1.4511.00
258_G345_D1.4291.00
352_K362_P1.4251.00
217_V253_I1.4231.00
252_R256_R1.4081.00
264_V422_V1.4021.00
194_L223_A1.4021.00
329_W333_L1.3981.00
34_E37_R1.3901.00
148_V192_A1.3891.00
342_E375_W1.3861.00
55_A62_F1.3811.00
350_A368_H1.3811.00
77_G80_T1.3791.00
89_E103_V1.3791.00
362_P366_E1.3711.00
28_A37_R1.3671.00
351_L418_A1.3621.00
225_D257_H1.3601.00
192_A232_T1.3551.00
366_E388_F1.3531.00
281_H284_Y1.3521.00
385_R428_G1.3461.00
44_F47_G1.3391.00
55_A58_A1.3371.00
77_G81_T1.3351.00
132_D143_D1.3331.00
100_D113_L1.3331.00
159_V224_L1.3301.00
222_A225_D1.3281.00
243_H267_D1.3171.00
128_F184_W1.3151.00
373_A384_G1.3121.00
273_E276_P1.3121.00
240_V263_V1.3031.00
387_A421_D1.2941.00
115_S118_E1.2871.00
104_A109_A1.2861.00
124_D127_A1.2841.00
69_Q72_E1.2831.00
69_Q73_S1.2811.00
90_L111_F1.2771.00
228_A235_E1.2691.00
147_A195_R1.2661.00
218_D222_A1.2661.00
255_D344_I1.2631.00
79_V83_D1.2631.00
355_R388_F1.2561.00
221_V225_D1.2501.00
259_G345_D1.2501.00
326_G330_D1.2461.00
31_L36_G1.2351.00
78_D81_T1.2341.00
130_E147_A1.2281.00
69_Q74_A1.2241.00
154_P234_D1.2231.00
221_V257_H1.2201.00
157_G192_A1.2191.00
218_D256_R1.2151.00
350_A369_R1.2051.00
263_V346_A1.2001.00
256_R340_L1.1991.00
146_L192_A1.1971.00
331_S334_D1.1931.00
29_A38_E1.1921.00
237_A261_A1.1901.00
330_D333_L1.1651.00
209_E212_L1.1631.00
137_A140_V1.1611.00
391_G398_T1.1591.00
133_V226_E1.1571.00
424_E428_G1.1541.00
282_L286_L1.1531.00
321_L325_P1.1441.00
322_R325_P1.1431.00
161_V240_V1.1421.00
62_F66_L1.1391.00
140_V207_P1.1321.00
149_P192_A1.1291.00
224_L260_V1.1241.00
102_R113_L1.1211.00
159_V260_V1.1161.00
251_P368_H1.1151.00
264_V349_F1.1131.00
421_D424_E1.0961.00
281_H285_F1.0931.00
149_P155_F1.0901.00
355_R390_D1.0901.00
138_G199_R1.0881.00
265_S268_G1.0871.00
228_A231_D1.0841.00
157_G224_L1.0741.00
392_L401_E1.0711.00
70_Y75_G1.0701.00
44_F48_L1.0701.00
157_G238_L1.0651.00
43_A47_G1.0641.00
325_P328_W1.0641.00
31_L35_T1.0601.00
71_G76_V1.0601.00
251_P270_S1.0601.00
272_T275_D1.0561.00
135_V222_A1.0521.00
158_V426_V1.0511.00
371_L374_D1.0511.00
323_D328_W1.0401.00
161_V220_A1.0311.00
192_A233_V1.0311.00
283_R286_L1.0301.00
355_R362_P1.0291.00
119_P123_A1.0291.00
341_A371_L1.0281.00
209_E213_D1.0271.00
26_T41_L1.0221.00
74_A77_G1.0211.00
80_T83_D1.0201.00
54_D58_A1.0181.00
104_A108_V1.0131.00
263_V348_V1.0101.00
372_L382_E1.0091.00
280_R283_R1.0081.00
341_A375_W0.9961.00
370_E374_D0.9941.00
87_S105_D0.9901.00
261_A347_P0.9831.00
369_R386_V0.9821.00
369_R384_G0.9811.00
97_Q100_D0.9781.00
116_E119_P0.9761.00
423_A427_R0.9711.00
24_T28_A0.9701.00
142_L208_E0.9671.00
255_D368_H0.9631.00
262_G347_P0.9631.00
185_G188_T0.9621.00
158_V241_A0.9571.00
120_P123_A0.9571.00
161_V249_A0.9561.00
78_D82_D0.9531.00
105_D109_A0.9531.00
416_E420_R0.9471.00
265_S350_A0.9421.00
43_A48_L0.9411.00
216_V272_T0.9401.00
228_A238_L0.9401.00
43_A46_A0.9391.00
91_V99_L0.9371.00
341_A368_H0.9351.00
71_G75_G0.9351.00
93_A99_L0.9211.00
267_D396_F0.9191.00
270_S368_H0.9171.00
369_R373_A0.9151.00
165_G168_D0.9131.00
60_E64_Y0.9131.00
241_A266_L0.9121.00
341_A344_I0.9071.00
348_V382_E0.9051.00
196_Y223_A0.9041.00
356_A391_G0.9011.00
143_D204_D0.9001.00
136_D226_E0.9001.00
55_A59_L0.8991.00
79_V82_D0.8991.00
61_E66_L0.8971.00
131_R230_A0.8961.00
350_A365_V0.8961.00
106_G109_A0.8901.00
118_E121_A0.8871.00
365_V386_V0.8861.00
57_D60_E0.8791.00
90_L102_R0.8761.00
23_A26_T0.8741.00
74_A78_D0.8711.00
72_E77_G0.8691.00
248_L252_R0.8591.00
225_D228_A0.8481.00
137_A222_A0.8461.00
281_H359_E0.8451.00
262_G426_V0.8441.00
65_G68_G0.8441.00
225_D235_E0.8421.00
233_V238_L0.8401.00
180_Q183_A0.8401.00
159_V194_L0.8391.00
63_R66_L0.8331.00
72_E75_G0.8291.00
345_D382_E0.8251.00
75_G82_D0.8251.00
22_A26_T0.8221.00
70_Y76_V0.8211.00
271_G336_D0.8201.00
44_F49_Q0.8191.00
26_T45_S0.8181.00
110_D113_L0.8151.00
92_F102_R0.8141.00
75_G79_V0.8131.00
351_L387_A0.8131.00
358_P393_G0.8131.00
81_T84_G0.8121.00
281_H286_L0.8101.00
279_V284_Y0.8081.00
137_A218_D0.8061.00
27_E31_L0.8061.00
376_R384_G0.8061.00
384_G387_A0.8051.00
376_R383_A0.8041.00
26_T42_D0.8031.00
31_L37_R0.8031.00
211_T216_V0.8021.00
264_V351_L0.8011.00
30_A36_G0.7991.00
148_V232_T0.7971.00
86_V107_E0.7951.00
63_R67_Y0.7921.00
163_G244_S0.7921.00
251_P268_G0.7911.00
92_F97_Q0.7861.00
34_E38_E0.7861.00
199_R211_T0.7861.00
75_G78_D0.7851.00
320_V323_D0.7841.00
265_S348_V0.7791.00
75_G81_T0.7771.00
419_V422_V0.7731.00
364_L367_M0.7691.00
61_E68_G0.7691.00
245_Q248_L0.7671.00
55_A61_E0.7671.00
144_G226_E0.7591.00
185_G189_E0.7581.00
252_R255_D0.7571.00
279_V285_F0.7561.00
158_V186_L0.7551.00
385_R388_F0.7541.00
157_G227_L0.7531.00
70_Y74_A0.7531.00
275_D278_D0.7501.00
56_E59_L0.7491.00
134_T143_D0.7431.00
64_Y68_G0.7421.00
279_V283_R0.7381.00
150_D188_T0.7341.00
250_A254_A0.7301.00
26_T43_A0.7291.00
73_S81_T0.7270.99
70_Y73_S0.7260.99
348_V372_L0.7230.99
96_S129_T0.7230.99
259_G346_A0.7230.99
74_A79_V0.7230.99
183_A193_A0.7220.99
366_E386_V0.7200.99
244_S394_H0.7190.99
146_L232_T0.7180.99
22_A28_A0.7170.99
389_Y392_L0.7130.99
266_L351_L0.7120.99
250_A265_S0.7090.99
280_R285_F0.7090.99
37_R41_L0.7060.99
46_A67_Y0.7050.99
151_G155_F0.7050.99
129_T148_V0.7040.99
53_L56_E0.7040.99
212_L215_V0.7000.99
267_D395_Y0.7000.99
255_D340_L0.7000.99
183_A195_R0.6990.99
286_L322_R0.6990.99
100_D115_S0.6960.99
62_F67_Y0.6950.99
148_V155_F0.6950.99
51_G55_A0.6890.99
279_V286_L0.6890.99
418_A422_V0.6890.99
103_V112_A0.6880.99
147_A183_A0.6860.99
158_V239_F0.6860.99
245_Q249_A0.6850.99
265_S270_S0.6850.99
162_H198_K0.6820.99
160_L241_A0.6800.99
217_V221_V0.6800.99
201_H205_V0.6790.99
113_L116_E0.6780.99
41_L45_S0.6770.99
387_A390_D0.6770.99
355_R391_G0.6750.99
385_R389_Y0.6750.99
214_T331_S0.6740.99
63_R68_G0.6720.99
198_K220_A0.6720.99
22_A25_A0.6690.99
133_V194_L0.6680.99
280_R286_L0.6650.99
26_T30_A0.6650.99
269_P272_T0.6640.99
24_T47_G0.6620.99
323_D327_R0.6610.99
143_D208_E0.6610.99
73_S77_G0.6600.99
217_V252_R0.6580.99
362_P386_V0.6560.99
389_Y421_D0.6540.99
53_L62_F0.6540.99
77_G83_D0.6540.99
90_L104_A0.6510.99
52_E58_A0.6500.99
78_D83_D0.6500.99
126_D151_G0.6490.99
278_D282_L0.6490.99
183_A187_A0.6440.99
54_D60_E0.6440.99
144_G196_Y0.6440.99
280_R284_Y0.6380.99
122_Y127_A0.6360.99
45_S48_L0.6360.99
197_E204_D0.6350.99
214_T256_R0.6340.99
348_V368_H0.6330.99
274_P367_M0.6320.99
265_S368_H0.6290.99
241_A422_V0.6270.99
30_A33_S0.6240.98
262_G425_W0.6230.98
419_V423_A0.6210.98
221_V256_R0.6210.98
51_G54_D0.6200.98
33_S37_R0.6200.98
156_A234_D0.6170.98
71_G79_V0.6160.98
103_V114_P0.6160.98
76_V80_T0.6160.98
278_D281_H0.6160.98
41_L44_F0.6150.98
160_L195_R0.6130.98
104_A111_F0.6110.98
26_T47_G0.6100.98
25_A30_A0.6080.98
351_L389_Y0.6080.98
347_P383_A0.6050.98
152_D155_F0.6050.98
252_R340_L0.6040.98
31_L38_E0.6030.98
274_P278_D0.6030.98
72_E78_D0.6020.98
267_D360_A0.6020.98
383_A428_G0.6010.98
238_L261_A0.6000.98
275_D364_L0.5990.98
273_E332_V0.5980.98
207_P211_T0.5960.98
385_R390_D0.5930.98
30_A39_A0.5910.98
46_A49_Q0.5890.98
71_G81_T0.5890.98
224_L228_A0.5880.98
28_A54_D0.5870.98
279_V282_L0.5850.98
60_E66_L0.5830.98
60_E67_Y0.5830.98
267_D352_K0.5820.98
398_T401_E0.5810.98
352_K365_V0.5810.98
384_G389_Y0.5800.98
62_F68_G0.5790.98
77_G82_D0.5780.97
154_P232_T0.5770.97
174_D178_L0.5770.97
243_H395_Y0.5760.97
348_V384_G0.5740.97
223_A227_L0.5710.97
217_V249_A0.5710.97
262_G346_A0.5710.97
48_L52_E0.5690.97
182_F419_V0.5670.97
70_Y77_G0.5650.97
220_A249_A0.5650.97
51_G56_E0.5640.97
184_W187_A0.5630.97
26_T46_A0.5630.97
72_E76_V0.5620.97
384_G388_F0.5620.97
258_G346_A0.5610.97
197_E201_H0.5590.97
133_V230_A0.5580.97
163_G249_A0.5570.97
71_G77_G0.5570.97
71_G78_D0.5570.97
128_F150_D0.5560.97
393_G397_Q0.5560.97
363_E367_M0.5560.97
383_A388_F0.5550.97
158_V191_I0.5540.97
207_P210_H0.5540.97
47_G51_G0.5520.97
69_Q79_V0.5510.97
174_D177_K0.5510.97
26_T29_A0.5510.97
160_L183_A0.5510.97
33_S36_G0.5500.97
138_G218_D0.5490.97
74_A80_T0.5470.97
70_Y79_V0.5470.97
383_A387_A0.5460.96
28_A43_A0.5450.96
40_V44_F0.5450.96
104_A107_E0.5430.96
49_Q52_E0.5430.96
334_D340_L0.5400.96
331_S335_Y0.5400.96
155_F232_T0.5370.96
320_V325_P0.5370.96
210_H216_V0.5350.96
241_A426_V0.5350.96
338_G341_A0.5340.96
39_A44_F0.5340.96
73_S79_V0.5320.96
23_A41_L0.5300.96
243_H396_F0.5290.96
140_V208_E0.5290.96
76_V79_V0.5280.96
275_D279_V0.5270.96
56_E61_E0.5260.96
336_D339_A0.5240.96
30_A34_E0.5220.95
382_E387_A0.5220.95
23_A28_A0.5220.95
186_L423_A0.5220.95
73_S78_D0.5220.95
365_V369_R0.5210.95
37_R54_D0.5200.95
367_M371_L0.5180.95
349_F387_A0.5160.95
266_L396_F0.5160.95
43_A49_Q0.5150.95
162_H201_H0.5140.95
62_F65_G0.5120.95
42_D47_G0.5110.95
140_V199_R0.5110.95
104_A110_D0.5100.95
177_K181_D0.5090.95
74_A81_T0.5090.95
28_A41_L0.5050.95
45_S49_Q0.5050.95
127_A184_W0.5040.95
267_D393_G0.5030.94
271_G364_L0.5020.94
209_E216_V0.5020.94
41_L48_L0.5020.94
115_S119_P0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2z3zA 2 0.8287 100 0.435 Contact Map
4q1vA 2 0.8542 100 0.447 Contact Map
1xfdA 2 0.8565 100 0.45 Contact Map
4wjlA 2 0.8542 100 0.457 Contact Map
3azoA 1 0.8657 100 0.462 Contact Map
4a5sA 2 0.8565 100 0.47 Contact Map
4hxfB 4 0.8426 100 0.472 Contact Map
1z68A 2 0.8495 100 0.474 Contact Map
2ecfA 2 0.8495 100 0.479 Contact Map
3iujA 1 0.8449 100 0.495 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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