GREMLIN Database
Q9HPY0 - Uncharacterized protein
UniProt: Q9HPY0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 303 (263)
Sequences: 242 (190)
Seq/√Len: 11.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
34_S59_R5.7161.00
33_A168_A5.3641.00
94_A106_D5.2931.00
20_Q151_N4.0980.99
87_G91_S3.8550.99
58_L85_V3.7930.99
79_P98_A3.1980.97
116_G119_L3.0970.96
54_G71_L3.0400.96
68_V72_T3.0380.96
112_Y129_A2.9980.95
39_A86_V2.9600.95
151_N160_E2.8190.93
114_A129_A2.7510.93
120_A124_T2.7380.92
195_E198_R2.6970.92
68_V83_V2.6720.91
189_H195_E2.6710.91
148_H197_E2.5500.89
40_I67_V2.5490.89
48_V177_G2.5270.89
160_E191_H2.4790.88
3_F151_N2.4010.86
18_A143_L2.3890.86
94_A108_Q2.3850.86
29_V46_A2.3260.84
58_L67_V2.1570.79
112_Y133_E2.1130.78
106_D113_T2.0240.75
124_T204_D2.0050.74
12_T15_V1.9220.71
151_N193_I1.8990.70
121_N124_T1.8870.69
243_R246_G1.8550.68
189_H198_R1.8450.67
50_Y72_T1.8380.67
56_D60_A1.8350.67
94_A113_T1.7940.65
32_F51_G1.7780.64
258_A263_E1.7690.64
129_A133_E1.7430.63
92_V108_Q1.7090.61
20_Q193_I1.7090.61
33_A39_A1.6690.59
35_A179_D1.6470.58
44_S80_Q1.6160.57
169_K172_G1.5850.55
16_G143_L1.5580.54
91_S152_D1.5420.53
3_F125_V1.4900.50
114_A132_F1.4790.50
64_A91_S1.4780.50
141_E204_D1.4700.49
202_I206_T1.4560.49
260_N265_H1.4480.48
102_D144_L1.4410.48
65_D69_A1.4340.48
17_V86_V1.4300.47
84_G113_T1.4190.47
64_A87_G1.4150.47
191_H194_D1.4110.47
245_F250_R1.4090.46
161_Q188_D1.3960.46
5_I114_A1.3540.44
24_V207_L1.3430.43
109_G112_Y1.3070.41
49_A53_D1.3050.41
59_R88_Q1.2810.40
20_Q121_N1.2680.40
21_S188_D1.2670.40
257_Q266_D1.2660.39
24_V184_V1.2390.38
5_I139_L1.2380.38
53_D74_T1.2340.38
130_D137_G1.2300.38
68_V85_V1.2190.37
14_A169_K1.1930.36
54_G57_L1.1900.36
120_A151_N1.1860.36
62_H70_E1.1810.36
174_Y261_N1.1670.35
132_F139_L1.1650.35
8_R15_V1.1560.34
245_F249_E1.1560.34
12_T199_V1.1450.34
68_V127_A1.1410.34
40_I65_D1.1370.34
39_A84_G1.1360.34
50_Y83_V1.1290.33
109_G186_V1.1240.33
53_D56_D1.1230.33
58_L71_L1.1210.33
26_V164_A1.1200.33
99_E136_D1.1190.33
9_D51_G1.1180.33
20_Q256_F1.1080.32
40_I85_V1.1060.32
147_L167_V1.1060.32
17_V229_A1.0920.32
37_A85_V1.0850.31
236_F259_V1.0840.31
59_R227_V1.0830.31
33_A166_Y1.0740.31
10_P15_V1.0680.31
32_F150_G1.0580.30
54_G216_Y1.0530.30
231_L235_G1.0510.30
47_N71_L1.0440.30
258_A262_F1.0440.30
103_H125_V1.0420.29
255_A259_V1.0410.29
138_G141_E1.0400.29
40_I200_F1.0350.29
17_V28_S1.0280.29
44_S100_C1.0160.28
20_Q150_G1.0160.28
5_I206_T1.0140.28
151_N191_H1.0130.28
35_A189_H1.0110.28
23_F119_L1.0010.28
125_V174_Y1.0000.28
7_A139_L0.9980.28
100_C104_A0.9910.27
104_A179_D0.9870.27
27_G164_A0.9760.27
25_A248_A0.9740.27
213_P227_V0.9730.27
50_Y71_L0.9700.27
7_A114_A0.9630.26
150_G227_V0.9610.26
219_L227_V0.9600.26
127_A130_D0.9550.26
40_I51_G0.9530.26
46_A100_C0.9470.26
84_G115_Q0.9450.26
15_V39_A0.9380.25
176_G179_D0.9380.25
24_V187_D0.9370.25
115_Q128_M0.9290.25
45_L258_A0.9260.25
70_E110_D0.9170.25
7_A210_R0.9140.24
40_I58_L0.9020.24
57_L90_G0.9020.24
18_A180_R0.9010.24
188_D195_E0.9000.24
34_S37_A0.8960.24
5_I128_M0.8890.24
112_Y186_V0.8860.23
25_A139_L0.8840.23
147_L252_A0.8830.23
3_F116_G0.8810.23
174_Y205_I0.8720.23
21_S30_V0.8680.23
29_V56_D0.8650.23
14_A140_P0.8590.23
24_V185_R0.8580.22
20_Q160_E0.8570.22
130_D190_D0.8530.22
84_G112_Y0.8500.22
35_A146_A0.8480.22
67_V92_V0.8440.22
107_R126_D0.8400.22
54_G67_V0.8400.22
14_A204_D0.8360.22
145_A258_A0.8270.21
3_F166_Y0.8240.21
212_A216_Y0.8230.21
30_V159_G0.8200.21
221_G227_V0.8200.21
69_A134_D0.8130.21
259_V266_D0.8060.21
9_D127_A0.8040.21
21_S159_G0.8030.21
23_F205_I0.8010.21
109_G179_D0.8010.21
51_G180_R0.8000.21
188_D198_R0.7830.20
75_D100_C0.7790.20
258_A266_D0.7780.20
9_D32_F0.7780.20
60_A191_H0.7770.20
39_A113_T0.7740.20
9_D12_T0.7740.20
84_G94_A0.7730.20
103_H143_L0.7720.20
11_E70_E0.7720.20
64_A129_A0.7680.20
66_E189_H0.7650.19
14_A139_L0.7580.19
5_I89_D0.7570.19
34_S56_D0.7570.19
74_T227_V0.7560.19
37_A152_D0.7540.19
54_G91_S0.7520.19
32_F44_S0.7510.19
252_A263_E0.7490.19
70_E73_N0.7450.19
184_V199_V0.7440.19
20_Q124_T0.7380.19
67_V222_D0.7330.18
132_F153_A0.7320.18
128_M139_L0.7320.18
52_S115_Q0.7310.18
228_L232_S0.7280.18
124_T151_N0.7220.18
44_S50_Y0.7210.18
116_G125_V0.7190.18
79_P95_F0.7180.18
59_R150_G0.7160.18
20_Q178_N0.7160.18
105_S125_V0.7160.18
110_D123_A0.7140.18
23_F174_Y0.7140.18
112_Y141_E0.7130.18
116_G121_N0.7130.18
25_A187_D0.7120.18
229_A232_S0.7110.18
76_D251_D0.7100.18
45_L114_A0.7090.18
158_R161_Q0.7090.18
122_R126_D0.7060.18
64_A108_Q0.7060.18
86_V111_H0.7060.18
14_A124_T0.7050.18
237_Y243_R0.7030.18
48_V253_L0.7000.17
30_V41_A0.6990.17
249_E259_V0.6990.17
263_E266_D0.6950.17
59_R67_V0.6930.17
40_I87_G0.6890.17
261_N265_H0.6890.17
88_Q190_D0.6860.17
59_R85_V0.6850.17
193_I259_V0.6840.17
173_G261_N0.6780.17
44_S141_E0.6780.17
8_R181_W0.6740.17
64_A68_V0.6720.17
47_N54_G0.6690.17
6_V168_A0.6640.16
105_S119_L0.6630.16
184_V187_D0.6620.16
254_A266_D0.6620.16
228_L237_Y0.6580.16
211_V215_E0.6570.16
137_G144_L0.6540.16
64_A79_P0.6520.16
28_S48_V0.6520.16
79_P263_E0.6510.16
23_F116_G0.6510.16
158_R188_D0.6500.16
169_K181_W0.6500.16
56_D152_D0.6490.16
95_F230_A0.6490.16
103_H174_Y0.6460.16
28_S142_R0.6450.16
138_G145_A0.6440.16
41_A161_Q0.6440.16
37_A107_R0.6420.16
29_V178_N0.6400.16
128_M149_A0.6400.16
144_L247_D0.6330.16
54_G192_P0.6310.16
7_A227_V0.6300.16
112_Y181_W0.6290.16
86_V113_T0.6290.16
44_S188_D0.6260.15
108_Q147_L0.6240.15
250_R254_A0.6230.15
9_D60_A0.6220.15
21_S156_D0.6220.15
204_D215_E0.6190.15
21_S179_D0.6190.15
262_F265_H0.6180.15
15_V168_A0.6150.15
96_T159_G0.6140.15
3_F115_Q0.6140.15
125_V140_P0.6130.15
254_A259_V0.6130.15
175_D265_H0.6130.15
24_V265_H0.6120.15
56_D140_P0.6100.15
57_L104_A0.6090.15
262_F267_L0.6070.15
107_R130_D0.6060.15
65_D173_G0.6020.15
84_G106_D0.6010.15
8_R12_T0.6010.15
205_I260_N0.6000.15
44_S214_T0.6000.15
161_Q195_E0.6000.15
14_A268_A0.6000.15
63_S251_D0.5980.15
16_G31_P0.5960.15
68_V227_V0.5960.15
172_G180_R0.5950.15
89_D136_D0.5940.15
114_A257_Q0.5930.15
22_K116_G0.5920.15
201_H251_D0.5920.15
66_E69_A0.5920.15
12_T56_D0.5910.15
72_T95_F0.5900.15
23_F46_A0.5900.15
40_I54_G0.5880.15
103_H205_I0.5870.14
50_Y256_F0.5870.14
25_A92_V0.5860.14
19_V115_Q0.5800.14
78_A118_I0.5800.14
6_V86_V0.5800.14
11_E145_A0.5780.14
57_L71_L0.5770.14
214_T230_A0.5750.14
261_N264_N0.5730.14
34_S141_E0.5700.14
138_G229_A0.5690.14
6_V144_L0.5680.14
111_H124_T0.5670.14
116_G261_N0.5670.14
65_D232_S0.5660.14
84_G236_F0.5630.14
139_L153_A0.5620.14
21_S158_R0.5620.14
251_D266_D0.5600.14
165_L264_N0.5580.14
76_D215_E0.5580.14
5_I225_E0.5550.14
124_T200_F0.5540.14
51_G62_H0.5510.14
18_A139_L0.5500.14
112_Y123_A0.5490.14
50_Y220_A0.5480.14
13_D36_D0.5480.14
100_C106_D0.5480.14
18_A193_I0.5480.14
127_A240_A0.5470.14
184_V206_T0.5450.13
72_T197_E0.5430.13
9_D21_S0.5430.13
90_G104_A0.5420.13
22_K174_Y0.5420.13
76_D218_E0.5410.13
84_G157_Q0.5410.13
29_V67_V0.5410.13
47_N179_D0.5400.13
245_F266_D0.5380.13
230_A240_A0.5380.13
121_N152_D0.5370.13
5_I18_A0.5360.13
29_V194_D0.5360.13
18_A124_T0.5360.13
227_V231_L0.5360.13
246_G249_E0.5350.13
44_S193_I0.5330.13
160_E200_F0.5330.13
86_V213_P0.5330.13
25_A185_R0.5330.13
22_K236_F0.5310.13
120_A123_A0.5290.13
32_F64_A0.5290.13
126_D133_E0.5290.13
118_I166_Y0.5280.13
253_L256_F0.5280.13
129_A186_V0.5270.13
152_D223_T0.5270.13
181_W228_L0.5270.13
131_T194_D0.5240.13
247_D268_A0.5230.13
200_F266_D0.5230.13
106_D174_Y0.5210.13
114_A128_M0.5160.13
25_A79_P0.5140.13
74_T140_P0.5140.13
8_R111_H0.5140.13
18_A103_H0.5130.13
18_A174_Y0.5130.13
67_V215_E0.5130.13
31_P164_A0.5110.13
74_T83_V0.5110.13
42_T75_D0.5110.13
40_I89_D0.5070.13
36_D59_R0.5070.13
140_P160_E0.5070.13
58_L121_N0.5060.13
114_A256_F0.5060.13
22_K119_L0.5050.13
258_A267_L0.5040.13
87_G193_I0.5030.13
108_Q191_H0.5030.13
28_S45_L0.5020.13
16_G231_L0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2imhA 2 0.7294 100 0.383 Contact Map
4fetB 1 0.033 69 0.966 Contact Map
3bkhA 1 0.2871 66.4 0.967 Contact Map
4lpqA 1 0.297 62.6 0.968 Contact Map
4o0cA 2 0.4092 59.9 0.968 Contact Map
4nsoA 1 0.0297 57.6 0.969 Contact Map
4pv2B 2 0.3828 55.2 0.969 Contact Map
3c17A 2 0.3993 43.7 0.971 Contact Map
2gezB 2 0.3828 39.9 0.972 Contact Map
4g54A 1 0.5446 34.6 0.973 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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