GREMLIN Database
Q9HPX7 - Uncharacterized protein
UniProt: Q9HPX7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 92 (87)
Sequences: 291 (131)
Seq/√Len: 14.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
82_R85_E2.8400.96
41_G45_P2.7330.95
81_R85_E2.5810.94
38_I52_E2.4110.91
40_H43_L2.3870.91
73_R77_E2.3060.89
24_L30_L2.0630.83
61_L67_Y1.9790.80
22_H25_A1.9320.78
31_E38_I1.8330.74
45_P58_K1.8100.73
6_G9_R1.8040.73
53_K76_R1.7940.73
59_G67_Y1.7330.70
5_T74_G1.7050.69
73_R76_R1.6630.67
15_V28_D1.6360.65
35_T48_D1.5980.63
5_T42_R1.5940.63
6_G10_D1.5740.62
45_P74_G1.5740.62
21_P67_Y1.5660.62
19_D87_Q1.5330.60
16_A26_I1.4770.57
41_G58_K1.4360.55
29_E41_G1.3940.53
38_I73_R1.3640.51
5_T8_Q1.3050.48
17_G21_P1.2970.47
17_G85_E1.2640.46
10_D81_R1.2550.45
60_E72_H1.2500.45
13_Y81_R1.2360.44
22_H30_L1.2240.43
15_V70_L1.2030.42
58_K84_W1.1920.42
15_V21_P1.1750.41
4_L8_Q1.1400.39
29_E80_A1.1280.38
2_H74_G1.1010.37
22_H61_L1.0730.36
53_K88_Y1.0670.35
39_H63_Q1.0460.34
45_P48_D1.0350.34
33_Y84_W1.0130.33
56_I75_T0.9900.32
29_E33_Y0.9680.31
8_Q27_K0.9650.30
3_D87_Q0.9250.29
54_G73_R0.9210.28
81_R84_W0.9160.28
77_E80_A0.9020.28
82_R86_T0.8990.28
34_Y38_I0.8990.28
29_E55_L0.8670.26
74_G79_E0.8600.26
33_Y71_T0.8520.26
45_P49_T0.8500.25
15_V56_I0.8490.25
9_R49_T0.8400.25
56_I79_E0.8210.24
7_F64_R0.8160.24
38_I59_G0.8000.23
3_D34_Y0.7970.23
49_T53_K0.7900.23
6_G21_P0.7890.23
2_H35_T0.7780.23
39_H62_D0.7650.22
24_L34_Y0.7630.22
13_Y85_E0.7600.22
43_L62_D0.7600.22
11_L37_E0.7490.21
52_E72_H0.7440.21
23_G66_N0.7280.21
80_A85_E0.7220.21
19_D26_I0.7200.20
78_L86_T0.7190.20
3_D40_H0.7190.20
58_K66_N0.7110.20
40_H62_D0.7090.20
58_K81_R0.7010.20
41_G65_T0.6900.19
9_R12_L0.6880.19
4_L31_E0.6790.19
9_R21_P0.6690.19
68_Y71_T0.6680.19
35_T39_H0.6580.18
5_T46_N0.6570.18
48_D83_E0.6550.18
55_L77_E0.6540.18
51_V65_T0.6500.18
20_E70_L0.6500.18
29_E53_K0.6400.18
54_G80_A0.6400.18
41_G66_N0.6360.18
11_L49_T0.6320.18
42_R55_L0.6270.17
20_E24_L0.6260.17
13_Y17_G0.6260.17
13_Y84_W0.6240.17
61_L75_T0.6190.17
74_G83_E0.6070.17
3_D76_R0.6030.17
16_A72_H0.6010.17
20_E30_L0.6000.17
37_E73_R0.5980.16
32_Q35_T0.5940.16
10_D17_G0.5880.16
14_V71_T0.5870.16
40_H55_L0.5870.16
47_L65_T0.5820.16
20_E69_T0.5810.16
31_E49_T0.5810.16
51_V56_I0.5800.16
45_P63_Q0.5740.16
54_G70_L0.5720.16
41_G51_V0.5710.16
35_T78_L0.5610.15
21_P78_L0.5500.15
9_R15_V0.5450.15
45_P60_E0.5430.15
11_L46_N0.5430.15
10_D13_Y0.5410.15
29_E88_Y0.5340.15
23_G64_R0.5290.15
28_D79_E0.5280.14
48_D74_G0.5230.14
51_V81_R0.5130.14
3_D56_I0.5070.14
20_E56_I0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2co5A 2 0.9783 98.7 0.746 Contact Map
3l9fA 2 0.9022 98.6 0.759 Contact Map
1yg2A 2 0.8478 98.4 0.774 Contact Map
3f8bA 2 0.9674 98.4 0.776 Contact Map
1xmaA 2 0.9565 98.3 0.777 Contact Map
3elkA 3 0.9674 98.3 0.779 Contact Map
2e1nA 2 0.9457 98.3 0.78 Contact Map
2zfwA 2 0.9783 98.3 0.78 Contact Map
2eshA 2 0.9783 98.3 0.781 Contact Map
2dqlA 2 0.9783 98.2 0.782 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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