Q9HPX5 - HALSA - GREMLIN Contacts

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Q9HPX5 - Htr-like protein

UniProt:	Q9HPX5	Sequences: MGDTRIDRGRAAWWAIGATLTAALVYVVYTFVGTFVLGFFLYYATRPVYRRVDRHLRSSSVAAVVSLLVLALPVVVLLSYTTAVGIQELTRVLNAPQIDLTTVEALVQPYVDVSRAVQDPQSLLGQPSVRAAINTTLRSAGQYAGFLGTAFVHLFAVITIAFYLLRDDTRLAEWFHSRFADSDGVVRAYTAAIDADFSNIFFGNILFAFITGVIASITFNVLQIVFPSSLSIPYPTLMGLLTGAASLIPVVGIKLVWIPLLGWLAVAAARSGGGYGFVAVFGVVAAVVIDFIPDLVVRPYVSGRDLHLGLVMLAYVFGPLIWGWYGIFLGPMVLVFVVHFARLVLPELVAGEGIAPVPAGADDTPASDADPESAADPDDTAA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	382 (322)
Sequences:	10979 (8512)
Seq/√Len:	474.4

ECOLI - YDIK PERM YHHT TQSA
BACSU - YUBA YTVI YUEF YDBI YRRI
HALSA - Q9HPX5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
218_T	285_A	5.099	1.00
216_S	239_G	4.908	1.00
51_R	55_H	4.481	1.00
314_A	334_L	3.067	1.00
43_Y	194_D	2.850	1.00
212_G	243_G	2.793	1.00
53_D	59_S	2.637	1.00
277_F	281_F	2.627	1.00
280_V	284_V	2.471	1.00
216_S	220_N	2.411	1.00
51_R	54_R	2.408	1.00
41_L	161_A	2.353	1.00
58_S	61_V	2.279	1.00
212_G	239_G	2.244	1.00
261_L	283_V	2.167	1.00
338_V	342_R	2.160	1.00
26_Y	29_Y	2.023	1.00
219_F	232_I	1.976	1.00
95_A	98_I	1.961	1.00
261_L	279_A	1.961	1.00
192_A	343_L	1.939	1.00
116_A	119_D	1.937	1.00
111_V	114_S	1.925	1.00
46_R	50_R	1.915	1.00
188_A	343_L	1.908	1.00
117_V	120_P	1.908	1.00
101_T	104_E	1.903	1.00
281_F	284_V	1.857	1.00
60_S	64_V	1.839	1.00
205_I	247_L	1.802	1.00
38_G	161_A	1.785	1.00
203_G	301_V	1.774	1.00
193_I	336_F	1.755	1.00
215_A	242_T	1.753	1.00
241_L	245_A	1.737	1.00
49_Y	66_S	1.732	1.00
162_F	166_R	1.723	1.00
284_V	288_V	1.716	1.00
300_Y	304_R	1.695	1.00
119_D	122_S	1.685	1.00
49_Y	63_A	1.680	1.00
176_H	187_R	1.669	1.00
48_V	66_S	1.661	1.00
63_A	67_L	1.657	1.00
222_L	231_S	1.631	1.00
63_A	162_F	1.629	1.00
157_V	161_A	1.625	1.00
121_Q	125_G	1.616	1.00
235_P	239_G	1.613	1.00
93_L	97_Q	1.607	1.00
119_D	123_L	1.606	1.00
22_A	26_Y	1.601	1.00
167_D	307_H	1.592	1.00
106_L	110_Y	1.586	1.00
122_S	126_Q	1.582	1.00
278_V	281_F	1.577	1.00
217_I	220_N	1.575	1.00
160_I	309_G	1.565	1.00
23_A	27_V	1.562	1.00
233_P	267_A	1.551	1.00
75_V	79_S	1.549	1.00
52_V	69_V	1.544	1.00
179_F	186_V	1.534	1.00
60_S	166_R	1.526	1.00
216_S	235_P	1.508	1.00
319_P	327_I	1.507	1.00
268_A	278_V	1.503	1.00
211_T	246_S	1.502	1.00
46_R	59_S	1.490	1.00
215_A	289_I	1.488	1.00
116_A	121_Q	1.485	1.00
220_N	235_P	1.485	1.00
106_L	109_P	1.482	1.00
88_E	93_L	1.463	1.00
90_T	94_N	1.463	1.00
102_T	105_A	1.439	1.00
19_T	23_A	1.425	1.00
57_R	65_V	1.407	1.00
35_F	313_L	1.389	1.00
160_I	164_L	1.380	1.00
245_A	256_V	1.378	1.00
277_F	280_V	1.378	1.00
287_V	291_F	1.376	1.00
98_I	102_T	1.373	1.00
18_A	22_A	1.369	1.00
214_I	289_I	1.367	1.00
120_P	123_L	1.366	1.00
283_V	287_V	1.354	1.00
257_W	261_L	1.350	1.00
222_L	232_I	1.346	1.00
11_A	15_A	1.336	1.00
87_Q	91_R	1.326	1.00
118_Q	122_S	1.323	1.00
292_I	297_V	1.320	1.00
104_E	108_Q	1.304	1.00
264_L	282_G	1.291	1.00
123_L	126_Q	1.288	1.00
45_T	165_L	1.273	1.00
238_M	260_L	1.263	1.00
297_V	301_V	1.260	1.00
98_I	101_T	1.250	1.00
196_D	335_V	1.244	1.00
173_E	177_S	1.241	1.00
22_A	25_V	1.240	1.00
207_F	293_P	1.238	1.00
97_Q	101_T	1.226	1.00
105_A	109_P	1.222	1.00
131_A	134_N	1.214	1.00
17_G	21_T	1.210	1.00
122_S	125_G	1.209	1.00
49_Y	59_S	1.208	1.00
45_T	70_L	1.200	1.00
218_T	222_L	1.188	1.00
218_T	281_F	1.184	1.00
49_Y	62_A	1.184	1.00
290_D	294_D	1.183	1.00
38_G	157_V	1.180	1.00
41_L	157_V	1.178	1.00
96_P	99_D	1.176	1.00
167_D	170_R	1.174	1.00
49_Y	165_L	1.171	1.00
192_A	342_R	1.163	1.00
132_A	136_T	1.163	1.00
49_Y	53_D	1.152	1.00
217_I	221_V	1.150	1.00
46_R	168_D	1.149	1.00
260_L	282_G	1.147	1.00
315_Y	327_I	1.147	1.00
48_V	51_R	1.146	1.00
281_F	285_A	1.143	1.00
107_V	111_V	1.141	1.00
108_Q	111_V	1.141	1.00
82_T	86_I	1.140	1.00
64_V	68_L	1.138	1.00
79_S	83_A	1.134	1.00
202_F	206_L	1.129	1.00
42_Y	164_L	1.127	1.00
310_L	334_L	1.127	1.00
180_A	183_D	1.115	1.00
205_I	209_F	1.113	1.00
264_L	279_A	1.109	1.00
232_I	264_L	1.107	1.00
53_D	62_A	1.103	1.00
188_A	192_A	1.102	1.00
140_A	144_A	1.099	1.00
71_A	75_V	1.098	1.00
170_R	173_E	1.097	1.00
60_S	162_F	1.096	1.00
62_A	66_S	1.089	1.00
211_T	289_I	1.086	1.00
35_F	160_I	1.086	1.00
95_A	99_D	1.084	1.00
129_V	132_A	1.081	1.00
189_Y	340_F	1.080	1.00
117_V	123_L	1.078	1.00
318_G	322_W	1.078	1.00
110_Y	113_V	1.070	1.00
34_T	38_G	1.067	1.00
208_A	246_S	1.056	1.00
12_A	16_I	1.052	1.00
38_G	42_Y	1.046	1.00
314_A	318_G	1.042	1.00
91_R	94_N	1.039	1.00
318_G	334_L	1.038	1.00
216_S	236_T	1.033	1.00
128_S	131_A	1.032	1.00
116_A	120_P	1.031	1.00
90_T	93_L	1.030	1.00
61_V	64_V	1.027	1.00
212_G	216_S	1.025	1.00
239_G	243_G	1.023	1.00
84_V	88_E	1.021	1.00
206_L	210_I	1.019	1.00
296_V	300_Y	1.018	1.00
314_A	330_G	1.016	1.00
15_A	19_T	1.012	1.00
294_D	298_R	1.011	1.00
51_R	56_L	1.009	1.00
37_L	157_V	1.002	1.00
285_A	289_I	0.999	1.00
118_Q	121_Q	0.999	1.00
209_F	243_G	0.997	1.00
39_F	164_L	0.986	1.00
199_N	203_G	0.986	1.00
325_Y	329_L	0.983	1.00
23_A	26_Y	0.982	1.00
174_W	177_S	0.981	1.00
150_A	154_L	0.980	1.00
219_F	282_G	0.977	1.00
211_T	253_I	0.968	1.00
105_A	108_Q	0.968	1.00
204_N	298_R	0.967	1.00
67_L	161_A	0.960	1.00
160_I	313_L	0.957	1.00
288_V	292_I	0.952	1.00
144_A	148_G	0.952	1.00
302_S	311_V	0.950	1.00
185_V	347_E	0.947	1.00
218_T	289_I	0.946	1.00
263_W	267_A	0.941	1.00
199_N	305_D	0.938	1.00
38_G	160_I	0.935	1.00
109_P	112_D	0.935	1.00
219_F	238_M	0.931	1.00
50_R	53_D	0.928	1.00
102_T	106_L	0.928	1.00
52_V	56_L	0.928	1.00
222_L	285_A	0.924	1.00
340_F	344_V	0.923	1.00
156_A	160_I	0.922	1.00
115_R	118_Q	0.920	1.00
14_W	18_A	0.919	1.00
234_Y	237_L	0.919	1.00
243_G	247_L	0.914	1.00
207_F	297_V	0.913	1.00
219_F	242_T	0.913	1.00
84_V	87_Q	0.912	1.00
241_L	256_V	0.912	1.00
222_L	281_F	0.908	1.00
207_F	211_T	0.907	1.00
117_V	121_Q	0.902	1.00
265_A	279_A	0.899	1.00
107_V	110_Y	0.899	1.00
195_A	199_N	0.896	1.00
222_L	282_G	0.895	1.00
222_L	278_V	0.892	1.00
337_V	341_A	0.891	1.00
292_I	296_V	0.891	1.00
255_L	259_P	0.888	1.00
91_R	95_A	0.888	1.00
168_D	172_A	0.885	1.00
88_E	91_R	0.885	1.00
99_D	103_V	0.883	1.00
101_T	105_A	0.880	1.00
213_V	217_I	0.877	1.00
15_A	18_A	0.865	1.00
215_A	219_F	0.864	1.00
310_L	338_V	0.863	1.00
239_G	242_T	0.862	1.00
13_W	17_G	0.859	1.00
21_T	24_L	0.859	1.00
276_G	279_A	0.858	1.00
330_G	334_L	0.856	1.00
52_V	66_S	0.856	1.00
87_Q	90_T	0.849	1.00
211_T	215_A	0.848	1.00
170_R	174_W	0.847	1.00
276_G	280_V	0.847	1.00
143_Y	147_L	0.841	1.00
279_A	283_V	0.833	1.00
26_Y	30_T	0.833	1.00
238_M	263_W	0.832	1.00
31_F	317_F	0.831	1.00
207_F	298_R	0.831	1.00
19_T	22_A	0.829	1.00
53_D	56_L	0.828	1.00
172_A	176_H	0.828	1.00
89_L	93_L	0.826	1.00
57_R	62_A	0.822	1.00
210_I	297_V	0.820	1.00
186_V	190_T	0.816	1.00
57_R	61_V	0.814	1.00
262_G	266_V	0.807	1.00
86_I	89_L	0.804	1.00
136_T	139_S	0.803	1.00
50_R	54_R	0.803	1.00
220_N	239_G	0.802	1.00
17_G	24_L	0.801	1.00
176_H	183_D	0.801	1.00
213_V	216_S	0.800	1.00
189_Y	343_L	0.797	1.00
208_A	247_L	0.791	1.00
42_Y	161_A	0.788	1.00
185_V	188_A	0.787	1.00
246_S	253_I	0.784	1.00
313_L	317_F	0.780	1.00
207_F	302_S	0.780	1.00
133_I	136_T	0.779	1.00
16_I	20_L	0.778	1.00
27_V	30_T	0.775	1.00
11_A	14_W	0.775	1.00
94_N	98_I	0.773	1.00
192_A	339_H	0.769	1.00
208_A	212_G	0.769	1.00
184_G	188_A	0.768	1.00
59_S	169_T	0.766	1.00
306_L	334_L	0.765	1.00
209_F	213_V	0.763	1.00
130_R	134_N	0.763	1.00
207_F	246_S	0.760	1.00
220_N	231_S	0.759	1.00
100_L	104_E	0.756	1.00
282_G	286_A	0.756	1.00
261_L	265_A	0.755	1.00
80_Y	84_V	0.755	1.00
174_W	178_R	0.754	1.00
291_F	295_L	0.752	1.00
257_W	286_A	0.744	1.00
242_T	256_V	0.743	1.00
18_A	21_T	0.741	1.00
24_L	28_V	0.740	1.00
303_G	311_V	0.737	1.00
187_R	191_A	0.736	1.00
161_A	165_L	0.732	1.00
106_L	111_V	0.728	1.00
211_T	298_R	0.726	1.00
290_D	293_P	0.720	1.00
107_V	112_D	0.720	1.00
19_T	26_Y	0.719	1.00
111_V	115_R	0.719	1.00
183_D	187_R	0.718	1.00
45_T	66_S	0.718	1.00
293_P	298_R	0.714	1.00
210_I	214_I	0.704	1.00
298_R	302_S	0.704	1.00
135_T	138_R	0.701	1.00
136_T	140_A	0.699	1.00
178_R	341_A	0.697	1.00
207_F	301_V	0.696	1.00
52_V	57_R	0.696	1.00
221_V	231_S	0.695	1.00
108_Q	112_D	0.694	1.00
128_S	133_I	0.693	1.00
215_A	239_G	0.689	1.00
192_A	196_D	0.689	1.00
131_A	135_T	0.688	1.00
246_S	298_R	0.686	1.00
46_R	165_L	0.684	1.00
73_P	77_L	0.679	1.00
256_V	260_L	0.678	1.00
212_G	240_L	0.675	1.00
250_V	308_L	0.675	1.00
156_A	316_V	0.675	1.00
45_T	48_V	0.674	1.00
146_F	149_T	0.673	1.00
120_P	125_G	0.673	1.00
50_R	169_T	0.672	1.00
42_Y	46_R	0.670	1.00
267_A	278_V	0.668	1.00
149_T	153_H	0.668	1.00
185_V	343_L	0.665	1.00
150_A	153_H	0.665	1.00
189_Y	193_I	0.661	1.00
264_L	268_A	0.660	1.00
132_A	135_T	0.660	1.00
334_L	338_V	0.659	1.00
196_D	199_N	0.659	1.00
206_L	301_V	0.658	1.00
45_T	161_A	0.658	1.00
179_F	182_S	0.658	1.00
215_A	285_A	0.655	1.00
318_G	333_V	0.654	1.00
86_I	90_T	0.653	1.00
208_A	211_T	0.649	1.00
14_W	17_G	0.649	1.00
76_V	80_Y	0.648	1.00
193_I	339_H	0.647	1.00
141_G	145_G	0.646	1.00
311_V	331_P	0.645	1.00
13_W	16_I	0.645	1.00
52_V	65_V	0.643	1.00
183_D	186_V	0.640	1.00
173_E	176_H	0.640	1.00
25_V	28_V	0.640	1.00
22_A	30_T	0.638	1.00
211_T	293_P	0.638	1.00
298_R	301_V	0.636	1.00
120_P	124_L	0.635	1.00
137_L	141_G	0.634	1.00
12_A	15_A	0.633	1.00
242_T	246_S	0.630	1.00
24_L	27_V	0.629	1.00
133_I	137_L	0.627	0.99
67_L	162_F	0.626	0.99
208_A	243_G	0.625	0.99
20_L	24_L	0.625	0.99
174_W	310_L	0.624	0.99
172_A	191_A	0.623	0.99
113_V	116_A	0.623	0.99
35_F	164_L	0.620	0.99
147_L	151_F	0.616	0.99
206_L	209_F	0.611	0.99
300_Y	303_G	0.610	0.99
212_G	236_T	0.609	0.99
269_A	278_V	0.608	0.99
291_F	294_D	0.606	0.99
42_Y	165_L	0.605	0.99
198_S	202_F	0.604	0.99
176_H	180_A	0.604	0.99
34_T	153_H	0.602	0.99
34_T	303_G	0.600	0.99
121_Q	126_Q	0.599	0.99
116_A	125_G	0.599	0.99
95_A	233_P	0.598	0.99
308_L	312_M	0.598	0.99
25_V	29_Y	0.598	0.99
52_V	62_A	0.596	0.99
191_A	195_A	0.595	0.99
135_T	139_S	0.595	0.99
134_N	138_R	0.594	0.99
118_Q	123_L	0.594	0.99
78_L	82_T	0.590	0.99
243_G	250_V	0.589	0.99
211_T	290_D	0.589	0.99
322_W	326_G	0.589	0.99
37_L	41_L	0.589	0.99
315_Y	331_P	0.587	0.99
85_G	89_L	0.587	0.99
69_V	72_L	0.584	0.99
176_H	179_F	0.578	0.99
204_N	246_S	0.577	0.99
152_V	156_A	0.575	0.99
175_F	178_R	0.575	0.99
146_F	150_A	0.574	0.99
173_E	187_R	0.572	0.99
203_G	305_D	0.572	0.99
103_V	106_L	0.571	0.99
171_L	174_W	0.571	0.99
103_V	107_V	0.570	0.99
15_A	22_A	0.569	0.99
72_L	75_V	0.568	0.99
149_T	295_L	0.567	0.99
202_F	305_D	0.566	0.99
259_P	262_G	0.565	0.99
293_P	297_V	0.565	0.99
265_A	276_G	0.565	0.99
241_L	259_P	0.565	0.99
139_S	143_Y	0.564	0.99
58_S	62_A	0.564	0.99
163_Y	167_D	0.563	0.99
81_T	85_G	0.562	0.99
22_A	29_Y	0.562	0.99
324_W	327_I	0.560	0.99
253_I	290_D	0.559	0.99
242_T	253_I	0.558	0.99
137_L	140_A	0.558	0.99
73_P	76_V	0.556	0.99
219_F	239_G	0.553	0.99
100_L	103_V	0.551	0.99
164_L	309_G	0.546	0.99
325_Y	330_G	0.543	0.99
63_A	166_R	0.543	0.99
12_A	17_G	0.542	0.99
53_D	58_S	0.542	0.99
286_A	290_D	0.541	0.99
253_I	256_V	0.541	0.99
16_I	19_T	0.541	0.99
215_A	243_G	0.535	0.98
115_R	119_D	0.534	0.98
211_T	243_G	0.532	0.98
232_I	267_A	0.532	0.98
128_S	132_A	0.531	0.98
256_V	290_D	0.531	0.98
154_L	158_I	0.530	0.98
203_G	335_V	0.526	0.98
256_V	331_P	0.526	0.98
144_A	147_L	0.526	0.98
219_F	286_A	0.525	0.98
121_Q	124_L	0.524	0.98
172_A	190_T	0.523	0.98
56_L	65_V	0.521	0.98
99_D	102_T	0.521	0.98
206_L	305_D	0.521	0.98
207_F	253_I	0.520	0.98
196_D	339_H	0.520	0.98
38_G	164_L	0.516	0.98
91_R	234_Y	0.515	0.98
68_L	72_L	0.515	0.98
306_L	311_V	0.514	0.98
279_A	286_A	0.514	0.98
341_A	345_L	0.513	0.98
297_V	300_Y	0.511	0.98
264_L	269_A	0.508	0.98
114_S	118_Q	0.507	0.98
33_G	36_V	0.507	0.98
232_I	260_L	0.507	0.98
236_T	239_G	0.507	0.98
220_N	236_T	0.505	0.98
189_Y	192_A	0.505	0.98
339_H	343_L	0.504	0.98
62_A	65_V	0.502	0.98
279_A	285_A	0.501	0.98
108_Q	114_S	0.500	0.98

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4m64A	1	0.8848	52	0.949	Contact Map
4pypA	1	0.8272	37.9	0.953	Contact Map
4tphA	2	0.8168	19.1	0.96	Contact Map
3w4tA	1	0.8246	17.2	0.961	Contact Map
3wdoA	1	0.9005	14.9	0.962	Contact Map
4zw9A	1	0.8325	13.4	0.962	Contact Map
3vouA	4	0.3403	13.3	0.963	Contact Map
2mn6B	2	0.123	12	0.963	Contact Map
3rvyA	3	0.2304	11.4	0.964	Contact Map
4p6vB	1	0.1466	11.3	0.964	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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