GREMLIN Database
Q9HPX5 - Htr-like protein
UniProt: Q9HPX5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 382 (322)
Sequences: 10979 (8512)
Seq/√Len: 474.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
218_T285_A5.0991.00
216_S239_G4.9081.00
51_R55_H4.4811.00
314_A334_L3.0671.00
43_Y194_D2.8501.00
212_G243_G2.7931.00
53_D59_S2.6371.00
277_F281_F2.6271.00
280_V284_V2.4711.00
216_S220_N2.4111.00
51_R54_R2.4081.00
41_L161_A2.3531.00
58_S61_V2.2791.00
212_G239_G2.2441.00
261_L283_V2.1671.00
338_V342_R2.1601.00
26_Y29_Y2.0231.00
219_F232_I1.9761.00
95_A98_I1.9611.00
261_L279_A1.9611.00
192_A343_L1.9391.00
116_A119_D1.9371.00
111_V114_S1.9251.00
46_R50_R1.9151.00
188_A343_L1.9081.00
117_V120_P1.9081.00
101_T104_E1.9031.00
281_F284_V1.8571.00
60_S64_V1.8391.00
205_I247_L1.8021.00
38_G161_A1.7851.00
203_G301_V1.7741.00
193_I336_F1.7551.00
215_A242_T1.7531.00
241_L245_A1.7371.00
49_Y66_S1.7321.00
162_F166_R1.7231.00
284_V288_V1.7161.00
300_Y304_R1.6951.00
119_D122_S1.6851.00
49_Y63_A1.6801.00
176_H187_R1.6691.00
48_V66_S1.6611.00
63_A67_L1.6571.00
222_L231_S1.6311.00
63_A162_F1.6291.00
157_V161_A1.6251.00
121_Q125_G1.6161.00
235_P239_G1.6131.00
93_L97_Q1.6071.00
119_D123_L1.6061.00
22_A26_Y1.6011.00
167_D307_H1.5921.00
106_L110_Y1.5861.00
122_S126_Q1.5821.00
278_V281_F1.5771.00
217_I220_N1.5751.00
160_I309_G1.5651.00
23_A27_V1.5621.00
233_P267_A1.5511.00
75_V79_S1.5491.00
52_V69_V1.5441.00
179_F186_V1.5341.00
60_S166_R1.5261.00
216_S235_P1.5081.00
319_P327_I1.5071.00
268_A278_V1.5031.00
211_T246_S1.5021.00
46_R59_S1.4901.00
215_A289_I1.4881.00
116_A121_Q1.4851.00
220_N235_P1.4851.00
106_L109_P1.4821.00
88_E93_L1.4631.00
90_T94_N1.4631.00
102_T105_A1.4391.00
19_T23_A1.4251.00
57_R65_V1.4071.00
35_F313_L1.3891.00
160_I164_L1.3801.00
245_A256_V1.3781.00
277_F280_V1.3781.00
287_V291_F1.3761.00
98_I102_T1.3731.00
18_A22_A1.3691.00
214_I289_I1.3671.00
120_P123_L1.3661.00
283_V287_V1.3541.00
257_W261_L1.3501.00
222_L232_I1.3461.00
11_A15_A1.3361.00
87_Q91_R1.3261.00
118_Q122_S1.3231.00
292_I297_V1.3201.00
104_E108_Q1.3041.00
264_L282_G1.2911.00
123_L126_Q1.2881.00
45_T165_L1.2731.00
238_M260_L1.2631.00
297_V301_V1.2601.00
98_I101_T1.2501.00
196_D335_V1.2441.00
173_E177_S1.2411.00
22_A25_V1.2401.00
207_F293_P1.2381.00
97_Q101_T1.2261.00
105_A109_P1.2221.00
131_A134_N1.2141.00
17_G21_T1.2101.00
122_S125_G1.2091.00
49_Y59_S1.2081.00
45_T70_L1.2001.00
218_T222_L1.1881.00
218_T281_F1.1841.00
49_Y62_A1.1841.00
290_D294_D1.1831.00
38_G157_V1.1801.00
41_L157_V1.1781.00
96_P99_D1.1761.00
167_D170_R1.1741.00
49_Y165_L1.1711.00
192_A342_R1.1631.00
132_A136_T1.1631.00
49_Y53_D1.1521.00
217_I221_V1.1501.00
46_R168_D1.1491.00
260_L282_G1.1471.00
315_Y327_I1.1471.00
48_V51_R1.1461.00
281_F285_A1.1431.00
107_V111_V1.1411.00
108_Q111_V1.1411.00
82_T86_I1.1401.00
64_V68_L1.1381.00
79_S83_A1.1341.00
202_F206_L1.1291.00
42_Y164_L1.1271.00
310_L334_L1.1271.00
180_A183_D1.1151.00
205_I209_F1.1131.00
264_L279_A1.1091.00
232_I264_L1.1071.00
53_D62_A1.1031.00
188_A192_A1.1021.00
140_A144_A1.0991.00
71_A75_V1.0981.00
170_R173_E1.0971.00
60_S162_F1.0961.00
62_A66_S1.0891.00
211_T289_I1.0861.00
35_F160_I1.0861.00
95_A99_D1.0841.00
129_V132_A1.0811.00
189_Y340_F1.0801.00
117_V123_L1.0781.00
318_G322_W1.0781.00
110_Y113_V1.0701.00
34_T38_G1.0671.00
208_A246_S1.0561.00
12_A16_I1.0521.00
38_G42_Y1.0461.00
314_A318_G1.0421.00
91_R94_N1.0391.00
318_G334_L1.0381.00
216_S236_T1.0331.00
128_S131_A1.0321.00
116_A120_P1.0311.00
90_T93_L1.0301.00
61_V64_V1.0271.00
212_G216_S1.0251.00
239_G243_G1.0231.00
84_V88_E1.0211.00
206_L210_I1.0191.00
296_V300_Y1.0181.00
314_A330_G1.0161.00
15_A19_T1.0121.00
294_D298_R1.0111.00
51_R56_L1.0091.00
37_L157_V1.0021.00
285_A289_I0.9991.00
118_Q121_Q0.9991.00
209_F243_G0.9971.00
39_F164_L0.9861.00
199_N203_G0.9861.00
325_Y329_L0.9831.00
23_A26_Y0.9821.00
174_W177_S0.9811.00
150_A154_L0.9801.00
219_F282_G0.9771.00
211_T253_I0.9681.00
105_A108_Q0.9681.00
204_N298_R0.9671.00
67_L161_A0.9601.00
160_I313_L0.9571.00
288_V292_I0.9521.00
144_A148_G0.9521.00
302_S311_V0.9501.00
185_V347_E0.9471.00
218_T289_I0.9461.00
263_W267_A0.9411.00
199_N305_D0.9381.00
38_G160_I0.9351.00
109_P112_D0.9351.00
219_F238_M0.9311.00
50_R53_D0.9281.00
102_T106_L0.9281.00
52_V56_L0.9281.00
222_L285_A0.9241.00
340_F344_V0.9231.00
156_A160_I0.9221.00
115_R118_Q0.9201.00
14_W18_A0.9191.00
234_Y237_L0.9191.00
243_G247_L0.9141.00
207_F297_V0.9131.00
219_F242_T0.9131.00
84_V87_Q0.9121.00
241_L256_V0.9121.00
222_L281_F0.9081.00
207_F211_T0.9071.00
117_V121_Q0.9021.00
265_A279_A0.8991.00
107_V110_Y0.8991.00
195_A199_N0.8961.00
222_L282_G0.8951.00
222_L278_V0.8921.00
337_V341_A0.8911.00
292_I296_V0.8911.00
255_L259_P0.8881.00
91_R95_A0.8881.00
168_D172_A0.8851.00
88_E91_R0.8851.00
99_D103_V0.8831.00
101_T105_A0.8801.00
213_V217_I0.8771.00
15_A18_A0.8651.00
215_A219_F0.8641.00
310_L338_V0.8631.00
239_G242_T0.8621.00
13_W17_G0.8591.00
21_T24_L0.8591.00
276_G279_A0.8581.00
330_G334_L0.8561.00
52_V66_S0.8561.00
87_Q90_T0.8491.00
211_T215_A0.8481.00
170_R174_W0.8471.00
276_G280_V0.8471.00
143_Y147_L0.8411.00
279_A283_V0.8331.00
26_Y30_T0.8331.00
238_M263_W0.8321.00
31_F317_F0.8311.00
207_F298_R0.8311.00
19_T22_A0.8291.00
53_D56_L0.8281.00
172_A176_H0.8281.00
89_L93_L0.8261.00
57_R62_A0.8221.00
210_I297_V0.8201.00
186_V190_T0.8161.00
57_R61_V0.8141.00
262_G266_V0.8071.00
86_I89_L0.8041.00
136_T139_S0.8031.00
50_R54_R0.8031.00
220_N239_G0.8021.00
17_G24_L0.8011.00
176_H183_D0.8011.00
213_V216_S0.8001.00
189_Y343_L0.7971.00
208_A247_L0.7911.00
42_Y161_A0.7881.00
185_V188_A0.7871.00
246_S253_I0.7841.00
313_L317_F0.7801.00
207_F302_S0.7801.00
133_I136_T0.7791.00
16_I20_L0.7781.00
27_V30_T0.7751.00
11_A14_W0.7751.00
94_N98_I0.7731.00
192_A339_H0.7691.00
208_A212_G0.7691.00
184_G188_A0.7681.00
59_S169_T0.7661.00
306_L334_L0.7651.00
209_F213_V0.7631.00
130_R134_N0.7631.00
207_F246_S0.7601.00
220_N231_S0.7591.00
100_L104_E0.7561.00
282_G286_A0.7561.00
261_L265_A0.7551.00
80_Y84_V0.7551.00
174_W178_R0.7541.00
291_F295_L0.7521.00
257_W286_A0.7441.00
242_T256_V0.7431.00
18_A21_T0.7411.00
24_L28_V0.7401.00
303_G311_V0.7371.00
187_R191_A0.7361.00
161_A165_L0.7321.00
106_L111_V0.7281.00
211_T298_R0.7261.00
290_D293_P0.7201.00
107_V112_D0.7201.00
19_T26_Y0.7191.00
111_V115_R0.7191.00
183_D187_R0.7181.00
45_T66_S0.7181.00
293_P298_R0.7141.00
210_I214_I0.7041.00
298_R302_S0.7041.00
135_T138_R0.7011.00
136_T140_A0.6991.00
178_R341_A0.6971.00
207_F301_V0.6961.00
52_V57_R0.6961.00
221_V231_S0.6951.00
108_Q112_D0.6941.00
128_S133_I0.6931.00
215_A239_G0.6891.00
192_A196_D0.6891.00
131_A135_T0.6881.00
246_S298_R0.6861.00
46_R165_L0.6841.00
73_P77_L0.6791.00
256_V260_L0.6781.00
212_G240_L0.6751.00
250_V308_L0.6751.00
156_A316_V0.6751.00
45_T48_V0.6741.00
146_F149_T0.6731.00
120_P125_G0.6731.00
50_R169_T0.6721.00
42_Y46_R0.6701.00
267_A278_V0.6681.00
149_T153_H0.6681.00
185_V343_L0.6651.00
150_A153_H0.6651.00
189_Y193_I0.6611.00
264_L268_A0.6601.00
132_A135_T0.6601.00
334_L338_V0.6591.00
196_D199_N0.6591.00
206_L301_V0.6581.00
45_T161_A0.6581.00
179_F182_S0.6581.00
215_A285_A0.6551.00
318_G333_V0.6541.00
86_I90_T0.6531.00
208_A211_T0.6491.00
14_W17_G0.6491.00
76_V80_Y0.6481.00
193_I339_H0.6471.00
141_G145_G0.6461.00
311_V331_P0.6451.00
13_W16_I0.6451.00
52_V65_V0.6431.00
183_D186_V0.6401.00
173_E176_H0.6401.00
25_V28_V0.6401.00
22_A30_T0.6381.00
211_T293_P0.6381.00
298_R301_V0.6361.00
120_P124_L0.6351.00
137_L141_G0.6341.00
12_A15_A0.6331.00
242_T246_S0.6301.00
24_L27_V0.6291.00
133_I137_L0.6270.99
67_L162_F0.6260.99
208_A243_G0.6250.99
20_L24_L0.6250.99
174_W310_L0.6240.99
172_A191_A0.6230.99
113_V116_A0.6230.99
35_F164_L0.6200.99
147_L151_F0.6160.99
206_L209_F0.6110.99
300_Y303_G0.6100.99
212_G236_T0.6090.99
269_A278_V0.6080.99
291_F294_D0.6060.99
42_Y165_L0.6050.99
198_S202_F0.6040.99
176_H180_A0.6040.99
34_T153_H0.6020.99
34_T303_G0.6000.99
121_Q126_Q0.5990.99
116_A125_G0.5990.99
95_A233_P0.5980.99
308_L312_M0.5980.99
25_V29_Y0.5980.99
52_V62_A0.5960.99
191_A195_A0.5950.99
135_T139_S0.5950.99
134_N138_R0.5940.99
118_Q123_L0.5940.99
78_L82_T0.5900.99
243_G250_V0.5890.99
211_T290_D0.5890.99
322_W326_G0.5890.99
37_L41_L0.5890.99
315_Y331_P0.5870.99
85_G89_L0.5870.99
69_V72_L0.5840.99
176_H179_F0.5780.99
204_N246_S0.5770.99
152_V156_A0.5750.99
175_F178_R0.5750.99
146_F150_A0.5740.99
173_E187_R0.5720.99
203_G305_D0.5720.99
103_V106_L0.5710.99
171_L174_W0.5710.99
103_V107_V0.5700.99
15_A22_A0.5690.99
72_L75_V0.5680.99
149_T295_L0.5670.99
202_F305_D0.5660.99
259_P262_G0.5650.99
293_P297_V0.5650.99
265_A276_G0.5650.99
241_L259_P0.5650.99
139_S143_Y0.5640.99
58_S62_A0.5640.99
163_Y167_D0.5630.99
81_T85_G0.5620.99
22_A29_Y0.5620.99
324_W327_I0.5600.99
253_I290_D0.5590.99
242_T253_I0.5580.99
137_L140_A0.5580.99
73_P76_V0.5560.99
219_F239_G0.5530.99
100_L103_V0.5510.99
164_L309_G0.5460.99
325_Y330_G0.5430.99
63_A166_R0.5430.99
12_A17_G0.5420.99
53_D58_S0.5420.99
286_A290_D0.5410.99
253_I256_V0.5410.99
16_I19_T0.5410.99
215_A243_G0.5350.98
115_R119_D0.5340.98
211_T243_G0.5320.98
232_I267_A0.5320.98
128_S132_A0.5310.98
256_V290_D0.5310.98
154_L158_I0.5300.98
203_G335_V0.5260.98
256_V331_P0.5260.98
144_A147_L0.5260.98
219_F286_A0.5250.98
121_Q124_L0.5240.98
172_A190_T0.5230.98
56_L65_V0.5210.98
99_D102_T0.5210.98
206_L305_D0.5210.98
207_F253_I0.5200.98
196_D339_H0.5200.98
38_G164_L0.5160.98
91_R234_Y0.5150.98
68_L72_L0.5150.98
306_L311_V0.5140.98
279_A286_A0.5140.98
341_A345_L0.5130.98
297_V300_Y0.5110.98
264_L269_A0.5080.98
114_S118_Q0.5070.98
33_G36_V0.5070.98
232_I260_L0.5070.98
236_T239_G0.5070.98
220_N236_T0.5050.98
189_Y192_A0.5050.98
339_H343_L0.5040.98
62_A65_V0.5020.98
279_A285_A0.5010.98
108_Q114_S0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4m64A 1 0.8848 52 0.949 Contact Map
4pypA 1 0.8272 37.9 0.953 Contact Map
4tphA 2 0.8168 19.1 0.96 Contact Map
3w4tA 1 0.8246 17.2 0.961 Contact Map
3wdoA 1 0.9005 14.9 0.962 Contact Map
4zw9A 1 0.8325 13.4 0.962 Contact Map
3vouA 4 0.3403 13.3 0.963 Contact Map
2mn6B 2 0.123 12 0.963 Contact Map
3rvyA 3 0.2304 11.4 0.964 Contact Map
4p6vB 1 0.1466 11.3 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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