GREMLIN Database
Q9HPX3 - Uncharacterized protein
UniProt: Q9HPX3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 223 (194)
Sequences: 6953 (4100)
Seq/√Len: 294.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
169_A197_D3.9511.00
184_T187_D2.9941.00
120_S152_A2.8521.00
79_A123_G2.8081.00
183_R187_D2.5391.00
147_E173_A2.3861.00
207_D213_A2.3801.00
89_A112_L2.1921.00
113_C149_A2.1821.00
178_A191_Y2.1601.00
57_L83_A2.1581.00
166_R170_D2.1341.00
116_V151_A2.1031.00
117_R121_D2.1011.00
189_F193_S2.0011.00
107_R134_V1.9781.00
147_E174_L1.9251.00
182_V191_Y1.9211.00
132_A164_V1.9091.00
60_A84_I1.8471.00
113_C117_R1.8041.00
188_V199_V1.7871.00
113_C148_R1.7401.00
167_D170_D1.7331.00
113_C145_A1.7291.00
73_D76_A1.7281.00
108_D111_R1.7001.00
189_F217_A1.6891.00
183_R204_P1.6741.00
71_L87_V1.6681.00
122_E126_V1.6471.00
79_A122_E1.6471.00
75_A122_E1.6461.00
100_G108_D1.6191.00
61_V78_C1.6171.00
144_Q171_A1.5861.00
112_L142_L1.5831.00
187_D190_E1.5601.00
71_L119_A1.5411.00
69_G73_D1.5401.00
43_A46_D1.5341.00
67_R70_P1.5231.00
31_R60_A1.4941.00
65_A71_L1.4741.00
177_V198_A1.4701.00
30_D215_Y1.4631.00
144_Q147_E1.4541.00
140_P171_A1.4481.00
165_V178_A1.4421.00
48_Q51_E1.4291.00
79_A124_A1.4271.00
68_L72_R1.4171.00
147_E172_T1.4141.00
141_V144_Q1.4131.00
190_E193_S1.4101.00
114_E117_R1.4071.00
117_R149_A1.3701.00
139_L168_V1.3541.00
111_R114_E1.3531.00
177_V200_S1.3511.00
130_V156_V1.3351.00
128_V146_I1.3341.00
169_A176_V1.3251.00
87_V119_A1.3191.00
188_V214_V1.3001.00
110_S114_E1.2991.00
186_D190_E1.2991.00
40_D70_P1.2761.00
153_A177_V1.2671.00
144_Q148_R1.2661.00
110_S145_A1.2571.00
178_A182_V1.2541.00
157_D161_S1.2451.00
164_V167_D1.2391.00
45_V48_Q1.2121.00
46_D49_L1.2021.00
103_E161_S1.1951.00
44_W48_Q1.1821.00
120_S126_V1.1721.00
201_V214_V1.1631.00
112_L146_I1.1601.00
128_V151_A1.1441.00
78_C85_L1.1341.00
127_S153_A1.1271.00
143_A168_V1.1091.00
185_R189_F1.1031.00
166_R191_Y1.1031.00
141_V145_A1.0951.00
116_V128_V1.0931.00
172_T176_V1.0911.00
106_L142_L1.0871.00
33_R155_H1.0711.00
157_D162_R1.0661.00
72_R118_A1.0461.00
72_R76_A1.0451.00
159_M162_R1.0331.00
178_A196_A1.0231.00
44_W47_D1.0211.00
73_D77_V1.0171.00
185_R217_A1.0061.00
33_R60_A1.0051.00
132_A137_V0.9821.00
116_V146_I0.9801.00
42_V77_V0.9781.00
118_A121_D0.9781.00
205_S211_V0.9781.00
145_A149_A0.9761.00
158_A161_S0.9731.00
109_T141_V0.9691.00
106_L130_V0.9641.00
132_A158_A0.9591.00
185_R213_A0.9531.00
68_L114_E0.9531.00
45_V49_L0.9501.00
93_Q96_L0.9461.00
31_R84_I0.9391.00
71_L115_Q0.9371.00
142_L146_I0.9251.00
158_A165_V0.9241.00
110_S113_C0.9211.00
46_D50_S0.9071.00
167_D171_A0.9041.00
191_Y194_Y0.9041.00
181_G203_R0.9021.00
75_A85_L0.9021.00
75_A119_A0.8911.00
47_D51_E0.8891.00
140_P167_D0.8881.00
136_G167_D0.8851.00
69_G118_A0.8831.00
191_Y196_A0.8831.00
157_D160_D0.8751.00
205_S210_R0.8711.00
139_L164_V0.8701.00
143_A172_T0.8691.00
105_L115_Q0.8691.00
43_A49_L0.8661.00
116_V149_A0.8641.00
106_L138_H0.8571.00
68_L111_R0.8541.00
76_A79_A0.8481.00
136_G164_V0.8431.00
63_V74_V0.8381.00
182_V188_V0.8361.00
89_A128_V0.8231.00
138_H141_V0.8201.00
49_L52_L0.8181.00
156_V176_V0.8171.00
130_V139_L0.8161.00
44_W50_S0.8121.00
100_G104_T0.8101.00
46_D51_E0.8051.00
48_Q52_L0.8041.00
97_C104_T0.8041.00
155_H200_S0.8011.00
38_P41_P0.7940.99
112_L116_V0.7940.99
39_A74_V0.7840.99
29_V32_D0.7840.99
182_V199_V0.7800.99
76_A80_A0.7790.99
179_N200_S0.7790.99
136_G171_A0.7770.99
117_R148_R0.7650.99
204_P207_D0.7620.99
78_C82_D0.7590.99
60_A127_S0.7550.99
146_I151_A0.7510.99
135_Q162_R0.7490.99
84_I127_S0.7480.99
163_R167_D0.7460.99
130_V142_L0.7440.99
120_S149_A0.7420.99
77_V81_H0.7420.99
47_D50_S0.7320.99
166_R194_Y0.7270.99
90_H179_N0.7260.99
43_A47_D0.7250.99
26_R55_A0.7240.99
44_W52_L0.7210.99
104_T107_R0.7170.99
153_A175_F0.7150.99
140_P168_V0.7150.99
140_P144_Q0.7150.99
45_V51_E0.7130.99
213_A217_A0.7120.99
25_A56_F0.7110.99
185_R214_V0.7110.99
45_V50_S0.7110.99
151_A154_I0.7110.99
154_I174_L0.7090.99
86_E155_H0.7020.99
156_V168_V0.7000.99
38_P64_R0.6990.99
44_W49_L0.6990.99
135_Q160_D0.6980.99
192_L199_V0.6930.99
27_A212_R0.6920.99
212_R216_A0.6910.99
66_V100_G0.6910.99
72_R122_E0.6880.98
185_R188_V0.6840.98
142_L145_A0.6830.98
77_V80_A0.6800.98
34_E59_P0.6740.98
130_V143_A0.6740.98
72_R121_D0.6730.98
209_E212_R0.6710.98
52_L59_P0.6670.98
165_V176_V0.6670.98
100_G111_R0.6660.98
158_A162_R0.6650.98
29_V205_S0.6620.98
70_P73_D0.6610.98
106_L133_G0.6590.98
96_L101_A0.6590.98
45_V52_L0.6530.98
68_L118_A0.6530.98
68_L115_Q0.6520.98
39_A70_P0.6510.98
63_V71_L0.6420.98
156_V159_M0.6400.98
61_V82_D0.6380.98
89_A146_I0.6360.97
187_D191_Y0.6360.97
125_A152_A0.6350.97
189_F192_L0.6340.97
143_A154_I0.6320.97
109_T145_A0.6280.97
44_W51_E0.6220.97
114_E118_A0.6190.97
186_D189_F0.6160.97
36_F64_R0.6140.97
47_D52_L0.6100.97
80_A123_G0.6100.97
188_V192_L0.6090.97
42_V46_D0.6060.97
94_D98_D0.6060.97
119_A126_V0.6030.97
120_S151_A0.6020.97
34_E61_V0.6010.96
168_V171_A0.6000.96
108_D114_E0.5980.96
145_A148_R0.5980.96
130_V154_I0.5970.96
186_D217_A0.5940.96
94_D97_C0.5920.96
40_D67_R0.5910.96
201_V210_R0.5910.96
43_A50_S0.5890.96
109_T113_C0.5880.96
53_D56_F0.5820.96
51_E81_H0.5770.96
140_P143_A0.5750.95
107_R138_H0.5750.95
43_A48_Q0.5700.95
192_L196_A0.5680.95
207_D210_R0.5660.95
66_V101_A0.5620.95
140_P164_V0.5620.95
201_V205_S0.5580.95
107_R135_Q0.5570.95
85_L122_E0.5550.95
97_C134_V0.5510.94
92_R161_S0.5470.94
51_E54_D0.5460.94
140_P172_T0.5430.94
156_V161_S0.5390.94
136_G140_P0.5390.94
155_H177_V0.5340.93
58_R83_A0.5320.93
36_F39_A0.5320.93
113_C146_I0.5310.93
106_L112_L0.5250.93
190_E194_Y0.5230.93
183_R202_G0.5220.93
86_E127_S0.5220.93
170_D195_G0.5210.93
204_P210_R0.5190.92
163_R166_R0.5160.92
90_H200_S0.5160.92
87_V116_V0.5150.92
105_L111_R0.5150.92
46_D52_L0.5140.92
138_H142_L0.5100.92
115_Q118_A0.5090.92
47_D81_H0.5070.91
169_A195_G0.5050.91
60_A153_A0.5040.91
182_V201_V0.5020.91
135_Q138_H0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3b0pA 1 0.9865 100 0.401 Contact Map
4xp7A 1 0.9596 100 0.413 Contact Map
4bfaA 1 0.991 100 0.423 Contact Map
1vhnA 1 0.9686 100 0.43 Contact Map
1gteA 4 0.9865 100 0.539 Contact Map
4ef8A 2 0.9776 100 0.571 Contact Map
1o94A 2 0.9955 100 0.575 Contact Map
3k30A 2 0.9955 100 0.581 Contact Map
1ps9A 1 1 100 0.583 Contact Map
3tjlA 2 1 100 0.589 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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