GREMLIN Database
DHYS - Probable deoxyhypusine synthase
UniProt: Q9HPX2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 330 (301)
Sequences: 798 (427)
Seq/√Len: 24.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
313_A318_V6.8231.00
80_V188_I6.6141.00
180_A193_A6.0921.00
74_T259_A4.9601.00
64_M246_G3.9031.00
176_R193_A3.6341.00
161_E181_T3.5831.00
203_A254_V3.3991.00
250_V315_A3.2541.00
189_L199_V3.1781.00
250_V319_F3.0891.00
125_V142_F3.0861.00
313_A317_L3.0761.00
63_E307_N2.9881.00
176_R196_D2.9161.00
57_A311_I2.8200.99
111_I189_L2.8000.99
204_L228_I2.7780.99
214_Y240_L2.7410.99
70_T238_E2.7410.99
275_I318_V2.7010.99
92_V192_A2.6770.99
89_A93_R2.5740.99
248_I322_L2.4930.99
190_K194_D2.4810.99
91_L323_V2.3710.98
245_T263_N2.3570.98
200_F234_A2.2700.97
32_S93_R2.2200.97
92_V100_I2.1800.97
88_V188_I2.1650.97
36_D39_E2.1350.96
29_Y37_F2.1020.96
92_V97_V2.1010.96
174_F226_I1.9720.94
173_A230_D1.9450.94
93_R185_E1.8920.93
159_F213_L1.8890.93
54_L322_L1.8340.92
135_I142_F1.8250.91
168_V225_G1.8200.91
44_Y317_L1.8150.91
170_T230_D1.8150.91
73_L97_V1.8120.91
27_R46_T1.7590.90
146_D150_W1.7510.90
98_D245_T1.6880.88
60_I63_E1.6770.88
132_E301_D1.6660.87
200_F238_E1.6490.87
58_V325_G1.6110.85
136_N145_S1.6040.85
275_I313_A1.5580.83
213_L229_L1.5530.83
61_T248_I1.5460.83
292_E298_K1.5360.82
29_Y36_D1.5320.82
172_T234_A1.5320.82
255_P286_S1.5270.82
229_L232_Y1.5060.81
225_G230_D1.4830.80
177_E181_T1.4760.80
54_L58_V1.4590.79
163_F224_V1.4510.79
248_I319_F1.4000.76
53_H56_D1.3960.76
213_L226_I1.3840.75
162_F174_F1.3770.75
81_S109_E1.3590.74
311_I318_V1.3580.74
93_R194_D1.3280.72
121_G142_F1.3260.72
25_D117_P1.3190.71
95_N195_N1.3130.71
60_I308_Y1.3120.71
41_L321_L1.3060.71
50_Q53_H1.2970.70
54_L317_L1.2810.69
99_V238_E1.2520.67
229_L250_V1.2480.67
175_A189_L1.2460.67
191_N195_N1.2350.66
174_F213_L1.2260.66
161_E164_A1.2230.66
101_I259_A1.2220.65
104_S207_A1.2160.65
29_Y47_T1.2130.65
112_I151_L1.2110.65
292_E296_W1.2010.64
40_L93_R1.1960.64
81_S138_L1.1720.62
51_A321_L1.1700.62
191_N194_D1.1630.62
29_Y34_E1.1620.61
177_E180_A1.1500.61
79_I84_L1.1410.60
65_R96_Y1.1380.60
176_R180_A1.1320.59
51_A111_I1.1290.59
54_L311_I1.1210.59
45_A59_D1.1200.59
91_L248_I1.1200.59
27_R186_D1.1120.58
271_Y314_E1.1090.58
180_A194_D1.1070.58
247_L269_A1.1040.57
84_L316_T1.1030.57
72_Y259_A1.0960.57
160_E216_Y1.0960.57
67_D244_T1.0920.57
33_G39_E1.0910.57
103_T203_A1.0880.56
74_T203_A1.0840.56
90_H94_E1.0640.55
92_V197_I1.0560.54
54_L61_T1.0560.54
38_F325_G1.0500.54
47_T84_L1.0490.54
151_L208_E1.0390.53
128_A201_C1.0390.53
168_V230_D1.0220.52
237_E241_L1.0120.51
295_S298_K1.0110.51
45_A55_A1.0060.50
311_I322_L0.9940.50
61_T322_L0.9940.50
247_L260_I0.9880.49
32_S94_E0.9850.49
118_F138_L0.9800.49
76_T290_P0.9790.49
37_F322_L0.9760.48
126_D129_A0.9610.47
164_A221_D0.9600.47
109_E285_L0.9580.47
188_I192_A0.9580.47
26_V120_M0.9560.47
111_I314_E0.9540.47
105_G140_N0.9540.47
60_I309_A0.9530.47
79_I82_S0.9490.46
277_T282_D0.9470.46
40_L324_A0.9470.46
109_E261_M0.9470.46
250_V275_I0.9440.46
53_H312_E0.9410.46
57_A273_V0.9410.46
31_F37_F0.9370.45
29_Y44_Y0.9340.45
99_V263_N0.9260.45
88_V307_N0.9240.45
83_G110_D0.9230.45
110_D187_S0.9220.44
79_I115_A0.9080.43
121_G135_I0.9070.43
52_S77_S0.9060.43
170_T178_L0.9030.43
41_L324_A0.9020.43
115_A178_L0.8930.42
252_A286_S0.8860.42
290_P299_I0.8780.41
257_H261_M0.8770.41
83_G256_K0.8750.41
37_F41_L0.8650.40
165_D177_E0.8640.40
80_V250_V0.8640.40
218_Q237_E0.8630.40
290_P310_L0.8630.40
103_T254_V0.8590.40
70_T242_A0.8570.40
61_T311_I0.8560.40
314_E317_L0.8550.40
49_F200_F0.8550.40
139_G257_H0.8550.40
54_L115_A0.8550.40
168_V227_E0.8480.39
115_A204_L0.8470.39
257_H284_S0.8470.39
69_A271_Y0.8420.39
70_T99_V0.8410.39
161_E177_E0.8390.39
236_I264_L0.8320.38
155_L159_F0.8320.38
70_T245_T0.8290.38
62_R66_E0.8290.38
167_K173_A0.8270.38
235_L238_E0.8220.37
189_L193_A0.8190.37
70_T98_D0.8180.37
228_I232_Y0.8140.37
44_Y47_T0.8120.37
129_A301_D0.8120.37
84_L88_V0.8120.37
208_E212_F0.8080.37
287_G292_E0.8070.36
237_E270_D0.8070.36
77_S106_S0.8050.36
188_I287_G0.8050.36
79_I265_F0.8040.36
162_F169_R0.8010.36
66_E196_D0.7990.36
118_F141_I0.7980.36
299_I309_A0.7970.36
50_Q78_N0.7960.36
292_E295_S0.7950.36
37_F40_L0.7950.36
168_V173_A0.7950.36
60_I275_I0.7860.35
155_L209_I0.7860.35
283_G298_K0.7810.35
257_H289_P0.7800.35
170_T235_L0.7710.34
26_V97_V0.7650.34
128_A294_V0.7650.34
31_F135_I0.7620.34
63_E161_E0.7610.33
105_G207_A0.7590.33
129_A133_E0.7580.33
174_F241_L0.7570.33
110_D297_G0.7530.33
151_L155_L0.7530.33
59_D63_E0.7520.33
301_D322_L0.7520.33
258_H263_N0.7520.33
311_I315_A0.7490.33
42_D325_G0.7490.33
288_A292_E0.7460.33
76_T142_F0.7450.32
188_I199_V0.7410.32
278_G282_D0.7400.32
43_S47_T0.7380.32
232_Y236_I0.7370.32
106_S314_E0.7350.32
128_A132_E0.7340.32
105_G139_G0.7330.32
95_N197_I0.7300.32
203_A259_A0.7290.31
161_E180_A0.7290.31
185_E275_I0.7280.31
226_I238_E0.7270.31
42_D59_D0.7270.31
32_S89_A0.7270.31
156_Y170_T0.7260.31
287_G298_K0.7250.31
193_A204_L0.7240.31
56_D307_N0.7230.31
232_Y235_L0.7230.31
280_E287_G0.7190.31
35_F40_L0.7190.31
34_E40_L0.7160.31
89_A191_N0.7160.31
36_D328_E0.7150.31
252_A292_E0.7120.30
81_S261_M0.7120.30
81_S108_T0.7030.30
87_V244_T0.7020.30
135_I170_T0.7000.30
112_I152_E0.7000.30
105_G258_H0.6990.30
226_I239_G0.6990.30
163_F216_Y0.6970.30
136_N149_V0.6930.29
45_A56_D0.6920.29
148_Y152_E0.6890.29
288_A298_K0.6880.29
258_H278_G0.6870.29
71_I97_V0.6840.29
131_R160_E0.6830.29
60_I271_Y0.6820.29
87_V192_A0.6790.28
92_V191_N0.6740.28
200_F230_D0.6670.28
58_V322_L0.6660.28
82_S104_S0.6650.28
135_I294_V0.6640.28
283_G296_W0.6640.28
75_L284_S0.6620.27
60_I274_Y0.6600.27
55_A286_S0.6590.27
73_L100_I0.6540.27
239_G263_N0.6540.27
81_S208_E0.6540.27
319_F323_V0.6540.27
157_D223_E0.6530.27
24_P275_I0.6520.27
131_R267_G0.6470.27
230_D234_A0.6470.27
34_E37_F0.6470.27
33_G132_E0.6460.27
28_G86_E0.6450.26
122_E125_V0.6450.26
27_R33_G0.6430.26
34_E39_E0.6430.26
190_K195_N0.6420.26
229_L236_I0.6410.26
167_K221_D0.6410.26
38_F107_L0.6410.26
120_M200_F0.6400.26
36_D317_L0.6400.26
38_F324_A0.6380.26
257_H268_G0.6370.26
38_F42_D0.6350.26
178_L209_I0.6330.26
27_R317_L0.6330.26
75_L105_G0.6280.26
78_N109_E0.6270.25
234_A238_E0.6250.25
201_C226_I0.6250.25
48_G123_W0.6240.25
235_L279_M0.6230.25
81_S282_D0.6220.25
232_Y237_E0.6210.25
48_G85_R0.6210.25
58_V70_T0.6210.25
108_T262_T0.6190.25
54_L244_T0.6180.25
183_D194_D0.6160.25
25_D41_L0.6150.25
108_T261_M0.6140.25
112_I203_A0.6140.25
159_F226_I0.6130.25
63_E66_E0.6130.25
196_D219_G0.6090.25
108_T208_E0.6090.25
76_T105_G0.6080.24
286_S314_E0.6070.24
153_E157_D0.6050.24
61_T65_R0.6050.24
75_L278_G0.6040.24
84_L87_V0.6040.24
39_E317_L0.6030.24
139_G284_S0.6030.24
105_G113_K0.6010.24
48_G82_S0.6000.24
108_T112_I0.5990.24
180_A213_L0.5990.24
112_I209_I0.5990.24
99_V234_A0.5990.24
122_E142_F0.5970.24
156_Y159_F0.5960.24
113_K136_N0.5950.24
264_L288_A0.5940.24
293_A296_W0.5940.24
108_T211_N0.5930.24
61_T273_V0.5910.24
255_P260_I0.5910.24
148_Y257_H0.5900.24
32_S316_T0.5900.24
191_N197_I0.5900.24
255_P314_E0.5890.23
109_E211_N0.5880.23
94_E327_F0.5880.23
42_D174_F0.5880.23
57_A312_E0.5880.23
59_D62_R0.5880.23
53_H314_E0.5870.23
50_Q85_R0.5870.23
44_Y132_E0.5850.23
78_N81_S0.5840.23
232_Y264_L0.5830.23
93_R191_N0.5800.23
49_F119_K0.5790.23
110_D256_K0.5780.23
227_E239_G0.5770.23
28_G113_K0.5770.23
111_I199_V0.5760.23
131_R134_G0.5750.23
118_F148_Y0.5730.23
78_N261_M0.5720.23
155_L174_F0.5720.23
50_Q77_S0.5720.23
304_A322_L0.5710.23
60_I246_G0.5700.23
36_D313_A0.5650.22
76_T274_Y0.5640.22
152_E216_Y0.5630.22
126_D161_E0.5630.22
255_P312_E0.5620.22
36_D242_A0.5600.22
227_E232_Y0.5560.22
97_V100_I0.5550.22
44_Y146_D0.5550.22
136_N264_L0.5540.22
74_T101_I0.5530.22
293_A298_K0.5530.22
138_L209_I0.5520.22
105_G148_Y0.5520.22
89_A192_A0.5490.21
227_E230_D0.5490.21
287_G295_S0.5490.21
41_L322_L0.5490.21
78_N105_G0.5460.21
75_L286_S0.5460.21
58_V275_I0.5450.21
252_A298_K0.5450.21
262_T269_A0.5440.21
48_G140_N0.5430.21
96_Y122_E0.5420.21
74_T212_F0.5380.21
48_G139_G0.5380.21
29_Y258_H0.5370.21
89_A184_D0.5370.21
301_D314_E0.5350.21
238_E241_L0.5350.21
45_A126_D0.5340.21
255_P278_G0.5320.21
138_L250_V0.5320.21
216_Y233_D0.5320.21
51_A183_D0.5320.21
156_Y312_E0.5320.21
137_R320_P0.5310.21
113_K118_F0.5310.21
129_A180_A0.5310.21
83_G121_G0.5300.21
161_E165_D0.5290.21
184_D189_L0.5280.20
26_V242_A0.5280.20
77_S105_G0.5270.20
288_A296_W0.5270.20
126_D167_K0.5260.20
39_E161_E0.5250.20
161_E241_L0.5240.20
89_A177_E0.5240.20
174_F204_L0.5230.20
32_S328_E0.5220.20
49_F103_T0.5210.20
25_D44_Y0.5210.20
128_A196_D0.5210.20
176_R234_A0.5190.20
123_W139_G0.5180.20
257_H263_N0.5180.20
31_F100_I0.5170.20
37_F244_T0.5160.20
258_H280_E0.5160.20
152_E264_L0.5150.20
202_P235_L0.5150.20
46_T313_A0.5140.20
45_A71_I0.5130.20
66_E243_D0.5130.20
170_T300_K0.5120.20
24_P27_R0.5100.20
85_R277_T0.5090.20
26_V100_I0.5090.20
37_F54_L0.5080.20
85_R207_A0.5080.20
25_D155_L0.5070.20
57_A227_E0.5060.19
146_D309_A0.5040.19
42_D229_L0.5030.19
194_D197_I0.5030.19
78_N148_Y0.5020.19
188_I286_S0.5020.19
67_D201_C0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1rlzA 4 0.9788 100 0.054 Contact Map
4p63A 4 0.9091 100 0.057 Contact Map
3c2qA 4 0.8273 95.6 0.946 Contact Map
2hnaA 1 0.3788 31 0.972 Contact Map
3lyeA 4 0.5636 25.9 0.974 Contact Map
1f4pA 1 0.3818 23.2 0.974 Contact Map
3fa4A 5 0.5697 22.9 0.974 Contact Map
1uuyA 3 0.4182 21.1 0.975 Contact Map
3fw9A 1 0.5606 19.8 0.975 Contact Map
3bpqA 2 0.1121 19.5 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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