DHYS - HALSA - GREMLIN Contacts

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DHYS - Probable deoxyhypusine synthase

UniProt:	Q9HPX2	Sequences: MTGDDADETHENVVPGSDEDLDTPDVRGYDFSGEFDFFELLDSYATTGFQASHLADAVDITREMREDDATIYLTLTSNIVSSGLREVVAHLVRENYVDVIITTSGSLTEDIIKTAKPFKMGEWDVDEAALREEGINRLGNIFVPSDRYVWLEEYLYDFFEEFFADQKVRTPTAFARELGATLDDEDSILKNAADNDIPVFCPALTDAEIGNFLYYYRQGYDSEVGIEILDDYDALIEEGLLADTTGLICVGAGVPKHHAIMTNLFRGGADYAVYISTGMEGDGSLSGAPPEEAVSWGKIKDEDAEPNYALIEAEATLVFPLLVAGAFENP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	330 (301)
Sequences:	798 (427)
Seq/√Len:	24.6

HALSA - DHYS
SULSO - DHYS

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
313_A	318_V	6.823	1.00
80_V	188_I	6.614	1.00
180_A	193_A	6.092	1.00
74_T	259_A	4.960	1.00
64_M	246_G	3.903	1.00
176_R	193_A	3.634	1.00
161_E	181_T	3.583	1.00
203_A	254_V	3.399	1.00
250_V	315_A	3.254	1.00
189_L	199_V	3.178	1.00
250_V	319_F	3.089	1.00
125_V	142_F	3.086	1.00
313_A	317_L	3.076	1.00
63_E	307_N	2.988	1.00
176_R	196_D	2.916	1.00
57_A	311_I	2.820	0.99
111_I	189_L	2.800	0.99
204_L	228_I	2.778	0.99
214_Y	240_L	2.741	0.99
70_T	238_E	2.741	0.99
275_I	318_V	2.701	0.99
92_V	192_A	2.677	0.99
89_A	93_R	2.574	0.99
248_I	322_L	2.493	0.99
190_K	194_D	2.481	0.99
91_L	323_V	2.371	0.98
245_T	263_N	2.357	0.98
200_F	234_A	2.270	0.97
32_S	93_R	2.220	0.97
92_V	100_I	2.180	0.97
88_V	188_I	2.165	0.97
36_D	39_E	2.135	0.96
29_Y	37_F	2.102	0.96
92_V	97_V	2.101	0.96
174_F	226_I	1.972	0.94
173_A	230_D	1.945	0.94
93_R	185_E	1.892	0.93
159_F	213_L	1.889	0.93
54_L	322_L	1.834	0.92
135_I	142_F	1.825	0.91
168_V	225_G	1.820	0.91
44_Y	317_L	1.815	0.91
170_T	230_D	1.815	0.91
73_L	97_V	1.812	0.91
27_R	46_T	1.759	0.90
146_D	150_W	1.751	0.90
98_D	245_T	1.688	0.88
60_I	63_E	1.677	0.88
132_E	301_D	1.666	0.87
200_F	238_E	1.649	0.87
58_V	325_G	1.611	0.85
136_N	145_S	1.604	0.85
275_I	313_A	1.558	0.83
213_L	229_L	1.553	0.83
61_T	248_I	1.546	0.83
292_E	298_K	1.536	0.82
29_Y	36_D	1.532	0.82
172_T	234_A	1.532	0.82
255_P	286_S	1.527	0.82
229_L	232_Y	1.506	0.81
225_G	230_D	1.483	0.80
177_E	181_T	1.476	0.80
54_L	58_V	1.459	0.79
163_F	224_V	1.451	0.79
248_I	319_F	1.400	0.76
53_H	56_D	1.396	0.76
213_L	226_I	1.384	0.75
162_F	174_F	1.377	0.75
81_S	109_E	1.359	0.74
311_I	318_V	1.358	0.74
93_R	194_D	1.328	0.72
121_G	142_F	1.326	0.72
25_D	117_P	1.319	0.71
95_N	195_N	1.313	0.71
60_I	308_Y	1.312	0.71
41_L	321_L	1.306	0.71
50_Q	53_H	1.297	0.70
54_L	317_L	1.281	0.69
99_V	238_E	1.252	0.67
229_L	250_V	1.248	0.67
175_A	189_L	1.246	0.67
191_N	195_N	1.235	0.66
174_F	213_L	1.226	0.66
161_E	164_A	1.223	0.66
101_I	259_A	1.222	0.65
104_S	207_A	1.216	0.65
29_Y	47_T	1.213	0.65
112_I	151_L	1.211	0.65
292_E	296_W	1.201	0.64
40_L	93_R	1.196	0.64
81_S	138_L	1.172	0.62
51_A	321_L	1.170	0.62
191_N	194_D	1.163	0.62
29_Y	34_E	1.162	0.61
177_E	180_A	1.150	0.61
79_I	84_L	1.141	0.60
65_R	96_Y	1.138	0.60
176_R	180_A	1.132	0.59
51_A	111_I	1.129	0.59
54_L	311_I	1.121	0.59
45_A	59_D	1.120	0.59
91_L	248_I	1.120	0.59
27_R	186_D	1.112	0.58
271_Y	314_E	1.109	0.58
180_A	194_D	1.107	0.58
247_L	269_A	1.104	0.57
84_L	316_T	1.103	0.57
72_Y	259_A	1.096	0.57
160_E	216_Y	1.096	0.57
67_D	244_T	1.092	0.57
33_G	39_E	1.091	0.57
103_T	203_A	1.088	0.56
74_T	203_A	1.084	0.56
90_H	94_E	1.064	0.55
92_V	197_I	1.056	0.54
54_L	61_T	1.056	0.54
38_F	325_G	1.050	0.54
47_T	84_L	1.049	0.54
151_L	208_E	1.039	0.53
128_A	201_C	1.039	0.53
168_V	230_D	1.022	0.52
237_E	241_L	1.012	0.51
295_S	298_K	1.011	0.51
45_A	55_A	1.006	0.50
311_I	322_L	0.994	0.50
61_T	322_L	0.994	0.50
247_L	260_I	0.988	0.49
32_S	94_E	0.985	0.49
118_F	138_L	0.980	0.49
76_T	290_P	0.979	0.49
37_F	322_L	0.976	0.48
126_D	129_A	0.961	0.47
164_A	221_D	0.960	0.47
109_E	285_L	0.958	0.47
188_I	192_A	0.958	0.47
26_V	120_M	0.956	0.47
111_I	314_E	0.954	0.47
105_G	140_N	0.954	0.47
60_I	309_A	0.953	0.47
79_I	82_S	0.949	0.46
277_T	282_D	0.947	0.46
40_L	324_A	0.947	0.46
109_E	261_M	0.947	0.46
250_V	275_I	0.944	0.46
53_H	312_E	0.941	0.46
57_A	273_V	0.941	0.46
31_F	37_F	0.937	0.45
29_Y	44_Y	0.934	0.45
99_V	263_N	0.926	0.45
88_V	307_N	0.924	0.45
83_G	110_D	0.923	0.45
110_D	187_S	0.922	0.44
79_I	115_A	0.908	0.43
121_G	135_I	0.907	0.43
52_S	77_S	0.906	0.43
170_T	178_L	0.903	0.43
41_L	324_A	0.902	0.43
115_A	178_L	0.893	0.42
252_A	286_S	0.886	0.42
290_P	299_I	0.878	0.41
257_H	261_M	0.877	0.41
83_G	256_K	0.875	0.41
37_F	41_L	0.865	0.40
165_D	177_E	0.864	0.40
80_V	250_V	0.864	0.40
218_Q	237_E	0.863	0.40
290_P	310_L	0.863	0.40
103_T	254_V	0.859	0.40
70_T	242_A	0.857	0.40
61_T	311_I	0.856	0.40
314_E	317_L	0.855	0.40
49_F	200_F	0.855	0.40
139_G	257_H	0.855	0.40
54_L	115_A	0.855	0.40
168_V	227_E	0.848	0.39
115_A	204_L	0.847	0.39
257_H	284_S	0.847	0.39
69_A	271_Y	0.842	0.39
70_T	99_V	0.841	0.39
161_E	177_E	0.839	0.39
236_I	264_L	0.832	0.38
155_L	159_F	0.832	0.38
70_T	245_T	0.829	0.38
62_R	66_E	0.829	0.38
167_K	173_A	0.827	0.38
235_L	238_E	0.822	0.37
189_L	193_A	0.819	0.37
70_T	98_D	0.818	0.37
228_I	232_Y	0.814	0.37
44_Y	47_T	0.812	0.37
129_A	301_D	0.812	0.37
84_L	88_V	0.812	0.37
208_E	212_F	0.808	0.37
287_G	292_E	0.807	0.36
237_E	270_D	0.807	0.36
77_S	106_S	0.805	0.36
188_I	287_G	0.805	0.36
79_I	265_F	0.804	0.36
162_F	169_R	0.801	0.36
66_E	196_D	0.799	0.36
118_F	141_I	0.798	0.36
299_I	309_A	0.797	0.36
50_Q	78_N	0.796	0.36
292_E	295_S	0.795	0.36
37_F	40_L	0.795	0.36
168_V	173_A	0.795	0.36
60_I	275_I	0.786	0.35
155_L	209_I	0.786	0.35
283_G	298_K	0.781	0.35
257_H	289_P	0.780	0.35
170_T	235_L	0.771	0.34
26_V	97_V	0.765	0.34
128_A	294_V	0.765	0.34
31_F	135_I	0.762	0.34
63_E	161_E	0.761	0.33
105_G	207_A	0.759	0.33
129_A	133_E	0.758	0.33
174_F	241_L	0.757	0.33
110_D	297_G	0.753	0.33
151_L	155_L	0.753	0.33
59_D	63_E	0.752	0.33
301_D	322_L	0.752	0.33
258_H	263_N	0.752	0.33
311_I	315_A	0.749	0.33
42_D	325_G	0.749	0.33
288_A	292_E	0.746	0.33
76_T	142_F	0.745	0.32
188_I	199_V	0.741	0.32
278_G	282_D	0.740	0.32
43_S	47_T	0.738	0.32
232_Y	236_I	0.737	0.32
106_S	314_E	0.735	0.32
128_A	132_E	0.734	0.32
105_G	139_G	0.733	0.32
95_N	197_I	0.730	0.32
203_A	259_A	0.729	0.31
161_E	180_A	0.729	0.31
185_E	275_I	0.728	0.31
226_I	238_E	0.727	0.31
42_D	59_D	0.727	0.31
32_S	89_A	0.727	0.31
156_Y	170_T	0.726	0.31
287_G	298_K	0.725	0.31
193_A	204_L	0.724	0.31
56_D	307_N	0.723	0.31
232_Y	235_L	0.723	0.31
280_E	287_G	0.719	0.31
35_F	40_L	0.719	0.31
34_E	40_L	0.716	0.31
89_A	191_N	0.716	0.31
36_D	328_E	0.715	0.31
252_A	292_E	0.712	0.30
81_S	261_M	0.712	0.30
81_S	108_T	0.703	0.30
87_V	244_T	0.702	0.30
135_I	170_T	0.700	0.30
112_I	152_E	0.700	0.30
105_G	258_H	0.699	0.30
226_I	239_G	0.699	0.30
163_F	216_Y	0.697	0.30
136_N	149_V	0.693	0.29
45_A	56_D	0.692	0.29
148_Y	152_E	0.689	0.29
288_A	298_K	0.688	0.29
258_H	278_G	0.687	0.29
71_I	97_V	0.684	0.29
131_R	160_E	0.683	0.29
60_I	271_Y	0.682	0.29
87_V	192_A	0.679	0.28
92_V	191_N	0.674	0.28
200_F	230_D	0.667	0.28
58_V	322_L	0.666	0.28
82_S	104_S	0.665	0.28
135_I	294_V	0.664	0.28
283_G	296_W	0.664	0.28
75_L	284_S	0.662	0.27
60_I	274_Y	0.660	0.27
55_A	286_S	0.659	0.27
73_L	100_I	0.654	0.27
239_G	263_N	0.654	0.27
81_S	208_E	0.654	0.27
319_F	323_V	0.654	0.27
157_D	223_E	0.653	0.27
24_P	275_I	0.652	0.27
131_R	267_G	0.647	0.27
230_D	234_A	0.647	0.27
34_E	37_F	0.647	0.27
33_G	132_E	0.646	0.27
28_G	86_E	0.645	0.26
122_E	125_V	0.645	0.26
27_R	33_G	0.643	0.26
34_E	39_E	0.643	0.26
190_K	195_N	0.642	0.26
229_L	236_I	0.641	0.26
167_K	221_D	0.641	0.26
38_F	107_L	0.641	0.26
120_M	200_F	0.640	0.26
36_D	317_L	0.640	0.26
38_F	324_A	0.638	0.26
257_H	268_G	0.637	0.26
38_F	42_D	0.635	0.26
178_L	209_I	0.633	0.26
27_R	317_L	0.633	0.26
75_L	105_G	0.628	0.26
78_N	109_E	0.627	0.25
234_A	238_E	0.625	0.25
201_C	226_I	0.625	0.25
48_G	123_W	0.624	0.25
235_L	279_M	0.623	0.25
81_S	282_D	0.622	0.25
232_Y	237_E	0.621	0.25
48_G	85_R	0.621	0.25
58_V	70_T	0.621	0.25
108_T	262_T	0.619	0.25
54_L	244_T	0.618	0.25
183_D	194_D	0.616	0.25
25_D	41_L	0.615	0.25
108_T	261_M	0.614	0.25
112_I	203_A	0.614	0.25
159_F	226_I	0.613	0.25
63_E	66_E	0.613	0.25
196_D	219_G	0.609	0.25
108_T	208_E	0.609	0.25
76_T	105_G	0.608	0.24
286_S	314_E	0.607	0.24
153_E	157_D	0.605	0.24
61_T	65_R	0.605	0.24
75_L	278_G	0.604	0.24
84_L	87_V	0.604	0.24
39_E	317_L	0.603	0.24
139_G	284_S	0.603	0.24
105_G	113_K	0.601	0.24
48_G	82_S	0.600	0.24
108_T	112_I	0.599	0.24
180_A	213_L	0.599	0.24
112_I	209_I	0.599	0.24
99_V	234_A	0.599	0.24
122_E	142_F	0.597	0.24
156_Y	159_F	0.596	0.24
113_K	136_N	0.595	0.24
264_L	288_A	0.594	0.24
293_A	296_W	0.594	0.24
108_T	211_N	0.593	0.24
61_T	273_V	0.591	0.24
255_P	260_I	0.591	0.24
148_Y	257_H	0.590	0.24
32_S	316_T	0.590	0.24
191_N	197_I	0.590	0.24
255_P	314_E	0.589	0.23
109_E	211_N	0.588	0.23
94_E	327_F	0.588	0.23
42_D	174_F	0.588	0.23
57_A	312_E	0.588	0.23
59_D	62_R	0.588	0.23
53_H	314_E	0.587	0.23
50_Q	85_R	0.587	0.23
44_Y	132_E	0.585	0.23
78_N	81_S	0.584	0.23
232_Y	264_L	0.583	0.23
93_R	191_N	0.580	0.23
49_F	119_K	0.579	0.23
110_D	256_K	0.578	0.23
227_E	239_G	0.577	0.23
28_G	113_K	0.577	0.23
111_I	199_V	0.576	0.23
131_R	134_G	0.575	0.23
118_F	148_Y	0.573	0.23
78_N	261_M	0.572	0.23
155_L	174_F	0.572	0.23
50_Q	77_S	0.572	0.23
304_A	322_L	0.571	0.23
60_I	246_G	0.570	0.23
36_D	313_A	0.565	0.22
76_T	274_Y	0.564	0.22
152_E	216_Y	0.563	0.22
126_D	161_E	0.563	0.22
255_P	312_E	0.562	0.22
36_D	242_A	0.560	0.22
227_E	232_Y	0.556	0.22
97_V	100_I	0.555	0.22
44_Y	146_D	0.555	0.22
136_N	264_L	0.554	0.22
74_T	101_I	0.553	0.22
293_A	298_K	0.553	0.22
138_L	209_I	0.552	0.22
105_G	148_Y	0.552	0.22
89_A	192_A	0.549	0.21
227_E	230_D	0.549	0.21
287_G	295_S	0.549	0.21
41_L	322_L	0.549	0.21
78_N	105_G	0.546	0.21
75_L	286_S	0.546	0.21
58_V	275_I	0.545	0.21
252_A	298_K	0.545	0.21
262_T	269_A	0.544	0.21
48_G	140_N	0.543	0.21
96_Y	122_E	0.542	0.21
74_T	212_F	0.538	0.21
48_G	139_G	0.538	0.21
29_Y	258_H	0.537	0.21
89_A	184_D	0.537	0.21
301_D	314_E	0.535	0.21
238_E	241_L	0.535	0.21
45_A	126_D	0.534	0.21
255_P	278_G	0.532	0.21
138_L	250_V	0.532	0.21
216_Y	233_D	0.532	0.21
51_A	183_D	0.532	0.21
156_Y	312_E	0.532	0.21
137_R	320_P	0.531	0.21
113_K	118_F	0.531	0.21
129_A	180_A	0.531	0.21
83_G	121_G	0.530	0.21
161_E	165_D	0.529	0.21
184_D	189_L	0.528	0.20
26_V	242_A	0.528	0.20
77_S	105_G	0.527	0.20
288_A	296_W	0.527	0.20
126_D	167_K	0.526	0.20
39_E	161_E	0.525	0.20
161_E	241_L	0.524	0.20
89_A	177_E	0.524	0.20
174_F	204_L	0.523	0.20
32_S	328_E	0.522	0.20
49_F	103_T	0.521	0.20
25_D	44_Y	0.521	0.20
128_A	196_D	0.521	0.20
176_R	234_A	0.519	0.20
123_W	139_G	0.518	0.20
257_H	263_N	0.518	0.20
31_F	100_I	0.517	0.20
37_F	244_T	0.516	0.20
258_H	280_E	0.516	0.20
152_E	264_L	0.515	0.20
202_P	235_L	0.515	0.20
46_T	313_A	0.514	0.20
45_A	71_I	0.513	0.20
66_E	243_D	0.513	0.20
170_T	300_K	0.512	0.20
24_P	27_R	0.510	0.20
85_R	277_T	0.509	0.20
26_V	100_I	0.509	0.20
37_F	54_L	0.508	0.20
85_R	207_A	0.508	0.20
25_D	155_L	0.507	0.20
57_A	227_E	0.506	0.19
146_D	309_A	0.504	0.19
42_D	229_L	0.503	0.19
194_D	197_I	0.503	0.19
78_N	148_Y	0.502	0.19
188_I	286_S	0.502	0.19
67_D	201_C	0.500	0.19

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1rlzA	4	0.9788	100	0.054	Contact Map
4p63A	4	0.9091	100	0.057	Contact Map
3c2qA	4	0.8273	95.6	0.946	Contact Map
2hnaA	1	0.3788	31	0.972	Contact Map
3lyeA	4	0.5636	25.9	0.974	Contact Map
1f4pA	1	0.3818	23.2	0.974	Contact Map
3fa4A	5	0.5697	22.9	0.974	Contact Map
1uuyA	3	0.4182	21.1	0.975	Contact Map
3fw9A	1	0.5606	19.8	0.975	Contact Map
3bpqA	2	0.1121	19.5	0.975	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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