Q9HPX0 - HALSA - GREMLIN Contacts

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Q9HPX0 - Aspartate-semialdehyde dehydrogenase

UniProt:	Q9HPX0	Sequences: MTTVGVLGATGAVGQRFVQLLAGHETFELSVVTASPDSAGETYRDAANWGLDTPVPESIAELPVQPTTPAAIPDDTALLFSALPSDVGAEVEPALCEAGFVVSSNASNERRAGDVPLVVPEVNADHLGLIDVQRDARGWDGALVKNPNCSTITMVPTLAALTEFGLDRVHVATLQAVSGAGYSGVTSMEILDNVVPHIGGEERKMETESRKLLGEFTGAEVQHHDAVVSASCNRVPTLDGHLENVFVETSDHPAPADVAAAFEDAPTLDLPSAPDPLIETFTAPERPQPRLDRMRGDGMAIAAGGIQTTDTGIQYNCLAHNTIRGAAGASILNGELLAREGWV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	343 (296)
Sequences:	7205 (3777)
Seq/√Len:	219.5

ECOLI - ARGC USG DHAS
BACSU - ARGC DHAS
HALSA - Q9HPX0
SULSO - Q97ZL8 Q97WN3 ARGC

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
258_V	313_I	3.761	1.00
159_A	163_E	3.655	1.00
5_G	76_T	3.406	1.00
150_S	175_Q	3.191	1.00
146_N	333_N	2.939	1.00
27_F	334_G	2.848	1.00
279_E	302_A	2.800	1.00
3_T	28_E	2.716	1.00
101_V	337_L	2.710	1.00
42_T	61_E	2.577	1.00
168_R	248_E	2.525	1.00
260_A	264_D	2.517	1.00
254_A	257_D	2.469	1.00
194_V	235_V	2.443	1.00
78_L	334_G	2.437	1.00
154_M	171_V	2.314	1.00
177_V	190_I	2.281	1.00
24_H	335_E	2.274	1.00
157_T	245_V	2.193	1.00
153_T	243_E	2.142	1.00
42_T	63_P	2.068	1.00
324_R	332_L	2.053	1.00
3_T	30_S	2.051	1.00
163_E	265_A	2.039	1.00
80_F	334_G	2.028	1.00
167_D	250_S	2.013	1.00
16_R	19_Q	2.006	1.00
20_L	331_I	2.005	1.00
167_D	248_E	1.962	1.00
154_M	243_E	1.960	1.00
259_A	263_E	1.952	1.00
153_T	319_A	1.950	1.00
17_F	80_F	1.923	1.00
279_E	300_A	1.921	1.00
157_T	315_Y	1.917	1.00
172_A	244_N	1.910	1.00
144_V	337_L	1.896	1.00
36_P	66_P	1.881	1.00
257_D	260_A	1.881	1.00
44_R	61_E	1.861	1.00
150_S	173_T	1.859	1.00
126_H	222_Q	1.845	1.00
21_L	27_F	1.820	1.00
287_P	304_G	1.796	1.00
89_A	108_N	1.783	1.00
2_T	338_A	1.782	1.00
67_T	91_V	1.762	1.00
158_L	169_V	1.758	1.00
155_V	212_L	1.753	1.00
161_L	249_T	1.736	1.00
9_A	32_V	1.704	1.00
182_Y	186_T	1.695	1.00
203_R	210_R	1.668	1.00
16_R	239_D	1.667	1.00
273_A	276_P	1.637	1.00
237_T	289_P	1.616	1.00
255_P	259_A	1.616	1.00
4_V	78_L	1.614	1.00
4_V	27_F	1.614	1.00
165_G	250_S	1.605	1.00
170_H	246_F	1.591	1.00
173_T	243_E	1.581	1.00
157_T	317_C	1.562	1.00
41_E	45_D	1.539	1.00
38_S	41_E	1.535	1.00
323_I	328_G	1.532	1.00
186_T	189_E	1.523	1.00
94_A	97_E	1.506	1.00
245_V	317_C	1.487	1.00
249_T	313_I	1.466	1.00
90_E	94_A	1.463	1.00
3_T	77_A	1.460	1.00
101_V	142_A	1.457	1.00
13_V	327_A	1.456	1.00
161_L	313_I	1.451	1.00
199_G	207_T	1.429	1.00
161_L	262_F	1.421	1.00
192_D	293_R	1.421	1.00
125_D	142_A	1.410	1.00
255_P	306_I	1.410	1.00
252_H	308_T	1.399	1.00
7_L	81_S	1.393	1.00
299_M	323_I	1.371	1.00
262_F	315_Y	1.361	1.00
86_D	108_N	1.355	1.00
154_M	245_V	1.344	1.00
260_A	263_E	1.336	1.00
78_L	338_A	1.330	1.00
22_A	58_S	1.328	1.00
81_S	92_E	1.315	1.00
191_L	238_L	1.312	1.00
3_T	31_V	1.306	1.00
96_C	143_L	1.292	1.00
72_I	95_L	1.290	1.00
79_L	100_F	1.286	1.00
245_V	315_Y	1.285	1.00
248_E	312_G	1.283	1.00
91_V	94_A	1.276	1.00
73_P	98_A	1.271	1.00
5_G	79_L	1.265	1.00
154_M	209_S	1.264	1.00
299_M	328_G	1.260	1.00
171_V	245_V	1.239	1.00
197_H	284_P	1.235	1.00
256_A	260_A	1.234	1.00
157_T	262_F	1.233	1.00
301_I	319_A	1.226	1.00
288_Q	291_L	1.222	1.00
93_P	97_E	1.206	1.00
42_T	45_D	1.204	1.00
168_R	312_G	1.189	1.00
172_A	246_F	1.173	1.00
35_S	38_S	1.169	1.00
247_V	313_I	1.162	1.00
242_L	318_L	1.150	1.00
101_V	144_V	1.142	1.00
153_T	173_T	1.139	1.00
307_Q	310_D	1.138	1.00
178_S	238_L	1.137	1.00
159_A	216_F	1.136	1.00
92_E	102_V	1.121	1.00
21_L	29_L	1.119	1.00
235_V	289_P	1.118	1.00
180_A	184_G	1.115	1.00
32_V	62_L	1.108	1.00
223_H	226_A	1.108	1.00
264_D	273_A	1.105	1.00
112_A	215_E	1.103	1.00
158_L	247_V	1.102	1.00
174_L	235_V	1.100	1.00
10_T	64_V	1.095	1.00
323_I	331_I	1.093	1.00
89_A	118_V	1.091	1.00
259_A	280_T	1.091	1.00
301_I	317_C	1.078	1.00
252_H	311_T	1.070	1.00
94_A	98_A	1.068	1.00
18_V	29_L	1.060	1.00
193_N	288_Q	1.058	1.00
68_T	71_A	1.057	1.00
124_A	336_L	1.052	1.00
169_V	247_V	1.049	1.00
255_P	308_T	1.044	1.00
18_V	43_Y	1.030	1.00
242_L	316_N	1.027	1.00
242_L	289_P	1.021	1.00
65_Q	71_A	1.020	1.00
247_V	315_Y	1.018	1.00
125_D	222_Q	1.017	1.00
156_P	301_I	1.015	1.00
20_L	328_G	1.011	1.00
13_V	326_A	1.006	1.00
184_G	188_M	1.001	1.00
251_D	257_D	1.000	1.00
185_V	189_E	0.998	1.00
76_T	79_L	0.989	1.00
240_G	321_N	0.981	1.00
174_L	246_F	0.972	1.00
39_A	66_P	0.967	1.00
157_T	160_A	0.966	1.00
66_P	69_P	0.963	1.00
210_R	309_T	0.962	1.00
161_L	258_V	0.952	1.00
34_A	38_S	0.950	1.00
5_G	31_V	0.947	1.00
95_L	102_V	0.945	1.00
69_P	94_A	0.943	1.00
80_F	330_S	0.943	1.00
70_A	98_A	0.941	1.00
233_N	244_N	0.937	1.00
31_V	65_Q	0.936	1.00
119_V	155_V	0.931	1.00
30_S	76_T	0.931	1.00
10_T	35_S	0.930	1.00
184_G	189_E	0.926	0.99
200_G	207_T	0.926	0.99
103_S	334_G	0.925	0.99
109_E	119_V	0.922	0.99
229_S	246_F	0.921	0.99
286_R	316_N	0.919	0.99
199_G	204_K	0.917	0.99
153_T	317_C	0.915	0.99
249_T	253_P	0.911	0.99
194_V	289_P	0.909	0.99
27_F	338_A	0.907	0.99
87_V	90_E	0.906	0.99
252_H	261_A	0.904	0.99
7_L	67_T	0.898	0.99
117_L	120_P	0.894	0.99
78_L	101_V	0.888	0.99
24_H	27_F	0.888	0.99
195_V	288_Q	0.888	0.99
189_E	238_L	0.883	0.99
114_D	141_G	0.880	0.99
92_E	143_L	0.872	0.99
256_A	259_A	0.868	0.99
138_G	337_L	0.865	0.99
158_L	245_V	0.865	0.99
246_F	314_Q	0.863	0.99
83_L	106_A	0.861	0.99
2_T	78_L	0.859	0.99
164_F	261_A	0.856	0.99
125_D	128_G	0.853	0.99
162_T	223_H	0.852	0.99
117_L	123_N	0.850	0.99
210_R	310_D	0.845	0.99
38_S	64_V	0.836	0.99
79_L	95_L	0.834	0.99
303_A	315_Y	0.834	0.99
25_E	58_S	0.834	0.99
291_L	302_A	0.833	0.99
146_N	326_A	0.828	0.99
298_G	302_A	0.827	0.99
249_T	258_V	0.827	0.99
259_A	284_P	0.825	0.99
149_C	179_G	0.825	0.99
180_A	195_V	0.822	0.99
210_R	214_G	0.820	0.99
239_D	322_T	0.816	0.99
72_I	76_T	0.816	0.99
194_V	233_N	0.815	0.99
111_R	145_K	0.811	0.99
334_G	338_A	0.805	0.99
273_A	285_E	0.804	0.99
83_L	88_G	0.800	0.98
164_F	253_P	0.794	0.98
172_A	233_N	0.794	0.98
43_Y	64_V	0.793	0.98
59_I	62_L	0.792	0.98
289_P	292_D	0.792	0.98
286_R	304_G	0.791	0.98
71_A	75_D	0.790	0.98
20_L	323_I	0.788	0.98
83_L	87_V	0.786	0.98
127_L	336_L	0.785	0.98
19_Q	23_G	0.779	0.98
152_I	329_A	0.778	0.98
255_P	258_V	0.777	0.98
253_P	261_A	0.774	0.98
22_A	60_A	0.772	0.98
244_N	314_Q	0.770	0.98
290_R	293_R	0.768	0.98
93_P	96_C	0.768	0.98
153_T	318_L	0.767	0.98
222_Q	226_A	0.765	0.98
249_T	252_H	0.765	0.98
111_R	207_T	0.763	0.98
199_G	202_E	0.761	0.98
156_P	265_A	0.758	0.98
244_N	316_N	0.758	0.98
174_L	233_N	0.757	0.98
196_P	233_N	0.756	0.98
24_H	299_M	0.750	0.98
69_P	90_E	0.749	0.98
121_E	324_R	0.748	0.98
196_P	316_N	0.739	0.97
166_L	247_V	0.738	0.97
199_G	206_E	0.737	0.97
158_L	171_V	0.737	0.97
253_P	258_V	0.734	0.97
171_V	209_S	0.731	0.97
159_A	162_T	0.731	0.97
86_D	89_A	0.725	0.97
222_Q	225_D	0.725	0.97
105_N	329_A	0.724	0.97
171_V	243_E	0.724	0.97
95_L	106_A	0.724	0.97
240_G	293_R	0.724	0.97
289_P	293_R	0.724	0.97
62_L	65_Q	0.719	0.97
196_P	242_L	0.718	0.97
166_L	250_S	0.715	0.97
214_G	222_Q	0.715	0.97
105_N	146_N	0.712	0.97
185_V	188_M	0.712	0.97
174_L	194_V	0.700	0.97
151_T	155_V	0.698	0.96
206_E	210_R	0.694	0.96
138_G	336_L	0.693	0.96
306_I	313_I	0.689	0.96
29_L	62_L	0.688	0.96
6_V	21_L	0.685	0.96
103_S	337_L	0.684	0.96
70_A	73_P	0.684	0.96
93_P	109_E	0.683	0.96
110_R	208_E	0.682	0.96
210_R	227_V	0.681	0.96
112_A	211_K	0.681	0.96
259_A	306_I	0.678	0.96
29_L	60_A	0.677	0.96
212_L	215_E	0.677	0.96
305_G	308_T	0.676	0.96
111_R	211_K	0.676	0.96
73_P	97_E	0.673	0.96
187_S	195_V	0.670	0.96
78_L	103_S	0.668	0.95
6_V	17_F	0.666	0.95
162_T	166_L	0.664	0.95
23_G	323_I	0.662	0.95
29_L	32_V	0.662	0.95
19_Q	22_A	0.661	0.95
80_F	103_S	0.659	0.95
153_T	301_I	0.658	0.95
162_T	169_V	0.658	0.95
163_E	264_D	0.655	0.95
35_S	40_G	0.655	0.95
153_T	241_H	0.651	0.95
9_A	14_G	0.647	0.95
4_V	29_L	0.646	0.95
81_S	102_V	0.645	0.95
263_E	273_A	0.644	0.94
159_A	265_A	0.643	0.94
286_R	289_P	0.640	0.94
93_P	102_V	0.638	0.94
243_E	317_C	0.636	0.94
12_A	185_V	0.631	0.94
229_S	312_G	0.629	0.94
141_G	144_V	0.628	0.94
107_S	207_T	0.627	0.94
336_L	339_R	0.626	0.94
192_D	238_L	0.626	0.94
254_A	308_T	0.625	0.94
276_P	285_E	0.625	0.94
161_L	247_V	0.624	0.94
249_T	306_I	0.624	0.94
240_G	292_D	0.624	0.94
6_V	18_V	0.623	0.93
81_S	88_G	0.622	0.93
171_V	230_A	0.621	0.93
190_I	234_R	0.621	0.93
122_V	156_P	0.620	0.93
263_E	280_T	0.619	0.93
44_R	60_A	0.619	0.93
21_L	331_I	0.619	0.93
88_G	109_E	0.618	0.93
201_E	210_R	0.617	0.93
92_E	95_L	0.616	0.93
302_A	318_L	0.615	0.93
124_A	128_G	0.615	0.93
157_T	301_I	0.613	0.93
65_Q	75_D	0.605	0.92
2_T	77_A	0.605	0.92
85_S	107_S	0.604	0.92
101_V	338_A	0.601	0.92
116_P	123_N	0.600	0.92
86_D	115_V	0.600	0.92
313_I	316_N	0.599	0.92
123_N	126_H	0.599	0.92
201_E	214_G	0.598	0.92
4_V	334_G	0.595	0.92
170_H	244_N	0.594	0.92
63_P	66_P	0.594	0.92
95_L	98_A	0.592	0.92
21_L	334_G	0.591	0.92
239_D	293_R	0.590	0.92
147_P	152_I	0.590	0.92
76_T	100_F	0.590	0.92
153_T	321_N	0.589	0.91
81_S	95_L	0.589	0.91
120_P	124_A	0.588	0.91
239_D	321_N	0.587	0.91
86_D	106_A	0.586	0.91
165_G	248_E	0.586	0.91
176_A	239_D	0.584	0.91
149_C	208_E	0.578	0.91
151_T	243_E	0.576	0.91
224_H	227_V	0.576	0.91
69_P	98_A	0.569	0.90
37_D	40_G	0.568	0.90
119_V	122_V	0.567	0.90
170_H	248_E	0.565	0.90
116_P	141_G	0.565	0.90
110_R	149_C	0.564	0.90
193_N	290_R	0.564	0.90
154_M	173_T	0.561	0.89
89_A	112_A	0.561	0.89
64_V	67_T	0.560	0.89
229_S	314_Q	0.559	0.89
287_P	292_D	0.557	0.89
162_T	165_G	0.557	0.89
9_A	64_V	0.555	0.89
4_V	80_F	0.554	0.89
299_M	332_L	0.553	0.89
329_A	333_N	0.551	0.89
164_F	257_D	0.551	0.89
154_M	317_C	0.547	0.88
110_R	179_G	0.546	0.88
103_S	330_S	0.546	0.88
157_T	303_A	0.546	0.88
73_P	95_L	0.545	0.88
238_L	293_R	0.545	0.88
72_I	79_L	0.543	0.88
66_P	71_A	0.542	0.88
152_I	319_A	0.540	0.88
29_L	45_D	0.540	0.88
10_T	38_S	0.539	0.87
44_R	59_I	0.539	0.87
7_L	83_L	0.539	0.87
167_D	311_T	0.539	0.87
262_F	280_T	0.539	0.87
80_F	331_I	0.539	0.87
95_L	100_F	0.537	0.87
126_H	143_L	0.535	0.87
235_V	241_H	0.534	0.87
179_G	208_E	0.534	0.87
31_V	76_T	0.533	0.87
39_A	63_P	0.533	0.87
8_G	11_G	0.532	0.87
106_A	330_S	0.532	0.87
87_V	106_A	0.529	0.86
18_V	22_A	0.528	0.86
203_R	310_D	0.527	0.86
115_V	118_V	0.527	0.86
60_A	64_V	0.524	0.86
96_C	99_G	0.522	0.86
60_A	63_P	0.522	0.86
148_N	211_K	0.520	0.86
127_L	138_G	0.519	0.85
18_V	32_V	0.517	0.85
227_V	310_D	0.516	0.85
139_W	336_L	0.516	0.85
121_E	124_A	0.516	0.85
101_V	141_G	0.515	0.85
154_M	169_V	0.515	0.85
184_G	187_S	0.514	0.85
171_V	228_V	0.513	0.85
201_E	314_Q	0.512	0.85
229_S	310_D	0.512	0.85
138_G	141_G	0.511	0.85
45_D	285_E	0.511	0.85
58_S	61_E	0.511	0.85
175_Q	179_G	0.511	0.85
84_P	107_S	0.509	0.84
185_V	238_L	0.509	0.84
156_P	324_R	0.508	0.84
292_D	298_G	0.506	0.84
68_T	90_E	0.503	0.84
68_T	91_V	0.503	0.84
151_T	319_A	0.503	0.84
214_G	226_A	0.502	0.83
285_E	288_Q	0.502	0.83
155_V	241_H	0.500	0.83
235_V	238_L	0.500	0.83
17_F	331_I	0.500	0.83

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1vknA	4	0.9125	100	0.223	Contact Map
3hskA	4	0.9854	100	0.24	Contact Map
2ep5A	4	0.9913	100	0.251	Contact Map
1ys4A	4	0.9942	100	0.253	Contact Map
1xygA	4	0.9271	100	0.254	Contact Map
4dplA	4	0.9708	100	0.259	Contact Map
3uw3A	2	0.8892	100	0.269	Contact Map
2yv3A	2	0.8688	100	0.277	Contact Map
1t4bA	2	0.8834	100	0.278	Contact Map
2r00A	2	0.8921	100	0.283	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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