GREMLIN Database
Q9HPX0 - Aspartate-semialdehyde dehydrogenase
UniProt: Q9HPX0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 343 (296)
Sequences: 7205 (3777)
Seq/√Len: 219.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
258_V313_I3.7611.00
159_A163_E3.6551.00
5_G76_T3.4061.00
150_S175_Q3.1911.00
146_N333_N2.9391.00
27_F334_G2.8481.00
279_E302_A2.8001.00
3_T28_E2.7161.00
101_V337_L2.7101.00
42_T61_E2.5771.00
168_R248_E2.5251.00
260_A264_D2.5171.00
254_A257_D2.4691.00
194_V235_V2.4431.00
78_L334_G2.4371.00
154_M171_V2.3141.00
177_V190_I2.2811.00
24_H335_E2.2741.00
157_T245_V2.1931.00
153_T243_E2.1421.00
42_T63_P2.0681.00
324_R332_L2.0531.00
3_T30_S2.0511.00
163_E265_A2.0391.00
80_F334_G2.0281.00
167_D250_S2.0131.00
16_R19_Q2.0061.00
20_L331_I2.0051.00
167_D248_E1.9621.00
154_M243_E1.9601.00
259_A263_E1.9521.00
153_T319_A1.9501.00
17_F80_F1.9231.00
279_E300_A1.9211.00
157_T315_Y1.9171.00
172_A244_N1.9101.00
144_V337_L1.8961.00
36_P66_P1.8811.00
257_D260_A1.8811.00
44_R61_E1.8611.00
150_S173_T1.8591.00
126_H222_Q1.8451.00
21_L27_F1.8201.00
287_P304_G1.7961.00
89_A108_N1.7831.00
2_T338_A1.7821.00
67_T91_V1.7621.00
158_L169_V1.7581.00
155_V212_L1.7531.00
161_L249_T1.7361.00
9_A32_V1.7041.00
182_Y186_T1.6951.00
203_R210_R1.6681.00
16_R239_D1.6671.00
273_A276_P1.6371.00
237_T289_P1.6161.00
255_P259_A1.6161.00
4_V78_L1.6141.00
4_V27_F1.6141.00
165_G250_S1.6051.00
170_H246_F1.5911.00
173_T243_E1.5811.00
157_T317_C1.5621.00
41_E45_D1.5391.00
38_S41_E1.5351.00
323_I328_G1.5321.00
186_T189_E1.5231.00
94_A97_E1.5061.00
245_V317_C1.4871.00
249_T313_I1.4661.00
90_E94_A1.4631.00
3_T77_A1.4601.00
101_V142_A1.4571.00
13_V327_A1.4561.00
161_L313_I1.4511.00
199_G207_T1.4291.00
161_L262_F1.4211.00
192_D293_R1.4211.00
125_D142_A1.4101.00
255_P306_I1.4101.00
252_H308_T1.3991.00
7_L81_S1.3931.00
299_M323_I1.3711.00
262_F315_Y1.3611.00
86_D108_N1.3551.00
154_M245_V1.3441.00
260_A263_E1.3361.00
78_L338_A1.3301.00
22_A58_S1.3281.00
81_S92_E1.3151.00
191_L238_L1.3121.00
3_T31_V1.3061.00
96_C143_L1.2921.00
72_I95_L1.2901.00
79_L100_F1.2861.00
245_V315_Y1.2851.00
248_E312_G1.2831.00
91_V94_A1.2761.00
73_P98_A1.2711.00
5_G79_L1.2651.00
154_M209_S1.2641.00
299_M328_G1.2601.00
171_V245_V1.2391.00
197_H284_P1.2351.00
256_A260_A1.2341.00
157_T262_F1.2331.00
301_I319_A1.2261.00
288_Q291_L1.2221.00
93_P97_E1.2061.00
42_T45_D1.2041.00
168_R312_G1.1891.00
172_A246_F1.1731.00
35_S38_S1.1691.00
247_V313_I1.1621.00
242_L318_L1.1501.00
101_V144_V1.1421.00
153_T173_T1.1391.00
307_Q310_D1.1381.00
178_S238_L1.1371.00
159_A216_F1.1361.00
92_E102_V1.1211.00
21_L29_L1.1191.00
235_V289_P1.1181.00
180_A184_G1.1151.00
32_V62_L1.1081.00
223_H226_A1.1081.00
264_D273_A1.1051.00
112_A215_E1.1031.00
158_L247_V1.1021.00
174_L235_V1.1001.00
10_T64_V1.0951.00
323_I331_I1.0931.00
89_A118_V1.0911.00
259_A280_T1.0911.00
301_I317_C1.0781.00
252_H311_T1.0701.00
94_A98_A1.0681.00
18_V29_L1.0601.00
193_N288_Q1.0581.00
68_T71_A1.0571.00
124_A336_L1.0521.00
169_V247_V1.0491.00
255_P308_T1.0441.00
18_V43_Y1.0301.00
242_L316_N1.0271.00
242_L289_P1.0211.00
65_Q71_A1.0201.00
247_V315_Y1.0181.00
125_D222_Q1.0171.00
156_P301_I1.0151.00
20_L328_G1.0111.00
13_V326_A1.0061.00
184_G188_M1.0011.00
251_D257_D1.0001.00
185_V189_E0.9981.00
76_T79_L0.9891.00
240_G321_N0.9811.00
174_L246_F0.9721.00
39_A66_P0.9671.00
157_T160_A0.9661.00
66_P69_P0.9631.00
210_R309_T0.9621.00
161_L258_V0.9521.00
34_A38_S0.9501.00
5_G31_V0.9471.00
95_L102_V0.9451.00
69_P94_A0.9431.00
80_F330_S0.9431.00
70_A98_A0.9411.00
233_N244_N0.9371.00
31_V65_Q0.9361.00
119_V155_V0.9311.00
30_S76_T0.9311.00
10_T35_S0.9301.00
184_G189_E0.9260.99
200_G207_T0.9260.99
103_S334_G0.9250.99
109_E119_V0.9220.99
229_S246_F0.9210.99
286_R316_N0.9190.99
199_G204_K0.9170.99
153_T317_C0.9150.99
249_T253_P0.9110.99
194_V289_P0.9090.99
27_F338_A0.9070.99
87_V90_E0.9060.99
252_H261_A0.9040.99
7_L67_T0.8980.99
117_L120_P0.8940.99
78_L101_V0.8880.99
24_H27_F0.8880.99
195_V288_Q0.8880.99
189_E238_L0.8830.99
114_D141_G0.8800.99
92_E143_L0.8720.99
256_A259_A0.8680.99
138_G337_L0.8650.99
158_L245_V0.8650.99
246_F314_Q0.8630.99
83_L106_A0.8610.99
2_T78_L0.8590.99
164_F261_A0.8560.99
125_D128_G0.8530.99
162_T223_H0.8520.99
117_L123_N0.8500.99
210_R310_D0.8450.99
38_S64_V0.8360.99
79_L95_L0.8340.99
303_A315_Y0.8340.99
25_E58_S0.8340.99
291_L302_A0.8330.99
146_N326_A0.8280.99
298_G302_A0.8270.99
249_T258_V0.8270.99
259_A284_P0.8250.99
149_C179_G0.8250.99
180_A195_V0.8220.99
210_R214_G0.8200.99
239_D322_T0.8160.99
72_I76_T0.8160.99
194_V233_N0.8150.99
111_R145_K0.8110.99
334_G338_A0.8050.99
273_A285_E0.8040.99
83_L88_G0.8000.98
164_F253_P0.7940.98
172_A233_N0.7940.98
43_Y64_V0.7930.98
59_I62_L0.7920.98
289_P292_D0.7920.98
286_R304_G0.7910.98
71_A75_D0.7900.98
20_L323_I0.7880.98
83_L87_V0.7860.98
127_L336_L0.7850.98
19_Q23_G0.7790.98
152_I329_A0.7780.98
255_P258_V0.7770.98
253_P261_A0.7740.98
22_A60_A0.7720.98
244_N314_Q0.7700.98
290_R293_R0.7680.98
93_P96_C0.7680.98
153_T318_L0.7670.98
222_Q226_A0.7650.98
249_T252_H0.7650.98
111_R207_T0.7630.98
199_G202_E0.7610.98
156_P265_A0.7580.98
244_N316_N0.7580.98
174_L233_N0.7570.98
196_P233_N0.7560.98
24_H299_M0.7500.98
69_P90_E0.7490.98
121_E324_R0.7480.98
196_P316_N0.7390.97
166_L247_V0.7380.97
199_G206_E0.7370.97
158_L171_V0.7370.97
253_P258_V0.7340.97
171_V209_S0.7310.97
159_A162_T0.7310.97
86_D89_A0.7250.97
222_Q225_D0.7250.97
105_N329_A0.7240.97
171_V243_E0.7240.97
95_L106_A0.7240.97
240_G293_R0.7240.97
289_P293_R0.7240.97
62_L65_Q0.7190.97
196_P242_L0.7180.97
166_L250_S0.7150.97
214_G222_Q0.7150.97
105_N146_N0.7120.97
185_V188_M0.7120.97
174_L194_V0.7000.97
151_T155_V0.6980.96
206_E210_R0.6940.96
138_G336_L0.6930.96
306_I313_I0.6890.96
29_L62_L0.6880.96
6_V21_L0.6850.96
103_S337_L0.6840.96
70_A73_P0.6840.96
93_P109_E0.6830.96
110_R208_E0.6820.96
210_R227_V0.6810.96
112_A211_K0.6810.96
259_A306_I0.6780.96
29_L60_A0.6770.96
212_L215_E0.6770.96
305_G308_T0.6760.96
111_R211_K0.6760.96
73_P97_E0.6730.96
187_S195_V0.6700.96
78_L103_S0.6680.95
6_V17_F0.6660.95
162_T166_L0.6640.95
23_G323_I0.6620.95
29_L32_V0.6620.95
19_Q22_A0.6610.95
80_F103_S0.6590.95
153_T301_I0.6580.95
162_T169_V0.6580.95
163_E264_D0.6550.95
35_S40_G0.6550.95
153_T241_H0.6510.95
9_A14_G0.6470.95
4_V29_L0.6460.95
81_S102_V0.6450.95
263_E273_A0.6440.94
159_A265_A0.6430.94
286_R289_P0.6400.94
93_P102_V0.6380.94
243_E317_C0.6360.94
12_A185_V0.6310.94
229_S312_G0.6290.94
141_G144_V0.6280.94
107_S207_T0.6270.94
336_L339_R0.6260.94
192_D238_L0.6260.94
254_A308_T0.6250.94
276_P285_E0.6250.94
161_L247_V0.6240.94
249_T306_I0.6240.94
240_G292_D0.6240.94
6_V18_V0.6230.93
81_S88_G0.6220.93
171_V230_A0.6210.93
190_I234_R0.6210.93
122_V156_P0.6200.93
263_E280_T0.6190.93
44_R60_A0.6190.93
21_L331_I0.6190.93
88_G109_E0.6180.93
201_E210_R0.6170.93
92_E95_L0.6160.93
302_A318_L0.6150.93
124_A128_G0.6150.93
157_T301_I0.6130.93
65_Q75_D0.6050.92
2_T77_A0.6050.92
85_S107_S0.6040.92
101_V338_A0.6010.92
116_P123_N0.6000.92
86_D115_V0.6000.92
313_I316_N0.5990.92
123_N126_H0.5990.92
201_E214_G0.5980.92
4_V334_G0.5950.92
170_H244_N0.5940.92
63_P66_P0.5940.92
95_L98_A0.5920.92
21_L334_G0.5910.92
239_D293_R0.5900.92
147_P152_I0.5900.92
76_T100_F0.5900.92
153_T321_N0.5890.91
81_S95_L0.5890.91
120_P124_A0.5880.91
239_D321_N0.5870.91
86_D106_A0.5860.91
165_G248_E0.5860.91
176_A239_D0.5840.91
149_C208_E0.5780.91
151_T243_E0.5760.91
224_H227_V0.5760.91
69_P98_A0.5690.90
37_D40_G0.5680.90
119_V122_V0.5670.90
170_H248_E0.5650.90
116_P141_G0.5650.90
110_R149_C0.5640.90
193_N290_R0.5640.90
154_M173_T0.5610.89
89_A112_A0.5610.89
64_V67_T0.5600.89
229_S314_Q0.5590.89
287_P292_D0.5570.89
162_T165_G0.5570.89
9_A64_V0.5550.89
4_V80_F0.5540.89
299_M332_L0.5530.89
329_A333_N0.5510.89
164_F257_D0.5510.89
154_M317_C0.5470.88
110_R179_G0.5460.88
103_S330_S0.5460.88
157_T303_A0.5460.88
73_P95_L0.5450.88
238_L293_R0.5450.88
72_I79_L0.5430.88
66_P71_A0.5420.88
152_I319_A0.5400.88
29_L45_D0.5400.88
10_T38_S0.5390.87
44_R59_I0.5390.87
7_L83_L0.5390.87
167_D311_T0.5390.87
262_F280_T0.5390.87
80_F331_I0.5390.87
95_L100_F0.5370.87
126_H143_L0.5350.87
235_V241_H0.5340.87
179_G208_E0.5340.87
31_V76_T0.5330.87
39_A63_P0.5330.87
8_G11_G0.5320.87
106_A330_S0.5320.87
87_V106_A0.5290.86
18_V22_A0.5280.86
203_R310_D0.5270.86
115_V118_V0.5270.86
60_A64_V0.5240.86
96_C99_G0.5220.86
60_A63_P0.5220.86
148_N211_K0.5200.86
127_L138_G0.5190.85
18_V32_V0.5170.85
227_V310_D0.5160.85
139_W336_L0.5160.85
121_E124_A0.5160.85
101_V141_G0.5150.85
154_M169_V0.5150.85
184_G187_S0.5140.85
171_V228_V0.5130.85
201_E314_Q0.5120.85
229_S310_D0.5120.85
138_G141_G0.5110.85
45_D285_E0.5110.85
58_S61_E0.5110.85
175_Q179_G0.5110.85
84_P107_S0.5090.84
185_V238_L0.5090.84
156_P324_R0.5080.84
292_D298_G0.5060.84
68_T90_E0.5030.84
68_T91_V0.5030.84
151_T319_A0.5030.84
214_G226_A0.5020.83
285_E288_Q0.5020.83
155_V241_H0.5000.83
235_V238_L0.5000.83
17_F331_I0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vknA 4 0.9125 100 0.223 Contact Map
3hskA 4 0.9854 100 0.24 Contact Map
2ep5A 4 0.9913 100 0.251 Contact Map
1ys4A 4 0.9942 100 0.253 Contact Map
1xygA 4 0.9271 100 0.254 Contact Map
4dplA 4 0.9708 100 0.259 Contact Map
3uw3A 2 0.8892 100 0.269 Contact Map
2yv3A 2 0.8688 100 0.277 Contact Map
1t4bA 2 0.8834 100 0.278 Contact Map
2r00A 2 0.8921 100 0.283 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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