GREMLIN Database
Q9HPW9 - Phosphoglycerate dehydrogenase
UniProt: Q9HPW9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 234 (223)
Sequences: 19453 (13089)
Seq/√Len: 876.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
134_D137_A4.0101.00
135_A163_T3.1281.00
157_D160_A2.7961.00
62_V78_L2.5491.00
125_L154_G2.4641.00
166_R192_F2.3681.00
61_T84_D2.3601.00
110_H140_T2.2621.00
113_L137_A2.1461.00
86_I115_R2.1131.00
61_T86_I2.0941.00
63_T112_A2.0741.00
67_L87_G2.0571.00
41_W45_Q2.0551.00
114_A140_T1.9961.00
143_P169_S1.9741.00
131_G179_D1.9561.00
222_R227_D1.9091.00
27_L78_L1.8951.00
139_D169_S1.8711.00
34_A118_Y1.8521.00
108_A111_D1.8091.00
36_N39_E1.7991.00
73_A76_D1.7831.00
163_T167_R1.7751.00
131_G157_D1.7491.00
28_G37_L1.7371.00
110_H137_A1.6901.00
4_L11_V1.6831.00
138_F164_A1.6681.00
63_T116_T1.6631.00
30_V118_Y1.6541.00
29_S174_A1.6521.00
146_V172_G1.6431.00
135_A139_D1.6361.00
145_S170_I1.6171.00
20_P58_G1.6131.00
133_I138_F1.6011.00
27_L81_F1.5951.00
125_L130_R1.5811.00
32_T38_H1.5771.00
3_R6_E1.5731.00
162_V166_R1.5481.00
166_R188_P1.5321.00
111_D115_R1.5261.00
158_T179_D1.5221.00
141_L145_S1.5061.00
162_V192_F1.5051.00
64_V71_G1.5031.00
147_L156_V1.4981.00
221_S225_A1.4941.00
133_I137_A1.4911.00
192_F195_V1.4801.00
62_V83_V1.4491.00
42_R45_Q1.4201.00
127_D130_R1.4201.00
117_D142_P1.4121.00
130_R154_G1.4091.00
55_H60_S1.4011.00
25_Q202_A1.3991.00
136_A140_T1.3931.00
84_D105_D1.3911.00
3_R7_R1.3861.00
161_L173_A1.3811.00
137_A140_T1.3751.00
73_A77_R1.3731.00
33_F172_G1.3661.00
78_L83_V1.3601.00
60_S207_D1.3591.00
20_P73_A1.3581.00
24_E77_R1.3551.00
56_E211_R1.3501.00
135_A160_A1.3421.00
222_R230_E1.3291.00
113_L133_I1.3271.00
121_L155_V1.3181.00
74_V122_A1.3071.00
146_V171_R1.3011.00
151_A155_V1.2951.00
122_A150_V1.2821.00
26_V74_V1.2701.00
43_R48_E1.2621.00
26_V150_V1.2541.00
42_R46_R1.2511.00
223_L229_L1.2081.00
121_L147_L1.2011.00
76_D82_D1.1971.00
64_V75_V1.1971.00
25_Q29_S1.1931.00
38_H41_W1.1871.00
33_F146_V1.1841.00
84_D115_R1.1711.00
47_R191_N1.1581.00
65_V123_T1.1531.00
214_D218_E1.1521.00
218_E222_R1.1481.00
64_V120_V1.1461.00
20_P77_R1.1441.00
112_A116_T1.1411.00
86_I107_A1.1371.00
123_T155_V1.1371.00
86_I116_T1.1211.00
178_T197_L1.1171.00
65_V132_L1.1131.00
109_V137_A1.1121.00
67_L72_H1.1051.00
136_A139_D1.0921.00
23_A77_R1.0921.00
31_L81_F1.0831.00
89_R93_S1.0801.00
30_V78_L1.0761.00
110_H136_A1.0741.00
65_V133_I1.0671.00
10_A229_L1.0651.00
183_L187_H1.0631.00
33_F174_A1.0621.00
142_P145_S1.0561.00
30_V62_V1.0521.00
74_V120_V1.0391.00
119_L141_L1.0371.00
18_H203_G1.0361.00
118_Y146_V1.0321.00
218_E230_E1.0301.00
61_T115_R1.0171.00
180_P184_P1.0171.00
159_D188_P1.0141.00
25_Q198_T1.0021.00
33_F196_L0.9991.00
132_L155_V0.9921.00
162_V188_P0.9911.00
28_G31_L0.9871.00
165_I195_V0.9751.00
134_D160_A0.9691.00
164_A169_S0.9561.00
105_D115_R0.9561.00
120_V150_V0.9551.00
76_D79_Q0.9431.00
210_P214_D0.9401.00
34_A60_S0.9361.00
109_V113_L0.9351.00
25_Q174_A0.9221.00
219_N222_R0.9201.00
90_Y128_T0.9171.00
34_A55_H0.9141.00
74_V78_L0.9071.00
144_E169_S0.9031.00
79_Q103_G0.9021.00
166_R191_N0.9001.00
164_A170_I0.8971.00
65_V119_L0.8941.00
65_V109_V0.8931.00
158_T180_P0.8921.00
123_T132_L0.8811.00
72_H93_S0.8801.00
21_S56_E0.8771.00
158_T187_H0.8771.00
29_S196_L0.8761.00
134_D157_D0.8701.00
62_V120_V0.8661.00
138_F147_L0.8591.00
116_T119_L0.8541.00
75_V85_T0.8541.00
110_H114_A0.8491.00
107_A111_D0.8431.00
180_P183_L0.8431.00
38_H42_R0.8401.00
67_L75_V0.8381.00
27_L77_R0.8331.00
156_V161_L0.8311.00
56_E205_T0.8291.00
58_G82_D0.8281.00
87_G104_F0.8251.00
55_H206_P0.8241.00
133_I147_L0.8241.00
65_V121_L0.8161.00
64_V74_V0.8071.00
124_P129_T0.8051.00
92_P106_D0.7991.00
32_T196_L0.7991.00
121_L133_I0.7971.00
172_G196_L0.7971.00
34_A146_V0.7941.00
19_A69_A0.7921.00
32_T37_L0.7881.00
135_A169_S0.7801.00
111_D114_A0.7771.00
57_L83_V0.7741.00
183_L186_D0.7721.00
19_A73_A0.7711.00
144_E171_R0.7691.00
40_G201_N0.7661.00
27_L74_V0.7641.00
42_R193_E0.7611.00
55_H207_D0.7611.00
26_V122_A0.7591.00
14_A215_I0.7591.00
28_G32_T0.7561.00
103_G107_A0.7561.00
104_F107_A0.7511.00
109_V132_L0.7431.00
100_E103_G0.7431.00
211_R214_D0.7401.00
138_F141_L0.7401.00
20_P24_E0.7381.00
34_A38_H0.7361.00
113_L119_L0.7351.00
159_D163_T0.7331.00
158_T189_L0.7321.00
87_G106_D0.7311.00
173_A195_V0.7301.00
217_A221_S0.7291.00
175_L195_V0.7271.00
107_A115_R0.7261.00
138_F169_S0.7241.00
163_T166_R0.7201.00
16_G69_A0.7151.00
26_V120_V0.7121.00
139_D167_R0.7061.00
23_A73_A0.7051.00
43_R46_R0.7011.00
22_I202_A0.7011.00
178_T183_L0.6991.00
125_L129_T0.6981.00
60_S118_Y0.6961.00
113_L140_T0.6941.00
30_V74_V0.6931.00
165_I173_A0.6921.00
77_R81_F0.6901.00
159_D179_D0.6901.00
16_G215_I0.6881.00
88_V109_V0.6851.00
21_S208_Y0.6831.00
161_L170_I0.6831.00
20_P56_E0.6761.00
135_A167_R0.6751.00
107_A112_A0.6741.00
27_L30_V0.6731.00
55_H144_E0.6651.00
187_H191_N0.6651.00
113_L141_L0.6641.00
121_L151_A0.6601.00
24_E35_R0.6601.00
165_I194_N0.6591.00
43_R51_H0.6581.00
21_S24_E0.6561.00
61_T116_T0.6501.00
61_T117_D0.6491.00
58_G211_R0.6431.00
204_H209_W0.6401.00
41_W44_Q0.6381.00
89_R92_P0.6371.00
30_V57_L0.6351.00
14_A212_L0.6341.00
119_L145_S0.6311.00
40_G199_P0.6301.00
163_T169_S0.6301.00
156_V173_A0.6301.00
72_H76_D0.6281.00
222_R228_S0.6281.00
206_P210_P0.6281.00
30_V120_V0.6251.00
17_I212_L0.6251.00
184_P188_P0.6201.00
218_E221_S0.6201.00
154_G179_D0.6201.00
12_T219_N0.6201.00
44_Q190_W0.6161.00
16_G19_A0.6151.00
183_L190_W0.6131.00
119_L142_P0.6121.00
77_R80_G0.6121.00
164_A167_R0.6121.00
20_P82_D0.6121.00
126_T129_T0.6111.00
43_R50_R0.6101.00
158_T162_V0.6031.00
184_P187_H0.6021.00
146_V174_A0.5981.00
29_S32_T0.5931.00
61_T142_P0.5861.00
43_R52_Y0.5851.00
215_I219_N0.5841.00
130_R179_D0.5841.00
26_V29_S0.5831.00
135_A164_A0.5771.00
40_G52_Y0.5761.00
222_R229_L0.5761.00
60_S117_D0.5751.00
17_I203_G0.5751.00
152_R200_H0.5701.00
63_T88_V0.5671.00
161_L175_L0.5651.00
62_V74_V0.5641.00
14_A17_I0.5631.00
86_I112_A0.5571.00
44_Q178_T0.5541.00
216_V219_N0.5541.00
75_V87_G0.5541.00
60_S83_V0.5531.00
190_W197_L0.5511.00
17_I208_Y0.5511.00
25_Q35_R0.5501.00
144_E170_I0.5501.00
30_V148_V0.5491.00
174_A196_L0.5491.00
7_R10_A0.5491.00
131_G154_G0.5481.00
94_K100_E0.5481.00
17_I215_I0.5471.00
34_A57_L0.5461.00
39_E43_R0.5451.00
32_T41_W0.5421.00
214_D217_A0.5391.00
41_W197_L0.5371.00
168_Q194_N0.5361.00
67_L89_R0.5351.00
40_G43_R0.5341.00
21_S205_T0.5311.00
123_T151_A0.5311.00
65_V112_A0.5291.00
123_T129_T0.5291.00
79_Q85_T0.5251.00
67_L106_D0.5251.00
83_V118_Y0.5231.00
166_R193_E0.5231.00
215_I218_E0.5201.00
56_E207_D0.5131.00
57_L81_F0.5091.00
221_S227_D0.5081.00
55_H171_R0.5081.00
18_H21_S0.5061.00
180_P187_H0.5051.00
162_V195_V0.5011.00
103_G106_D0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1sc6A 4 0.9316 100 0.17 Contact Map
1mx3A 3 0.9915 100 0.171 Contact Map
3ba1A 2 0.9744 100 0.176 Contact Map
4g2nA 3 0.9829 100 0.178 Contact Map
3k5pA 3 0.9615 100 0.178 Contact Map
2w2kA 2 0.9915 100 0.179 Contact Map
2g76A 2 0.9444 100 0.18 Contact Map
1dxyA 5 0.9829 100 0.18 Contact Map
3jtmA 2 0.9957 100 0.18 Contact Map
2j6iA 2 0.9957 100 0.18 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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