GREMLIN Database
Q9HPW6 - Htr12 transducer
UniProt: Q9HPW6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 420 (342)
Sequences: 8798 (7415)
Seq/√Len: 400.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
120_V125_E3.6111.00
122_E125_E2.7711.00
96_A114_L2.4991.00
120_V123_Q2.3861.00
238_E241_D2.3501.00
127_V131_Q2.2711.00
239_H305_D2.2101.00
248_D252_D2.2001.00
210_E214_R2.1491.00
242_E245_Q2.0761.00
239_H309_D2.0621.00
325_S329_T2.0561.00
186_E189_A2.0551.00
214_R217_A2.0401.00
225_A319_A1.9701.00
224_D227_D1.9581.00
237_R314_A1.9151.00
287_D290_E1.8761.00
329_T333_E1.8621.00
385_D389_D1.8611.00
121_V125_E1.8491.00
235_S309_D1.8401.00
233_T313_T1.8071.00
132_R136_D1.8071.00
224_D228_T1.7941.00
124_R128_K1.7731.00
114_L117_V1.7611.00
326_S329_T1.7561.00
123_Q127_V1.7471.00
138_V141_A1.7451.00
228_T231_V1.7411.00
292_S296_V1.7391.00
216_L335_V1.7381.00
80_T83_R1.7331.00
103_N106_A1.7051.00
110_A114_L1.7031.00
226_G324_V1.6911.00
232_N313_T1.6851.00
396_Q399_D1.6831.00
234_A238_E1.6821.00
217_A221_A1.6761.00
207_A210_E1.6421.00
193_E196_Q1.6371.00
102_H107_V1.6291.00
368_E371_A1.6281.00
182_A186_E1.6121.00
232_N312_E1.6071.00
204_R340_A1.6061.00
132_R135_T1.6031.00
221_A224_D1.5971.00
244_D307_E1.5961.00
311_E315_K1.5871.00
300_E304_A1.5701.00
231_V235_S1.5691.00
222_F327_A1.5641.00
332_E336_E1.5631.00
347_E350_E1.5531.00
134_L141_A1.5531.00
112_E115_T1.5501.00
238_E242_E1.5461.00
154_D158_E1.5451.00
128_K131_Q1.5241.00
199_T203_E1.5151.00
322_D326_S1.5111.00
203_E207_A1.5091.00
336_E340_A1.5051.00
402_S406_Q1.5021.00
220_E224_D1.4961.00
200_E203_E1.4961.00
375_T378_E1.4951.00
395_E399_D1.4941.00
142_V146_R1.4771.00
192_D196_Q1.4691.00
385_D388_A1.4671.00
137_D141_A1.4591.00
206_E210_E1.4551.00
196_Q200_E1.4491.00
194_V352_I1.4481.00
142_V145_L1.4471.00
403_D406_Q1.4461.00
242_E298_D1.4371.00
84_T87_L1.4351.00
213_E217_A1.4271.00
144_E147_D1.4241.00
94_A114_L1.4241.00
388_A392_A1.4161.00
171_N175_A1.4051.00
318_A322_D1.3971.00
346_G350_E1.3951.00
231_V234_A1.3941.00
158_E161_D1.3901.00
294_Q298_D1.3851.00
126_R129_R1.3691.00
234_A237_R1.3661.00
196_Q199_T1.3541.00
297_G301_A1.3481.00
367_A371_A1.3481.00
225_A323_Q1.3421.00
361_E364_E1.3401.00
265_N286_K1.3381.00
172_D175_A1.3361.00
235_S238_E1.3361.00
333_E336_E1.3321.00
283_E286_K1.3301.00
378_E381_D1.3291.00
123_Q128_K1.3201.00
249_V295_Q1.3201.00
168_S172_D1.3191.00
399_D403_D1.3171.00
125_E129_R1.3171.00
120_V131_Q1.3161.00
214_R330_A1.3151.00
357_A361_E1.3131.00
111_V115_T1.3091.00
127_V130_A1.3011.00
336_E339_D1.2931.00
98_A112_E1.2881.00
131_Q135_T1.2861.00
233_T317_V1.2861.00
322_D325_S1.2671.00
124_R131_Q1.2651.00
252_D255_D1.2621.00
265_N283_E1.2611.00
137_D140_A1.2561.00
178_S182_A1.2561.00
219_V327_A1.2541.00
210_E213_E1.2521.00
234_A318_A1.2461.00
154_D157_Q1.2441.00
107_V114_L1.2421.00
378_E382_A1.2371.00
131_Q134_L1.2331.00
120_V130_A1.2301.00
357_A360_D1.2291.00
147_D151_G1.2281.00
126_R130_A1.2271.00
315_K318_A1.2261.00
81_S84_T1.2211.00
245_Q248_D1.2191.00
97_S100_P1.2181.00
360_D364_E1.2181.00
110_A115_T1.2131.00
216_L220_E1.2051.00
251_N300_E1.2041.00
246_L302_L1.2011.00
80_T84_T1.1981.00
229_V320_A1.1891.00
301_A305_D1.1851.00
169_D375_T1.1831.00
399_D402_S1.1831.00
239_H242_E1.1751.00
374_D378_E1.1751.00
233_T314_A1.1731.00
157_Q161_D1.1711.00
240_L310_S1.1711.00
133_T136_D1.1641.00
223_A328_R1.1601.00
382_A385_D1.1571.00
96_A112_E1.1551.00
77_I80_T1.1541.00
203_E206_E1.1481.00
209_R339_D1.1451.00
98_A114_L1.1441.00
218_A326_S1.1391.00
294_Q297_G1.1361.00
129_R132_R1.1361.00
128_K132_R1.1351.00
339_D343_S1.1341.00
119_D122_E1.1301.00
219_V222_F1.1261.00
209_R213_E1.1211.00
237_R241_D1.1211.00
217_A220_E1.1191.00
230_S318_A1.1181.00
74_G77_I1.1181.00
168_S171_N1.1171.00
407_S410_D1.1161.00
94_A98_A1.1131.00
125_E128_K1.1121.00
121_V124_R1.1111.00
124_R127_V1.1101.00
70_V77_I1.1081.00
232_N316_S1.1041.00
227_D231_V1.1011.00
368_E372_A1.1001.00
94_A112_E1.1001.00
377_V381_D1.0981.00
151_G154_D1.0961.00
110_A113_V1.0941.00
389_D392_A1.0931.00
69_A73_R1.0871.00
109_G115_T1.0841.00
111_V114_L1.0831.00
113_V116_I1.0651.00
385_D392_A1.0631.00
104_D110_A1.0621.00
95_K98_A1.0601.00
354_E357_A1.0521.00
392_A395_E1.0491.00
338_Q341_I1.0381.00
340_A343_S1.0331.00
161_D164_A1.0311.00
185_Q189_A1.0281.00
208_S338_Q1.0281.00
119_D123_Q1.0261.00
315_K319_A1.0261.00
201_A345_I1.0241.00
215_V334_L1.0241.00
98_A109_G1.0211.00
143_T147_D1.0211.00
135_T138_V1.0201.00
319_A322_D1.0181.00
204_R207_A1.0171.00
159_I163_A1.0161.00
93_H100_P1.0081.00
312_E315_K1.0071.00
122_E126_R1.0061.00
176_D179_D1.0011.00
97_S117_V1.0001.00
120_V124_R0.9951.00
175_A178_S0.9871.00
123_Q131_Q0.9851.00
304_A308_A0.9851.00
100_P104_D0.9781.00
290_E294_Q0.9751.00
102_H109_G0.9711.00
381_D385_D0.9681.00
226_G320_A0.9671.00
189_A193_E0.9601.00
69_A72_E0.9581.00
98_A101_L0.9521.00
107_V112_E0.9521.00
251_N296_V0.9511.00
208_S341_I0.9501.00
96_A100_P0.9491.00
221_A323_Q0.9471.00
83_R86_E0.9461.00
405_E409_R0.9461.00
211_A333_E0.9451.00
128_K134_L0.9431.00
223_A325_S0.9421.00
350_E353_A0.9401.00
343_S347_E0.9391.00
330_A333_E0.9391.00
406_Q409_R0.9371.00
298_D301_A0.9331.00
134_L138_V0.9281.00
256_Q284_E0.9251.00
136_D140_A0.9251.00
138_V142_V0.9231.00
364_E368_E0.9151.00
175_A179_D0.9141.00
242_E302_L0.9131.00
130_A135_T0.9131.00
283_E287_D0.9111.00
150_E154_D0.9101.00
242_E305_D0.9071.00
205_A208_S0.9041.00
308_A312_E0.9041.00
404_I411_A0.8991.00
165_E168_S0.8981.00
112_E117_V0.8961.00
329_T332_E0.8921.00
113_V117_V0.8911.00
82_V87_L0.8831.00
165_E169_D0.8791.00
367_A370_S0.8741.00
98_A110_A0.8721.00
122_E127_V0.8721.00
134_L137_D0.8711.00
125_E131_Q0.8711.00
114_L118_T0.8701.00
218_A323_Q0.8701.00
166_Q173_I0.8691.00
107_V110_A0.8661.00
229_V316_S0.8601.00
408_V411_A0.8601.00
162_L379_R0.8601.00
100_P109_G0.8571.00
139_E142_V0.8531.00
390_V393_A0.8471.00
222_F324_V0.8411.00
97_S101_L0.8341.00
230_S321_N0.8311.00
73_R76_A0.8291.00
364_E367_A0.8291.00
307_E311_E0.8261.00
147_D150_E0.8231.00
321_N325_S0.8211.00
392_A396_Q0.8201.00
223_A227_D0.8171.00
225_A228_T0.8151.00
140_A143_T0.8131.00
164_A168_S0.8091.00
251_N297_G0.8091.00
160_S164_A0.8071.00
350_E354_E0.8071.00
95_K100_P0.8061.00
248_D251_N0.8051.00
303_V307_E0.8021.00
112_E116_I0.7971.00
261_A285_V0.7971.00
140_A144_E0.7961.00
206_E209_R0.7961.00
93_H97_S0.7931.00
84_T92_Q0.7911.00
240_L306_I0.7911.00
343_S346_G0.7891.00
159_I162_L0.7881.00
397_Q411_A0.7821.00
221_A225_A0.7771.00
70_V75_E0.7771.00
124_R134_L0.7761.00
205_A342_A0.7741.00
400_M403_D0.7731.00
286_K290_E0.7731.00
258_N286_K0.7721.00
104_D109_G0.7711.00
84_T88_P0.7701.00
347_E351_G0.7681.00
105_G109_G0.7651.00
189_A192_D0.7641.00
87_L90_G0.7641.00
121_V131_Q0.7611.00
77_I82_V0.7601.00
76_A80_T0.7581.00
209_R342_A0.7571.00
153_A157_Q0.7551.00
96_A101_L0.7541.00
229_V317_V0.7531.00
386_E389_D0.7531.00
247_V251_N0.7491.00
255_D293_Q0.7481.00
120_V128_K0.7471.00
172_D176_D0.7441.00
71_L75_E0.7431.00
115_T118_T0.7431.00
123_Q130_A0.7381.00
166_Q169_D0.7361.00
135_T139_E0.7351.00
95_K111_V0.7321.00
293_Q297_G0.7321.00
94_A97_S0.7311.00
361_E365_T0.7271.00
166_Q170_V0.7261.00
106_A109_G0.7241.00
119_D127_V0.7211.00
297_G300_E0.7111.00
261_A286_K0.7111.00
391_A395_E0.7101.00
104_D115_T0.7081.00
397_Q401_L0.7081.00
93_H98_A0.7081.00
96_A115_T0.7071.00
230_S234_A0.7071.00
202_R206_E0.7061.00
123_Q134_L0.7031.00
228_T319_A0.6981.00
292_S302_L0.6921.00
95_K115_T0.6911.00
109_G114_L0.6911.00
89_A92_Q0.6891.00
182_A185_Q0.6881.00
218_A330_A0.6830.99
274_D285_V0.6820.99
72_E77_I0.6770.99
77_I98_A0.6760.99
201_A359_T0.6740.99
219_V331_A0.6740.99
236_L313_T0.6730.99
255_D266_I0.6720.99
97_S111_V0.6710.99
247_V300_E0.6700.99
96_A110_A0.6670.99
146_R150_E0.6660.99
70_V110_A0.6660.99
109_G112_E0.6650.99
124_R130_A0.6610.99
382_A386_E0.6590.99
274_D279_S0.6580.99
227_D321_N0.6570.99
245_Q249_V0.6560.99
104_D107_V0.6530.99
80_T87_L0.6530.99
105_G110_A0.6520.99
212_A331_A0.6510.99
252_D291_Q0.6490.99
181_S185_Q0.6440.99
202_R346_G0.6420.99
291_Q294_Q0.6420.99
353_A357_A0.6400.99
129_R133_T0.6380.99
86_E90_G0.6370.99
75_E78_R0.6360.99
93_H114_L0.6310.99
228_T232_N0.6300.99
82_V88_P0.6260.99
77_I84_T0.6260.99
179_D182_A0.6250.99
99_T114_L0.6200.99
220_E332_E0.6180.99
402_S405_E0.6170.99
97_S113_V0.6130.99
142_V156_S0.6110.99
246_L249_V0.6100.99
215_V327_A0.6080.99
102_H105_G0.6040.99
395_E398_T0.6030.99
221_A326_S0.6030.99
84_T93_H0.6010.99
157_Q160_S0.6000.99
161_D165_E0.6000.99
123_Q132_R0.5990.99
91_A114_L0.5980.99
120_V127_V0.5970.99
104_D114_L0.5970.99
156_S159_I0.5950.99
93_H96_A0.5940.99
166_Q380_A0.5940.99
141_A145_L0.5920.99
192_D360_D0.5900.99
128_K135_T0.5870.98
123_Q126_R0.5850.98
166_Q180_L0.5850.98
86_E89_A0.5850.98
92_Q96_A0.5830.98
226_G229_V0.5830.98
143_T146_R0.5810.98
232_N309_D0.5800.98
137_D142_V0.5800.98
113_V118_T0.5790.98
403_D407_S0.5790.98
127_V132_R0.5780.98
78_R82_V0.5770.98
318_A321_N0.5770.98
160_S163_A0.5760.98
207_A337_N0.5740.98
78_R81_S0.5710.98
289_A292_S0.5710.98
356_A359_T0.5710.98
226_G317_V0.5690.98
82_V96_A0.5680.98
102_H108_I0.5660.98
95_K102_H0.5650.98
130_A133_T0.5640.98
262_L270_R0.5640.98
241_D245_Q0.5630.98
103_N109_G0.5630.98
139_E143_T0.5600.98
88_P91_A0.5590.98
200_E204_R0.5580.98
92_Q98_A0.5580.98
92_Q95_K0.5570.98
119_D131_Q0.5560.98
109_G118_T0.5550.98
230_S317_V0.5530.98
100_P115_T0.5530.98
251_N255_D0.5520.98
397_Q404_I0.5510.98
235_S239_H0.5510.98
228_T316_S0.5480.98
218_A221_A0.5480.98
108_I115_T0.5470.98
308_A311_E0.5460.98
211_A214_R0.5460.98
87_L91_A0.5460.98
193_E351_G0.5450.98
310_S313_T0.5450.98
76_A82_V0.5420.97
97_S114_L0.5410.97
155_A158_E0.5410.97
401_L404_I0.5400.97
98_A102_H0.5370.97
235_S312_E0.5370.97
324_V327_A0.5370.97
406_Q410_D0.5370.97
106_A111_V0.5360.97
259_M269_A0.5360.97
375_T379_R0.5350.97
212_A338_Q0.5320.97
95_K109_G0.5320.97
84_T114_L0.5310.97
401_L411_A0.5290.97
83_R87_L0.5280.97
323_Q326_S0.5280.97
145_L152_V0.5280.97
82_V112_E0.5280.97
240_L246_L0.5250.97
80_T86_E0.5210.97
335_V339_D0.5200.97
86_E91_A0.5190.97
371_A374_D0.5190.97
178_S181_S0.5180.97
91_A94_A0.5170.97
84_T91_A0.5170.97
236_L306_I0.5160.97
365_T368_E0.5150.97
92_Q117_V0.5110.96
84_T112_E0.5090.96
73_R78_R0.5080.96
74_G78_R0.5080.96
70_V78_R0.5070.96
404_I408_V0.5060.96
306_I310_S0.5060.96
142_V149_G0.5040.96
95_K114_L0.5040.96
127_V135_T0.5030.96
87_L92_Q0.5030.96
96_A99_T0.5020.96
301_A304_A0.5020.96
184_I187_V0.5010.96
75_E84_T0.5010.96
96_A117_V0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zx6A 2 0.7119 100 0.376 Contact Map
2ch7A 2 0.7214 100 0.429 Contact Map
1qu7A 2 0.5405 100 0.441 Contact Map
3g67A 2 0.4976 100 0.522 Contact Map
4i3mA 2 0.3381 99.6 0.805 Contact Map
3gdiA 2 0.3738 99.5 0.808 Contact Map
2gj3A 7 0.2786 99.5 0.81 Contact Map
3lyxA 2 0.2762 99.5 0.811 Contact Map
3rtyA 4 0.4643 99.5 0.815 Contact Map
4lrzE 2 0.2643 99.5 0.815 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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