Q9HPW6 - HALSA - GREMLIN Contacts

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Q9HPW6 - Htr12 transducer

UniProt:	Q9HPW6	Sequences: MGEEVWRGALSQFFTAFPEPLFVVDRDGTVVLWNDAIVEMTGVEAADAVGTPSIELFGTEGETQTLAEAVLERGEAIRETSVRTSELPAGAQHAKASATPLHNDGAVIGAVEVLTIVTDVVEQRERVKRAQRTLTDDVEAAVTELRDVGEGVADASQEISDLAAEQASDVNDIAADVSDLSATIQEVAASADEVRQRSTEARERAEASREAAERVLAAVEAFADAGDTVSVNTASLREHLDEIDQLVDVINDIADQTNMLALNANIEAARAGEDGSGFSVVAEEVKDLAEQSQQQVGDIEALVADIEADSEETAKSVAAANDQVSSARTAAEELVENQDAIASAIGETAEGIAEIAAATDEQAETAAEISAAIDTVVERADAVADETADVAAANEQQTDMLSDIEQSVRDAERVLTSDDE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	420 (342)
Sequences:	8798 (7415)
Seq/√Len:	400.9

ECOLI - AER MCP2 MCP3 MCP4 MCP1
BACSU - TLPA MCPC MCPA MCPB TLPB YVAQ YOAH TLPC HEMAT YFMS
HALSA - Q9HPW6 Q9HQX8 Q9HRN6 Q9HS86 Q9HP10 Q9HR88 HTR4 HTR2 Q9HRA1 Q9HPQ5 COST HTR7 Q9HPA2 HMAT HTR9 HTR1 Q9HQT5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
120_V	125_E	3.611	1.00
122_E	125_E	2.771	1.00
96_A	114_L	2.499	1.00
120_V	123_Q	2.386	1.00
238_E	241_D	2.350	1.00
127_V	131_Q	2.271	1.00
239_H	305_D	2.210	1.00
248_D	252_D	2.200	1.00
210_E	214_R	2.149	1.00
242_E	245_Q	2.076	1.00
239_H	309_D	2.062	1.00
325_S	329_T	2.056	1.00
186_E	189_A	2.055	1.00
214_R	217_A	2.040	1.00
225_A	319_A	1.970	1.00
224_D	227_D	1.958	1.00
237_R	314_A	1.915	1.00
287_D	290_E	1.876	1.00
329_T	333_E	1.862	1.00
385_D	389_D	1.861	1.00
121_V	125_E	1.849	1.00
235_S	309_D	1.840	1.00
233_T	313_T	1.807	1.00
132_R	136_D	1.807	1.00
224_D	228_T	1.794	1.00
124_R	128_K	1.773	1.00
114_L	117_V	1.761	1.00
326_S	329_T	1.756	1.00
123_Q	127_V	1.747	1.00
138_V	141_A	1.745	1.00
228_T	231_V	1.741	1.00
292_S	296_V	1.739	1.00
216_L	335_V	1.738	1.00
80_T	83_R	1.733	1.00
103_N	106_A	1.705	1.00
110_A	114_L	1.703	1.00
226_G	324_V	1.691	1.00
232_N	313_T	1.685	1.00
396_Q	399_D	1.683	1.00
234_A	238_E	1.682	1.00
217_A	221_A	1.676	1.00
207_A	210_E	1.642	1.00
193_E	196_Q	1.637	1.00
102_H	107_V	1.629	1.00
368_E	371_A	1.628	1.00
182_A	186_E	1.612	1.00
232_N	312_E	1.607	1.00
204_R	340_A	1.606	1.00
132_R	135_T	1.603	1.00
221_A	224_D	1.597	1.00
244_D	307_E	1.596	1.00
311_E	315_K	1.587	1.00
300_E	304_A	1.570	1.00
231_V	235_S	1.569	1.00
222_F	327_A	1.564	1.00
332_E	336_E	1.563	1.00
347_E	350_E	1.553	1.00
134_L	141_A	1.553	1.00
112_E	115_T	1.550	1.00
238_E	242_E	1.546	1.00
154_D	158_E	1.545	1.00
128_K	131_Q	1.524	1.00
199_T	203_E	1.515	1.00
322_D	326_S	1.511	1.00
203_E	207_A	1.509	1.00
336_E	340_A	1.505	1.00
402_S	406_Q	1.502	1.00
220_E	224_D	1.496	1.00
200_E	203_E	1.496	1.00
375_T	378_E	1.495	1.00
395_E	399_D	1.494	1.00
142_V	146_R	1.477	1.00
192_D	196_Q	1.469	1.00
385_D	388_A	1.467	1.00
137_D	141_A	1.459	1.00
206_E	210_E	1.455	1.00
196_Q	200_E	1.449	1.00
194_V	352_I	1.448	1.00
142_V	145_L	1.447	1.00
403_D	406_Q	1.446	1.00
242_E	298_D	1.437	1.00
84_T	87_L	1.435	1.00
213_E	217_A	1.427	1.00
144_E	147_D	1.424	1.00
94_A	114_L	1.424	1.00
388_A	392_A	1.416	1.00
171_N	175_A	1.405	1.00
318_A	322_D	1.397	1.00
346_G	350_E	1.395	1.00
231_V	234_A	1.394	1.00
158_E	161_D	1.390	1.00
294_Q	298_D	1.385	1.00
126_R	129_R	1.369	1.00
234_A	237_R	1.366	1.00
196_Q	199_T	1.354	1.00
297_G	301_A	1.348	1.00
367_A	371_A	1.348	1.00
225_A	323_Q	1.342	1.00
361_E	364_E	1.340	1.00
265_N	286_K	1.338	1.00
172_D	175_A	1.336	1.00
235_S	238_E	1.336	1.00
333_E	336_E	1.332	1.00
283_E	286_K	1.330	1.00
378_E	381_D	1.329	1.00
123_Q	128_K	1.320	1.00
249_V	295_Q	1.320	1.00
168_S	172_D	1.319	1.00
399_D	403_D	1.317	1.00
125_E	129_R	1.317	1.00
120_V	131_Q	1.316	1.00
214_R	330_A	1.315	1.00
357_A	361_E	1.313	1.00
111_V	115_T	1.309	1.00
127_V	130_A	1.301	1.00
336_E	339_D	1.293	1.00
98_A	112_E	1.288	1.00
131_Q	135_T	1.286	1.00
233_T	317_V	1.286	1.00
322_D	325_S	1.267	1.00
124_R	131_Q	1.265	1.00
252_D	255_D	1.262	1.00
265_N	283_E	1.261	1.00
137_D	140_A	1.256	1.00
178_S	182_A	1.256	1.00
219_V	327_A	1.254	1.00
210_E	213_E	1.252	1.00
234_A	318_A	1.246	1.00
154_D	157_Q	1.244	1.00
107_V	114_L	1.242	1.00
378_E	382_A	1.237	1.00
131_Q	134_L	1.233	1.00
120_V	130_A	1.230	1.00
357_A	360_D	1.229	1.00
147_D	151_G	1.228	1.00
126_R	130_A	1.227	1.00
315_K	318_A	1.226	1.00
81_S	84_T	1.221	1.00
245_Q	248_D	1.219	1.00
97_S	100_P	1.218	1.00
360_D	364_E	1.218	1.00
110_A	115_T	1.213	1.00
216_L	220_E	1.205	1.00
251_N	300_E	1.204	1.00
246_L	302_L	1.201	1.00
80_T	84_T	1.198	1.00
229_V	320_A	1.189	1.00
301_A	305_D	1.185	1.00
169_D	375_T	1.183	1.00
399_D	402_S	1.183	1.00
239_H	242_E	1.175	1.00
374_D	378_E	1.175	1.00
233_T	314_A	1.173	1.00
157_Q	161_D	1.171	1.00
240_L	310_S	1.171	1.00
133_T	136_D	1.164	1.00
223_A	328_R	1.160	1.00
382_A	385_D	1.157	1.00
96_A	112_E	1.155	1.00
77_I	80_T	1.154	1.00
203_E	206_E	1.148	1.00
209_R	339_D	1.145	1.00
98_A	114_L	1.144	1.00
218_A	326_S	1.139	1.00
294_Q	297_G	1.136	1.00
129_R	132_R	1.136	1.00
128_K	132_R	1.135	1.00
339_D	343_S	1.134	1.00
119_D	122_E	1.130	1.00
219_V	222_F	1.126	1.00
209_R	213_E	1.121	1.00
237_R	241_D	1.121	1.00
217_A	220_E	1.119	1.00
230_S	318_A	1.118	1.00
74_G	77_I	1.118	1.00
168_S	171_N	1.117	1.00
407_S	410_D	1.116	1.00
94_A	98_A	1.113	1.00
125_E	128_K	1.112	1.00
121_V	124_R	1.111	1.00
124_R	127_V	1.110	1.00
70_V	77_I	1.108	1.00
232_N	316_S	1.104	1.00
227_D	231_V	1.101	1.00
368_E	372_A	1.100	1.00
94_A	112_E	1.100	1.00
377_V	381_D	1.098	1.00
151_G	154_D	1.096	1.00
110_A	113_V	1.094	1.00
389_D	392_A	1.093	1.00
69_A	73_R	1.087	1.00
109_G	115_T	1.084	1.00
111_V	114_L	1.083	1.00
113_V	116_I	1.065	1.00
385_D	392_A	1.063	1.00
104_D	110_A	1.062	1.00
95_K	98_A	1.060	1.00
354_E	357_A	1.052	1.00
392_A	395_E	1.049	1.00
338_Q	341_I	1.038	1.00
340_A	343_S	1.033	1.00
161_D	164_A	1.031	1.00
185_Q	189_A	1.028	1.00
208_S	338_Q	1.028	1.00
119_D	123_Q	1.026	1.00
315_K	319_A	1.026	1.00
201_A	345_I	1.024	1.00
215_V	334_L	1.024	1.00
98_A	109_G	1.021	1.00
143_T	147_D	1.021	1.00
135_T	138_V	1.020	1.00
319_A	322_D	1.018	1.00
204_R	207_A	1.017	1.00
159_I	163_A	1.016	1.00
93_H	100_P	1.008	1.00
312_E	315_K	1.007	1.00
122_E	126_R	1.006	1.00
176_D	179_D	1.001	1.00
97_S	117_V	1.000	1.00
120_V	124_R	0.995	1.00
175_A	178_S	0.987	1.00
123_Q	131_Q	0.985	1.00
304_A	308_A	0.985	1.00
100_P	104_D	0.978	1.00
290_E	294_Q	0.975	1.00
102_H	109_G	0.971	1.00
381_D	385_D	0.968	1.00
226_G	320_A	0.967	1.00
189_A	193_E	0.960	1.00
69_A	72_E	0.958	1.00
98_A	101_L	0.952	1.00
107_V	112_E	0.952	1.00
251_N	296_V	0.951	1.00
208_S	341_I	0.950	1.00
96_A	100_P	0.949	1.00
221_A	323_Q	0.947	1.00
83_R	86_E	0.946	1.00
405_E	409_R	0.946	1.00
211_A	333_E	0.945	1.00
128_K	134_L	0.943	1.00
223_A	325_S	0.942	1.00
350_E	353_A	0.940	1.00
343_S	347_E	0.939	1.00
330_A	333_E	0.939	1.00
406_Q	409_R	0.937	1.00
298_D	301_A	0.933	1.00
134_L	138_V	0.928	1.00
256_Q	284_E	0.925	1.00
136_D	140_A	0.925	1.00
138_V	142_V	0.923	1.00
364_E	368_E	0.915	1.00
175_A	179_D	0.914	1.00
242_E	302_L	0.913	1.00
130_A	135_T	0.913	1.00
283_E	287_D	0.911	1.00
150_E	154_D	0.910	1.00
242_E	305_D	0.907	1.00
205_A	208_S	0.904	1.00
308_A	312_E	0.904	1.00
404_I	411_A	0.899	1.00
165_E	168_S	0.898	1.00
112_E	117_V	0.896	1.00
329_T	332_E	0.892	1.00
113_V	117_V	0.891	1.00
82_V	87_L	0.883	1.00
165_E	169_D	0.879	1.00
367_A	370_S	0.874	1.00
98_A	110_A	0.872	1.00
122_E	127_V	0.872	1.00
134_L	137_D	0.871	1.00
125_E	131_Q	0.871	1.00
114_L	118_T	0.870	1.00
218_A	323_Q	0.870	1.00
166_Q	173_I	0.869	1.00
107_V	110_A	0.866	1.00
229_V	316_S	0.860	1.00
408_V	411_A	0.860	1.00
162_L	379_R	0.860	1.00
100_P	109_G	0.857	1.00
139_E	142_V	0.853	1.00
390_V	393_A	0.847	1.00
222_F	324_V	0.841	1.00
97_S	101_L	0.834	1.00
230_S	321_N	0.831	1.00
73_R	76_A	0.829	1.00
364_E	367_A	0.829	1.00
307_E	311_E	0.826	1.00
147_D	150_E	0.823	1.00
321_N	325_S	0.821	1.00
392_A	396_Q	0.820	1.00
223_A	227_D	0.817	1.00
225_A	228_T	0.815	1.00
140_A	143_T	0.813	1.00
164_A	168_S	0.809	1.00
251_N	297_G	0.809	1.00
160_S	164_A	0.807	1.00
350_E	354_E	0.807	1.00
95_K	100_P	0.806	1.00
248_D	251_N	0.805	1.00
303_V	307_E	0.802	1.00
112_E	116_I	0.797	1.00
261_A	285_V	0.797	1.00
140_A	144_E	0.796	1.00
206_E	209_R	0.796	1.00
93_H	97_S	0.793	1.00
84_T	92_Q	0.791	1.00
240_L	306_I	0.791	1.00
343_S	346_G	0.789	1.00
159_I	162_L	0.788	1.00
397_Q	411_A	0.782	1.00
221_A	225_A	0.777	1.00
70_V	75_E	0.777	1.00
124_R	134_L	0.776	1.00
205_A	342_A	0.774	1.00
400_M	403_D	0.773	1.00
286_K	290_E	0.773	1.00
258_N	286_K	0.772	1.00
104_D	109_G	0.771	1.00
84_T	88_P	0.770	1.00
347_E	351_G	0.768	1.00
105_G	109_G	0.765	1.00
189_A	192_D	0.764	1.00
87_L	90_G	0.764	1.00
121_V	131_Q	0.761	1.00
77_I	82_V	0.760	1.00
76_A	80_T	0.758	1.00
209_R	342_A	0.757	1.00
153_A	157_Q	0.755	1.00
96_A	101_L	0.754	1.00
229_V	317_V	0.753	1.00
386_E	389_D	0.753	1.00
247_V	251_N	0.749	1.00
255_D	293_Q	0.748	1.00
120_V	128_K	0.747	1.00
172_D	176_D	0.744	1.00
71_L	75_E	0.743	1.00
115_T	118_T	0.743	1.00
123_Q	130_A	0.738	1.00
166_Q	169_D	0.736	1.00
135_T	139_E	0.735	1.00
95_K	111_V	0.732	1.00
293_Q	297_G	0.732	1.00
94_A	97_S	0.731	1.00
361_E	365_T	0.727	1.00
166_Q	170_V	0.726	1.00
106_A	109_G	0.724	1.00
119_D	127_V	0.721	1.00
297_G	300_E	0.711	1.00
261_A	286_K	0.711	1.00
391_A	395_E	0.710	1.00
104_D	115_T	0.708	1.00
397_Q	401_L	0.708	1.00
93_H	98_A	0.708	1.00
96_A	115_T	0.707	1.00
230_S	234_A	0.707	1.00
202_R	206_E	0.706	1.00
123_Q	134_L	0.703	1.00
228_T	319_A	0.698	1.00
292_S	302_L	0.692	1.00
95_K	115_T	0.691	1.00
109_G	114_L	0.691	1.00
89_A	92_Q	0.689	1.00
182_A	185_Q	0.688	1.00
218_A	330_A	0.683	0.99
274_D	285_V	0.682	0.99
72_E	77_I	0.677	0.99
77_I	98_A	0.676	0.99
201_A	359_T	0.674	0.99
219_V	331_A	0.674	0.99
236_L	313_T	0.673	0.99
255_D	266_I	0.672	0.99
97_S	111_V	0.671	0.99
247_V	300_E	0.670	0.99
96_A	110_A	0.667	0.99
146_R	150_E	0.666	0.99
70_V	110_A	0.666	0.99
109_G	112_E	0.665	0.99
124_R	130_A	0.661	0.99
382_A	386_E	0.659	0.99
274_D	279_S	0.658	0.99
227_D	321_N	0.657	0.99
245_Q	249_V	0.656	0.99
104_D	107_V	0.653	0.99
80_T	87_L	0.653	0.99
105_G	110_A	0.652	0.99
212_A	331_A	0.651	0.99
252_D	291_Q	0.649	0.99
181_S	185_Q	0.644	0.99
202_R	346_G	0.642	0.99
291_Q	294_Q	0.642	0.99
353_A	357_A	0.640	0.99
129_R	133_T	0.638	0.99
86_E	90_G	0.637	0.99
75_E	78_R	0.636	0.99
93_H	114_L	0.631	0.99
228_T	232_N	0.630	0.99
82_V	88_P	0.626	0.99
77_I	84_T	0.626	0.99
179_D	182_A	0.625	0.99
99_T	114_L	0.620	0.99
220_E	332_E	0.618	0.99
402_S	405_E	0.617	0.99
97_S	113_V	0.613	0.99
142_V	156_S	0.611	0.99
246_L	249_V	0.610	0.99
215_V	327_A	0.608	0.99
102_H	105_G	0.604	0.99
395_E	398_T	0.603	0.99
221_A	326_S	0.603	0.99
84_T	93_H	0.601	0.99
157_Q	160_S	0.600	0.99
161_D	165_E	0.600	0.99
123_Q	132_R	0.599	0.99
91_A	114_L	0.598	0.99
120_V	127_V	0.597	0.99
104_D	114_L	0.597	0.99
156_S	159_I	0.595	0.99
93_H	96_A	0.594	0.99
166_Q	380_A	0.594	0.99
141_A	145_L	0.592	0.99
192_D	360_D	0.590	0.99
128_K	135_T	0.587	0.98
123_Q	126_R	0.585	0.98
166_Q	180_L	0.585	0.98
86_E	89_A	0.585	0.98
92_Q	96_A	0.583	0.98
226_G	229_V	0.583	0.98
143_T	146_R	0.581	0.98
232_N	309_D	0.580	0.98
137_D	142_V	0.580	0.98
113_V	118_T	0.579	0.98
403_D	407_S	0.579	0.98
127_V	132_R	0.578	0.98
78_R	82_V	0.577	0.98
318_A	321_N	0.577	0.98
160_S	163_A	0.576	0.98
207_A	337_N	0.574	0.98
78_R	81_S	0.571	0.98
289_A	292_S	0.571	0.98
356_A	359_T	0.571	0.98
226_G	317_V	0.569	0.98
82_V	96_A	0.568	0.98
102_H	108_I	0.566	0.98
95_K	102_H	0.565	0.98
130_A	133_T	0.564	0.98
262_L	270_R	0.564	0.98
241_D	245_Q	0.563	0.98
103_N	109_G	0.563	0.98
139_E	143_T	0.560	0.98
88_P	91_A	0.559	0.98
200_E	204_R	0.558	0.98
92_Q	98_A	0.558	0.98
92_Q	95_K	0.557	0.98
119_D	131_Q	0.556	0.98
109_G	118_T	0.555	0.98
230_S	317_V	0.553	0.98
100_P	115_T	0.553	0.98
251_N	255_D	0.552	0.98
397_Q	404_I	0.551	0.98
235_S	239_H	0.551	0.98
228_T	316_S	0.548	0.98
218_A	221_A	0.548	0.98
108_I	115_T	0.547	0.98
308_A	311_E	0.546	0.98
211_A	214_R	0.546	0.98
87_L	91_A	0.546	0.98
193_E	351_G	0.545	0.98
310_S	313_T	0.545	0.98
76_A	82_V	0.542	0.97
97_S	114_L	0.541	0.97
155_A	158_E	0.541	0.97
401_L	404_I	0.540	0.97
98_A	102_H	0.537	0.97
235_S	312_E	0.537	0.97
324_V	327_A	0.537	0.97
406_Q	410_D	0.537	0.97
106_A	111_V	0.536	0.97
259_M	269_A	0.536	0.97
375_T	379_R	0.535	0.97
212_A	338_Q	0.532	0.97
95_K	109_G	0.532	0.97
84_T	114_L	0.531	0.97
401_L	411_A	0.529	0.97
83_R	87_L	0.528	0.97
323_Q	326_S	0.528	0.97
145_L	152_V	0.528	0.97
82_V	112_E	0.528	0.97
240_L	246_L	0.525	0.97
80_T	86_E	0.521	0.97
335_V	339_D	0.520	0.97
86_E	91_A	0.519	0.97
371_A	374_D	0.519	0.97
178_S	181_S	0.518	0.97
91_A	94_A	0.517	0.97
84_T	91_A	0.517	0.97
236_L	306_I	0.516	0.97
365_T	368_E	0.515	0.97
92_Q	117_V	0.511	0.96
84_T	112_E	0.509	0.96
73_R	78_R	0.508	0.96
74_G	78_R	0.508	0.96
70_V	78_R	0.507	0.96
404_I	408_V	0.506	0.96
306_I	310_S	0.506	0.96
142_V	149_G	0.504	0.96
95_K	114_L	0.504	0.96
127_V	135_T	0.503	0.96
87_L	92_Q	0.503	0.96
96_A	99_T	0.502	0.96
301_A	304_A	0.502	0.96
184_I	187_V	0.501	0.96
75_E	84_T	0.501	0.96
96_A	117_V	0.500	0.96

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3zx6A	2	0.7119	100	0.376	Contact Map
2ch7A	2	0.7214	100	0.429	Contact Map
1qu7A	2	0.5405	100	0.441	Contact Map
3g67A	2	0.4976	100	0.522	Contact Map
4i3mA	2	0.3381	99.6	0.805	Contact Map
3gdiA	2	0.3738	99.5	0.808	Contact Map
2gj3A	7	0.2786	99.5	0.81	Contact Map
3lyxA	2	0.2762	99.5	0.811	Contact Map
3rtyA	4	0.4643	99.5	0.815	Contact Map
4lrzE	2	0.2643	99.5	0.815	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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