GREMLIN Database
HISX - Histidinol dehydrogenase
UniProt: Q9HPW5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 425 (410)
Sequences: 3821 (2157)
Seq/√Len: 106.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
37_R41_E4.1481.00
51_S57_E4.0691.00
41_E48_A3.5781.00
62_D176_R3.2471.00
35_L187_G3.1521.00
120_R150_Q3.1391.00
154_A189_F3.0681.00
129_T257_P3.0631.00
288_A292_R2.9491.00
243_A277_A2.9321.00
329_D332_A2.8011.00
235_V315_A2.7711.00
89_I137_L2.7571.00
90_R94_E2.7211.00
123_V140_V2.6901.00
331_E389_R2.5471.00
84_D401_T2.5311.00
150_Q176_R2.5271.00
73_A163_P2.4941.00
306_R310_E2.4931.00
309_S336_R2.4901.00
268_E272_A2.4851.00
37_R49_L2.4541.00
277_A280_A2.3611.00
407_D419_D2.3221.00
71_A170_H2.3111.00
119_R338_D2.2831.00
144_V175_D2.2591.00
83_E171_A2.1491.00
305_A311_A2.1321.00
67_M177_V2.1171.00
271_A304_V2.0821.00
271_A302_V2.0771.00
48_A52_E2.0581.00
292_R296_D2.0411.00
86_A90_R2.0411.00
407_D412_E2.0321.00
238_E267_D2.0311.00
399_R422_F2.0301.00
43_D193_T2.0151.00
403_T419_D2.0031.00
55_D159_E1.9911.00
233_L315_A1.9891.00
212_A216_E1.9561.00
37_R48_A1.9431.00
41_E44_V1.9431.00
312_V337_I1.9411.00
256_D259_A1.9341.00
140_V174_A1.9321.00
149_E338_D1.9281.00
200_Q371_R1.9261.00
86_A141_I1.9241.00
30_D209_W1.9101.00
33_E37_R1.9071.00
36_D40_S1.9041.00
275_T302_V1.8991.00
235_V311_A1.8651.00
232_L251_A1.8561.00
68_E72_D1.8491.00
68_E170_H1.8171.00
239_T328_S1.7841.00
269_A273_A1.7611.00
119_R339_S1.7591.00
79_Y83_E1.7581.00
282_L291_I1.7551.00
265_T271_A1.7401.00
286_E412_E1.7241.00
416_A419_D1.7241.00
119_R149_E1.7111.00
90_R144_V1.6991.00
62_D178_Y1.6921.00
352_A417_S1.6871.00
312_V333_L1.6841.00
392_R396_A1.6761.00
353_A402_V1.6501.00
32_A216_E1.6231.00
191_Y220_D1.6191.00
118_V201_T1.6001.00
66_E179_Q1.6001.00
238_E266_D1.5951.00
307_S310_E1.5511.00
325_I337_I1.5341.00
330_D345_L1.5321.00
153_V169_A1.5281.00
47_R61_L1.5141.00
247_A281_R1.5021.00
79_Y167_A1.4951.00
69_R73_A1.4941.00
116_R385_T1.4921.00
266_D305_A1.4881.00
102_R110_E1.4781.00
78_V408_A1.4591.00
211_T226_L1.4561.00
71_A167_A1.4491.00
43_D195_T1.4241.00
178_Y197_D1.4211.00
277_A281_R1.4171.00
76_D80_D1.4141.00
263_A274_I1.4121.00
403_T407_D1.4041.00
180_V196_V1.4021.00
81_A405_L1.3981.00
86_A137_L1.3901.00
155_T161_I1.3861.00
137_L141_I1.3811.00
122_G189_F1.3811.00
327_A333_L1.3761.00
238_E328_S1.3731.00
65_D69_R1.3651.00
98_P379_D1.3481.00
285_R291_I1.3471.00
358_A388_Q1.3370.99
243_A280_A1.3370.99
121_V201_T1.3260.99
81_A404_T1.3160.99
136_V153_V1.3090.99
379_D384_S1.3040.99
403_T415_A1.2990.99
154_A185_A1.2950.99
152_A176_R1.2940.99
348_Y392_R1.2930.99
273_A276_D1.2900.99
293_A296_D1.2880.99
28_R32_A1.2800.99
82_I171_A1.2800.99
167_A170_H1.2790.99
70_A166_L1.2710.99
168_A172_A1.2660.99
343_V385_T1.2660.99
190_A217_V1.2650.99
257_P293_A1.2640.99
326_Q347_G1.2610.99
407_D415_A1.2600.99
339_S383_R1.2580.99
279_A292_R1.2510.99
233_L264_V1.2490.99
38_V187_G1.2480.99
152_A189_F1.2470.99
270_T274_I1.2330.99
86_A171_A1.2310.99
151_V175_D1.2190.99
35_L220_D1.2140.99
28_R216_E1.2110.99
74_V79_Y1.2110.99
191_Y217_V1.2070.99
239_T347_G1.2020.99
69_R160_T1.2010.99
135_S139_G1.2000.99
395_L418_V1.1930.99
235_V264_V1.1920.99
78_V164_V1.1910.99
241_E244_F1.1870.99
129_T287_R1.1850.99
415_A419_D1.1840.99
208_K212_A1.1780.99
98_P382_L1.1700.99
63_V166_L1.1620.99
283_D288_A1.1600.99
32_A36_D1.1440.98
293_A297_N1.1370.98
315_A320_A1.1340.98
63_V179_Q1.1330.98
201_T380_T1.1320.98
264_V314_F1.1260.98
281_R416_A1.1210.98
44_V194_E1.1190.98
235_V325_I1.1190.98
154_A180_V1.1160.98
343_V387_V1.1160.98
46_L180_V1.1150.98
217_V221_V1.1030.98
245_V274_I1.0980.98
139_G363_V1.0880.98
35_L217_V1.0840.98
264_V305_A1.0790.98
357_A402_V1.0770.98
240_A245_V1.0760.98
27_V212_A1.0690.97
243_A420_A1.0680.97
327_A330_D1.0660.97
116_R383_R1.0650.97
29_S33_E1.0640.97
34_I183_A1.0540.97
82_I405_L1.0540.97
110_E389_R1.0530.97
242_P273_A1.0510.97
357_A401_T1.0470.97
319_A370_A1.0470.97
265_T302_V1.0440.97
123_V151_V1.0380.97
50_A184_Q1.0320.97
236_A270_T1.0310.97
268_E304_V1.0290.97
250_L291_I1.0280.97
49_L53_F1.0270.97
71_A79_Y1.0260.97
118_V121_V1.0250.97
144_V172_A1.0220.97
98_P115_F1.0150.97
377_S384_S1.0070.96
250_L413_G1.0050.96
369_T372_V1.0030.96
305_A314_F1.0000.96
265_T304_V0.9980.96
94_E145_V0.9970.96
235_V312_V0.9960.96
234_V249_L0.9850.96
353_A390_L0.9700.95
61_L180_V0.9670.95
232_L324_S0.9630.95
276_D280_A0.9630.95
35_L191_Y0.9630.95
118_V222_E0.9620.95
80_D83_E0.9600.95
251_A352_A0.9590.95
241_E347_G0.9590.95
63_V70_A0.9580.95
104_S107_A0.9570.95
249_L263_A0.9550.95
334_L345_L0.9530.95
264_V315_A0.9510.95
31_V212_A0.9490.95
135_S363_V0.9490.95
39_E220_D0.9420.95
35_L39_E0.9370.95
363_V376_L0.9360.95
280_A284_D0.9360.95
139_G203_V0.9350.95
325_I345_L0.9330.94
350_P417_S0.9330.94
68_E71_A0.9320.94
308_M333_L0.9300.94
82_I168_A0.9290.94
34_I38_V0.9290.94
97_L382_L0.9280.94
28_R212_A0.9250.94
283_D292_R0.9240.94
236_A240_A0.9230.94
95_A103_E0.9200.94
87_A90_R0.9170.94
266_D311_A0.9160.94
416_A420_A0.9110.94
75_P78_V0.9110.94
390_L398_L0.9090.94
395_L399_R0.9070.94
30_D33_E0.9040.93
44_V48_A0.9010.93
50_A58_V0.8990.93
275_T279_A0.8990.93
245_V270_T0.8980.93
37_R52_E0.8970.93
247_A420_A0.8930.93
402_V418_V0.8920.93
105_F109_R0.8880.93
140_V172_A0.8850.93
41_E52_E0.8770.92
67_M71_A0.8750.92
38_V183_A0.8720.92
353_A398_L0.8680.92
334_L387_V0.8610.92
235_V308_M0.8610.92
83_E167_A0.8610.92
212_A215_A0.8610.92
308_M311_A0.8600.92
188_A196_V0.8590.92
265_T270_T0.8580.92
244_F347_G0.8570.92
81_A401_T0.8570.92
283_D286_E0.8560.91
67_M170_H0.8530.91
77_D404_T0.8520.91
78_V404_T0.8510.91
119_R200_Q0.8500.91
39_E191_Y0.8480.91
90_R141_I0.8470.91
125_A153_V0.8460.91
25_D29_S0.8460.91
46_L183_A0.8440.91
101_W113_R0.8430.91
310_E313_M0.8430.91
91_A95_A0.8420.91
342_S388_Q0.8350.90
289_D292_R0.8340.90
281_R420_A0.8320.90
342_S386_T0.8310.90
375_G386_T0.8310.90
266_D308_M0.8280.90
87_A91_A0.8270.90
150_Q178_Y0.8250.90
337_I343_V0.8240.90
25_D32_A0.8240.90
34_I49_L0.8230.90
176_R197_D0.8230.90
101_W112_G0.8220.90
107_A397_A0.8180.90
334_L343_V0.8180.90
279_A283_D0.8170.89
152_A197_D0.8150.89
46_L188_A0.8150.89
46_L193_T0.8140.89
243_A423_E0.8130.89
242_P274_I0.8130.89
379_D382_L0.8100.89
272_A275_T0.8030.89
313_M316_E0.8030.89
200_Q339_S0.7990.88
136_V168_A0.7990.88
66_E160_T0.7970.88
342_S387_V0.7960.88
249_L278_V0.7950.88
123_V139_G0.7910.88
243_A281_R0.7900.88
93_H96_Q0.7860.88
88_N357_A0.7850.88
133_P405_L0.7850.88
92_F360_T0.7830.87
316_E336_R0.7820.87
97_L145_V0.7810.87
41_E45_A0.7790.87
234_V245_V0.7780.87
85_A89_I0.7780.87
312_V336_R0.7780.87
350_P395_L0.7760.87
396_A422_F0.7760.87
47_R51_S0.7760.87
96_Q361_N0.7740.87
393_E396_A0.7700.86
91_A94_E0.7700.86
56_V157_P0.7680.86
264_V311_A0.7670.86
64_T179_Q0.7660.86
157_P161_I0.7640.86
152_A178_Y0.7610.86
240_A270_T0.7580.86
178_Y196_V0.7570.86
139_G376_L0.7560.85
328_S347_G0.7560.85
26_A29_S0.7560.85
85_A357_A0.7550.85
188_A193_T0.7540.85
202_V217_V0.7540.85
33_E36_D0.7540.85
35_L216_E0.7530.85
71_A171_A0.7530.85
27_V208_K0.7520.85
377_S382_L0.7520.85
94_E97_L0.7520.85
233_L318_Y0.7510.85
406_A415_A0.7510.85
131_A410_G0.7510.85
150_Q197_D0.7500.85
222_E372_V0.7490.85
51_S56_V0.7470.85
136_V174_A0.7450.85
198_T368_G0.7440.85
33_E52_E0.7420.84
412_E416_A0.7420.84
353_A395_L0.7420.84
287_R290_T0.7410.84
47_R58_V0.7410.84
30_D52_E0.7400.84
43_D194_E0.7390.84
342_S358_A0.7390.84
91_A103_E0.7390.84
404_T408_A0.7390.84
232_L261_V0.7360.84
251_A417_S0.7340.84
49_L184_Q0.7340.84
47_R59_G0.7320.84
250_L282_L0.7320.84
167_A171_A0.7320.84
123_V203_V0.7300.83
276_D279_A0.7300.83
312_V327_A0.7280.83
360_T388_Q0.7260.83
357_A398_L0.7260.83
44_V47_R0.7250.83
86_A172_A0.7250.83
376_L380_T0.7240.83
46_L50_A0.7220.83
390_L394_G0.7210.83
272_A276_D0.7190.83
193_T196_V0.7180.82
144_V174_A0.7180.82
244_F326_Q0.7150.82
30_D49_L0.7150.82
139_G361_N0.7140.82
113_R377_S0.7140.82
374_G384_S0.7130.82
202_V221_V0.7090.82
285_R413_G0.7080.82
269_A272_A0.7070.81
332_A335_D0.7070.81
115_F382_L0.7050.81
62_D150_Q0.7040.81
208_K258_N0.7020.81
137_L168_A0.7010.81
399_R403_T0.7000.81
187_G217_V0.7000.81
116_R338_D0.6960.80
278_V295_L0.6950.80
222_E373_T0.6940.80
41_E49_L0.6930.80
238_E269_A0.6920.80
83_E87_A0.6910.80
407_D416_A0.6900.80
289_D293_A0.6900.80
51_S58_V0.6890.80
27_V31_V0.6880.80
170_H177_V0.6850.79
26_A30_D0.6840.79
240_A347_G0.6830.79
217_V220_D0.6830.79
63_V66_E0.6820.79
37_R40_S0.6810.79
130_A411_L0.6810.79
395_L402_V0.6810.79
349_A390_L0.6800.79
242_P270_T0.6790.79
285_R416_A0.6790.79
87_A94_E0.6780.79
122_G154_A0.6780.79
77_D400_E0.6780.79
400_E404_T0.6770.79
102_R331_E0.6760.78
74_V167_A0.6760.78
84_D357_A0.6750.78
47_R57_E0.6740.78
66_E69_R0.6740.78
344_F354_G0.6690.78
215_A219_G0.6660.77
84_D87_A0.6650.77
270_T273_A0.6650.77
47_R60_N0.6600.77
311_A315_A0.6590.77
46_L49_L0.6580.77
308_M312_V0.6580.77
330_D334_L0.6560.76
308_M327_A0.6560.76
97_L100_D0.6550.76
261_V300_S0.6550.76
88_N402_V0.6500.76
69_R72_D0.6490.76
29_S32_A0.6490.76
308_M315_A0.6470.75
131_A162_N0.6460.75
251_A413_G0.6450.75
316_E334_L0.6450.75
71_A166_L0.6440.75
250_L285_R0.6440.75
71_A83_E0.6440.75
120_R200_Q0.6420.75
316_E338_D0.6410.75
50_A55_D0.6350.74
73_A160_T0.6350.74
320_A323_L0.6350.74
180_V188_A0.6330.74
164_V408_A0.6300.73
118_V148_V0.6280.73
45_A49_L0.6260.73
235_V327_A0.6260.73
340_A343_V0.6250.73
275_T278_V0.6240.73
123_V174_A0.6240.73
46_L61_L0.6220.73
178_Y195_T0.6210.72
227_A361_N0.6200.72
100_D115_F0.6200.72
62_D152_A0.6180.72
282_L292_R0.6180.72
114_R335_D0.6180.72
136_V172_A0.6150.72
226_L373_T0.6150.72
266_D307_S0.6140.72
86_A89_I0.6140.72
285_R412_E0.6130.71
219_G372_V0.6100.71
412_E419_D0.6090.71
65_D68_E0.6090.71
201_T222_E0.6080.71
198_T220_D0.6080.71
280_A283_D0.6070.71
315_A337_I0.6070.71
291_I295_L0.6060.71
199_V221_V0.6050.70
23_G26_A0.6040.70
240_A326_Q0.6030.70
349_A388_Q0.6010.70
92_F386_T0.6010.70
312_V343_V0.6000.70
123_V153_V0.6000.70
281_R285_R0.5990.70
85_A405_L0.5980.70
284_D416_A0.5980.70
244_F348_Y0.5980.70
102_R387_V0.5970.69
90_R145_V0.5960.69
82_I164_V0.5940.69
80_D84_D0.5940.69
139_G153_V0.5920.69
96_Q113_R0.5920.69
129_T225_F0.5900.69
130_A287_R0.5890.68
120_R199_V0.5840.68
287_R410_G0.5840.68
120_R152_A0.5830.68
330_D389_R0.5830.68
67_M167_A0.5800.67
82_I167_A0.5790.67
203_V363_V0.5740.66
110_E391_D0.5740.66
166_L381_F0.5730.66
355_D362_H0.5730.66
253_A261_V0.5720.66
16_A19_E0.5710.66
313_M317_E0.5710.66
35_L46_L0.5710.66
245_V326_Q0.5700.66
34_I53_F0.5690.66
278_V283_D0.5680.66
16_A301_G0.5670.66
63_V177_V0.5670.66
252_Q355_D0.5660.65
153_V174_A0.5650.65
102_R112_G0.5630.65
46_L196_V0.5620.65
344_F351_V0.5610.65
271_A275_T0.5600.65
233_L314_F0.5600.65
244_F420_A0.5570.64
342_S360_T0.5570.64
249_L261_V0.5560.64
294_A300_S0.5560.64
395_L422_F0.5560.64
23_G27_V0.5540.64
309_S313_M0.5540.64
286_E291_I0.5540.64
250_L295_L0.5530.64
317_E371_R0.5520.63
38_V56_V0.5510.63
88_N105_F0.5510.63
67_M79_Y0.5500.63
30_D38_V0.5500.63
43_D188_A0.5490.63
324_S361_N0.5490.63
132_Y411_L0.5480.63
80_D401_T0.5470.63
35_L190_A0.5470.63
121_V203_V0.5460.63
391_D394_G0.5460.63
77_D81_A0.5440.62
337_I385_T0.5440.62
100_D114_R0.5440.62
114_R385_T0.5440.62
116_R387_V0.5430.62
17_L20_R0.5430.62
70_A167_A0.5410.62
157_P180_V0.5410.62
74_V171_A0.5390.62
166_L177_V0.5390.62
203_V376_L0.5390.62
38_V154_A0.5380.61
398_L401_T0.5370.61
154_A157_P0.5360.61
237_D240_A0.5360.61
215_A218_R0.5360.61
118_V380_T0.5350.61
260_S318_Y0.5340.61
286_E407_D0.5340.61
394_G398_L0.5330.61
63_V157_P0.5330.61
266_D270_T0.5330.61
265_T274_I0.5330.61
403_T422_F0.5320.61
267_D270_T0.5310.60
229_P258_N0.5310.60
101_W114_R0.5300.60
127_G130_A0.5300.60
47_R195_T0.5290.60
150_Q175_D0.5280.60
352_A418_V0.5280.60
31_V216_E0.5260.60
155_T158_A0.5260.60
115_F384_S0.5260.60
79_Y171_A0.5250.60
111_L342_S0.5250.60
79_Y170_H0.5250.60
114_R387_V0.5230.59
48_A51_S0.5230.59
119_R316_E0.5220.59
277_A418_V0.5180.59
112_G331_E0.5180.59
395_L420_A0.5170.58
95_A101_W0.5170.58
113_R384_S0.5170.58
238_E273_A0.5160.58
215_A372_V0.5160.58
67_M166_L0.5150.58
168_A405_L0.5150.58
137_L172_A0.5130.58
225_F342_S0.5110.58
78_V405_L0.5090.57
127_G132_Y0.5090.57
25_D36_D0.5070.57
218_R373_T0.5060.57
350_P399_R0.5060.57
93_H145_V0.5060.57
40_S276_D0.5040.57
93_H361_N0.5040.57
74_V78_V0.5030.56
154_A178_Y0.5030.56
303_F314_F0.5030.56
211_T227_A0.5020.56
350_P418_V0.5010.56
398_L402_V0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4g09A 2 0.9859 100 0.021 Contact Map
1kaeA 2 0.9906 100 0.032 Contact Map
4gicA 2 0.8729 100 0.053 Contact Map
3my7A 2 0.7906 97.9 0.948 Contact Map
4itaA 2 0.8188 97.8 0.949 Contact Map
4ghkA 3 0.8141 97.6 0.952 Contact Map
1o20A 3 0.8376 97.6 0.952 Contact Map
3lnsA 2 0.8306 97.5 0.952 Contact Map
1euhA 4 0.8424 97.5 0.952 Contact Map
3vz0A 2 0.8188 97.5 0.953 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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