GREMLIN Database
Q9HPW2 - Uncharacterized protein
UniProt: Q9HPW2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 79 (73)
Sequences: 112 (75)
Seq/√Len: 8.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
73_E78_H3.4790.95
15_A18_E3.2900.94
28_F45_S3.0240.90
54_M58_G2.5210.80
40_W78_H2.1970.69
30_V77_A2.1570.68
40_W72_E2.1470.67
53_A63_N1.8850.57
16_T73_E1.7550.51
16_T40_W1.6510.47
53_A60_I1.6020.45
26_P45_S1.5530.43
71_P77_A1.5410.42
54_M69_R1.5280.41
21_T45_S1.4640.39
18_E26_P1.4320.38
14_V56_S1.3960.36
12_L69_R1.3930.36
39_R77_A1.3570.35
25_G72_E1.3560.35
25_G78_H1.3430.34
55_D71_P1.2760.31
40_W73_E1.2400.30
52_N58_G1.2350.30
47_C58_G1.2240.30
61_E66_G1.1760.28
33_T64_G1.1570.27
6_G12_L1.1560.27
11_P29_V1.1360.27
16_T42_W1.1150.26
11_P60_I1.1100.26
16_T28_F1.0730.24
70_K76_A1.0660.24
42_W60_I1.0600.24
49_S52_N1.0580.24
55_D59_R1.0570.24
34_P37_E1.0430.24
8_D13_Y1.0400.23
17_D45_S1.0340.23
24_D63_N1.0140.23
24_D71_P1.0120.23
58_G72_E0.9990.22
18_E49_S0.9970.22
70_K74_W0.9940.22
51_D56_S0.9650.21
41_G69_R0.9040.20
15_A42_W0.9010.19
52_N63_N0.8900.19
11_P39_R0.8890.19
56_S76_A0.8760.19
14_V31_Y0.8660.19
21_T73_E0.8530.18
20_E47_C0.8470.18
23_Q74_W0.8230.17
21_T57_M0.8070.17
50_I54_M0.8060.17
12_L64_G0.7990.17
23_Q72_E0.7960.17
28_F61_E0.7870.17
35_D50_I0.7840.16
15_A33_T0.7820.16
25_G68_F0.7740.16
15_A71_P0.7730.16
26_P49_S0.7680.16
68_F73_E0.7580.16
25_G29_V0.7560.16
10_Q13_Y0.7340.15
50_I76_A0.7190.15
6_G51_D0.7130.15
42_W54_M0.7110.15
21_T76_A0.7050.15
40_W66_G0.7000.15
20_E28_F0.6940.14
21_T26_P0.6910.14
9_S77_A0.6880.14
48_E76_A0.6790.14
13_Y50_I0.6710.14
6_G20_E0.6690.14
8_D30_V0.6680.14
34_P64_G0.6520.14
52_N60_I0.6370.13
32_R64_G0.6290.13
18_E46_N0.6270.13
33_T37_E0.6100.13
38_R78_H0.6080.13
51_D63_N0.6060.13
32_R42_W0.6010.13
15_A41_G0.5840.12
54_M63_N0.5820.12
54_M59_R0.5730.12
21_T74_W0.5720.12
28_F68_F0.5700.12
20_E64_G0.5700.12
21_T56_S0.5660.12
47_C72_E0.5550.12
41_G50_I0.5540.12
35_D48_E0.5450.12
38_R68_F0.5400.12
74_W77_A0.5390.11
12_L50_I0.5350.11
7_E60_I0.5280.11
30_V70_K0.5270.11
68_F72_E0.5250.11
16_T78_H0.5210.11
36_R64_G0.5200.11
14_V30_V0.5160.11
34_P42_W0.5120.11
50_I61_E0.5060.11
12_L71_P0.5000.11
24_D51_D0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4l2nA 2 0.9367 64.2 0.901 Contact Map
1zvfA 2 0.9114 51.2 0.909 Contact Map
1vq8Z 1 0.7595 44.5 0.913 Contact Map
4bbrM 1 0.481 43.7 0.913 Contact Map
1nuiA 1 0.519 30.6 0.92 Contact Map
1twfL 1 0.4937 28.3 0.921 Contact Map
2k4xA 1 0.6203 27.2 0.922 Contact Map
4k95A 4 0.519 25 0.923 Contact Map
5c1zA 2 0.8481 24.8 0.924 Contact Map
2vutI 1 0.481 23.5 0.924 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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