Q9HPW1 - HALSA - GREMLIN Contacts

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Q9HPW1 - 2',3'-cyclic-nucleotide 2'-phosphodiesterase

UniProt:	Q9HPW1	Sequences: MDLYSAVDPDVATFGNHDFDYGPSRTAAVVADSPQTWVSANVYHDGDRVAGVEPWTLVERDGTTLGFFGVLDADTPALNPMASDLTVTDPIQAATDAEAALRDAGAEYVIALSHLGRGDDELAAATTVDAVLGGHIASERVERLDGTLLTRPGAGGDVVFEIDIAADTVTRHQVDNAPRHDGVTAALRDRLADAGLDAVVGHVTPPMERTERTLFEGESRIGNFVADAYRWAADADVGLQNAGGVRDGPALAGDVTVADLVSVVPFAEPVSVAELTGRELLDVFRAGNGSGGLGFAEPDWWHAHVSGATLEWRDGDGLVSASVGGDPVDPDATYTLATTDYLFYSDDEFPALDAGHRIDQLDTQHEVLASYARQEGINPETEGRIRFHADD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	391 (369)
Sequences:	5252 (3910)
Seq/√Len:	203.5

ECOLI - USHA CPDB
BACSU - YUND NTPES YHCR
HALSA - Q9HPW1 Q9HPZ0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
281_L	330_P	3.760	1.00
274_E	333_T	3.480	1.00
278_R	282_D	3.416	1.00
199_V	254_D	3.228	1.00
58_V	67_F	2.990	1.00
276_T	279_E	2.927	1.00
55_W	97_A	2.925	1.00
311_E	320_S	2.903	1.00
329_D	332_A	2.785	1.00
11_V	67_F	2.732	1.00
185_A	189_D	2.717	1.00
281_L	321_A	2.674	1.00
321_A	328_V	2.641	1.00
121_E	125_A	2.599	1.00
97_A	100_A	2.536	1.00
88_T	93_A	2.530	1.00
70_V	94_A	2.525	1.00
66_G	101_L	2.503	1.00
201_G	372_A	2.501	1.00
309_T	322_S	2.471	1.00
180_H	185_A	2.379	1.00
66_G	106_A	2.356	1.00
95_T	99_A	2.347	1.00
5_S	34_P	2.282	1.00
100_A	104_A	2.274	1.00
202_H	254_D	2.207	1.00
274_E	335_T	2.179	1.00
322_S	327_P	2.088	1.00
230_R	306_S	2.057	1.00
57_L	64_T	2.019	1.00
43_Y	88_T	2.010	1.00
102_R	127_T	1.929	1.00
123_A	131_V	1.929	1.00
272_V	335_T	1.925	1.00
278_R	330_P	1.914	1.00
182_G	186_A	1.912	1.00
130_A	162_I	1.902	1.00
60_R	65_L	1.892	1.00
63_T	108_Y	1.884	1.00
6_A	187_L	1.879	1.00
101_L	106_A	1.848	1.00
39_S	71_L	1.839	1.00
33_S	37_W	1.791	1.00
5_S	35_Q	1.789	1.00
57_L	106_A	1.789	1.00
313_R	316_D	1.775	1.00
111_A	128_V	1.770	1.00
227_D	306_S	1.759	1.00
275_L	336_L	1.750	1.00
259_D	262_S	1.739	1.00
45_D	84_D	1.730	1.00
99_A	103_D	1.725	1.00
130_A	148_L	1.704	1.00
276_T	333_T	1.700	1.00
285_R	317_G	1.695	1.00
44_H	47_D	1.683	1.00
198_A	373_R	1.681	1.00
11_V	56_T	1.680	1.00
59_E	62_G	1.665	1.00
237_V	280_L	1.657	1.00
102_R	109_V	1.655	1.00
275_L	280_L	1.650	1.00
11_V	36_T	1.647	1.00
59_E	64_T	1.625	1.00
88_T	96_D	1.588	1.00
11_V	38_V	1.579	1.00
131_V	149_L	1.566	1.00
130_A	164_I	1.565	1.00
98_E	127_T	1.549	1.00
284_F	321_A	1.533	1.00
257_V	369_A	1.524	1.00
68_F	94_A	1.515	1.00
285_R	315_G	1.500	1.00
204_T	378_N	1.497	1.00
25_R	28_A	1.496	1.00
89_D	92_Q	1.491	1.00
366_E	370_S	1.477	1.00
203_V	255_V	1.477	1.00
278_R	331_D	1.474	1.00
136_I	151_R	1.460	1.00
45_D	86_T	1.460	1.00
98_E	109_V	1.444	1.00
167_D	171_R	1.438	1.00
286_A	351_A	1.432	1.00
326_D	332_A	1.429	1.00
75_T	87_V	1.416	1.00
93_A	97_A	1.411	1.00
206_P	252_A	1.404	1.00
255_V	372_A	1.395	1.00
132_L	162_I	1.395	1.00
236_D	332_A	1.395	1.00
114_H	135_H	1.386	1.00
121_E	124_A	1.386	1.00
198_A	257_V	1.379	1.00
54_P	97_A	1.378	1.00
280_L	328_V	1.374	1.00
288_N	312_W	1.368	1.00
275_L	279_E	1.366	1.00
231_W	374_Q	1.365	1.00
231_W	375_E	1.360	1.00
251_L	259_D	1.355	1.00
4_Y	9_P	1.351	1.00
167_D	173_Q	1.351	1.00
5_S	33_S	1.349	1.00
12_A	35_Q	1.343	1.00
36_T	56_T	1.342	1.00
225_V	245_V	1.340	1.00
55_W	100_A	1.339	1.00
200_V	260_L	1.338	1.00
73_A	90_P	1.337	1.00
6_A	183_V	1.330	1.00
273_A	343_F	1.329	1.00
283_V	351_A	1.328	1.00
186_A	189_D	1.323	1.00
17_H	20_D	1.302	1.00
12_A	37_W	1.301	1.00
53_E	56_T	1.298	1.00
277_G	334_Y	1.290	1.00
95_T	126_T	1.279	1.00
106_A	109_V	1.264	1.00
95_T	125_A	1.243	1.00
218_E	223_N	1.243	1.00
55_W	66_G	1.240	1.00
197_D	258_A	1.237	1.00
108_Y	166_A	1.212	1.00
92_Q	95_T	1.204	1.00
239_L	280_L	1.203	1.00
193_D	197_D	1.202	1.00
153_G	157_D	1.196	1.00
68_F	111_A	1.196	1.00
132_L	150_T	1.196	1.00
43_Y	93_A	1.191	1.00
11_V	58_V	1.182	1.00
139_E	144_L	1.182	1.00
94_A	128_V	1.181	1.00
154_A	157_D	1.174	1.00
116_G	136_I	1.174	1.00
91_I	125_A	1.161	1.00
231_W	371_Y	1.160	1.00
229_Y	238_G	1.155	1.00
68_F	97_A	1.152	1.00
305_V	308_A	1.152	1.00
279_E	354_A	1.150	1.00
199_V	202_H	1.149	1.00
96_D	100_A	1.142	1.00
233_A	272_V	1.139	1.00
287_G	303_A	1.127	1.00
10_D	60_R	1.124	1.00
311_E	319_V	1.123	1.00
13_T	38_V	1.120	1.00
168_T	172_H	1.111	1.00
153_G	158_V	1.108	1.00
276_T	331_D	1.103	1.00
270_V	337_A	1.099	1.00
68_F	101_L	1.097	1.00
14_F	30_V	1.096	1.00
363_T	366_E	1.090	1.00
6_A	184_T	1.089	1.00
63_T	107_E	1.088	1.00
199_V	256_T	1.084	1.00
369_A	373_R	1.083	1.00
94_A	122_L	1.076	1.00
274_E	357_R	1.073	1.00
91_I	95_T	1.071	1.00
115_L	122_L	1.070	1.00
228_A	371_Y	1.069	1.00
237_V	336_L	1.067	1.00
23_P	27_A	1.067	1.00
98_E	128_V	1.064	1.00
101_L	109_V	1.061	1.00
323_V	334_Y	1.061	1.00
345_S	348_E	1.060	1.00
16_N	135_H	1.060	1.00
28_A	31_A	1.056	1.00
25_R	29_V	1.055	1.00
309_T	325_G	1.054	1.00
13_T	69_G	1.048	1.00
232_A	370_S	1.043	1.00
206_P	251_L	1.040	1.00
93_A	96_D	1.036	1.00
225_V	264_V	1.032	1.00
269_P	340_D	1.026	1.00
39_S	42_V	1.024	1.00
120_D	133_G	1.024	1.00
205_P	220_R	1.023	1.00
14_F	52_V	1.022	1.00
203_V	206_P	1.021	1.00
237_V	323_V	1.020	1.00
16_N	114_H	1.019	1.00
329_D	334_Y	1.015	1.00
44_H	48_R	1.007	1.00
56_T	67_F	1.007	1.00
141_V	144_L	1.007	1.00
114_H	137_A	1.006	1.00
195_G	198_A	1.003	1.00
243_G	246_R	0.999	1.00
67_F	112_L	0.999	1.00
30_V	37_W	0.996	1.00
184_T	187_L	0.994	1.00
285_R	318_L	0.991	1.00
279_E	355_G	0.983	1.00
222_G	304_H	0.981	1.00
308_A	323_V	0.979	1.00
170_T	173_Q	0.974	1.00
221_I	263_V	0.973	1.00
260_L	365_H	0.973	1.00
167_D	170_T	0.973	1.00
20_D	79_N	0.967	1.00
283_V	352_L	0.961	0.99
274_E	356_H	0.960	0.99
55_W	104_A	0.959	0.99
226_A	238_G	0.959	0.99
232_A	367_V	0.959	0.99
150_T	162_I	0.957	0.99
23_P	85_L	0.954	0.99
313_R	317_G	0.954	0.99
230_R	235_A	0.953	0.99
108_Y	164_I	0.951	0.99
372_A	377_I	0.948	0.99
29_V	32_D	0.948	0.99
284_F	310_L	0.947	0.99
226_A	240_Q	0.943	0.99
288_N	310_L	0.941	0.99
246_R	266_F	0.931	0.99
4_Y	35_Q	0.926	0.99
109_V	127_T	0.923	0.99
70_V	113_S	0.922	0.99
16_N	137_A	0.919	0.99
370_S	373_R	0.915	0.99
143_R	146_G	0.915	0.99
230_R	238_G	0.915	0.99
237_V	308_A	0.909	0.99
187_L	191_L	0.907	0.99
13_T	39_S	0.905	0.99
269_P	359_D	0.905	0.99
224_F	228_A	0.904	0.99
10_D	58_V	0.900	0.99
144_L	149_L	0.897	0.99
235_A	337_A	0.897	0.99
238_G	337_A	0.893	0.99
247_D	262_S	0.893	0.99
101_L	104_A	0.893	0.99
281_L	328_V	0.891	0.99
207_M	220_R	0.890	0.99
186_A	190_R	0.890	0.99
168_T	171_R	0.889	0.99
235_A	335_T	0.887	0.99
240_Q	244_G	0.885	0.99
116_G	135_H	0.883	0.99
279_E	282_D	0.882	0.99
42_V	85_L	0.878	0.99
73_A	89_D	0.873	0.99
229_Y	270_V	0.869	0.99
90_P	122_L	0.868	0.99
3_L	184_T	0.867	0.99
260_L	369_A	0.866	0.99
140_R	146_G	0.861	0.99
203_V	207_M	0.860	0.99
113_S	133_G	0.860	0.99
23_P	84_D	0.858	0.99
55_W	101_L	0.855	0.99
133_G	151_R	0.854	0.99
43_Y	50_A	0.851	0.99
241_N	244_G	0.850	0.99
76_P	87_V	0.848	0.99
92_Q	96_D	0.845	0.99
97_A	101_L	0.845	0.99
237_V	334_Y	0.842	0.99
273_A	338_T	0.840	0.99
303_A	310_L	0.838	0.99
152_P	160_F	0.835	0.99
227_D	231_W	0.831	0.98
36_T	53_E	0.830	0.98
43_Y	86_T	0.830	0.98
40_A	93_A	0.829	0.98
94_A	111_A	0.829	0.98
362_D	370_S	0.829	0.98
59_E	65_L	0.828	0.98
242_A	300_W	0.824	0.98
78_L	135_H	0.821	0.98
57_L	66_G	0.820	0.98
278_R	281_L	0.820	0.98
57_L	104_A	0.818	0.98
187_L	190_R	0.817	0.98
284_F	318_L	0.812	0.98
74_D	77_A	0.810	0.98
144_L	147_T	0.805	0.98
88_T	92_Q	0.804	0.98
82_A	87_V	0.804	0.98
110_I	130_A	0.804	0.98
233_A	337_A	0.803	0.98
17_H	114_H	0.801	0.98
66_G	109_V	0.799	0.98
42_V	71_L	0.798	0.98
222_G	245_V	0.797	0.98
346_D	349_F	0.797	0.98
247_D	263_V	0.795	0.98
9_P	12_A	0.793	0.98
228_A	367_V	0.792	0.98
98_E	102_R	0.791	0.98
340_D	344_Y	0.791	0.98
305_V	310_L	0.790	0.98
282_D	351_A	0.788	0.98
63_T	166_A	0.785	0.98
189_D	192_A	0.781	0.98
229_Y	339_T	0.780	0.98
371_Y	375_E	0.780	0.98
42_V	87_V	0.776	0.98
64_T	107_E	0.772	0.98
244_G	266_F	0.772	0.98
266_F	341_Y	0.768	0.97
126_T	147_T	0.765	0.97
64_T	105_G	0.765	0.97
209_R	221_I	0.765	0.97
359_D	362_D	0.759	0.97
67_F	110_I	0.759	0.97
340_D	364_Q	0.757	0.97
239_L	336_L	0.756	0.97
140_R	144_L	0.754	0.97
168_T	173_Q	0.753	0.97
179_R	182_G	0.753	0.97
90_P	93_A	0.752	0.97
113_S	131_V	0.752	0.97
60_R	67_F	0.751	0.97
109_V	128_V	0.750	0.97
256_T	259_D	0.749	0.97
16_N	20_D	0.748	0.97
209_R	248_G	0.747	0.97
284_F	305_V	0.744	0.97
183_V	186_A	0.743	0.97
284_F	308_A	0.742	0.97
338_T	343_F	0.741	0.97
14_F	37_W	0.741	0.97
223_N	306_S	0.741	0.97
143_R	148_L	0.737	0.97
279_E	351_A	0.737	0.97
50_A	93_A	0.736	0.97
303_A	342_L	0.735	0.97
264_V	368_L	0.735	0.97
68_F	128_V	0.734	0.97
99_A	106_A	0.733	0.97
327_P	330_P	0.731	0.97
235_A	272_V	0.730	0.97
303_A	349_F	0.730	0.97
285_R	313_R	0.729	0.97
152_P	158_V	0.729	0.97
282_D	354_A	0.728	0.97
99_A	126_T	0.727	0.96
229_Y	264_V	0.726	0.96
40_A	54_P	0.725	0.96
230_R	335_T	0.724	0.96
282_D	286_A	0.723	0.96
65_L	110_I	0.722	0.96
267_A	365_H	0.721	0.96
326_D	329_D	0.720	0.96
235_A	238_G	0.717	0.96
28_A	32_D	0.716	0.96
268_E	340_D	0.714	0.96
17_H	266_F	0.705	0.96
226_A	306_S	0.705	0.96
230_R	236_D	0.703	0.96
185_A	188_R	0.700	0.96
351_A	354_A	0.700	0.96
286_A	301_W	0.698	0.96
232_A	362_D	0.697	0.96
286_A	289_G	0.695	0.95
281_L	316_D	0.691	0.95
264_V	364_Q	0.688	0.95
320_S	328_V	0.687	0.95
68_F	98_E	0.686	0.95
341_Y	346_D	0.684	0.95
355_G	358_I	0.683	0.95
260_L	372_A	0.683	0.95
200_V	369_A	0.683	0.95
132_L	160_F	0.682	0.95
280_L	283_V	0.682	0.95
17_H	137_A	0.682	0.95
202_H	376_G	0.676	0.95
169_V	173_Q	0.675	0.95
205_P	252_A	0.674	0.95
101_L	105_G	0.671	0.95
117_R	133_G	0.669	0.94
50_A	97_A	0.668	0.94
295_F	312_W	0.665	0.94
362_D	367_V	0.664	0.94
223_N	227_D	0.662	0.94
43_Y	48_R	0.661	0.94
370_S	374_Q	0.660	0.94
268_E	339_T	0.660	0.94
102_R	129_D	0.660	0.94
99_A	127_T	0.659	0.94
258_A	262_S	0.659	0.94
117_R	151_R	0.658	0.94
79_N	82_A	0.658	0.94
54_P	100_A	0.656	0.94
339_T	342_L	0.656	0.94
69_G	112_L	0.651	0.94
300_W	303_A	0.650	0.94
225_V	263_V	0.649	0.94
295_F	298_P	0.648	0.93
237_V	307_G	0.648	0.93
234_D	335_T	0.647	0.93
229_Y	364_Q	0.646	0.93
208_E	220_R	0.644	0.93
236_D	324_G	0.644	0.93
207_M	250_A	0.644	0.93
14_F	26_T	0.644	0.93
134_G	152_P	0.644	0.93
111_A	131_V	0.644	0.93
275_L	283_V	0.643	0.93
14_F	39_S	0.643	0.93
54_P	68_F	0.643	0.93
241_N	268_E	0.641	0.93
40_A	94_A	0.641	0.93
44_H	49_V	0.641	0.93
76_P	82_A	0.640	0.93
194_A	197_D	0.637	0.93
281_L	285_R	0.636	0.93
169_V	172_H	0.636	0.93
114_H	134_G	0.635	0.93
65_L	108_Y	0.633	0.93
13_T	112_L	0.631	0.93
3_L	188_R	0.630	0.93
271_S	343_F	0.630	0.93
75_T	79_N	0.629	0.92
141_V	147_T	0.627	0.92
328_V	334_Y	0.626	0.92
314_D	317_G	0.622	0.92
139_E	143_R	0.622	0.92
133_G	136_I	0.620	0.92
19_F	42_V	0.620	0.92
320_S	327_P	0.620	0.92
13_T	71_L	0.619	0.92
123_A	149_L	0.618	0.92
72_D	151_R	0.616	0.92
116_G	151_R	0.616	0.92
17_H	135_H	0.615	0.92
27_A	51_G	0.614	0.92
100_A	103_D	0.613	0.91
107_E	127_T	0.613	0.91
188_R	191_L	0.612	0.91
232_A	270_V	0.612	0.91
117_R	138_S	0.611	0.91
244_G	268_E	0.611	0.91
240_Q	339_T	0.610	0.91
40_A	68_F	0.609	0.91
72_D	75_T	0.608	0.91
29_V	33_S	0.608	0.91
230_R	337_A	0.608	0.91
209_R	212_R	0.606	0.91
244_G	339_T	0.606	0.91
216_E	298_P	0.605	0.91
66_G	105_G	0.604	0.91
14_F	19_F	0.603	0.91
20_D	75_T	0.601	0.91
277_G	328_V	0.600	0.91
330_P	333_T	0.600	0.91
40_A	97_A	0.598	0.90
175_D	178_P	0.598	0.90
3_L	187_L	0.597	0.90
122_L	125_A	0.595	0.90
43_Y	46_G	0.592	0.90
58_V	65_L	0.592	0.90
38_V	54_P	0.591	0.90
286_A	349_F	0.590	0.90
38_V	56_T	0.590	0.90
280_L	308_A	0.589	0.90
236_D	335_T	0.589	0.90
275_L	355_G	0.588	0.90
90_P	115_L	0.588	0.90
239_L	283_V	0.585	0.89
228_A	368_L	0.582	0.89
181_D	184_T	0.581	0.89
233_A	270_V	0.576	0.89
75_T	78_L	0.576	0.89
275_L	352_L	0.575	0.89
167_D	172_H	0.572	0.88
47_D	86_T	0.572	0.88
224_F	372_A	0.571	0.88
11_V	112_L	0.566	0.88
72_D	135_H	0.565	0.88
103_D	106_A	0.564	0.88
269_P	363_T	0.564	0.88
312_W	318_L	0.563	0.88
26_T	42_V	0.562	0.88
285_R	316_D	0.561	0.87
27_A	52_V	0.560	0.87
195_G	258_A	0.560	0.87
342_L	345_S	0.556	0.87
296_A	301_W	0.555	0.87
222_G	226_A	0.555	0.87
93_A	99_A	0.554	0.87
330_P	334_Y	0.552	0.87
238_G	306_S	0.552	0.87
43_Y	47_D	0.551	0.87
215_F	242_A	0.550	0.86
113_S	149_L	0.549	0.86
70_V	111_A	0.546	0.86
24_S	28_A	0.546	0.86
349_F	352_L	0.544	0.86
298_P	301_W	0.543	0.86
220_R	223_N	0.541	0.86
374_Q	377_I	0.541	0.86
280_L	284_F	0.541	0.86
182_G	185_A	0.540	0.85
255_V	260_L	0.538	0.85
323_V	326_D	0.538	0.85
46_G	86_T	0.536	0.85
39_S	52_V	0.536	0.85
230_R	307_G	0.535	0.85
312_W	320_S	0.533	0.85
73_A	115_L	0.533	0.85
124_A	144_L	0.533	0.85
227_D	230_R	0.532	0.85
77_A	348_E	0.532	0.85
209_R	215_F	0.531	0.84
280_L	336_L	0.529	0.84
241_N	265_P	0.529	0.84
203_V	250_A	0.529	0.84
116_G	137_A	0.529	0.84
113_S	120_D	0.528	0.84
308_A	321_A	0.527	0.84
166_A	170_T	0.527	0.84
39_S	50_A	0.523	0.84
141_V	145_D	0.523	0.84
225_V	240_Q	0.523	0.84
226_A	230_R	0.522	0.83
137_A	154_A	0.521	0.83
270_V	367_V	0.520	0.83
166_A	172_H	0.518	0.83
243_G	266_F	0.518	0.83
74_D	78_L	0.517	0.83
196_L	199_V	0.517	0.83
17_H	268_E	0.517	0.83
218_E	304_H	0.517	0.83
4_Y	33_S	0.516	0.83
184_T	188_R	0.516	0.83
354_A	357_R	0.515	0.83
152_P	156_G	0.514	0.83
82_A	85_L	0.513	0.82
58_V	61_D	0.512	0.82
375_E	378_N	0.512	0.82
362_D	366_E	0.512	0.82
226_A	229_Y	0.510	0.82
242_A	304_H	0.510	0.82
3_L	6_A	0.509	0.82
139_E	142_E	0.507	0.82
241_N	342_L	0.506	0.82
250_A	263_V	0.506	0.82
240_Q	364_Q	0.506	0.82
243_G	347_D	0.503	0.81
205_P	208_E	0.502	0.81
368_L	372_A	0.500	0.81
279_E	356_H	0.500	0.81

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2z1aA	1	0.9872	100	0.219	Contact Map
1hp1A	1	0.9744	100	0.224	Contact Map
4h2gA	2	0.9795	100	0.224	Contact Map
3ztvA	2	0.9923	100	0.23	Contact Map
3iveA	1	0.9642	100	0.23	Contact Map
4q7fA	1	0.9821	100	0.246	Contact Map
2wdcA	1	0.9668	100	0.28	Contact Map
3c9fA	2	0.9514	100	0.432	Contact Map
3jyfA	2	0.5141	100	0.612	Contact Map
3gveA	2	0.5115	100	0.617	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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