GREMLIN Database
Q9HPW1 - 2',3'-cyclic-nucleotide 2'-phosphodiesterase
UniProt: Q9HPW1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 391 (369)
Sequences: 5252 (3910)
Seq/√Len: 203.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
281_L330_P3.7601.00
274_E333_T3.4801.00
278_R282_D3.4161.00
199_V254_D3.2281.00
58_V67_F2.9901.00
276_T279_E2.9271.00
55_W97_A2.9251.00
311_E320_S2.9031.00
329_D332_A2.7851.00
11_V67_F2.7321.00
185_A189_D2.7171.00
281_L321_A2.6741.00
321_A328_V2.6411.00
121_E125_A2.5991.00
97_A100_A2.5361.00
88_T93_A2.5301.00
70_V94_A2.5251.00
66_G101_L2.5031.00
201_G372_A2.5011.00
309_T322_S2.4711.00
180_H185_A2.3791.00
66_G106_A2.3561.00
95_T99_A2.3471.00
5_S34_P2.2821.00
100_A104_A2.2741.00
202_H254_D2.2071.00
274_E335_T2.1791.00
322_S327_P2.0881.00
230_R306_S2.0571.00
57_L64_T2.0191.00
43_Y88_T2.0101.00
102_R127_T1.9291.00
123_A131_V1.9291.00
272_V335_T1.9251.00
278_R330_P1.9141.00
182_G186_A1.9121.00
130_A162_I1.9021.00
60_R65_L1.8921.00
63_T108_Y1.8841.00
6_A187_L1.8791.00
101_L106_A1.8481.00
39_S71_L1.8391.00
33_S37_W1.7911.00
5_S35_Q1.7891.00
57_L106_A1.7891.00
313_R316_D1.7751.00
111_A128_V1.7701.00
227_D306_S1.7591.00
275_L336_L1.7501.00
259_D262_S1.7391.00
45_D84_D1.7301.00
99_A103_D1.7251.00
130_A148_L1.7041.00
276_T333_T1.7001.00
285_R317_G1.6951.00
44_H47_D1.6831.00
198_A373_R1.6811.00
11_V56_T1.6801.00
59_E62_G1.6651.00
237_V280_L1.6571.00
102_R109_V1.6551.00
275_L280_L1.6501.00
11_V36_T1.6471.00
59_E64_T1.6251.00
88_T96_D1.5881.00
11_V38_V1.5791.00
131_V149_L1.5661.00
130_A164_I1.5651.00
98_E127_T1.5491.00
284_F321_A1.5331.00
257_V369_A1.5241.00
68_F94_A1.5151.00
285_R315_G1.5001.00
204_T378_N1.4971.00
25_R28_A1.4961.00
89_D92_Q1.4911.00
366_E370_S1.4771.00
203_V255_V1.4771.00
278_R331_D1.4741.00
136_I151_R1.4601.00
45_D86_T1.4601.00
98_E109_V1.4441.00
167_D171_R1.4381.00
286_A351_A1.4321.00
326_D332_A1.4291.00
75_T87_V1.4161.00
93_A97_A1.4111.00
206_P252_A1.4041.00
255_V372_A1.3951.00
132_L162_I1.3951.00
236_D332_A1.3951.00
114_H135_H1.3861.00
121_E124_A1.3861.00
198_A257_V1.3791.00
54_P97_A1.3781.00
280_L328_V1.3741.00
288_N312_W1.3681.00
275_L279_E1.3661.00
231_W374_Q1.3651.00
231_W375_E1.3601.00
251_L259_D1.3551.00
4_Y9_P1.3511.00
167_D173_Q1.3511.00
5_S33_S1.3491.00
12_A35_Q1.3431.00
36_T56_T1.3421.00
225_V245_V1.3401.00
55_W100_A1.3391.00
200_V260_L1.3381.00
73_A90_P1.3371.00
6_A183_V1.3301.00
273_A343_F1.3291.00
283_V351_A1.3281.00
186_A189_D1.3231.00
17_H20_D1.3021.00
12_A37_W1.3011.00
53_E56_T1.2981.00
277_G334_Y1.2901.00
95_T126_T1.2791.00
106_A109_V1.2641.00
95_T125_A1.2431.00
218_E223_N1.2431.00
55_W66_G1.2401.00
197_D258_A1.2371.00
108_Y166_A1.2121.00
92_Q95_T1.2041.00
239_L280_L1.2031.00
193_D197_D1.2021.00
153_G157_D1.1961.00
68_F111_A1.1961.00
132_L150_T1.1961.00
43_Y93_A1.1911.00
11_V58_V1.1821.00
139_E144_L1.1821.00
94_A128_V1.1811.00
154_A157_D1.1741.00
116_G136_I1.1741.00
91_I125_A1.1611.00
231_W371_Y1.1601.00
229_Y238_G1.1551.00
68_F97_A1.1521.00
305_V308_A1.1521.00
279_E354_A1.1501.00
199_V202_H1.1491.00
96_D100_A1.1421.00
233_A272_V1.1391.00
287_G303_A1.1271.00
10_D60_R1.1241.00
311_E319_V1.1231.00
13_T38_V1.1201.00
168_T172_H1.1111.00
153_G158_V1.1081.00
276_T331_D1.1031.00
270_V337_A1.0991.00
68_F101_L1.0971.00
14_F30_V1.0961.00
363_T366_E1.0901.00
6_A184_T1.0891.00
63_T107_E1.0881.00
199_V256_T1.0841.00
369_A373_R1.0831.00
94_A122_L1.0761.00
274_E357_R1.0731.00
91_I95_T1.0711.00
115_L122_L1.0701.00
228_A371_Y1.0691.00
237_V336_L1.0671.00
23_P27_A1.0671.00
98_E128_V1.0641.00
101_L109_V1.0611.00
323_V334_Y1.0611.00
345_S348_E1.0601.00
16_N135_H1.0601.00
28_A31_A1.0561.00
25_R29_V1.0551.00
309_T325_G1.0541.00
13_T69_G1.0481.00
232_A370_S1.0431.00
206_P251_L1.0401.00
93_A96_D1.0361.00
225_V264_V1.0321.00
269_P340_D1.0261.00
39_S42_V1.0241.00
120_D133_G1.0241.00
205_P220_R1.0231.00
14_F52_V1.0221.00
203_V206_P1.0211.00
237_V323_V1.0201.00
16_N114_H1.0191.00
329_D334_Y1.0151.00
44_H48_R1.0071.00
56_T67_F1.0071.00
141_V144_L1.0071.00
114_H137_A1.0061.00
195_G198_A1.0031.00
243_G246_R0.9991.00
67_F112_L0.9991.00
30_V37_W0.9961.00
184_T187_L0.9941.00
285_R318_L0.9911.00
279_E355_G0.9831.00
222_G304_H0.9811.00
308_A323_V0.9791.00
170_T173_Q0.9741.00
221_I263_V0.9731.00
260_L365_H0.9731.00
167_D170_T0.9731.00
20_D79_N0.9671.00
283_V352_L0.9610.99
274_E356_H0.9600.99
55_W104_A0.9590.99
226_A238_G0.9590.99
232_A367_V0.9590.99
150_T162_I0.9570.99
23_P85_L0.9540.99
313_R317_G0.9540.99
230_R235_A0.9530.99
108_Y164_I0.9510.99
372_A377_I0.9480.99
29_V32_D0.9480.99
284_F310_L0.9470.99
226_A240_Q0.9430.99
288_N310_L0.9410.99
246_R266_F0.9310.99
4_Y35_Q0.9260.99
109_V127_T0.9230.99
70_V113_S0.9220.99
16_N137_A0.9190.99
370_S373_R0.9150.99
143_R146_G0.9150.99
230_R238_G0.9150.99
237_V308_A0.9090.99
187_L191_L0.9070.99
13_T39_S0.9050.99
269_P359_D0.9050.99
224_F228_A0.9040.99
10_D58_V0.9000.99
144_L149_L0.8970.99
235_A337_A0.8970.99
238_G337_A0.8930.99
247_D262_S0.8930.99
101_L104_A0.8930.99
281_L328_V0.8910.99
207_M220_R0.8900.99
186_A190_R0.8900.99
168_T171_R0.8890.99
235_A335_T0.8870.99
240_Q244_G0.8850.99
116_G135_H0.8830.99
279_E282_D0.8820.99
42_V85_L0.8780.99
73_A89_D0.8730.99
229_Y270_V0.8690.99
90_P122_L0.8680.99
3_L184_T0.8670.99
260_L369_A0.8660.99
140_R146_G0.8610.99
203_V207_M0.8600.99
113_S133_G0.8600.99
23_P84_D0.8580.99
55_W101_L0.8550.99
133_G151_R0.8540.99
43_Y50_A0.8510.99
241_N244_G0.8500.99
76_P87_V0.8480.99
92_Q96_D0.8450.99
97_A101_L0.8450.99
237_V334_Y0.8420.99
273_A338_T0.8400.99
303_A310_L0.8380.99
152_P160_F0.8350.99
227_D231_W0.8310.98
36_T53_E0.8300.98
43_Y86_T0.8300.98
40_A93_A0.8290.98
94_A111_A0.8290.98
362_D370_S0.8290.98
59_E65_L0.8280.98
242_A300_W0.8240.98
78_L135_H0.8210.98
57_L66_G0.8200.98
278_R281_L0.8200.98
57_L104_A0.8180.98
187_L190_R0.8170.98
284_F318_L0.8120.98
74_D77_A0.8100.98
144_L147_T0.8050.98
88_T92_Q0.8040.98
82_A87_V0.8040.98
110_I130_A0.8040.98
233_A337_A0.8030.98
17_H114_H0.8010.98
66_G109_V0.7990.98
42_V71_L0.7980.98
222_G245_V0.7970.98
346_D349_F0.7970.98
247_D263_V0.7950.98
9_P12_A0.7930.98
228_A367_V0.7920.98
98_E102_R0.7910.98
340_D344_Y0.7910.98
305_V310_L0.7900.98
282_D351_A0.7880.98
63_T166_A0.7850.98
189_D192_A0.7810.98
229_Y339_T0.7800.98
371_Y375_E0.7800.98
42_V87_V0.7760.98
64_T107_E0.7720.98
244_G266_F0.7720.98
266_F341_Y0.7680.97
126_T147_T0.7650.97
64_T105_G0.7650.97
209_R221_I0.7650.97
359_D362_D0.7590.97
67_F110_I0.7590.97
340_D364_Q0.7570.97
239_L336_L0.7560.97
140_R144_L0.7540.97
168_T173_Q0.7530.97
179_R182_G0.7530.97
90_P93_A0.7520.97
113_S131_V0.7520.97
60_R67_F0.7510.97
109_V128_V0.7500.97
256_T259_D0.7490.97
16_N20_D0.7480.97
209_R248_G0.7470.97
284_F305_V0.7440.97
183_V186_A0.7430.97
284_F308_A0.7420.97
338_T343_F0.7410.97
14_F37_W0.7410.97
223_N306_S0.7410.97
143_R148_L0.7370.97
279_E351_A0.7370.97
50_A93_A0.7360.97
303_A342_L0.7350.97
264_V368_L0.7350.97
68_F128_V0.7340.97
99_A106_A0.7330.97
327_P330_P0.7310.97
235_A272_V0.7300.97
303_A349_F0.7300.97
285_R313_R0.7290.97
152_P158_V0.7290.97
282_D354_A0.7280.97
99_A126_T0.7270.96
229_Y264_V0.7260.96
40_A54_P0.7250.96
230_R335_T0.7240.96
282_D286_A0.7230.96
65_L110_I0.7220.96
267_A365_H0.7210.96
326_D329_D0.7200.96
235_A238_G0.7170.96
28_A32_D0.7160.96
268_E340_D0.7140.96
17_H266_F0.7050.96
226_A306_S0.7050.96
230_R236_D0.7030.96
185_A188_R0.7000.96
351_A354_A0.7000.96
286_A301_W0.6980.96
232_A362_D0.6970.96
286_A289_G0.6950.95
281_L316_D0.6910.95
264_V364_Q0.6880.95
320_S328_V0.6870.95
68_F98_E0.6860.95
341_Y346_D0.6840.95
355_G358_I0.6830.95
260_L372_A0.6830.95
200_V369_A0.6830.95
132_L160_F0.6820.95
280_L283_V0.6820.95
17_H137_A0.6820.95
202_H376_G0.6760.95
169_V173_Q0.6750.95
205_P252_A0.6740.95
101_L105_G0.6710.95
117_R133_G0.6690.94
50_A97_A0.6680.94
295_F312_W0.6650.94
362_D367_V0.6640.94
223_N227_D0.6620.94
43_Y48_R0.6610.94
370_S374_Q0.6600.94
268_E339_T0.6600.94
102_R129_D0.6600.94
99_A127_T0.6590.94
258_A262_S0.6590.94
117_R151_R0.6580.94
79_N82_A0.6580.94
54_P100_A0.6560.94
339_T342_L0.6560.94
69_G112_L0.6510.94
300_W303_A0.6500.94
225_V263_V0.6490.94
295_F298_P0.6480.93
237_V307_G0.6480.93
234_D335_T0.6470.93
229_Y364_Q0.6460.93
208_E220_R0.6440.93
236_D324_G0.6440.93
207_M250_A0.6440.93
14_F26_T0.6440.93
134_G152_P0.6440.93
111_A131_V0.6440.93
275_L283_V0.6430.93
14_F39_S0.6430.93
54_P68_F0.6430.93
241_N268_E0.6410.93
40_A94_A0.6410.93
44_H49_V0.6410.93
76_P82_A0.6400.93
194_A197_D0.6370.93
281_L285_R0.6360.93
169_V172_H0.6360.93
114_H134_G0.6350.93
65_L108_Y0.6330.93
13_T112_L0.6310.93
3_L188_R0.6300.93
271_S343_F0.6300.93
75_T79_N0.6290.92
141_V147_T0.6270.92
328_V334_Y0.6260.92
314_D317_G0.6220.92
139_E143_R0.6220.92
133_G136_I0.6200.92
19_F42_V0.6200.92
320_S327_P0.6200.92
13_T71_L0.6190.92
123_A149_L0.6180.92
72_D151_R0.6160.92
116_G151_R0.6160.92
17_H135_H0.6150.92
27_A51_G0.6140.92
100_A103_D0.6130.91
107_E127_T0.6130.91
188_R191_L0.6120.91
232_A270_V0.6120.91
117_R138_S0.6110.91
244_G268_E0.6110.91
240_Q339_T0.6100.91
40_A68_F0.6090.91
72_D75_T0.6080.91
29_V33_S0.6080.91
230_R337_A0.6080.91
209_R212_R0.6060.91
244_G339_T0.6060.91
216_E298_P0.6050.91
66_G105_G0.6040.91
14_F19_F0.6030.91
20_D75_T0.6010.91
277_G328_V0.6000.91
330_P333_T0.6000.91
40_A97_A0.5980.90
175_D178_P0.5980.90
3_L187_L0.5970.90
122_L125_A0.5950.90
43_Y46_G0.5920.90
58_V65_L0.5920.90
38_V54_P0.5910.90
286_A349_F0.5900.90
38_V56_T0.5900.90
280_L308_A0.5890.90
236_D335_T0.5890.90
275_L355_G0.5880.90
90_P115_L0.5880.90
239_L283_V0.5850.89
228_A368_L0.5820.89
181_D184_T0.5810.89
233_A270_V0.5760.89
75_T78_L0.5760.89
275_L352_L0.5750.89
167_D172_H0.5720.88
47_D86_T0.5720.88
224_F372_A0.5710.88
11_V112_L0.5660.88
72_D135_H0.5650.88
103_D106_A0.5640.88
269_P363_T0.5640.88
312_W318_L0.5630.88
26_T42_V0.5620.88
285_R316_D0.5610.87
27_A52_V0.5600.87
195_G258_A0.5600.87
342_L345_S0.5560.87
296_A301_W0.5550.87
222_G226_A0.5550.87
93_A99_A0.5540.87
330_P334_Y0.5520.87
238_G306_S0.5520.87
43_Y47_D0.5510.87
215_F242_A0.5500.86
113_S149_L0.5490.86
70_V111_A0.5460.86
24_S28_A0.5460.86
349_F352_L0.5440.86
298_P301_W0.5430.86
220_R223_N0.5410.86
374_Q377_I0.5410.86
280_L284_F0.5410.86
182_G185_A0.5400.85
255_V260_L0.5380.85
323_V326_D0.5380.85
46_G86_T0.5360.85
39_S52_V0.5360.85
230_R307_G0.5350.85
312_W320_S0.5330.85
73_A115_L0.5330.85
124_A144_L0.5330.85
227_D230_R0.5320.85
77_A348_E0.5320.85
209_R215_F0.5310.84
280_L336_L0.5290.84
241_N265_P0.5290.84
203_V250_A0.5290.84
116_G137_A0.5290.84
113_S120_D0.5280.84
308_A321_A0.5270.84
166_A170_T0.5270.84
39_S50_A0.5230.84
141_V145_D0.5230.84
225_V240_Q0.5230.84
226_A230_R0.5220.83
137_A154_A0.5210.83
270_V367_V0.5200.83
166_A172_H0.5180.83
243_G266_F0.5180.83
74_D78_L0.5170.83
196_L199_V0.5170.83
17_H268_E0.5170.83
218_E304_H0.5170.83
4_Y33_S0.5160.83
184_T188_R0.5160.83
354_A357_R0.5150.83
152_P156_G0.5140.83
82_A85_L0.5130.82
58_V61_D0.5120.82
375_E378_N0.5120.82
362_D366_E0.5120.82
226_A229_Y0.5100.82
242_A304_H0.5100.82
3_L6_A0.5090.82
139_E142_E0.5070.82
241_N342_L0.5060.82
250_A263_V0.5060.82
240_Q364_Q0.5060.82
243_G347_D0.5030.81
205_P208_E0.5020.81
368_L372_A0.5000.81
279_E356_H0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2z1aA 1 0.9872 100 0.219 Contact Map
1hp1A 1 0.9744 100 0.224 Contact Map
4h2gA 2 0.9795 100 0.224 Contact Map
3ztvA 2 0.9923 100 0.23 Contact Map
3iveA 1 0.9642 100 0.23 Contact Map
4q7fA 1 0.9821 100 0.246 Contact Map
2wdcA 1 0.9668 100 0.28 Contact Map
3c9fA 2 0.9514 100 0.432 Contact Map
3jyfA 2 0.5141 100 0.612 Contact Map
3gveA 2 0.5115 100 0.617 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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