GREMLIN Database
TRMBR - HTH-type sugar sensing transcriptional regulator TrmB
UniProt: Q9HPW0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 352 (286)
Sequences: 1023 (801)
Seq/√Len: 47.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
91_F95_V5.4881.00
139_S242_L3.7161.00
161_S186_A3.6851.00
23_E58_S3.6791.00
137_V203_G3.3701.00
91_F94_M3.3651.00
30_V65_V3.2701.00
132_A201_A3.1011.00
92_Q98_L3.0121.00
20_G58_S3.0101.00
98_L102_Y2.9671.00
165_V242_L2.9461.00
20_G23_E2.6181.00
135_E203_G2.5771.00
92_Q96_G2.5531.00
163_D239_D2.4711.00
99_E102_Y2.4491.00
95_V99_E2.4041.00
267_R301_I2.3961.00
92_Q99_E2.3721.00
91_F98_L2.3401.00
139_S193_I2.2801.00
95_V98_L2.2771.00
132_A136_L2.2591.00
98_L101_E2.2371.00
270_V281_Y2.2121.00
128_V205_Y2.1661.00
22_Y51_R2.1311.00
127_D131_E2.1271.00
140_L144_L2.1251.00
155_A158_R2.0701.00
56_V65_V2.0701.00
48_P51_R2.0551.00
94_M98_L2.0531.00
152_L176_D2.0441.00
171_N189_G2.0070.99
91_F99_E1.9700.99
130_A154_A1.9680.99
279_S293_A1.9660.99
115_V224_I1.9400.99
277_D283_T1.8520.99
117_S120_T1.7990.99
14_G18_N1.7930.99
228_S231_G1.7710.99
137_V200_V1.7320.98
153_A183_A1.7260.98
153_A157_D1.7240.98
195_T237_F1.7170.98
33_H44_R1.7170.98
139_S165_V1.6870.98
289_V293_A1.6870.98
129_I162_V1.6820.98
279_S289_V1.6780.98
168_P189_G1.6460.98
166_V187_A1.6310.98
36_L44_R1.6290.98
190_R246_A1.6260.98
142_P197_V1.6080.97
203_G235_S1.6030.97
193_I242_L1.5770.97
101_E104_Q1.5740.97
94_M97_A1.5690.97
22_Y47_I1.5580.97
52_V65_V1.5530.97
37_T40_D1.5470.97
148_F152_L1.5230.96
149_A179_D1.4830.96
23_E62_R1.4720.95
200_V235_S1.4510.95
137_V235_S1.4440.95
266_I295_R1.4180.94
94_M99_E1.3810.94
139_S198_I1.3800.94
42_A52_V1.3680.93
149_A152_L1.3290.92
200_V231_G1.3260.92
29_T41_I1.3210.92
289_V292_G1.3090.92
163_D243_W1.3030.92
24_V28_L1.2840.91
97_A100_A1.2780.91
97_A101_E1.2730.91
91_F102_Y1.2550.90
39_S43_D1.2520.90
134_F203_G1.2460.90
223_V230_L1.2390.89
267_R295_R1.2350.89
56_V75_I1.2340.89
91_F100_A1.2340.89
201_A270_V1.2300.89
99_E103_T1.2240.89
143_S197_V1.2230.89
292_G296_R1.2040.88
94_M102_Y1.1990.88
165_V227_Q1.1950.88
225_F230_L1.1920.87
152_L156_V1.1910.87
38_A52_V1.1840.87
26_A47_I1.1800.87
64_L83_A1.1790.87
228_S232_F1.1760.87
111_A226_D1.1700.86
30_V36_L1.1690.86
95_V102_Y1.1480.85
124_Y226_D1.1380.85
277_D293_A1.1370.85
88_Q293_A1.1290.84
149_A153_A1.1200.84
33_H36_L1.1150.84
227_Q232_F1.1090.83
138_C162_V1.1080.83
67_L280_V1.1010.83
27_Y31_L1.1010.83
166_V281_Y1.0950.82
29_T44_R1.0920.82
26_A52_V1.0880.82
136_L201_A1.0860.82
299_G304_T1.0730.81
121_I222_G1.0720.81
140_L197_V1.0600.80
125_F201_A1.0560.80
129_I149_A1.0520.80
31_L76_V1.0450.79
41_I52_V1.0370.79
303_E306_F1.0350.79
96_G134_F1.0290.78
238_F243_W1.0280.78
278_E294_D1.0200.78
273_L281_Y1.0180.78
125_F197_V1.0040.77
160_V202_D1.0030.77
129_I201_A0.9980.76
18_N84_F0.9970.76
26_A232_F0.9930.76
201_A295_R0.9900.76
137_V227_Q0.9880.75
37_T75_I0.9790.75
25_E102_Y0.9780.75
144_L197_V0.9590.73
190_R242_L0.9560.73
40_D43_D0.9520.73
92_Q95_V0.9460.72
65_V75_I0.9430.72
278_E290_L0.9430.72
62_R90_D0.9430.72
26_A41_I0.9380.72
136_L182_A0.9350.71
113_S224_I0.9320.71
271_R276_V0.9280.71
109_T199_A0.9260.71
205_Y226_D0.9240.70
125_F129_I0.9170.70
263_Y267_R0.9160.70
48_P52_V0.9150.70
156_V185_T0.9140.70
36_L65_V0.9140.70
39_S175_P0.9140.70
174_N208_Y0.9110.69
14_G24_V0.9090.69
181_A187_A0.9020.69
76_V299_G0.8940.68
267_R287_R0.8880.67
47_I52_V0.8880.67
96_G99_E0.8870.67
137_V156_V0.8870.67
136_L162_V0.8870.67
168_P171_N0.8850.67
64_L290_L0.8830.67
280_V292_G0.8790.67
293_A306_F0.8780.66
136_L173_P0.8750.66
191_R265_A0.8740.66
34_G196_P0.8730.66
95_V208_Y0.8700.66
140_L187_A0.8690.66
270_V295_R0.8680.66
142_P167_S0.8670.65
113_S124_Y0.8630.65
196_P233_L0.8620.65
269_C272_D0.8600.65
167_S197_V0.8530.64
107_R208_Y0.8510.64
96_G131_E0.8480.64
283_T302_V0.8470.64
30_V83_A0.8470.64
39_S50_P0.8450.63
48_P55_T0.8370.63
138_C199_A0.8340.62
141_T171_N0.8290.62
139_S227_Q0.8290.62
291_T294_D0.8290.62
39_S49_Q0.8270.62
198_I234_V0.8230.61
167_S295_R0.8200.61
277_D292_G0.8200.61
97_A186_A0.8190.61
230_L268_R0.8180.61
17_F217_D0.8150.61
150_D179_D0.8140.61
126_G130_A0.8120.60
300_R303_E0.8110.60
132_A155_A0.8060.60
302_V306_F0.8040.60
162_V187_A0.7950.59
112_V230_L0.7930.59
139_S195_T0.7930.59
80_P282_A0.7910.58
35_E130_A0.7890.58
127_D269_C0.7860.58
31_L174_N0.7820.57
41_I68_R0.7720.56
23_E55_T0.7670.56
18_N24_V0.7670.56
195_T233_L0.7650.56
165_V254_A0.7640.56
26_A55_T0.7580.55
26_A65_V0.7520.55
49_Q53_Y0.7510.54
165_V241_V0.7500.54
166_V184_T0.7500.54
270_V292_G0.7450.54
14_G75_I0.7440.54
231_G235_S0.7430.54
185_T197_V0.7390.53
148_F169_A0.7390.53
21_E25_E0.7370.53
17_F21_E0.7360.53
190_R284_V0.7350.53
133_D260_P0.7290.52
280_V283_T0.7270.52
81_E166_V0.7270.52
126_G191_R0.7270.52
274_Q296_R0.7260.52
92_Q102_Y0.7200.51
162_V185_T0.7150.51
200_V206_S0.7140.51
14_G85_A0.7100.50
129_I152_L0.7080.50
36_L121_I0.7070.50
176_D180_Y0.7070.50
144_L187_A0.7030.50
177_A187_A0.7020.50
163_D278_E0.7020.50
67_L227_Q0.7000.49
123_R127_D0.6980.49
188_R243_W0.6920.49
99_E104_Q0.6910.48
155_A164_V0.6900.48
104_Q121_I0.6900.48
187_A286_G0.6860.48
124_Y127_D0.6850.48
129_I155_A0.6820.48
94_M203_G0.6820.48
43_D101_E0.6800.47
26_A115_V0.6790.47
31_L293_A0.6780.47
136_L281_Y0.6780.47
266_I292_G0.6770.47
199_A209_A0.6770.47
19_L238_F0.6760.47
19_L283_T0.6750.47
42_A82_D0.6750.47
246_A282_A0.6740.47
183_A279_S0.6730.47
208_Y223_V0.6710.46
89_E292_G0.6710.46
122_V125_F0.6710.46
51_R55_T0.6700.46
141_T306_F0.6690.46
164_V242_L0.6680.46
131_E207_V0.6680.46
93_E97_A0.6670.46
84_F170_R0.6660.46
19_L273_L0.6630.46
166_V185_T0.6620.46
115_V296_R0.6610.45
121_I174_N0.6590.45
281_Y292_G0.6550.45
124_Y209_A0.6540.45
196_P209_A0.6540.45
134_F204_R0.6530.45
83_A282_A0.6530.45
126_G175_P0.6510.44
167_S293_A0.6480.44
50_P205_Y0.6480.44
134_F161_S0.6460.44
113_S226_D0.6460.44
39_S134_F0.6450.44
187_A270_V0.6440.44
53_Y57_R0.6440.44
209_A221_Y0.6430.44
88_Q95_V0.6420.44
27_Y80_P0.6420.44
302_V305_R0.6400.43
76_V155_A0.6400.43
94_M101_E0.6340.43
163_D188_R0.6340.43
152_L162_V0.6330.43
130_A136_L0.6330.43
152_L185_T0.6310.43
50_P71_R0.6300.42
277_D280_V0.6280.42
126_G154_A0.6270.42
23_E235_S0.6270.42
56_V118_R0.6270.42
43_D49_Q0.6250.42
31_L135_E0.6240.42
151_D173_P0.6230.42
139_S277_D0.6230.42
146_E149_A0.6230.42
129_I185_T0.6220.42
277_D284_V0.6220.42
35_E74_K0.6210.42
157_D183_A0.6210.42
138_C200_V0.6200.41
93_E109_T0.6190.41
70_S73_M0.6160.41
285_T290_L0.6160.41
77_A198_I0.6140.41
139_S234_V0.6130.41
23_E64_L0.6130.41
93_E112_V0.6100.40
152_L187_A0.6100.40
267_R298_Q0.6080.40
231_G290_L0.6060.40
78_L171_N0.6060.40
225_F305_R0.6020.40
68_R76_V0.6010.40
206_S231_G0.5990.39
154_A157_D0.5990.39
156_V184_T0.5980.39
121_I232_F0.5980.39
226_D229_A0.5950.39
72_P218_S0.5910.39
64_L206_S0.5910.39
242_L245_T0.5900.39
128_V134_F0.5900.39
155_A201_A0.5890.38
90_D249_S0.5860.38
47_I51_R0.5850.38
129_I164_V0.5840.38
225_F259_L0.5840.38
28_L101_E0.5830.38
96_G199_A0.5820.38
32_R92_Q0.5820.38
42_A65_V0.5820.38
197_V207_V0.5810.38
161_S200_V0.5800.38
41_I296_R0.5800.38
132_A266_I0.5790.38
183_A199_A0.5790.38
100_A301_I0.5780.37
66_E119_S0.5770.37
278_E285_T0.5770.37
168_P190_R0.5760.37
58_S61_D0.5760.37
126_G286_G0.5740.37
187_A227_Q0.5740.37
188_R291_T0.5740.37
33_H40_D0.5730.37
91_F97_A0.5730.37
181_A185_T0.5710.37
139_S237_F0.5710.37
288_D297_I0.5710.37
79_S293_A0.5700.37
52_V109_T0.5690.37
184_T288_D0.5690.37
40_D61_D0.5680.37
290_L294_D0.5680.37
108_N127_D0.5670.36
231_G293_A0.5670.36
206_S234_V0.5660.36
50_P54_D0.5640.36
68_R262_T0.5630.36
270_V283_T0.5630.36
110_E114_L0.5620.36
17_F275_S0.5600.36
125_F207_V0.5590.36
82_D111_A0.5570.35
56_V238_F0.5570.35
66_E76_V0.5570.35
167_S171_N0.5570.35
261_R264_A0.5560.35
48_P250_L0.5550.35
14_G46_D0.5550.35
38_A53_Y0.5540.35
78_L83_A0.5540.35
145_L176_D0.5500.35
131_E223_V0.5500.35
22_Y48_P0.5490.35
98_L103_T0.5480.35
78_L245_T0.5470.35
25_E97_A0.5450.34
165_V263_Y0.5440.34
16_G153_A0.5410.34
227_Q231_G0.5400.34
23_E135_E0.5390.34
132_A140_L0.5350.34
172_A189_G0.5350.34
278_E281_Y0.5340.33
47_I127_D0.5340.33
269_C273_L0.5320.33
60_G121_I0.5320.33
138_C164_V0.5300.33
208_Y233_L0.5290.33
122_V148_F0.5260.33
189_G197_V0.5230.32
280_V296_R0.5220.32
93_E102_Y0.5220.32
225_F234_V0.5210.32
284_V299_G0.5180.32
207_V227_Q0.5160.32
60_G88_Q0.5160.32
135_E156_V0.5160.32
162_V197_V0.5150.32
19_L105_P0.5120.31
69_E182_A0.5110.31
41_I187_A0.5110.31
104_Q264_A0.5100.31
122_V279_S0.5090.31
173_P292_G0.5080.31
190_R245_T0.5080.31
271_R274_Q0.5070.31
121_I127_D0.5060.31
78_L155_A0.5050.31
79_S127_D0.5030.31
263_Y271_R0.5020.31
122_V158_R0.5020.31
271_R278_E0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qphA 2 0.9233 100 0.404 Contact Map
2f5tX 2 0.6222 100 0.674 Contact Map
1byrA 2 0.4006 99.2 0.841 Contact Map
4ggjA 2 0.4489 99.2 0.844 Contact Map
4urjA 1 0.429 98.5 0.878 Contact Map
4gelA 2 0.4602 98.2 0.888 Contact Map
1qgpA 1 0.2045 98 0.895 Contact Map
1q1hA 1 0.2301 97.9 0.898 Contact Map
1sfxA 3 0.2955 97.8 0.899 Contact Map
4nb5A 4 0.3778 97.7 0.902 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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