Q9HPV9 - HALSA - GREMLIN Contacts

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Q9HPV9 - Translation initiation factor eIF-2B subunit delta

UniProt:	Q9HPV9	Sequences: MIDETAEEIREMRTHSSSVVAVKAARALEALLDSDYPTVAAYVRALERNSTALRRANPSHASLVTTQREVVSRVRDADPASIPEAQEVTAAAIDDVVARVNMGKHDAAAATAEHITDGQTLLTHDYSSTVLEAIELAAQDGAHLDVFVTEARPRHLGRKTVRALAQLDRVDPTLIVDGAAGHVLDDCDRVLLGMDCIVADTYYNRVGTYPIVAAAADAGTPVTVAGSAAKLVADGFQFTNDFRDTSEVIREPPAGFTVENPAYDATPTRLLDAVVTEDGRRTEFPLES	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	288 (274)
Sequences:	3221 (2115)
Seq/√Len:	127.8

BACSU - MTNA
HALSA - Q9HPV9 Q9HP11
SULSO - Q97UM6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
202_Y	271_L	3.544	1.00
209_Y	218_A	3.273	1.00
69_E	92_A	2.997	1.00
7_E	11_E	2.754	1.00
6_A	56_A	2.723	1.00
212_V	270_L	2.692	1.00
135_E	167_L	2.658	1.00
124_H	149_T	2.510	1.00
217_D	270_L	2.472	1.00
119_Q	189_R	2.469	1.00
31_L	49_N	2.453	1.00
50_S	71_V	2.420	1.00
12_M	154_R	2.409	1.00
115_I	189_R	2.405	1.00
107_A	225_A	2.286	1.00
217_D	269_R	2.271	1.00
69_E	99_R	2.245	1.00
50_S	67_Q	2.233	1.00
116_T	119_Q	2.217	1.00
28_L	50_S	2.213	1.00
145_D	173_T	2.197	1.00
181_G	210_P	2.192	1.00
191_L	225_A	2.109	1.00
192_L	208_T	2.080	1.00
26_R	97_V	2.069	1.00
81_S	84_E	2.069	1.00
54_R	68_R	2.049	1.00
54_R	64_V	2.040	1.00
148_V	172_P	2.036	1.00
176_V	179_A	2.021	1.00
29_E	90_A	1.997	1.00
174_L	256_F	1.967	1.00
6_A	52_A	1.966	1.00
47_E	71_V	1.937	1.00
190_V	215_A	1.902	1.00
197_I	226_G	1.894	1.00
122_L	149_T	1.887	1.00
112_A	140_D	1.884	1.00
172_P	256_F	1.786	1.00
70_V	89_T	1.785	1.00
120_T	145_D	1.755	1.00
7_E	13_R	1.752	1.00
174_L	252_P	1.751	1.00
122_L	187_C	1.742	1.00
38_T	41_A	1.742	1.00
192_L	222_V	1.735	1.00
120_T	188_D	1.702	1.00
161_V	174_L	1.692	1.00
201_T	268_T	1.678	1.00
203_Y	238_F	1.660	1.00
147_F	187_C	1.655	1.00
109_A	136_L	1.654	1.00
179_A	261_P	1.619	1.00
223_T	273_A	1.618	1.00
221_P	272_D	1.615	1.00
87_E	91_A	1.612	1.00
98_A	102_M	1.603	1.00
64_V	68_R	1.584	1.00
120_T	147_F	1.565	1.00
26_R	94_D	1.550	1.00
145_D	171_D	1.513	1.00
102_M	106_D	1.512	1.00
194_M	197_I	1.509	1.00
242_F	259_E	1.508	1.00
185_D	236_F	1.499	1.00
119_Q	188_D	1.495	1.00
106_D	109_A	1.495	1.00
133_A	225_A	1.478	1.00
194_M	226_G	1.472	1.00
183_V	259_E	1.464	1.00
92_A	95_D	1.458	1.00
208_T	266_T	1.457	1.00
176_V	248_V	1.452	1.00
136_L	139_Q	1.446	1.00
5_T	23_K	1.441	1.00
117_D	143_H	1.431	1.00
46_L	74_V	1.430	1.00
10_R	52_A	1.429	1.00
202_Y	224_V	1.417	1.00
122_L	211_I	1.405	1.00
192_L	224_V	1.394	1.00
246_S	249_I	1.366	1.00
91_A	95_D	1.359	1.00
47_E	75_R	1.339	1.00
51_T	55_R	1.338	1.00
113_E	140_D	1.311	1.00
54_R	67_Q	1.311	1.00
245_T	258_V	1.275	1.00
112_A	142_A	1.272	1.00
180_A	211_I	1.258	1.00
139_Q	167_L	1.255	1.00
100_V	104_K	1.249	1.00
200_D	235_G	1.239	1.00
115_I	119_Q	1.230	1.00
228_A	277_E	1.229	1.00
109_A	113_E	1.225	1.00
246_S	250_R	1.223	0.99
154_R	158_R	1.223	0.99
249_I	255_G	1.219	0.99
137_A	144_L	1.211	0.99
117_D	142_A	1.202	0.99
44_R	48_R	1.191	0.99
136_L	140_D	1.190	0.99
34_S	45_A	1.181	0.99
209_Y	267_P	1.171	0.99
73_R	92_A	1.163	0.99
67_Q	71_V	1.145	0.99
171_D	257_T	1.141	0.99
138_A	143_H	1.138	0.99
118_G	143_H	1.136	0.99
45_A	48_R	1.135	0.99
149_T	211_I	1.128	0.99
94_D	97_V	1.124	0.99
213_A	217_D	1.122	0.99
105_H	109_A	1.116	0.99
108_A	136_L	1.115	0.99
184_L	215_A	1.098	0.99
181_G	213_A	1.092	0.99
82_I	86_Q	1.091	0.99
162_R	166_Q	1.091	0.99
149_T	180_A	1.090	0.99
248_V	258_V	1.088	0.99
105_H	136_L	1.083	0.99
175_I	183_V	1.080	0.99
184_L	190_V	1.078	0.99
90_A	94_D	1.076	0.99
77_A	88_V	1.076	0.99
112_A	136_L	1.074	0.99
41_A	45_A	1.073	0.99
6_A	55_R	1.069	0.99
189_R	273_A	1.066	0.99
165_A	256_F	1.060	0.99
134_I	144_L	1.053	0.98
137_A	189_R	1.053	0.98
65_T	229_A	1.052	0.98
201_T	265_A	1.047	0.98
64_V	67_Q	1.042	0.98
114_H	273_A	1.038	0.98
103_G	228_A	1.038	0.98
146_V	164_L	1.036	0.98
28_L	70_V	1.033	0.98
28_L	71_V	1.031	0.98
273_A	280_R	1.027	0.98
119_Q	142_A	1.025	0.98
216_A	219_G	1.024	0.98
228_A	278_D	1.022	0.98
47_E	51_T	1.020	0.98
154_R	262_A	1.014	0.98
113_E	280_R	1.014	0.98
22_V	97_V	1.004	0.98
124_H	211_I	1.002	0.98
52_A	55_R	0.999	0.98
182_H	185_D	0.998	0.98
148_V	160_T	0.986	0.98
181_G	218_A	0.981	0.98
42_Y	86_Q	0.978	0.98
223_T	272_D	0.972	0.97
119_Q	137_A	0.964	0.97
180_A	210_P	0.963	0.97
127_S	230_K	0.957	0.97
6_A	10_R	0.953	0.97
127_S	172_P	0.950	0.97
110_A	113_E	0.941	0.97
145_D	172_P	0.936	0.97
182_H	259_E	0.932	0.97
22_V	104_K	0.925	0.97
146_V	170_V	0.923	0.96
249_I	258_V	0.922	0.96
178_G	248_V	0.919	0.96
118_G	144_L	0.919	0.96
108_A	132_E	0.917	0.96
33_D	90_A	0.913	0.96
56_A	64_V	0.909	0.96
181_G	214_A	0.908	0.96
197_I	274_V	0.906	0.96
94_D	98_A	0.904	0.96
210_P	214_A	0.901	0.96
181_G	209_Y	0.894	0.96
119_Q	144_L	0.890	0.96
150_E	177_D	0.883	0.95
190_V	211_I	0.883	0.95
92_A	96_V	0.881	0.95
138_A	171_D	0.870	0.95
120_T	144_L	0.866	0.95
154_R	179_A	0.863	0.95
29_E	86_Q	0.860	0.95
95_D	98_A	0.859	0.95
7_E	10_R	0.854	0.95
183_V	187_C	0.854	0.95
106_D	110_A	0.843	0.94
111_T	133_A	0.842	0.94
132_E	136_L	0.837	0.94
223_T	275_V	0.832	0.94
216_A	269_R	0.825	0.94
71_V	74_V	0.825	0.94
186_D	259_E	0.824	0.93
24_A	53_L	0.822	0.93
43_V	75_R	0.817	0.93
196_C	232_V	0.817	0.93
27_A	30_A	0.817	0.93
105_H	139_Q	0.809	0.93
5_T	27_A	0.801	0.93
5_T	30_A	0.800	0.92
115_I	121_L	0.800	0.92
92_A	99_R	0.797	0.92
167_L	170_V	0.792	0.92
68_R	72_S	0.789	0.92
184_L	218_A	0.786	0.92
156_L	205_R	0.784	0.92
121_L	143_H	0.781	0.92
133_A	191_L	0.779	0.91
18_S	129_T	0.775	0.91
243_R	247_E	0.772	0.91
73_R	77_A	0.771	0.91
201_T	235_G	0.771	0.91
24_A	63_L	0.769	0.91
173_T	257_T	0.768	0.91
110_A	279_G	0.767	0.91
86_Q	90_A	0.766	0.91
184_L	220_T	0.764	0.91
69_E	96_V	0.764	0.91
72_S	75_R	0.764	0.91
71_V	75_R	0.761	0.90
117_D	144_L	0.760	0.90
243_R	262_A	0.747	0.90
111_T	275_V	0.747	0.90
135_E	170_V	0.746	0.90
32_L	42_Y	0.746	0.90
227_S	230_K	0.745	0.90
127_S	133_A	0.743	0.89
147_F	186_D	0.741	0.89
224_V	271_L	0.740	0.89
77_A	85_A	0.735	0.89
189_R	223_T	0.728	0.88
83_P	87_E	0.728	0.88
165_A	172_P	0.728	0.88
6_A	67_Q	0.724	0.88
134_I	170_V	0.724	0.88
194_M	202_Y	0.724	0.88
24_A	66_T	0.719	0.88
235_G	238_F	0.719	0.88
153_P	157_G	0.718	0.88
190_V	222_V	0.718	0.88
107_A	133_A	0.714	0.87
132_E	135_E	0.714	0.87
114_H	223_T	0.713	0.87
34_S	42_Y	0.710	0.87
180_A	214_A	0.710	0.87
49_N	56_A	0.709	0.87
147_F	175_I	0.709	0.87
29_E	33_D	0.705	0.87
72_S	76_D	0.705	0.87
28_L	46_L	0.705	0.87
134_I	146_V	0.704	0.87
133_A	136_L	0.703	0.87
131_L	135_E	0.703	0.87
148_V	174_L	0.701	0.87
4_E	7_E	0.684	0.85
125_D	205_R	0.684	0.85
130_V	134_I	0.683	0.85
194_M	274_V	0.679	0.85
56_A	67_Q	0.676	0.84
112_A	280_R	0.675	0.84
126_Y	159_K	0.671	0.84
5_T	20_V	0.668	0.84
5_T	31_L	0.667	0.84
115_I	144_L	0.666	0.84
213_A	218_A	0.665	0.84
209_Y	213_A	0.664	0.83
20_V	66_T	0.664	0.83
121_L	189_R	0.663	0.83
28_L	74_V	0.661	0.83
203_Y	265_A	0.659	0.83
115_I	142_A	0.659	0.83
137_A	143_H	0.654	0.82
198_V	201_T	0.654	0.82
39_V	43_V	0.654	0.82
43_V	74_V	0.653	0.82
10_R	55_R	0.652	0.82
65_T	69_E	0.651	0.82
111_T	225_A	0.648	0.82
36_Y	45_A	0.647	0.82
154_R	260_N	0.647	0.82
125_D	156_L	0.646	0.82
103_G	107_A	0.645	0.82
161_V	253_P	0.643	0.81
19_V	23_K	0.643	0.81
43_V	78_D	0.641	0.81
131_L	163_A	0.641	0.81
121_L	134_I	0.638	0.81
138_A	170_V	0.638	0.81
109_A	140_D	0.637	0.81
131_L	134_I	0.635	0.81
125_D	151_A	0.634	0.81
28_L	67_Q	0.633	0.80
10_R	56_A	0.633	0.80
195_D	263_Y	0.632	0.80
202_Y	274_V	0.628	0.80
125_D	204_N	0.628	0.80
50_S	54_R	0.626	0.80
210_P	213_A	0.622	0.79
73_R	88_V	0.620	0.79
137_A	142_A	0.616	0.79
265_A	268_T	0.616	0.79
192_L	266_T	0.615	0.78
197_I	202_Y	0.612	0.78
131_L	160_T	0.611	0.78
122_L	190_V	0.611	0.78
212_V	222_V	0.610	0.78
66_T	70_V	0.610	0.78
29_E	94_D	0.609	0.78
43_V	47_E	0.609	0.78
198_V	235_G	0.608	0.78
102_M	105_H	0.607	0.78
153_P	177_D	0.605	0.77
245_T	257_T	0.604	0.77
103_G	277_E	0.603	0.77
116_T	189_R	0.601	0.77
120_T	186_D	0.600	0.77
183_V	186_D	0.599	0.77
181_G	217_D	0.598	0.77
226_G	274_V	0.598	0.77
216_A	270_L	0.598	0.77
116_T	142_A	0.598	0.77
84_E	87_E	0.595	0.76
195_D	205_R	0.593	0.76
165_A	253_P	0.592	0.76
189_R	221_P	0.591	0.76
82_I	85_A	0.591	0.76
250_R	254_A	0.589	0.75
228_A	231_L	0.588	0.75
43_V	85_A	0.588	0.75
161_V	256_F	0.588	0.75
231_L	276_T	0.586	0.75
134_I	138_A	0.586	0.75
42_Y	82_I	0.586	0.75
28_L	54_R	0.585	0.75
48_R	52_A	0.583	0.75
41_A	44_R	0.578	0.74
44_R	47_E	0.578	0.74
20_V	24_A	0.577	0.74
42_Y	85_A	0.576	0.74
275_V	280_R	0.575	0.74
21_A	65_T	0.575	0.74
6_A	49_N	0.574	0.74
51_T	54_R	0.574	0.74
148_V	161_V	0.574	0.74
54_R	71_V	0.571	0.73
66_T	96_V	0.571	0.73
88_V	91_A	0.568	0.73
214_A	218_A	0.568	0.73
41_A	245_T	0.560	0.72
161_V	172_P	0.559	0.72
26_R	29_E	0.558	0.72
252_P	256_F	0.557	0.71
35_D	86_Q	0.554	0.71
17_S	195_D	0.554	0.71
14_T	23_K	0.552	0.71
21_A	229_A	0.552	0.71
205_R	263_Y	0.550	0.70
36_Y	41_A	0.549	0.70
100_V	108_A	0.546	0.70
45_A	49_N	0.544	0.70
138_A	141_G	0.541	0.69
84_E	88_V	0.541	0.69
174_L	261_P	0.538	0.69
114_H	137_A	0.538	0.69
155_H	178_G	0.537	0.69
115_I	137_A	0.536	0.68
48_R	83_P	0.536	0.68
151_A	205_R	0.534	0.68
127_S	132_E	0.533	0.68
18_S	128_S	0.533	0.68
72_S	78_D	0.532	0.68
249_I	252_P	0.530	0.68
114_H	280_R	0.529	0.67
24_A	93_I	0.528	0.67
101_N	105_H	0.527	0.67
57_N	241_D	0.524	0.67
178_G	211_I	0.524	0.67
42_Y	175_I	0.524	0.67
191_L	224_V	0.523	0.67
127_S	173_T	0.523	0.67
238_F	265_A	0.523	0.67
247_E	263_Y	0.522	0.66
152_R	155_H	0.521	0.66
95_D	99_R	0.521	0.66
127_S	202_Y	0.521	0.66
28_L	32_L	0.520	0.66
161_V	252_P	0.520	0.66
62_S	96_V	0.520	0.66
22_V	96_V	0.518	0.66
70_V	74_V	0.518	0.66
195_D	204_N	0.517	0.66
218_A	270_L	0.517	0.66
120_T	183_V	0.514	0.65
155_H	248_V	0.513	0.65
118_G	142_A	0.513	0.65
223_T	280_R	0.513	0.65
202_Y	266_T	0.512	0.65
150_E	174_L	0.510	0.65
177_D	204_N	0.509	0.65
12_M	20_V	0.506	0.64
138_A	167_L	0.506	0.64
32_L	86_Q	0.506	0.64
116_T	188_D	0.504	0.64
119_Q	143_H	0.504	0.64
103_G	229_A	0.503	0.64
145_D	186_D	0.502	0.63
153_P	260_N	0.500	0.63
107_A	112_A	0.500	0.63

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3a11A	4	0.9861	100	0.097	Contact Map
2yvkA	2	0.9792	100	0.142	Contact Map
2a0uA	2	0.9861	100	0.147	Contact Map
1t5oA	2	0.9757	100	0.151	Contact Map
1t9kA	2	0.9722	100	0.163	Contact Map
4ldrA	2	0.9861	100	0.165	Contact Map
3ecsA	4	0.941	100	0.188	Contact Map
1vb5A	3	0.9236	100	0.267	Contact Map
1w2wB	2	0.5035	100	0.436	Contact Map
1w2wA	1	0.5035	99.8	0.738	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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