GREMLIN Database
Q9HPV9 - Translation initiation factor eIF-2B subunit delta
UniProt: Q9HPV9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 288 (274)
Sequences: 3221 (2115)
Seq/√Len: 127.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
202_Y271_L3.5441.00
209_Y218_A3.2731.00
69_E92_A2.9971.00
7_E11_E2.7541.00
6_A56_A2.7231.00
212_V270_L2.6921.00
135_E167_L2.6581.00
124_H149_T2.5101.00
217_D270_L2.4721.00
119_Q189_R2.4691.00
31_L49_N2.4531.00
50_S71_V2.4201.00
12_M154_R2.4091.00
115_I189_R2.4051.00
107_A225_A2.2861.00
217_D269_R2.2711.00
69_E99_R2.2451.00
50_S67_Q2.2331.00
116_T119_Q2.2171.00
28_L50_S2.2131.00
145_D173_T2.1971.00
181_G210_P2.1921.00
191_L225_A2.1091.00
192_L208_T2.0801.00
26_R97_V2.0691.00
81_S84_E2.0691.00
54_R68_R2.0491.00
54_R64_V2.0401.00
148_V172_P2.0361.00
176_V179_A2.0211.00
29_E90_A1.9971.00
174_L256_F1.9671.00
6_A52_A1.9661.00
47_E71_V1.9371.00
190_V215_A1.9021.00
197_I226_G1.8941.00
122_L149_T1.8871.00
112_A140_D1.8841.00
172_P256_F1.7861.00
70_V89_T1.7851.00
120_T145_D1.7551.00
7_E13_R1.7521.00
174_L252_P1.7511.00
122_L187_C1.7421.00
38_T41_A1.7421.00
192_L222_V1.7351.00
120_T188_D1.7021.00
161_V174_L1.6921.00
201_T268_T1.6781.00
203_Y238_F1.6601.00
147_F187_C1.6551.00
109_A136_L1.6541.00
179_A261_P1.6191.00
223_T273_A1.6181.00
221_P272_D1.6151.00
87_E91_A1.6121.00
98_A102_M1.6031.00
64_V68_R1.5841.00
120_T147_F1.5651.00
26_R94_D1.5501.00
145_D171_D1.5131.00
102_M106_D1.5121.00
194_M197_I1.5091.00
242_F259_E1.5081.00
185_D236_F1.4991.00
119_Q188_D1.4951.00
106_D109_A1.4951.00
133_A225_A1.4781.00
194_M226_G1.4721.00
183_V259_E1.4641.00
92_A95_D1.4581.00
208_T266_T1.4571.00
176_V248_V1.4521.00
136_L139_Q1.4461.00
5_T23_K1.4411.00
117_D143_H1.4311.00
46_L74_V1.4301.00
10_R52_A1.4291.00
202_Y224_V1.4171.00
122_L211_I1.4051.00
192_L224_V1.3941.00
246_S249_I1.3661.00
91_A95_D1.3591.00
47_E75_R1.3391.00
51_T55_R1.3381.00
113_E140_D1.3111.00
54_R67_Q1.3111.00
245_T258_V1.2751.00
112_A142_A1.2721.00
180_A211_I1.2581.00
139_Q167_L1.2551.00
100_V104_K1.2491.00
200_D235_G1.2391.00
115_I119_Q1.2301.00
228_A277_E1.2291.00
109_A113_E1.2251.00
246_S250_R1.2230.99
154_R158_R1.2230.99
249_I255_G1.2190.99
137_A144_L1.2110.99
117_D142_A1.2020.99
44_R48_R1.1910.99
136_L140_D1.1900.99
34_S45_A1.1810.99
209_Y267_P1.1710.99
73_R92_A1.1630.99
67_Q71_V1.1450.99
171_D257_T1.1410.99
138_A143_H1.1380.99
118_G143_H1.1360.99
45_A48_R1.1350.99
149_T211_I1.1280.99
94_D97_V1.1240.99
213_A217_D1.1220.99
105_H109_A1.1160.99
108_A136_L1.1150.99
184_L215_A1.0980.99
181_G213_A1.0920.99
82_I86_Q1.0910.99
162_R166_Q1.0910.99
149_T180_A1.0900.99
248_V258_V1.0880.99
105_H136_L1.0830.99
175_I183_V1.0800.99
184_L190_V1.0780.99
90_A94_D1.0760.99
77_A88_V1.0760.99
112_A136_L1.0740.99
41_A45_A1.0730.99
6_A55_R1.0690.99
189_R273_A1.0660.99
165_A256_F1.0600.99
134_I144_L1.0530.98
137_A189_R1.0530.98
65_T229_A1.0520.98
201_T265_A1.0470.98
64_V67_Q1.0420.98
114_H273_A1.0380.98
103_G228_A1.0380.98
146_V164_L1.0360.98
28_L70_V1.0330.98
28_L71_V1.0310.98
273_A280_R1.0270.98
119_Q142_A1.0250.98
216_A219_G1.0240.98
228_A278_D1.0220.98
47_E51_T1.0200.98
154_R262_A1.0140.98
113_E280_R1.0140.98
22_V97_V1.0040.98
124_H211_I1.0020.98
52_A55_R0.9990.98
182_H185_D0.9980.98
148_V160_T0.9860.98
181_G218_A0.9810.98
42_Y86_Q0.9780.98
223_T272_D0.9720.97
119_Q137_A0.9640.97
180_A210_P0.9630.97
127_S230_K0.9570.97
6_A10_R0.9530.97
127_S172_P0.9500.97
110_A113_E0.9410.97
145_D172_P0.9360.97
182_H259_E0.9320.97
22_V104_K0.9250.97
146_V170_V0.9230.96
249_I258_V0.9220.96
178_G248_V0.9190.96
118_G144_L0.9190.96
108_A132_E0.9170.96
33_D90_A0.9130.96
56_A64_V0.9090.96
181_G214_A0.9080.96
197_I274_V0.9060.96
94_D98_A0.9040.96
210_P214_A0.9010.96
181_G209_Y0.8940.96
119_Q144_L0.8900.96
150_E177_D0.8830.95
190_V211_I0.8830.95
92_A96_V0.8810.95
138_A171_D0.8700.95
120_T144_L0.8660.95
154_R179_A0.8630.95
29_E86_Q0.8600.95
95_D98_A0.8590.95
7_E10_R0.8540.95
183_V187_C0.8540.95
106_D110_A0.8430.94
111_T133_A0.8420.94
132_E136_L0.8370.94
223_T275_V0.8320.94
216_A269_R0.8250.94
71_V74_V0.8250.94
186_D259_E0.8240.93
24_A53_L0.8220.93
43_V75_R0.8170.93
196_C232_V0.8170.93
27_A30_A0.8170.93
105_H139_Q0.8090.93
5_T27_A0.8010.93
5_T30_A0.8000.92
115_I121_L0.8000.92
92_A99_R0.7970.92
167_L170_V0.7920.92
68_R72_S0.7890.92
184_L218_A0.7860.92
156_L205_R0.7840.92
121_L143_H0.7810.92
133_A191_L0.7790.91
18_S129_T0.7750.91
243_R247_E0.7720.91
73_R77_A0.7710.91
201_T235_G0.7710.91
24_A63_L0.7690.91
173_T257_T0.7680.91
110_A279_G0.7670.91
86_Q90_A0.7660.91
184_L220_T0.7640.91
69_E96_V0.7640.91
72_S75_R0.7640.91
71_V75_R0.7610.90
117_D144_L0.7600.90
243_R262_A0.7470.90
111_T275_V0.7470.90
135_E170_V0.7460.90
32_L42_Y0.7460.90
227_S230_K0.7450.90
127_S133_A0.7430.89
147_F186_D0.7410.89
224_V271_L0.7400.89
77_A85_A0.7350.89
189_R223_T0.7280.88
83_P87_E0.7280.88
165_A172_P0.7280.88
6_A67_Q0.7240.88
134_I170_V0.7240.88
194_M202_Y0.7240.88
24_A66_T0.7190.88
235_G238_F0.7190.88
153_P157_G0.7180.88
190_V222_V0.7180.88
107_A133_A0.7140.87
132_E135_E0.7140.87
114_H223_T0.7130.87
34_S42_Y0.7100.87
180_A214_A0.7100.87
49_N56_A0.7090.87
147_F175_I0.7090.87
29_E33_D0.7050.87
72_S76_D0.7050.87
28_L46_L0.7050.87
134_I146_V0.7040.87
133_A136_L0.7030.87
131_L135_E0.7030.87
148_V174_L0.7010.87
4_E7_E0.6840.85
125_D205_R0.6840.85
130_V134_I0.6830.85
194_M274_V0.6790.85
56_A67_Q0.6760.84
112_A280_R0.6750.84
126_Y159_K0.6710.84
5_T20_V0.6680.84
5_T31_L0.6670.84
115_I144_L0.6660.84
213_A218_A0.6650.84
209_Y213_A0.6640.83
20_V66_T0.6640.83
121_L189_R0.6630.83
28_L74_V0.6610.83
203_Y265_A0.6590.83
115_I142_A0.6590.83
137_A143_H0.6540.82
198_V201_T0.6540.82
39_V43_V0.6540.82
43_V74_V0.6530.82
10_R55_R0.6520.82
65_T69_E0.6510.82
111_T225_A0.6480.82
36_Y45_A0.6470.82
154_R260_N0.6470.82
125_D156_L0.6460.82
103_G107_A0.6450.82
161_V253_P0.6430.81
19_V23_K0.6430.81
43_V78_D0.6410.81
131_L163_A0.6410.81
121_L134_I0.6380.81
138_A170_V0.6380.81
109_A140_D0.6370.81
131_L134_I0.6350.81
125_D151_A0.6340.81
28_L67_Q0.6330.80
10_R56_A0.6330.80
195_D263_Y0.6320.80
202_Y274_V0.6280.80
125_D204_N0.6280.80
50_S54_R0.6260.80
210_P213_A0.6220.79
73_R88_V0.6200.79
137_A142_A0.6160.79
265_A268_T0.6160.79
192_L266_T0.6150.78
197_I202_Y0.6120.78
131_L160_T0.6110.78
122_L190_V0.6110.78
212_V222_V0.6100.78
66_T70_V0.6100.78
29_E94_D0.6090.78
43_V47_E0.6090.78
198_V235_G0.6080.78
102_M105_H0.6070.78
153_P177_D0.6050.77
245_T257_T0.6040.77
103_G277_E0.6030.77
116_T189_R0.6010.77
120_T186_D0.6000.77
183_V186_D0.5990.77
181_G217_D0.5980.77
226_G274_V0.5980.77
216_A270_L0.5980.77
116_T142_A0.5980.77
84_E87_E0.5950.76
195_D205_R0.5930.76
165_A253_P0.5920.76
189_R221_P0.5910.76
82_I85_A0.5910.76
250_R254_A0.5890.75
228_A231_L0.5880.75
43_V85_A0.5880.75
161_V256_F0.5880.75
231_L276_T0.5860.75
134_I138_A0.5860.75
42_Y82_I0.5860.75
28_L54_R0.5850.75
48_R52_A0.5830.75
41_A44_R0.5780.74
44_R47_E0.5780.74
20_V24_A0.5770.74
42_Y85_A0.5760.74
275_V280_R0.5750.74
21_A65_T0.5750.74
6_A49_N0.5740.74
51_T54_R0.5740.74
148_V161_V0.5740.74
54_R71_V0.5710.73
66_T96_V0.5710.73
88_V91_A0.5680.73
214_A218_A0.5680.73
41_A245_T0.5600.72
161_V172_P0.5590.72
26_R29_E0.5580.72
252_P256_F0.5570.71
35_D86_Q0.5540.71
17_S195_D0.5540.71
14_T23_K0.5520.71
21_A229_A0.5520.71
205_R263_Y0.5500.70
36_Y41_A0.5490.70
100_V108_A0.5460.70
45_A49_N0.5440.70
138_A141_G0.5410.69
84_E88_V0.5410.69
174_L261_P0.5380.69
114_H137_A0.5380.69
155_H178_G0.5370.69
115_I137_A0.5360.68
48_R83_P0.5360.68
151_A205_R0.5340.68
127_S132_E0.5330.68
18_S128_S0.5330.68
72_S78_D0.5320.68
249_I252_P0.5300.68
114_H280_R0.5290.67
24_A93_I0.5280.67
101_N105_H0.5270.67
57_N241_D0.5240.67
178_G211_I0.5240.67
42_Y175_I0.5240.67
191_L224_V0.5230.67
127_S173_T0.5230.67
238_F265_A0.5230.67
247_E263_Y0.5220.66
152_R155_H0.5210.66
95_D99_R0.5210.66
127_S202_Y0.5210.66
28_L32_L0.5200.66
161_V252_P0.5200.66
62_S96_V0.5200.66
22_V96_V0.5180.66
70_V74_V0.5180.66
195_D204_N0.5170.66
218_A270_L0.5170.66
120_T183_V0.5140.65
155_H248_V0.5130.65
118_G142_A0.5130.65
223_T280_R0.5130.65
202_Y266_T0.5120.65
150_E174_L0.5100.65
177_D204_N0.5090.65
12_M20_V0.5060.64
138_A167_L0.5060.64
32_L86_Q0.5060.64
116_T188_D0.5040.64
119_Q143_H0.5040.64
103_G229_A0.5030.64
145_D186_D0.5020.63
153_P260_N0.5000.63
107_A112_A0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3a11A 4 0.9861 100 0.097 Contact Map
2yvkA 2 0.9792 100 0.142 Contact Map
2a0uA 2 0.9861 100 0.147 Contact Map
1t5oA 2 0.9757 100 0.151 Contact Map
1t9kA 2 0.9722 100 0.163 Contact Map
4ldrA 2 0.9861 100 0.165 Contact Map
3ecsA 4 0.941 100 0.188 Contact Map
1vb5A 3 0.9236 100 0.267 Contact Map
1w2wB 2 0.5035 100 0.436 Contact Map
1w2wA 1 0.5035 99.8 0.738 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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