GREMLIN Database
Q9HPV7 - tRNA-splicing ligase RtcB
UniProt: Q9HPV7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 500 (404)
Sequences: 1228 (761)
Seq/√Len: 37.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
341_T363_E4.6441.00
432_Q436_E4.5501.00
432_Q435_D4.4631.00
209_F396_P3.5931.00
107_M405_V3.3741.00
31_A52_L3.3401.00
114_Y214_R3.3021.00
240_C304_I3.2791.00
89_D362_R3.2731.00
52_L67_C3.0961.00
214_R495_V3.0671.00
420_T486_G3.0111.00
260_E282_L2.9521.00
264_F277_P2.9451.00
431_T435_D2.9251.00
187_A285_S2.9081.00
153_L245_L2.8641.00
36_N475_D2.7771.00
126_D455_K2.7441.00
54_N270_N2.7091.00
61_A65_A2.7071.00
48_T71_G2.6001.00
127_A314_D2.5981.00
132_V308_V2.5561.00
52_L65_A2.5251.00
67_C71_G2.5221.00
439_G463_A2.4711.00
62_V364_L2.4571.00
472_D475_D2.4411.00
247_H251_S2.4351.00
373_R391_Q2.4121.00
407_R487_D2.3851.00
214_R493_Y2.3611.00
45_T48_T2.3551.00
106_R331_D2.3521.00
115_D232_D2.3411.00
47_N50_T2.2971.00
128_L210_L2.2340.99
236_V308_V2.2280.99
421_A480_S2.2180.99
136_L205_S2.2120.99
398_S401_A2.2010.99
92_I287_Y2.1910.99
131_A311_T2.1700.99
31_A65_A2.1410.99
402_G491_R2.1110.99
249_I293_A2.0570.99
150_D193_R2.0330.99
478_D488_P2.0280.99
114_Y232_D2.0000.99
260_E264_F2.0000.99
375_F391_Q1.9900.99
279_G284_A1.9860.99
256_R282_L1.9820.99
114_Y118_K1.9660.98
437_Y466_A1.9480.98
108_L305_T1.9250.98
407_R489_V1.9240.98
128_L308_V1.8920.98
132_V304_I1.8820.98
213_Q237_L1.8570.98
478_D481_A1.8540.98
260_E263_D1.8530.98
394_I405_V1.8530.98
113_T233_Q1.8520.98
114_Y495_V1.8280.98
55_V73_Q1.8030.97
244_G247_H1.7990.97
157_I174_C1.7860.97
236_V312_F1.7640.97
109_T327_D1.7580.97
434_K460_A1.7570.97
234_V495_V1.7380.97
31_A67_C1.7150.96
481_A488_P1.7000.96
62_V362_R1.6990.96
108_L326_M1.6880.96
128_L132_V1.6720.96
127_A130_D1.6690.96
221_D231_E1.6590.96
210_L308_V1.6550.96
445_A468_G1.6540.96
125_V496_C1.6430.95
104_G301_R1.6390.95
442_V466_A1.6350.95
236_V309_R1.6150.95
409_G487_D1.5940.95
109_T329_L1.5710.94
339_R363_E1.5640.94
405_V492_T1.5460.94
55_V65_A1.5290.93
47_N432_Q1.5210.93
55_V96_G1.5200.93
329_L405_V1.5060.93
35_A44_S1.4810.92
475_D478_D1.4740.92
401_A404_Y1.4720.92
280_S283_A1.4700.92
375_F418_G1.4600.91
79_V97_V1.4480.91
478_D482_G1.4390.91
118_K121_E1.4380.91
400_G403_S1.4040.90
64_P343_A1.3920.89
111_T324_L1.3920.89
112_L116_D1.3910.89
287_Y291_C1.3740.89
203_L210_L1.3720.89
444_D447_E1.3710.89
102_N298_W1.3620.88
437_Y468_G1.3560.88
451_D454_V1.3550.88
437_Y441_D1.3540.88
111_T233_Q1.3500.88
263_D282_L1.3390.87
174_C328_L1.3360.87
145_T148_D1.3360.87
92_I327_D1.3110.86
77_F96_G1.3090.86
117_V316_F1.3040.86
258_E271_K1.3000.86
257_I276_A1.2950.86
402_G474_D1.2880.85
372_T393_V1.2780.85
366_V373_R1.2680.84
209_F296_F1.2610.84
424_A467_P1.2420.83
263_D266_A1.2410.83
120_R123_A1.2350.83
272_D398_S1.2340.83
139_G202_S1.2250.82
294_I336_I1.2180.82
111_T325_G1.2170.82
278_A283_A1.2160.82
102_N333_S1.2060.81
47_N73_Q1.1980.81
392_P489_V1.1980.81
152_A200_M1.1930.80
151_A154_E1.1840.80
411_Q414_G1.1700.79
109_T328_L1.1630.79
278_A365_F1.1590.79
266_A275_A1.1570.78
442_V445_A1.1520.78
107_M329_L1.1520.78
453_H493_Y1.1470.78
155_R162_E1.1420.77
446_L497_N1.1410.77
78_P81_G1.1390.77
110_T326_M1.1310.77
290_M337_A1.1260.76
79_V96_G1.1250.76
416_T485_V1.1230.76
339_R365_F1.1110.75
167_V174_C1.1110.75
214_R232_D1.1100.75
266_A277_P1.1090.75
318_A324_L1.1070.75
49_L53_R1.1050.75
214_R234_V1.1030.75
44_S49_L1.1000.75
77_F83_A1.0830.74
303_L307_A1.0820.74
149_L152_A1.0820.74
338_K373_R1.0770.73
154_E185_L1.0740.73
127_A315_V1.0710.73
55_V83_A1.0690.73
33_V92_I1.0610.72
157_I299_V1.0600.72
264_F282_L1.0590.72
34_L415_R1.0580.72
411_Q415_R1.0580.72
278_A287_Y1.0490.71
250_C254_L1.0400.71
454_V462_I1.0390.70
262_P267_S1.0370.70
132_V311_T1.0370.70
253_Y285_S1.0280.70
256_R285_S1.0280.70
32_R64_P1.0270.70
340_E366_V1.0260.69
437_Y442_V1.0210.69
392_P407_R1.0190.69
397_G403_S1.0180.69
266_A282_L1.0150.69
261_H266_A1.0130.68
102_N336_I1.0130.68
124_L312_F1.0130.68
168_P343_A1.0120.68
108_L238_I1.0090.68
149_L153_L1.0040.68
134_C304_I0.9950.67
107_M235_V0.9920.67
109_T233_Q0.9840.66
150_D154_E0.9730.65
184_D288_G0.9730.65
52_L71_G0.9690.65
131_A314_D0.9620.64
122_A126_D0.9600.64
128_L212_V0.9570.64
250_C272_D0.9570.64
152_A156_G0.9570.64
137_G199_Q0.9540.64
296_F396_P0.9530.64
182_D291_C0.9390.63
323_A326_M0.9340.62
400_G467_P0.9230.61
33_V49_L0.9150.60
94_P209_F0.9140.60
36_N479_V0.9080.60
337_A497_N0.9060.60
192_A195_R0.9060.60
127_A311_T0.9020.59
46_D49_L0.8980.59
441_D445_A0.8970.59
152_A157_I0.8910.58
71_G420_T0.8880.58
465_E499_K0.8850.58
43_I48_T0.8840.58
304_I308_V0.8830.58
404_Y473_I0.8820.58
144_G152_A0.8790.57
92_I407_R0.8720.57
99_F247_H0.8670.56
38_S475_D0.8650.56
465_E470_Y0.8600.56
238_I304_I0.8590.56
58_M84_A0.8570.55
83_A96_G0.8530.55
74_G98_G0.8520.55
145_T149_L0.8510.55
137_G244_G0.8510.55
92_I365_F0.8490.55
157_I160_C0.8490.55
46_D73_Q0.8470.55
190_K194_D0.8470.55
251_S255_R0.8460.54
88_E279_G0.8410.54
426_R430_R0.8410.54
130_D311_T0.8370.54
152_A299_V0.8370.54
266_A362_R0.8370.54
139_G198_S0.8370.54
213_Q367_H0.8310.53
278_A284_A0.8310.53
99_F251_S0.8290.53
409_G486_G0.8290.53
402_G473_I0.8270.53
250_C365_F0.8270.53
428_M436_E0.8260.53
305_T309_R0.8250.53
112_L233_Q0.8250.53
55_V77_F0.8240.53
68_M81_G0.8230.52
69_P100_D0.8210.52
389_V409_G0.8210.52
439_G443_Q0.8190.52
248_Q252_D0.8160.52
221_D310_E0.8160.52
31_A34_L0.8150.52
237_L400_G0.8130.52
102_N240_C0.8120.51
134_C199_Q0.8080.51
242_S246_G0.8080.51
309_R312_F0.8060.51
441_D466_A0.8060.51
441_D444_D0.8060.51
221_D490_V0.8010.50
281_E285_S0.8000.50
171_R174_C0.7960.50
84_A373_R0.7960.50
253_Y289_A0.7960.50
261_H268_L0.7960.50
158_D162_E0.7940.50
414_G418_G0.7910.50
151_A163_E0.7910.50
46_D50_T0.7880.49
389_V407_R0.7880.49
260_E266_A0.7860.49
48_T73_Q0.7850.49
31_A53_R0.7830.49
305_T328_L0.7820.49
265_L277_P0.7790.49
94_P396_P0.7740.48
44_S396_P0.7730.48
71_G398_S0.7650.47
473_I477_V0.7640.47
170_D178_G0.7630.47
278_A339_R0.7610.47
310_E314_D0.7610.47
125_V129_Y0.7580.47
240_C398_S0.7570.47
158_D171_R0.7530.46
137_G205_S0.7500.46
200_M303_L0.7490.46
400_G424_A0.7470.46
330_Y392_P0.7470.46
420_T480_S0.7450.45
245_L249_I0.7450.45
125_V455_K0.7440.45
123_A126_D0.7430.45
115_D231_E0.7410.45
157_I161_V0.7410.45
77_F81_G0.7410.45
291_C298_W0.7390.45
74_G80_G0.7370.45
309_R313_A0.7360.45
33_V37_R0.7350.45
32_R63_A0.7330.44
94_P296_F0.7320.44
112_L324_L0.7300.44
92_I310_E0.7290.44
463_A468_G0.7280.44
85_F91_C0.7270.44
259_Q444_D0.7260.44
66_L473_I0.7260.44
170_D174_C0.7260.44
255_R258_E0.7240.44
57_G61_A0.7240.44
470_Y499_K0.7220.43
131_A310_E0.7200.43
421_A477_V0.7200.43
465_E471_K0.7190.43
312_F326_M0.7180.43
102_N294_I0.7170.43
212_V236_V0.7150.43
189_S192_A0.7120.43
78_P367_H0.7110.42
196_G497_N0.7100.42
72_H98_G0.7070.42
132_V416_T0.7070.42
336_I396_P0.7060.42
189_S252_D0.7060.42
243_R286_Y0.7060.42
151_A155_R0.7040.42
443_Q462_I0.7040.42
409_G414_G0.7020.42
440_G445_A0.7020.42
71_G415_R0.7000.42
310_E414_G0.6990.41
434_K459_G0.6980.41
182_D288_G0.6970.41
195_R248_Q0.6970.41
95_G247_H0.6960.41
479_V485_V0.6940.41
134_C498_V0.6940.41
171_R490_V0.6940.41
127_A131_A0.6930.41
253_Y293_A0.6930.41
82_V96_G0.6930.41
262_P271_K0.6930.41
438_Q463_A0.6920.41
33_V52_L0.6870.40
48_T52_L0.6870.40
102_N107_M0.6860.40
249_I292_A0.6860.40
294_I497_N0.6860.40
213_Q401_A0.6850.40
209_F480_S0.6820.40
431_T434_K0.6820.40
309_R316_F0.6790.40
170_D175_E0.6790.40
112_L234_V0.6790.40
99_F272_D0.6790.40
65_A96_G0.6780.40
212_V308_V0.6780.40
263_D287_Y0.6770.40
60_G277_P0.6770.40
106_R156_G0.6750.39
393_V406_L0.6740.39
237_L403_S0.6730.39
97_V297_A0.6700.39
442_V468_G0.6700.39
117_V120_R0.6690.39
264_F281_E0.6670.39
461_T466_A0.6670.39
477_V486_G0.6640.38
288_G292_A0.6630.38
189_S248_Q0.6620.38
129_Y498_V0.6620.38
454_V458_S0.6610.38
188_V248_Q0.6590.38
253_Y256_R0.6590.38
256_R260_E0.6590.38
155_R434_K0.6570.38
439_G460_A0.6570.38
71_G296_F0.6560.38
106_R330_Y0.6560.38
245_L292_A0.6560.38
209_F336_I0.6560.38
193_R245_L0.6550.38
107_M237_L0.6550.38
192_A248_Q0.6520.37
250_C253_Y0.6500.37
249_I290_M0.6500.37
60_G90_G0.6490.37
109_T493_Y0.6470.37
110_T234_V0.6470.37
404_Y486_G0.6470.37
428_M433_A0.6470.37
238_I290_M0.6440.37
54_N271_K0.6440.37
480_S486_G0.6420.37
92_I326_M0.6410.37
295_N392_P0.6410.37
67_C75_Y0.6400.36
77_F464_E0.6400.36
94_P293_A0.6390.36
255_R259_Q0.6380.36
268_L275_A0.6360.36
44_S209_F0.6360.36
305_T331_D0.6350.36
261_H264_F0.6350.36
116_D234_V0.6340.36
465_E469_V0.6340.36
184_D188_V0.6330.36
274_A308_V0.6310.36
119_G234_V0.6280.35
111_T162_E0.6270.35
171_R175_E0.6270.35
43_I427_L0.6260.35
90_G278_A0.6260.35
269_P400_G0.6260.35
253_Y282_L0.6250.35
298_W302_Q0.6240.35
92_I263_D0.6230.35
102_N416_T0.6200.35
149_L398_S0.6190.35
150_D153_L0.6190.35
456_A461_T0.6190.35
209_F237_L0.6190.35
158_D161_V0.6180.35
313_A324_L0.6170.35
64_P417_F0.6160.34
199_Q429_S0.6160.34
38_S43_I0.6150.34
45_T296_F0.6150.34
117_V313_A0.6150.34
210_L240_C0.6140.34
103_C207_N0.6140.34
471_K499_K0.6100.34
104_G203_L0.6100.34
100_D369_K0.6080.34
156_G295_N0.6080.34
97_V337_A0.6070.34
158_D281_E0.6060.34
338_K391_Q0.6050.34
196_G337_A0.6040.34
439_G458_S0.6030.33
117_V498_V0.6030.33
475_D479_V0.6030.33
81_G367_H0.6020.33
50_T54_N0.6010.33
114_Y432_Q0.6000.33
71_G197_A0.6000.33
235_V458_S0.6000.33
92_I108_L0.6000.33
115_D314_D0.6000.33
254_L416_T0.5960.33
55_V85_F0.5950.33
444_D478_D0.5910.33
124_L150_D0.5890.32
260_E265_L0.5880.32
342_H417_F0.5870.32
424_A473_I0.5860.32
287_Y339_R0.5860.32
397_G400_G0.5860.32
440_G444_D0.5860.32
190_K341_T0.5860.32
185_L189_S0.5850.32
287_Y365_F0.5850.32
263_D281_E0.5840.32
114_Y234_V0.5840.32
446_L464_E0.5840.32
132_V210_L0.5830.32
154_E162_E0.5830.32
474_D477_V0.5820.32
337_A365_F0.5820.32
342_H364_L0.5790.32
57_G65_A0.5780.31
82_V371_A0.5760.31
133_P203_L0.5740.31
106_R302_Q0.5730.31
473_I494_P0.5720.31
375_F392_P0.5700.31
99_F274_A0.5700.31
284_A444_D0.5700.31
66_L102_N0.5700.31
60_G93_S0.5690.31
421_A474_D0.5690.31
287_Y310_E0.5690.31
184_D187_A0.5670.31
220_D487_D0.5670.31
191_K251_S0.5660.31
329_L389_V0.5650.30
88_E117_V0.5640.30
185_L188_V0.5630.30
237_L396_P0.5630.30
288_G291_C0.5620.30
115_D414_G0.5620.30
80_G100_D0.5610.30
129_Y455_K0.5610.30
213_Q402_G0.5600.30
192_A196_G0.5590.30
153_L156_G0.5580.30
306_H310_E0.5580.30
426_R470_Y0.5580.30
136_L139_G0.5570.30
116_D248_Q0.5560.30
150_D157_I0.5550.30
144_G463_A0.5550.30
107_M492_T0.5540.30
437_Y461_T0.5530.30
70_D100_D0.5520.30
80_G98_G0.5520.30
35_A45_T0.5510.29
67_C272_D0.5510.29
174_C177_E0.5510.29
212_V234_V0.5510.29
120_R315_V0.5500.29
144_G160_C0.5470.29
153_L472_D0.5460.29
147_A177_E0.5460.29
71_G497_N0.5450.29
236_V417_F0.5440.29
158_D177_E0.5440.29
138_G478_D0.5440.29
31_A272_D0.5440.29
200_M307_A0.5440.29
46_D472_D0.5420.29
183_A189_S0.5410.29
398_S473_I0.5410.29
188_V195_R0.5400.29
312_F316_F0.5390.29
65_A79_V0.5390.29
77_F99_F0.5390.29
212_V427_L0.5380.28
273_L340_E0.5380.28
481_A487_D0.5380.28
369_K465_E0.5370.28
458_S462_I0.5360.28
58_M392_P0.5360.28
111_T326_M0.5360.28
94_P294_I0.5340.28
257_I274_A0.5340.28
102_N338_K0.5330.28
154_E158_D0.5320.28
213_Q398_S0.5310.28
212_V316_F0.5300.28
148_D163_E0.5290.28
430_R465_E0.5290.28
129_Y464_E0.5290.28
370_G426_R0.5280.28
129_Y304_I0.5280.28
373_R392_P0.5270.28
375_F389_V0.5270.28
284_A288_G0.5270.28
58_M295_N0.5260.28
292_A333_S0.5260.28
174_C202_S0.5250.28
213_Q494_P0.5240.27
126_D327_D0.5240.27
46_D151_A0.5240.27
53_R65_A0.5240.27
241_G425_G0.5240.27
133_P373_R0.5230.27
396_P424_A0.5220.27
122_A453_H0.5220.27
421_A455_K0.5210.27
338_K375_F0.5200.27
97_V286_Y0.5190.27
70_D94_P0.5180.27
150_D185_L0.5180.27
67_C307_A0.5180.27
124_L231_E0.5170.27
94_P337_A0.5170.27
131_A267_S0.5170.27
88_E132_V0.5140.27
82_V419_S0.5140.27
372_T466_A0.5140.27
113_T232_D0.5130.27
244_G289_A0.5130.27
133_P273_L0.5120.27
151_A198_S0.5100.27
243_R369_K0.5090.26
192_A252_D0.5090.26
115_D118_K0.5080.26
94_P261_H0.5080.26
71_G237_L0.5060.26
152_A155_R0.5060.26
332_V336_I0.5060.26
76_G82_V0.5050.26
196_G199_Q0.5040.26
125_V294_I0.5040.26
310_E315_V0.5040.26
62_V84_A0.5040.26
147_A153_L0.5030.26
240_C305_T0.5030.26
194_D198_S0.5030.26
48_T497_N0.5010.26
153_L157_I0.5010.26
69_P94_P0.5010.26
145_T493_Y0.5010.26
58_M91_C0.5000.26
429_S437_Y0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4dwrB 3 0.956 100 0.1 Contact Map
2epgA 1 0.878 100 0.11 Contact Map
3b47A 2 0.234 22.9 0.983 Contact Map
4a18J 2 0.292 16.9 0.984 Contact Map
3m92A 2 0.092 12.9 0.985 Contact Map
1pbyA 1 0.162 12.6 0.985 Contact Map
4mk6A 2 0.146 11.3 0.985 Contact Map
3b42A 2 0.246 9.6 0.985 Contact Map
1w2lA 1 0.162 9.3 0.986 Contact Map
4fgvA 1 0.132 8.5 0.986 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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