GREMLIN Database
Q9HPV3 - Phytoene synthase
UniProt: Q9HPV3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 322 (273)
Sequences: 3754 (2508)
Seq/√Len: 151.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
118_S121_D5.0191.00
217_E253_R4.7821.00
189_H211_A4.5501.00
66_A108_Q4.4921.00
155_S222_H4.0001.00
188_A211_A3.5791.00
185_T212_E2.9351.00
113_T121_D2.6261.00
35_P93_H2.6171.00
98_E102_T2.6081.00
117_R121_D2.5291.00
217_E250_R2.4141.00
258_D261_S2.3371.00
88_A92_D2.3311.00
251_L270_R2.3251.00
163_T220_Y2.3241.00
118_S184_Q2.3151.00
192_S195_D2.2751.00
66_A105_D2.2251.00
247_D270_R2.1571.00
106_A129_S2.0971.00
7_L88_A2.0831.00
155_S219_L2.0271.00
70_A101_T2.0171.00
70_A97_R2.0171.00
63_R108_Q1.9861.00
96_P139_S1.9601.00
117_R187_A1.9321.00
35_P92_D1.9221.00
38_V89_L1.8961.00
36_T137_M1.8791.00
124_E128_G1.8591.00
189_H207_D1.8541.00
63_R67_H1.8021.00
127_R154_A1.7841.00
206_R256_D1.7501.00
117_R183_S1.7311.00
276_A280_L1.7261.00
9_R12_A1.7031.00
119_H215_R1.6571.00
185_T211_A1.6261.00
120_D123_A1.6181.00
59_D112_D1.6171.00
185_T189_H1.5811.00
97_R101_T1.5761.00
183_S187_A1.5241.00
115_R193_H1.5221.00
39_L136_M1.5201.00
213_L249_H1.5181.00
129_S165_F1.5161.00
39_L140_I1.5061.00
195_D200_S1.4921.00
224_V246_A1.4861.00
106_A128_G1.4741.00
64_R68_V1.4621.00
219_L222_H1.4601.00
109_Q124_E1.4471.00
191_A208_A1.4371.00
135_Y154_A1.4341.00
170_R175_D1.4261.00
47_D51_D1.4261.00
58_P61_Q1.4191.00
123_A158_E1.4071.00
212_E215_R1.3991.00
158_E219_L1.3791.00
208_A212_E1.3671.00
210_R253_R1.3641.00
40_Y44_R1.3581.00
205_V209_I1.3511.00
32_V140_I1.3501.00
95_I136_M1.3421.00
161_Q164_N1.2981.00
273_S277_R1.2931.00
47_D168_D1.2931.00
127_R135_Y1.2851.00
213_L253_R1.2761.00
66_A101_T1.2721.00
130_S134_G1.2681.00
65_L69_R1.2671.00
185_T208_A1.2561.00
86_F100_V1.2391.00
39_L100_V1.2351.00
206_R258_D1.2231.00
110_D180_Y1.2211.00
185_T215_R1.2211.00
35_P89_L1.2161.00
46_T65_L1.2161.00
68_V71_A1.2131.00
210_R257_C1.2131.00
189_H208_A1.2111.00
51_D168_D1.2061.00
42_F104_I1.2021.00
251_L254_A1.2021.00
149_A229_H1.1941.00
214_D253_R1.1931.00
42_F46_T1.1921.00
57_P60_E1.1871.00
67_H71_A1.1781.00
213_L257_C1.1721.00
247_D250_R1.1711.00
217_E246_A1.1681.00
119_H212_E1.1621.00
57_P61_Q1.1611.00
277_R281_R1.1591.00
195_D204_Q1.1571.00
109_Q128_G1.1541.00
148_R229_H1.1541.00
32_V233_D1.1521.00
47_D172_D1.1511.00
166_L252_I1.1491.00
46_T104_I1.1471.00
20_T244_M1.1461.00
14_Q37_Y1.1391.00
203_P207_D1.1391.00
159_A163_T1.1321.00
119_H211_A1.1180.99
95_I100_V1.1130.99
73_L97_R1.0990.99
117_R184_Q1.0980.99
127_R132_A1.0930.99
113_T116_Y1.0930.99
255_Q262_Q1.0880.99
81_P85_A1.0850.99
183_S193_H1.0650.99
133_V164_N1.0650.99
29_P32_V1.0530.99
70_A74_G1.0520.99
247_D274_V1.0500.99
185_T188_A1.0490.99
105_D124_E1.0460.99
164_N167_R1.0450.99
87_A91_E1.0410.99
44_R134_G1.0370.99
99_E135_Y1.0340.99
224_V242_A1.0300.99
220_Y245_Y1.0300.99
230_L238_V1.0290.99
211_A215_R1.0240.99
131_V157_G1.0160.99
15_R22_H1.0150.99
184_Q188_A1.0050.99
93_H140_I1.0000.99
69_R73_L0.9950.99
122_L162_L0.9930.99
210_R214_D0.9790.99
32_V35_P0.9780.99
99_E139_S0.9760.99
194_D197_A0.9740.99
152_H226_G0.9680.99
64_R67_H0.9680.99
119_H185_T0.9630.98
60_E63_R0.9590.98
171_E176_Y0.9580.98
145_E148_R0.9580.98
34_Y85_A0.9550.98
44_R51_D0.9540.98
90_R100_V0.9500.98
44_R168_D0.9470.98
12_A16_R0.9410.98
170_R260_L0.9400.98
217_E249_H0.9340.98
71_A76_R0.9320.98
110_D178_R0.9290.98
69_R100_V0.9250.98
167_R245_Y0.9230.98
96_P99_E0.9170.98
163_T249_H0.9140.98
109_Q116_Y0.9140.98
191_A204_Q0.9120.98
61_Q64_R0.9080.98
45_L80_D0.9070.98
214_D218_R0.9050.98
46_T107_M0.9040.98
152_H229_H0.8990.98
68_V80_D0.8980.98
40_Y134_G0.8950.98
106_A165_F0.8900.97
17_T48_E0.8900.97
47_D164_N0.8830.97
47_D161_Q0.8790.97
11_K37_Y0.8760.97
218_R222_H0.8750.97
269_R273_S0.8700.97
191_A202_T0.8700.97
130_S161_Q0.8650.97
221_R246_A0.8600.97
44_R47_D0.8570.97
69_R72_A0.8540.97
44_R164_N0.8460.97
166_L249_H0.8450.96
65_L68_V0.8440.96
130_S164_N0.8350.96
193_H197_A0.8350.96
21_F44_R0.8350.96
60_E64_R0.8340.96
51_D164_N0.8300.96
21_F164_N0.8300.96
40_Y130_S0.8250.96
7_L34_Y0.8250.96
173_V197_A0.8200.96
115_R177_D0.8200.96
159_A220_Y0.8160.96
40_Y164_N0.8140.96
168_D172_D0.8090.96
103_F132_A0.8090.96
195_D202_T0.8080.95
12_A15_R0.8070.95
153_A157_G0.8060.95
21_F130_S0.8040.95
186_L208_A0.8010.95
68_V83_L0.7980.95
161_Q168_D0.7980.95
28_L36_T0.7950.95
115_R183_S0.7910.95
269_R276_A0.7870.95
85_A88_A0.7840.95
21_F40_Y0.7840.95
205_V259_V0.7760.94
86_F90_R0.7760.94
103_F107_M0.7690.94
9_R81_P0.7680.94
172_D180_Y0.7670.94
44_R48_E0.7660.94
137_M141_M0.7630.94
197_A200_S0.7630.94
141_M234_C0.7590.94
225_A228_E0.7540.93
268_L271_R0.7490.93
139_S150_R0.7480.93
247_D251_L0.7430.93
250_R253_R0.7430.93
59_D108_Q0.7420.93
270_R273_S0.7410.93
34_Y38_V0.7370.93
43_F129_S0.7360.93
252_I259_V0.7360.93
132_A157_G0.7350.93
11_K15_R0.7350.93
21_F133_V0.7350.93
131_V158_E0.7340.93
103_F160_F0.7310.92
266_L271_R0.7290.92
179_I193_H0.7280.92
179_I186_L0.7270.92
21_F134_G0.7270.92
234_C237_P0.7260.92
253_R257_C0.7250.92
134_G161_Q0.7240.92
62_R68_V0.7150.92
166_L213_L0.7140.92
43_F133_V0.7100.91
20_T167_R0.7100.91
202_T261_S0.7070.91
44_R130_S0.7000.91
27_F240_A0.7000.91
99_E127_R0.6970.91
40_Y47_D0.6950.90
191_A195_D0.6940.90
200_S204_Q0.6900.90
119_H219_L0.6870.90
227_I230_L0.6870.90
43_F136_M0.6840.90
191_A205_V0.6840.90
49_I61_Q0.6840.90
108_Q112_D0.6820.90
35_P38_V0.6810.89
138_L226_G0.6810.89
151_P155_S0.6800.89
137_M238_V0.6790.89
130_S168_D0.6770.89
218_R221_R0.6750.89
65_L72_A0.6730.89
162_L215_R0.6730.89
32_V231_P0.6720.89
202_T260_L0.6690.89
161_Q172_D0.6640.88
248_Q263_R0.6640.88
62_R69_R0.6630.88
227_I242_A0.6620.88
105_D108_Q0.6590.88
223_G242_A0.6580.88
69_R101_T0.6580.88
167_R178_R0.6580.88
19_R23_I0.6560.88
44_R161_Q0.6540.88
131_V165_F0.6520.87
163_T216_T0.6510.87
157_G167_R0.6500.87
7_L38_V0.6440.87
14_Q18_G0.6430.87
66_A70_A0.6420.87
44_R172_D0.6410.86
164_N168_D0.6410.86
251_L255_Q0.6400.86
105_D128_G0.6400.86
10_S82_V0.6380.86
255_Q258_D0.6370.86
44_R133_V0.6340.86
190_G198_A0.6290.85
236_F240_A0.6280.85
222_H225_A0.6280.85
151_P222_H0.6240.85
130_S180_Y0.6230.85
47_D130_S0.6210.85
131_V138_L0.6190.85
103_F136_M0.6190.85
72_A83_L0.6170.84
248_Q265_T0.6170.84
68_V72_A0.6160.84
163_T248_Q0.6130.84
155_S158_E0.6120.84
216_T249_H0.6090.84
51_D161_Q0.6070.83
226_G230_L0.6070.83
207_D210_R0.6050.83
130_S133_V0.6030.83
102_T127_R0.6020.83
30_E34_Y0.6020.83
164_N245_Y0.5960.82
171_E175_D0.5950.82
119_H123_A0.5920.82
182_P212_E0.5900.82
102_T105_D0.5900.82
10_S38_V0.5890.82
208_A211_A0.5860.81
156_L167_R0.5840.81
135_Y139_S0.5830.81
162_L219_L0.5820.81
134_G164_N0.5820.81
138_L150_R0.5810.81
78_P83_L0.5800.81
201_A206_R0.5780.80
14_Q24_A0.5780.80
127_R219_L0.5750.80
213_L217_E0.5750.80
110_D125_Y0.5750.80
40_Y51_D0.5740.80
31_R92_D0.5730.80
129_S133_V0.5710.80
67_H70_A0.5710.80
69_R97_R0.5710.80
246_A250_R0.5690.79
66_A69_R0.5680.79
40_Y161_Q0.5670.79
25_T36_T0.5670.79
134_G160_F0.5640.79
89_L93_H0.5640.79
164_N172_D0.5590.78
61_Q68_V0.5570.78
43_F241_A0.5570.78
141_M238_V0.5550.78
258_D262_Q0.5550.78
21_F51_D0.5550.78
76_R84_A0.5550.78
20_T23_I0.5540.77
85_A89_L0.5540.77
44_R160_F0.5510.77
220_Y249_H0.5500.77
251_L267_T0.5500.77
11_K34_Y0.5500.77
165_F172_D0.5500.77
58_P68_V0.5490.77
17_T25_T0.5480.77
48_E52_D0.5480.77
46_T141_M0.5470.77
82_V89_L0.5470.77
154_A158_E0.5450.76
20_T156_L0.5420.76
263_R266_L0.5380.75
59_D63_R0.5370.75
7_L89_L0.5360.75
205_V208_A0.5360.75
59_D69_R0.5350.75
51_D125_Y0.5340.75
266_L270_R0.5340.75
39_L133_V0.5330.75
20_T50_V0.5330.75
271_R274_V0.5310.74
108_Q111_V0.5310.74
228_E239_L0.5290.74
107_M129_S0.5280.74
100_V136_M0.5270.74
129_S164_N0.5260.74
161_Q165_F0.5250.74
134_G172_D0.5220.73
213_L252_I0.5210.73
156_L242_A0.5190.73
149_A238_V0.5190.73
102_T128_G0.5150.72
167_R220_Y0.5140.72
150_R154_A0.5120.72
79_D87_A0.5120.72
227_I239_L0.5120.72
64_R80_D0.5120.72
214_D228_E0.5120.72
206_R210_R0.5110.72
238_V241_A0.5110.72
165_F245_Y0.5090.71
101_T105_D0.5070.71
50_V107_M0.5070.71
130_S172_D0.5060.71
215_R219_L0.5050.71
224_V228_E0.5050.71
22_H37_Y0.5040.71
201_A205_V0.5040.71
106_A109_Q0.5030.70
160_F164_N0.5020.70
162_L216_T0.5020.70
41_A85_A0.5010.70
127_R158_E0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4hd1A 1 0.795 100 0.221 Contact Map
3wcaA 1 0.9845 100 0.222 Contact Map
3acxA 1 0.8602 100 0.227 Contact Map
3we9A 1 0.7453 100 0.25 Contact Map
3vj8A 1 0.9752 100 0.261 Contact Map
4dhdA 2 0.7516 95.3 0.921 Contact Map
1wy0A 2 0.7547 94.5 0.924 Contact Map
3mzvA 2 0.764 94.4 0.924 Contact Map
3oyrA 2 0.7609 94.1 0.925 Contact Map
4lfgA 2 0.6832 93.7 0.926 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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