GREMLIN Database
Q9HPU9 - Bacterio-opsin linked product
UniProt: Q9HPU9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 142 (137)
Sequences: 429 (359)
Seq/√Len: 30.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
71_V74_R5.2001.00
12_A16_D4.9301.00
20_F29_K3.9421.00
14_P94_G3.8711.00
93_S99_S3.1431.00
8_A137_T3.0421.00
20_F26_N3.0041.00
137_T141_E2.9431.00
14_P74_R2.6451.00
21_L92_L2.6371.00
49_R66_E2.5741.00
15_G73_E2.5230.99
14_P92_L2.4680.99
94_G97_T2.2020.99
66_E79_E2.0780.98
10_I17_V1.9400.97
92_L98_T1.7900.95
106_Y109_P1.7710.94
36_T53_R1.7300.94
38_T51_K1.6940.93
7_Q100_L1.6090.91
22_D70_R1.5760.90
53_R60_E1.5720.90
9_T99_S1.5360.89
6_Q130_A1.4750.87
114_E119_P1.4640.86
83_A90_Y1.4540.86
74_R94_G1.4370.85
20_F140_L1.4290.85
36_T114_E1.4250.85
19_S72_P1.3580.82
30_I136_L1.3560.82
107_D138_T1.3420.81
40_V49_R1.3190.80
54_Y106_Y1.3100.79
52_Y63_G1.3040.79
9_T97_T1.2850.78
21_L136_L1.2760.78
33_G128_E1.2520.76
41_E67_D1.2490.76
42_A46_G1.2090.74
26_N29_K1.1500.70
12_A20_F1.1450.69
18_F70_R1.1450.69
12_A140_L1.1440.69
51_K62_V1.1260.68
37_V59_V1.1170.68
82_G113_I1.1030.67
74_R96_D1.0930.66
31_T54_Y1.0760.65
22_D67_D1.0730.64
27_H34_L1.0390.62
108_L121_A1.0330.61
14_P97_T1.0140.60
68_I75_R1.0120.60
34_L54_Y1.0000.59
15_G19_S0.9930.58
107_D123_A0.9890.58
10_I137_T0.9890.58
26_N68_I0.9870.58
11_D141_E0.9770.57
86_G106_Y0.9620.56
36_T116_V0.9560.55
6_Q129_A0.9490.55
30_I67_D0.9460.55
69_E115_S0.9400.54
134_D138_T0.9400.54
36_T68_I0.9310.53
53_R62_V0.9300.53
103_E116_V0.9240.53
54_Y63_G0.9220.53
35_I55_K0.9180.52
56_L125_N0.9100.52
19_S38_T0.9060.51
68_I77_V0.8990.51
7_Q91_R0.8960.51
8_A20_F0.8910.50
12_A17_V0.8870.50
13_P98_T0.8730.49
87_T105_E0.8710.49
68_I95_D0.8700.48
72_P93_S0.8660.48
92_L100_L0.8640.48
6_Q126_K0.8570.47
21_L133_V0.8550.47
40_V126_K0.8500.47
55_K60_E0.8430.46
32_P135_N0.8430.46
63_G104_A0.8380.46
53_R71_V0.8290.45
37_V50_A0.8200.44
10_I141_E0.8180.44
52_Y102_Y0.8100.44
9_T94_G0.8090.44
80_L101_T0.8080.44
45_S67_D0.8000.43
3_T105_E0.7970.43
20_F139_F0.7950.42
125_N128_E0.7860.42
119_P126_K0.7850.42
55_K93_S0.7820.41
28_V76_L0.7790.41
32_P129_A0.7690.40
38_T59_V0.7680.40
19_S115_S0.7670.40
96_D103_E0.7570.40
30_I78_Q0.7530.39
36_T42_A0.7450.39
90_Y106_Y0.7430.38
50_A117_L0.7420.38
38_T134_D0.7410.38
22_D73_E0.7400.38
14_P64_T0.7390.38
31_T56_L0.7320.38
68_I79_E0.7310.38
27_H84_I0.7290.37
29_K139_F0.7260.37
51_K120_I0.7240.37
70_R82_G0.7200.37
20_F47_G0.7200.37
44_A48_K0.7190.37
42_A50_A0.7170.37
41_E99_S0.7070.36
86_G104_A0.7030.35
96_D134_D0.7000.35
7_Q66_E0.6980.35
120_I123_A0.6890.34
73_E92_L0.6890.34
43_L48_K0.6780.34
106_Y132_T0.6720.33
119_P129_A0.6690.33
19_S134_D0.6670.33
30_I65_V0.6640.33
5_E91_R0.6600.32
86_G113_I0.6540.32
50_A67_D0.6520.32
52_Y104_A0.6510.32
44_A70_R0.6420.31
31_T102_Y0.6350.31
130_A137_T0.6340.31
75_R96_D0.6270.30
52_Y65_V0.6220.30
5_E138_T0.6220.30
65_V128_E0.6220.30
57_A113_I0.6210.30
69_E77_V0.6180.29
51_K64_T0.6180.29
46_G59_V0.6120.29
123_A133_V0.6090.29
38_T53_R0.6090.29
57_A86_G0.6060.29
22_D39_D0.6060.29
117_L127_R0.5980.28
56_L59_V0.5980.28
18_F25_R0.5880.28
120_I138_T0.5870.27
134_D140_L0.5860.27
11_D55_K0.5840.27
63_G90_Y0.5840.27
25_R123_A0.5830.27
59_V84_I0.5800.27
61_L89_T0.5800.27
31_T52_Y0.5760.27
7_Q71_V0.5740.27
29_K60_E0.5740.27
27_H125_N0.5740.27
42_A45_S0.5740.27
82_G139_F0.5720.27
11_D45_S0.5710.26
5_E130_A0.5680.26
39_D48_K0.5670.26
73_E95_D0.5650.26
18_F73_E0.5640.26
30_I54_Y0.5640.26
35_I140_L0.5640.26
91_R96_D0.5630.26
41_E94_G0.5580.26
34_L52_Y0.5570.26
53_R107_D0.5500.25
40_V98_T0.5490.25
64_T103_E0.5490.25
55_K122_K0.5480.25
11_D73_E0.5410.25
119_P140_L0.5410.25
6_Q10_I0.5370.24
93_S105_E0.5360.24
74_R93_S0.5340.24
110_D114_E0.5330.24
29_K123_A0.5320.24
61_L79_E0.5280.24
16_D49_R0.5280.24
13_P92_L0.5240.24
11_D140_L0.5240.24
13_P58_G0.5210.23
38_T95_D0.5210.23
88_I100_L0.5180.23
30_I83_A0.5150.23
82_G133_V0.5140.23
67_D90_Y0.5110.23
20_F115_S0.5100.23
8_A16_D0.5080.23
31_T128_E0.5060.23
31_T65_V0.5050.23
91_R103_E0.5010.22
32_P133_V0.5000.22
63_G106_Y0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2d4rA 4 0.9859 99.9 0.413 Contact Map
3tfzA 2 0.993 99.9 0.452 Contact Map
3ggnA 2 0.8662 99.9 0.455 Contact Map
1t17A 1 0.9718 99.9 0.456 Contact Map
3tl1A 1 0.9789 99.9 0.47 Contact Map
2m47A 1 0.9789 99.9 0.481 Contact Map
2ns9A 2 0.9648 99.8 0.491 Contact Map
2pcsA 1 0.9648 99.8 0.491 Contact Map
3ijtA 2 0.9507 99.8 0.502 Contact Map
2le1A 1 0.9437 99.8 0.503 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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