GREMLIN Database
BRP - Probable beta-carotene 15,15'-dioxygenase Brp
UniProt: Q9HPU7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 359 (292)
Sequences: 179 (156)
Seq/√Len: 9.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
240_V256_Q4.6770.99
120_G244_V3.6660.97
70_E119_K3.3210.95
63_N70_E3.3210.95
119_K252_Y3.3210.95
63_N119_K3.3210.95
63_N252_Y3.3210.95
70_E252_Y3.3210.95
121_G151_G3.1710.93
116_A120_G2.9530.90
240_V338_I2.9320.90
256_Q338_I2.5440.82
240_V255_R2.3690.77
97_F337_I2.3300.75
253_S260_S2.3200.75
256_Q346_G2.3050.75
158_P240_V2.2820.74
59_M336_S2.2650.73
70_E112_A2.2580.73
63_N112_A2.2580.73
112_A119_K2.2580.73
112_A252_Y2.2580.73
105_P112_A2.1810.70
166_F259_R2.1740.70
256_Q260_S2.1730.70
123_G259_R2.1660.70
249_P334_F2.1340.68
116_A337_I2.1100.68
158_P256_Q2.0720.66
101_F334_F2.0520.65
227_E255_R2.0490.65
169_F343_V2.0290.64
116_A244_V2.0030.63
68_G339_A1.9800.62
101_F112_A1.9700.62
124_G255_R1.9650.62
30_L37_A1.9460.61
97_F335_V1.9340.60
116_A346_G1.9320.60
101_F105_P1.9010.59
124_G256_Q1.8640.58
58_G120_G1.8590.57
158_P255_R1.8550.57
197_G241_V1.8480.57
97_F101_F1.8370.56
173_M249_P1.8200.56
70_E120_G1.8190.56
63_N120_G1.8190.56
120_G252_Y1.8190.56
166_F332_S1.7620.53
150_R235_F1.7560.53
119_K339_A1.6930.50
252_Y339_A1.6930.50
70_E339_A1.6930.50
63_N339_A1.6930.50
68_G119_K1.6540.48
63_N68_G1.6540.48
68_G252_Y1.6540.48
251_W345_V1.6340.48
120_G332_S1.6300.47
231_L247_Y1.6220.47
65_P101_F1.5450.44
227_E245_G1.5320.43
156_V301_V1.5190.43
306_L310_L1.5130.42
86_Y155_M1.5000.42
69_Y260_S1.4860.41
151_G341_P1.4700.40
120_G166_F1.4610.40
250_L253_S1.4400.39
92_V310_L1.4370.39
259_R350_D1.4350.39
249_P253_S1.4180.38
240_V346_G1.4170.38
59_M339_A1.4050.38
169_F345_V1.4030.38
158_P338_I1.3920.37
92_V237_L1.3570.36
123_G255_R1.3570.36
52_A159_M1.3550.36
235_F243_A1.3480.35
53_G86_Y1.3270.35
154_V333_I1.3230.34
99_A195_V1.3210.34
97_F336_S1.3180.34
123_G333_I1.3140.34
54_V58_G1.3060.34
173_M331_W1.2940.33
90_Y342_H1.2920.33
90_Y248_F1.2890.33
244_V332_S1.2560.32
66_H70_E1.2510.32
66_H119_K1.2510.32
66_H252_Y1.2510.32
63_N66_H1.2510.32
66_H90_Y1.2380.31
231_L335_V1.2240.31
123_G231_L1.2190.30
67_G90_Y1.2170.30
78_R108_G1.2150.30
92_V141_P1.2060.30
234_Y242_I1.2010.30
106_V302_A1.1970.30
125_V346_G1.1960.30
143_R198_G1.1930.29
50_V53_G1.1840.29
154_V240_V1.1820.29
101_F249_P1.1720.29
58_G231_L1.1680.29
123_G350_D1.1600.28
338_I343_V1.1570.28
101_F336_S1.1550.28
189_I192_R1.1470.28
123_G346_G1.1460.28
155_M244_V1.1320.27
159_M251_W1.1310.27
112_A336_S1.1170.27
293_W336_S1.1140.27
141_P206_A1.1060.26
35_A38_V1.1030.26
105_P336_S1.1010.26
264_D293_W1.0730.25
259_R346_G1.0660.25
123_G166_F1.0520.25
125_V332_S1.0520.25
160_L208_L1.0410.24
109_L332_S1.0380.24
248_F342_H1.0350.24
100_L114_T1.0330.24
89_A276_M1.0230.24
101_F333_I1.0210.24
82_F86_Y1.0200.24
83_Q302_A1.0100.23
91_L258_A1.0090.23
185_L226_A1.0090.23
68_G332_S1.0030.23
90_Y252_Y0.9960.23
63_N90_Y0.9960.23
90_Y119_K0.9960.23
70_E90_Y0.9960.23
55_Y249_P0.9900.23
114_T201_G0.9850.22
151_G336_S0.9850.22
238_V296_L0.9850.22
101_F295_V0.9840.22
66_H342_H0.9810.22
63_N332_S0.9800.22
252_Y332_S0.9800.22
70_E332_S0.9800.22
119_K332_S0.9800.22
158_P346_G0.9770.22
59_M249_P0.9670.22
119_K256_Q0.9660.22
63_N256_Q0.9660.22
252_Y256_Q0.9660.22
70_E256_Q0.9660.22
67_G342_H0.9630.22
58_G126_Q0.9570.22
300_S334_F0.9560.22
101_F124_G0.9540.22
66_H248_F0.9530.22
68_G310_L0.9480.21
67_G248_F0.9470.21
256_Q339_A0.9430.21
98_G203_L0.9420.21
91_L100_L0.9380.21
335_V345_V0.9350.21
69_Y256_Q0.9330.21
159_M274_T0.9330.21
120_G155_M0.9290.21
124_G240_V0.9260.21
111_L222_L0.9250.21
71_H260_S0.9220.21
170_S251_W0.9140.20
150_R227_E0.9120.20
54_V290_L0.9090.20
243_A257_V0.9000.20
154_V332_S0.8970.20
121_G341_P0.8950.20
182_V196_L0.8950.20
116_A339_A0.8890.20
55_Y101_F0.8860.20
110_G160_L0.8860.20
125_V243_A0.8820.19
195_V310_L0.8810.19
157_V203_L0.8750.19
64_L226_A0.8740.19
73_E328_V0.8610.19
108_G297_I0.8500.19
332_S336_S0.8470.19
33_A107_A0.8440.18
67_G120_G0.8440.18
42_A229_L0.8390.18
164_D198_G0.8380.18
115_V253_S0.8360.18
27_L46_V0.8330.18
109_L262_A0.8180.18
260_S289_T0.8170.18
121_G251_W0.8170.18
100_L108_G0.8150.18
36_F306_L0.8150.18
94_I240_V0.8150.18
62_M249_P0.8140.18
56_L152_G0.8060.17
241_V348_W0.8040.17
173_M334_F0.8040.17
101_F113_V0.7980.17
338_I346_G0.7970.17
91_L110_G0.7960.17
240_V252_Y0.7940.17
70_E240_V0.7940.17
119_K240_V0.7940.17
63_N240_V0.7940.17
161_F235_F0.7940.17
84_G217_G0.7940.17
124_G158_P0.7930.17
37_A236_A0.7880.17
335_V339_A0.7870.17
116_A169_F0.7870.17
251_W335_V0.7860.17
91_L200_Y0.7840.17
71_H251_W0.7830.17
92_V96_A0.7810.17
53_G183_S0.7800.17
29_L33_A0.7800.17
235_F340_L0.7720.17
235_F257_V0.7700.17
55_Y74_N0.7590.16
62_M171_S0.7580.16
120_G339_A0.7480.16
69_Y297_I0.7430.16
53_G272_D0.7410.16
79_A85_K0.7390.16
95_A143_R0.7350.16
188_D298_V0.7350.16
166_F336_S0.7340.16
95_A168_A0.7290.16
109_L170_S0.7250.16
69_Y338_I0.7250.16
109_L244_V0.7240.16
90_Y341_P0.7230.15
299_G302_A0.7220.15
97_F340_L0.7210.15
27_L194_L0.7210.15
96_A201_G0.7180.15
38_V89_A0.7180.15
93_G340_L0.7180.15
170_S253_S0.7170.15
90_Y121_G0.7140.15
145_L198_G0.7140.15
70_E342_H0.7120.15
252_Y342_H0.7120.15
119_K342_H0.7120.15
63_N342_H0.7120.15
109_L335_V0.7120.15
49_E210_L0.7110.15
101_F297_I0.7100.15
74_N343_V0.7060.15
120_G331_W0.7060.15
255_R340_L0.7020.15
48_L51_Q0.7020.15
243_A341_P0.7010.15
158_P227_E0.6990.15
251_W334_F0.6980.15
256_Q293_W0.6970.15
60_V312_L0.6960.15
339_A346_G0.6950.15
93_G113_V0.6950.15
122_F240_V0.6930.15
103_V113_V0.6860.15
103_V250_L0.6820.15
243_A260_S0.6810.15
58_G101_F0.6790.15
150_R163_T0.6760.14
59_M97_F0.6750.14
96_A213_R0.6750.14
54_V166_F0.6740.14
33_A164_D0.6740.14
138_R216_A0.6720.14
329_A346_G0.6710.14
109_L120_G0.6710.14
69_Y339_A0.6650.14
300_S343_V0.6640.14
166_F244_V0.6610.14
224_D245_G0.6610.14
71_H249_P0.6610.14
62_M88_V0.6590.14
161_F236_A0.6530.14
255_R350_D0.6530.14
64_L80_A0.6520.14
246_L326_G0.6510.14
63_N248_F0.6480.14
70_E248_F0.6480.14
248_F252_Y0.6480.14
119_K248_F0.6480.14
68_G120_G0.6450.14
222_L233_A0.6430.14
143_R147_A0.6420.14
204_V232_I0.6390.14
71_H350_D0.6380.14
121_G243_A0.6360.14
103_V276_M0.6360.14
277_L308_A0.6350.14
158_P339_A0.6340.14
171_S179_P0.6330.14
149_V152_G0.6310.13
224_D238_V0.6310.13
90_Y151_G0.6310.13
169_F332_S0.6260.13
112_A332_S0.6220.13
46_V49_E0.6210.13
141_P275_G0.6210.13
212_Y229_L0.6200.13
97_F346_G0.6170.13
114_T188_D0.6160.13
101_F170_S0.6150.13
96_A234_Y0.6150.13
124_G170_S0.6140.13
59_M337_I0.6140.13
73_E233_A0.6120.13
72_F293_W0.6060.13
300_S327_L0.6060.13
197_G308_A0.6040.13
55_Y245_G0.6030.13
67_G252_Y0.6030.13
67_G119_K0.6030.13
63_N67_G0.6030.13
67_G70_E0.6030.13
115_V154_V0.6030.13
95_A197_G0.6000.13
297_I336_S0.5990.13
55_Y253_S0.5990.13
103_V308_A0.5980.13
235_F329_A0.5950.13
112_A249_P0.5950.13
47_P267_A0.5950.13
79_A100_L0.5950.13
68_G330_F0.5940.13
65_P239_P0.5940.13
43_G106_V0.5910.13
116_A119_K0.5900.13
63_N116_A0.5900.13
116_A252_Y0.5900.13
70_E116_A0.5900.13
108_G293_W0.5900.13
332_S339_A0.5890.13
101_F122_F0.5890.13
38_V226_A0.5890.13
88_V92_V0.5880.13
201_G204_V0.5880.13
151_G243_A0.5870.13
77_R298_V0.5850.13
57_L148_V0.5840.13
97_F334_F0.5840.13
38_V250_L0.5840.13
150_R158_P0.5830.13
208_L302_A0.5830.13
298_V301_V0.5820.13
173_M185_L0.5810.13
101_F332_S0.5800.12
57_L195_V0.5800.12
121_G247_Y0.5800.12
94_I264_D0.5790.12
251_W256_Q0.5780.12
69_Y101_F0.5780.12
301_V309_V0.5770.12
92_V200_Y0.5740.12
54_V95_A0.5730.12
243_A350_D0.5710.12
123_G235_F0.5690.12
204_V212_Y0.5680.12
101_F329_A0.5680.12
167_Y246_L0.5660.12
211_G221_F0.5660.12
311_W349_L0.5630.12
299_G306_L0.5620.12
201_G229_L0.5610.12
213_R299_G0.5580.12
120_G245_G0.5580.12
30_L254_A0.5570.12
142_Q202_A0.5560.12
83_Q115_V0.5550.12
114_T173_M0.5540.12
197_G203_L0.5530.12
59_M334_F0.5520.12
70_E249_P0.5520.12
63_N249_P0.5520.12
249_P252_Y0.5520.12
119_K249_P0.5520.12
65_P123_G0.5480.12
112_A120_G0.5470.12
260_S300_S0.5470.12
56_L59_M0.5450.12
113_V204_V0.5430.12
204_V330_F0.5400.12
99_A210_L0.5390.12
260_S338_I0.5390.12
184_A194_L0.5390.12
33_A268_M0.5370.12
325_V328_V0.5350.12
90_Y247_Y0.5340.12
240_V339_A0.5330.12
33_A41_G0.5320.12
53_G233_A0.5320.12
67_G339_A0.5310.12
108_G112_A0.5300.12
118_A122_F0.5280.12
77_R293_W0.5270.12
121_G235_F0.5260.11
170_S244_V0.5250.11
87_I310_L0.5230.11
62_M181_A0.5210.11
232_I306_L0.5180.11
94_I338_I0.5160.11
116_A228_T0.5160.11
71_H74_N0.5130.11
213_R277_L0.5120.11
69_Y249_P0.5110.11
60_V330_F0.5090.11
59_M112_A0.5090.11
249_P331_W0.5090.11
106_V299_G0.5080.11
31_A302_A0.5080.11
89_A149_V0.5070.11
334_F338_I0.5070.11
70_E101_F0.5050.11
101_F252_Y0.5050.11
63_N101_F0.5050.11
101_F119_K0.5050.11
46_V87_I0.5050.11
339_A345_V0.5040.11
220_S236_A0.5040.11
111_L329_A0.5040.11
120_G170_S0.5040.11
255_R338_I0.5020.11
100_L233_A0.5010.11
36_F148_V0.5000.11
166_F331_W0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2yevC 1 0.1643 3.5 0.977 Contact Map
2imuA 1 0.1253 3.3 0.978 Contact Map
2lonA 1 0.2312 2.5 0.979 Contact Map
3j1rA 5 0.0724 1.8 0.98 Contact Map
2mawA 1 0.3398 1.8 0.981 Contact Map
4kppA 1 0.1699 1.7 0.981 Contact Map
2l4jA 1 0.0529 1.7 0.981 Contact Map
3j2wE 1 0.1281 1.6 0.981 Contact Map
2latA 1 0.1031 1.4 0.982 Contact Map
2k8jX 1 0.0808 1.4 0.982 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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