GREMLIN Database
PRIS - DNA primase small subunit PriS
UniProt: Q9HPU3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 391 (355)
Sequences: 497 (367)
Seq/√Len: 19.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
19_R22_I5.0591.00
145_F317_L4.5751.00
135_D174_Y4.5051.00
311_L318_E4.3211.00
131_F175_V3.9821.00
52_T61_F3.9581.00
373_P377_G3.8961.00
36_I46_M3.4801.00
126_L151_Y3.2391.00
35_Y52_T3.1970.99
108_T111_E2.9030.99
203_R207_A2.9000.99
163_L171_I2.8990.99
130_D133_E2.8830.99
233_D249_A2.8420.99
34_G46_M2.7910.99
323_D326_A2.7820.99
196_L199_P2.6140.98
326_A329_D2.6010.98
92_G161_Y2.5450.97
34_G71_Y2.5380.97
126_L322_L2.4500.97
101_A114_Y2.3970.96
36_I44_T2.3830.96
95_L163_L2.3470.96
128_L211_W2.3110.95
34_G70_V2.2910.95
164_G167_E2.2640.95
158_A162_E2.2530.95
118_L121_C2.1930.94
266_G269_D2.1780.94
108_T121_C2.1310.93
135_D206_P2.1010.92
281_Y284_E2.0950.92
95_L172_V2.0640.92
344_H371_T2.0630.92
13_F34_G2.0570.91
226_L235_V1.9880.90
108_T112_D1.9820.90
165_S300_D1.9680.89
310_S319_V1.8710.87
164_G301_T1.8540.86
37_P44_T1.8280.86
59_T63_E1.8190.85
46_M74_A1.7920.84
176_R295_E1.7660.84
317_L337_V1.7350.82
36_I299_T1.7290.82
34_G69_H1.6950.81
132_L138_F1.6840.80
252_I259_N1.6730.80
222_F289_E1.6720.80
259_N262_A1.6610.79
331_D334_V1.6580.79
147_G152_H1.6400.79
105_P108_T1.6400.79
322_L326_A1.6320.78
259_N263_V1.6100.77
322_L327_L1.6060.77
186_V189_E1.6020.77
131_F293_I1.5990.77
112_D121_C1.5970.77
138_F163_L1.5830.76
138_F171_I1.5630.75
58_M62_L1.5420.74
224_D227_I1.5380.74
130_D145_F1.5320.74
26_P156_R1.5220.73
304_L315_S1.4700.70
278_A281_Y1.4420.69
115_A314_G1.4410.69
126_L327_L1.4350.68
277_V281_Y1.4340.68
118_L122_K1.4220.68
160_V163_L1.4220.68
74_A155_V1.4130.67
175_V293_I1.4060.67
299_T316_G1.4030.67
93_S301_T1.3960.66
122_K148_G1.3890.66
229_R233_D1.3890.66
248_S262_A1.3890.66
93_S307_L1.3810.65
97_F163_L1.3810.65
27_R92_G1.3780.65
133_E141_L1.3590.64
37_P47_V1.3470.63
50_K83_A1.3450.63
36_I69_H1.3440.63
221_A311_L1.3360.63
105_P121_C1.3350.63
173_D295_E1.3350.63
28_A33_W1.3340.63
127_R328_D1.3340.63
368_G374_E1.3270.62
69_H226_L1.3260.62
366_G369_V1.3070.61
13_F296_P1.3050.61
92_G162_E1.3010.61
209_G212_G1.3000.61
296_P299_T1.2970.60
102_D107_V1.2950.60
101_A307_L1.2920.60
30_D214_R1.2830.60
99_L121_C1.2770.59
77_Y88_K1.2590.58
35_Y39_T1.2550.58
136_F163_L1.2540.58
338_P342_V1.2530.58
141_L153_V1.2450.57
71_Y296_P1.2380.57
376_A380_M1.2360.57
52_T137_G1.2360.57
37_P45_T1.2330.56
35_Y65_K1.2280.56
348_V369_V1.2240.56
47_V50_K1.2220.56
296_P300_D1.2170.55
138_F160_V1.2170.55
202_K320_Q1.2160.55
73_S306_R1.2150.55
171_I227_I1.2110.55
168_R294_D1.2100.55
303_R306_R1.2090.55
176_R314_G1.1980.54
69_H74_A1.1950.54
19_R71_Y1.1940.54
141_L217_T1.1880.54
152_H294_D1.1810.53
147_G294_D1.1810.53
161_Y174_Y1.1790.53
69_H296_P1.1750.53
235_V252_I1.1700.52
94_D118_L1.1630.52
49_H102_D1.1620.52
141_L263_V1.1530.51
142_T156_R1.1500.51
300_D338_P1.1410.51
46_M299_T1.1340.50
13_F338_P1.1250.50
147_G168_R1.1240.50
152_H168_R1.1240.50
319_V332_P1.1190.49
146_S150_G1.1170.49
108_T118_L1.1130.49
73_S303_R1.0980.48
13_F17_Y1.0940.48
363_L366_G1.0880.47
61_F101_A1.0760.46
49_H80_P1.0700.46
151_Y207_A1.0680.46
145_F346_I1.0630.46
99_L108_T1.0500.45
318_E341_F1.0460.45
363_L367_P1.0450.44
161_Y293_I1.0420.44
39_T45_T1.0370.44
104_L142_T1.0360.44
39_T44_T1.0330.44
20_A296_P1.0210.43
309_G315_S1.0170.43
215_V338_P1.0150.43
374_E377_G1.0140.43
146_S152_H1.0090.42
147_G150_G1.0090.42
17_Y32_E1.0070.42
252_I262_A0.9990.42
79_A301_T0.9970.41
46_M70_V0.9880.41
132_L179_D0.9780.40
277_V280_R0.9780.40
111_E121_C0.9770.40
74_A300_D0.9770.40
252_I263_V0.9750.40
96_V186_V0.9710.40
221_A295_E0.9640.39
130_D172_V0.9620.39
31_R330_F0.9550.39
56_G59_T0.9480.38
180_L288_A0.9450.38
13_F68_R0.9450.38
306_R309_G0.9410.38
103_H305_I0.9360.38
12_R15_D0.9350.38
49_H313_G0.9340.38
146_S149_R0.9320.37
343_G353_E0.9320.37
139_E209_G0.9320.37
49_H211_W0.9300.37
300_D342_V0.9230.37
105_P111_E0.9190.37
19_R69_H0.9190.37
365_V373_P0.9160.37
84_T102_D0.9140.36
145_F333_L0.9120.36
122_K154_H0.9080.36
104_L291_A0.9080.36
50_K335_D0.9060.36
94_D305_I0.9050.36
250_R253_Y0.9030.36
32_E48_R0.8970.35
308_P312_H0.8950.35
242_D245_G0.8930.35
53_L129_L0.8930.35
97_F103_H0.8920.35
90_W295_E0.8900.35
93_S302_N0.8900.35
213_R347_T0.8900.35
93_S114_Y0.8890.35
64_R176_R0.8880.35
304_L321_R0.8860.35
205_L278_A0.8860.35
71_Y303_R0.8850.35
70_V226_L0.8850.35
49_H76_T0.8850.35
54_D57_S0.8830.35
260_T267_N0.8830.35
228_E233_D0.8820.35
12_R70_V0.8810.34
20_A71_Y0.8790.34
36_I88_K0.8770.34
181_A186_V0.8770.34
12_R314_G0.8760.34
90_W301_T0.8760.34
71_Y226_L0.8740.34
275_L279_R0.8740.34
151_Y203_R0.8740.34
19_R24_L0.8730.34
118_L305_I0.8720.34
54_D270_V0.8710.34
172_V175_V0.8690.34
129_L243_G0.8690.34
59_T158_A0.8680.34
261_T264_K0.8620.33
254_N269_D0.8610.33
132_L155_V0.8610.33
177_G204_M0.8600.33
145_F235_V0.8590.33
261_T331_D0.8580.33
275_L280_R0.8540.33
29_D156_R0.8500.33
16_V189_E0.8480.33
49_H81_G0.8450.32
135_D332_P0.8430.32
97_F130_D0.8410.32
36_I47_V0.8370.32
325_A353_E0.8370.32
272_P279_R0.8360.32
349_E353_E0.8340.32
34_G68_R0.8330.32
128_L300_D0.8310.32
103_H118_L0.8260.31
49_H169_R0.8230.31
149_R152_H0.8200.31
161_Y206_P0.8170.31
116_E333_L0.8160.31
167_E296_P0.8130.31
48_R52_T0.8130.31
253_Y261_T0.8110.31
334_V340_T0.8090.30
364_T376_A0.8070.30
145_F298_T0.8060.30
33_W248_S0.8000.30
125_L324_R0.8000.30
160_V171_I0.8000.30
219_L245_G0.7990.30
265_R269_D0.7950.30
142_T321_R0.7950.30
58_M311_L0.7940.30
172_V325_A0.7940.30
45_T69_H0.7930.30
71_Y151_Y0.7930.30
151_Y155_V0.7930.30
154_H305_I0.7830.29
82_A145_F0.7820.29
106_R117_M0.7820.29
230_G265_R0.7820.29
345_D349_E0.7800.29
13_F169_R0.7790.29
106_R178_N0.7750.29
226_L289_E0.7730.29
254_N378_V0.7680.28
242_D325_A0.7640.28
105_P112_D0.7640.28
163_L167_E0.7610.28
317_L333_L0.7610.28
63_E78_D0.7600.28
303_R309_G0.7600.28
61_F64_R0.7590.28
17_Y31_R0.7560.28
93_S126_L0.7550.28
20_A69_H0.7520.27
18_R59_T0.7510.27
69_H73_S0.7470.27
128_L313_G0.7450.27
217_T246_E0.7440.27
57_S343_G0.7430.27
110_G231_E0.7410.27
21_E218_R0.7400.27
239_T285_T0.7340.27
233_D331_D0.7320.26
369_V373_P0.7300.26
217_T325_A0.7280.26
73_S77_Y0.7270.26
69_H122_K0.7220.26
167_E307_L0.7200.26
204_M252_I0.7200.26
210_G334_V0.7180.26
94_D103_H0.7180.26
143_V153_V0.7130.26
154_H306_R0.7130.26
112_D290_Q0.7130.26
54_D263_V0.7120.25
291_A303_R0.7090.25
62_L281_Y0.7080.25
14_G18_R0.7070.25
34_G296_P0.7060.25
345_D348_V0.7040.25
104_L306_R0.7040.25
21_E171_I0.7030.25
300_D313_G0.7010.25
112_D120_K0.7000.25
50_K156_R0.7000.25
160_V367_P0.6970.25
153_V201_E0.6950.25
374_E381_M0.6910.24
169_R296_P0.6900.24
16_V206_P0.6890.24
372_V375_Y0.6870.24
235_V253_Y0.6850.24
189_E275_L0.6820.24
300_D368_G0.6810.24
26_P59_T0.6810.24
291_A306_R0.6780.24
165_S301_T0.6780.24
27_R203_R0.6770.24
122_K305_I0.6770.24
177_G296_P0.6760.24
366_G371_T0.6740.24
250_R256_V0.6740.24
71_Y225_D0.6740.24
37_P102_D0.6720.24
74_A83_A0.6710.24
44_T102_D0.6680.23
208_D212_G0.6650.23
279_R283_D0.6640.23
77_Y311_L0.6630.23
164_G171_I0.6600.23
110_G220_E0.6560.23
317_L335_D0.6540.23
139_E261_T0.6530.23
53_L57_S0.6530.23
119_S258_D0.6520.23
368_G373_P0.6490.23
117_M333_L0.6480.22
13_F300_D0.6480.22
363_L379_F0.6470.22
53_L155_V0.6470.22
69_H156_R0.6450.22
101_A113_S0.6430.22
48_R67_P0.6430.22
23_D199_P0.6430.22
249_A343_G0.6400.22
77_Y92_G0.6390.22
94_D112_D0.6380.22
174_Y201_E0.6350.22
372_V377_G0.6340.22
197_E263_V0.6320.22
150_G297_V0.6320.22
146_S297_V0.6320.22
33_W315_S0.6250.21
362_S379_F0.6250.21
271_H278_A0.6240.21
260_T263_V0.6240.21
80_P102_D0.6240.21
299_T317_L0.6230.21
52_T314_G0.6200.21
371_T379_F0.6190.21
39_T58_M0.6180.21
77_Y97_F0.6170.21
286_V321_R0.6170.21
16_V52_T0.6160.21
73_S154_H0.6140.21
251_A270_V0.6140.21
294_D297_V0.6130.21
93_S303_R0.6130.21
145_F188_A0.6130.21
175_V295_E0.6110.21
160_V290_Q0.6110.21
247_R270_V0.6100.21
112_D118_L0.6100.21
201_E204_M0.6070.21
298_T345_D0.6070.21
126_L323_D0.6060.21
51_S76_T0.6040.21
73_S104_L0.6040.21
75_G303_R0.6030.21
306_R313_G0.6020.20
73_S291_A0.6020.20
201_E379_F0.6020.20
144_T157_D0.6020.20
80_P97_F0.6010.20
128_L301_T0.6000.20
29_D172_V0.5990.20
14_G353_E0.5990.20
234_A237_T0.5980.20
102_D128_L0.5970.20
117_M145_F0.5970.20
270_V325_A0.5970.20
139_E237_T0.5970.20
309_G313_G0.5930.20
304_L312_H0.5920.20
135_D173_D0.5910.20
35_Y44_T0.5900.20
73_S309_G0.5900.20
103_H121_C0.5900.20
15_D237_T0.5890.20
74_A153_V0.5880.20
210_G350_L0.5860.20
88_K314_G0.5850.20
33_W94_D0.5830.20
198_N203_R0.5820.20
252_I278_A0.5810.20
134_R378_V0.5810.20
209_G325_A0.5810.20
71_Y306_R0.5810.20
28_A259_N0.5800.20
244_V375_Y0.5800.20
45_T84_T0.5800.20
221_A230_G0.5790.20
91_Q250_R0.5790.20
80_P211_W0.5790.20
98_D297_V0.5770.19
100_D297_V0.5770.19
365_V368_G0.5770.19
218_R289_E0.5760.19
135_D307_L0.5750.19
180_L188_A0.5750.19
247_R253_Y0.5740.19
286_V374_E0.5730.19
99_L118_L0.5730.19
261_T265_R0.5720.19
180_L187_E0.5710.19
129_L151_Y0.5700.19
102_D313_G0.5700.19
264_K273_A0.5690.19
342_V346_I0.5680.19
111_E223_A0.5680.19
46_M148_G0.5670.19
367_P378_V0.5660.19
68_R296_P0.5650.19
153_V185_L0.5650.19
263_V266_G0.5630.19
95_L298_T0.5620.19
168_R297_V0.5600.19
104_L303_R0.5590.19
58_M153_V0.5580.19
105_P309_G0.5570.19
372_V376_A0.5570.19
154_H303_R0.5570.19
151_Y327_L0.5560.19
377_G380_M0.5560.19
35_Y175_V0.5550.19
71_Y156_R0.5550.19
291_A309_G0.5520.18
344_H366_G0.5520.18
128_L377_G0.5510.18
104_L122_K0.5510.18
304_L308_P0.5500.18
362_S368_G0.5500.18
154_H291_A0.5490.18
197_E235_V0.5490.18
338_P341_F0.5480.18
209_G261_T0.5460.18
93_S306_R0.5460.18
143_V309_G0.5430.18
343_G347_T0.5430.18
152_H297_V0.5420.18
147_G297_V0.5420.18
74_A342_V0.5410.18
96_V218_R0.5410.18
33_W56_G0.5400.18
241_F248_S0.5370.18
104_L292_P0.5370.18
62_L325_A0.5360.18
53_L60_S0.5360.18
364_T378_V0.5350.18
148_G154_H0.5350.18
71_Y169_R0.5340.18
164_G217_T0.5340.18
122_K291_A0.5340.18
94_D309_G0.5330.18
104_L154_H0.5320.18
39_T62_L0.5310.18
244_V263_V0.5300.18
19_R34_G0.5290.18
248_S257_A0.5290.18
15_D238_L0.5270.18
96_V235_V0.5270.18
249_A253_Y0.5270.18
81_G165_S0.5270.18
135_D201_E0.5250.17
96_V113_S0.5210.17
154_H309_G0.5210.17
71_Y165_S0.5210.17
76_T333_L0.5200.17
90_W303_R0.5180.17
130_D295_E0.5170.17
169_R284_E0.5170.17
208_D286_V0.5160.17
141_L324_R0.5160.17
118_L125_L0.5160.17
244_V255_V0.5150.17
31_R294_D0.5150.17
105_P118_L0.5140.17
69_H303_R0.5130.17
55_L283_D0.5110.17
205_L276_T0.5100.17
93_S333_L0.5100.17
28_A228_E0.5090.17
108_T315_S0.5090.17
62_L182_L0.5080.17
108_T309_G0.5070.17
124_A214_R0.5070.17
302_N313_G0.5050.17
154_H313_G0.5040.17
30_D62_L0.5030.17
101_A151_Y0.5020.17
22_I226_L0.5010.17
107_V302_N0.5010.17
305_I319_V0.5010.17
103_H112_D0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4likA 1 0.89 100 0.23 Contact Map
4mm2A 1 0.9003 100 0.23 Contact Map
1zt2A 3 0.7519 100 0.367 Contact Map
1v33A 1 0.8491 100 0.395 Contact Map
2faoA 1 0.6317 68.9 0.969 Contact Map
2iruA 1 0.5934 52.2 0.972 Contact Map
2d69A 4 0.4783 21.2 0.977 Contact Map
3nwrA 2 0.4578 18.7 0.978 Contact Map
1ls9A 1 0.202 11.6 0.98 Contact Map
4wo7A 2 0.4066 10.1 0.981 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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