PRIS - HALSA - GREMLIN Contacts

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PRIS - DNA primase small subunit PriS

UniProt:	Q9HPU3	Sequences: MEERTRAYLRGRFGDVYRRAEIDLPPRADDREWGYIPWTAGPDTTMVRHKSTLDLGSMTSFLERKCPRHVYFSAGTYDAPGAATMDEKHWQGSDLVFDLDADHLPRVTLGEDSYAEMLSKCKDALLRLLDFLERDFGFEELTVTFSGGRGYHVHVRDAGVYELGSEERREIVDYVRGNDLALETLVEAEPVGGRGLENPTEKRMLPADGGWGRRVTTRLEAFADDLIERGEDDAVATLTEFDGVGERSARAIYNVVADNTTAVKRGNVDVHPAFLTVARRYIDETVAAEQAPIDEPVTTDTNRLIRLPGSLHGGSGLEVQRLDRAALDDFDPLVDAVPETFVGHDITVELPTEHTVELRGESLTVGPGVSTVPEYAGVFMMARGTAEKATE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	391 (355)
Sequences:	497 (367)
Seq/√Len:	19.5

HALSA - PRIS
SULSO - PRIS

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
19_R	22_I	5.059	1.00
145_F	317_L	4.575	1.00
135_D	174_Y	4.505	1.00
311_L	318_E	4.321	1.00
131_F	175_V	3.982	1.00
52_T	61_F	3.958	1.00
373_P	377_G	3.896	1.00
36_I	46_M	3.480	1.00
126_L	151_Y	3.239	1.00
35_Y	52_T	3.197	0.99
108_T	111_E	2.903	0.99
203_R	207_A	2.900	0.99
163_L	171_I	2.899	0.99
130_D	133_E	2.883	0.99
233_D	249_A	2.842	0.99
34_G	46_M	2.791	0.99
323_D	326_A	2.782	0.99
196_L	199_P	2.614	0.98
326_A	329_D	2.601	0.98
92_G	161_Y	2.545	0.97
34_G	71_Y	2.538	0.97
126_L	322_L	2.450	0.97
101_A	114_Y	2.397	0.96
36_I	44_T	2.383	0.96
95_L	163_L	2.347	0.96
128_L	211_W	2.311	0.95
34_G	70_V	2.291	0.95
164_G	167_E	2.264	0.95
158_A	162_E	2.253	0.95
118_L	121_C	2.193	0.94
266_G	269_D	2.178	0.94
108_T	121_C	2.131	0.93
135_D	206_P	2.101	0.92
281_Y	284_E	2.095	0.92
95_L	172_V	2.064	0.92
344_H	371_T	2.063	0.92
13_F	34_G	2.057	0.91
226_L	235_V	1.988	0.90
108_T	112_D	1.982	0.90
165_S	300_D	1.968	0.89
310_S	319_V	1.871	0.87
164_G	301_T	1.854	0.86
37_P	44_T	1.828	0.86
59_T	63_E	1.819	0.85
46_M	74_A	1.792	0.84
176_R	295_E	1.766	0.84
317_L	337_V	1.735	0.82
36_I	299_T	1.729	0.82
34_G	69_H	1.695	0.81
132_L	138_F	1.684	0.80
252_I	259_N	1.673	0.80
222_F	289_E	1.672	0.80
259_N	262_A	1.661	0.79
331_D	334_V	1.658	0.79
147_G	152_H	1.640	0.79
105_P	108_T	1.640	0.79
322_L	326_A	1.632	0.78
259_N	263_V	1.610	0.77
322_L	327_L	1.606	0.77
186_V	189_E	1.602	0.77
131_F	293_I	1.599	0.77
112_D	121_C	1.597	0.77
138_F	163_L	1.583	0.76
138_F	171_I	1.563	0.75
58_M	62_L	1.542	0.74
224_D	227_I	1.538	0.74
130_D	145_F	1.532	0.74
26_P	156_R	1.522	0.73
304_L	315_S	1.470	0.70
278_A	281_Y	1.442	0.69
115_A	314_G	1.441	0.69
126_L	327_L	1.435	0.68
277_V	281_Y	1.434	0.68
118_L	122_K	1.422	0.68
160_V	163_L	1.422	0.68
74_A	155_V	1.413	0.67
175_V	293_I	1.406	0.67
299_T	316_G	1.403	0.67
93_S	301_T	1.396	0.66
122_K	148_G	1.389	0.66
229_R	233_D	1.389	0.66
248_S	262_A	1.389	0.66
93_S	307_L	1.381	0.65
97_F	163_L	1.381	0.65
27_R	92_G	1.378	0.65
133_E	141_L	1.359	0.64
37_P	47_V	1.347	0.63
50_K	83_A	1.345	0.63
36_I	69_H	1.344	0.63
221_A	311_L	1.336	0.63
105_P	121_C	1.335	0.63
173_D	295_E	1.335	0.63
28_A	33_W	1.334	0.63
127_R	328_D	1.334	0.63
368_G	374_E	1.327	0.62
69_H	226_L	1.326	0.62
366_G	369_V	1.307	0.61
13_F	296_P	1.305	0.61
92_G	162_E	1.301	0.61
209_G	212_G	1.300	0.61
296_P	299_T	1.297	0.60
102_D	107_V	1.295	0.60
101_A	307_L	1.292	0.60
30_D	214_R	1.283	0.60
99_L	121_C	1.277	0.59
77_Y	88_K	1.259	0.58
35_Y	39_T	1.255	0.58
136_F	163_L	1.254	0.58
338_P	342_V	1.253	0.58
141_L	153_V	1.245	0.57
71_Y	296_P	1.238	0.57
376_A	380_M	1.236	0.57
52_T	137_G	1.236	0.57
37_P	45_T	1.233	0.56
35_Y	65_K	1.228	0.56
348_V	369_V	1.224	0.56
47_V	50_K	1.222	0.56
296_P	300_D	1.217	0.55
138_F	160_V	1.217	0.55
202_K	320_Q	1.216	0.55
73_S	306_R	1.215	0.55
171_I	227_I	1.211	0.55
168_R	294_D	1.210	0.55
303_R	306_R	1.209	0.55
176_R	314_G	1.198	0.54
69_H	74_A	1.195	0.54
19_R	71_Y	1.194	0.54
141_L	217_T	1.188	0.54
152_H	294_D	1.181	0.53
147_G	294_D	1.181	0.53
161_Y	174_Y	1.179	0.53
69_H	296_P	1.175	0.53
235_V	252_I	1.170	0.52
94_D	118_L	1.163	0.52
49_H	102_D	1.162	0.52
141_L	263_V	1.153	0.51
142_T	156_R	1.150	0.51
300_D	338_P	1.141	0.51
46_M	299_T	1.134	0.50
13_F	338_P	1.125	0.50
147_G	168_R	1.124	0.50
152_H	168_R	1.124	0.50
319_V	332_P	1.119	0.49
146_S	150_G	1.117	0.49
108_T	118_L	1.113	0.49
73_S	303_R	1.098	0.48
13_F	17_Y	1.094	0.48
363_L	366_G	1.088	0.47
61_F	101_A	1.076	0.46
49_H	80_P	1.070	0.46
151_Y	207_A	1.068	0.46
145_F	346_I	1.063	0.46
99_L	108_T	1.050	0.45
318_E	341_F	1.046	0.45
363_L	367_P	1.045	0.44
161_Y	293_I	1.042	0.44
39_T	45_T	1.037	0.44
104_L	142_T	1.036	0.44
39_T	44_T	1.033	0.44
20_A	296_P	1.021	0.43
309_G	315_S	1.017	0.43
215_V	338_P	1.015	0.43
374_E	377_G	1.014	0.43
146_S	152_H	1.009	0.42
147_G	150_G	1.009	0.42
17_Y	32_E	1.007	0.42
252_I	262_A	0.999	0.42
79_A	301_T	0.997	0.41
46_M	70_V	0.988	0.41
132_L	179_D	0.978	0.40
277_V	280_R	0.978	0.40
111_E	121_C	0.977	0.40
74_A	300_D	0.977	0.40
252_I	263_V	0.975	0.40
96_V	186_V	0.971	0.40
221_A	295_E	0.964	0.39
130_D	172_V	0.962	0.39
31_R	330_F	0.955	0.39
56_G	59_T	0.948	0.38
180_L	288_A	0.945	0.38
13_F	68_R	0.945	0.38
306_R	309_G	0.941	0.38
103_H	305_I	0.936	0.38
12_R	15_D	0.935	0.38
49_H	313_G	0.934	0.38
146_S	149_R	0.932	0.37
343_G	353_E	0.932	0.37
139_E	209_G	0.932	0.37
49_H	211_W	0.930	0.37
300_D	342_V	0.923	0.37
105_P	111_E	0.919	0.37
19_R	69_H	0.919	0.37
365_V	373_P	0.916	0.37
84_T	102_D	0.914	0.36
145_F	333_L	0.912	0.36
122_K	154_H	0.908	0.36
104_L	291_A	0.908	0.36
50_K	335_D	0.906	0.36
94_D	305_I	0.905	0.36
250_R	253_Y	0.903	0.36
32_E	48_R	0.897	0.35
308_P	312_H	0.895	0.35
242_D	245_G	0.893	0.35
53_L	129_L	0.893	0.35
97_F	103_H	0.892	0.35
90_W	295_E	0.890	0.35
93_S	302_N	0.890	0.35
213_R	347_T	0.890	0.35
93_S	114_Y	0.889	0.35
64_R	176_R	0.888	0.35
304_L	321_R	0.886	0.35
205_L	278_A	0.886	0.35
71_Y	303_R	0.885	0.35
70_V	226_L	0.885	0.35
49_H	76_T	0.885	0.35
54_D	57_S	0.883	0.35
260_T	267_N	0.883	0.35
228_E	233_D	0.882	0.35
12_R	70_V	0.881	0.34
20_A	71_Y	0.879	0.34
36_I	88_K	0.877	0.34
181_A	186_V	0.877	0.34
12_R	314_G	0.876	0.34
90_W	301_T	0.876	0.34
71_Y	226_L	0.874	0.34
275_L	279_R	0.874	0.34
151_Y	203_R	0.874	0.34
19_R	24_L	0.873	0.34
118_L	305_I	0.872	0.34
54_D	270_V	0.871	0.34
172_V	175_V	0.869	0.34
129_L	243_G	0.869	0.34
59_T	158_A	0.868	0.34
261_T	264_K	0.862	0.33
254_N	269_D	0.861	0.33
132_L	155_V	0.861	0.33
177_G	204_M	0.860	0.33
145_F	235_V	0.859	0.33
261_T	331_D	0.858	0.33
275_L	280_R	0.854	0.33
29_D	156_R	0.850	0.33
16_V	189_E	0.848	0.33
49_H	81_G	0.845	0.32
135_D	332_P	0.843	0.32
97_F	130_D	0.841	0.32
36_I	47_V	0.837	0.32
325_A	353_E	0.837	0.32
272_P	279_R	0.836	0.32
349_E	353_E	0.834	0.32
34_G	68_R	0.833	0.32
128_L	300_D	0.831	0.32
103_H	118_L	0.826	0.31
49_H	169_R	0.823	0.31
149_R	152_H	0.820	0.31
161_Y	206_P	0.817	0.31
116_E	333_L	0.816	0.31
167_E	296_P	0.813	0.31
48_R	52_T	0.813	0.31
253_Y	261_T	0.811	0.31
334_V	340_T	0.809	0.30
364_T	376_A	0.807	0.30
145_F	298_T	0.806	0.30
33_W	248_S	0.800	0.30
125_L	324_R	0.800	0.30
160_V	171_I	0.800	0.30
219_L	245_G	0.799	0.30
265_R	269_D	0.795	0.30
142_T	321_R	0.795	0.30
58_M	311_L	0.794	0.30
172_V	325_A	0.794	0.30
45_T	69_H	0.793	0.30
71_Y	151_Y	0.793	0.30
151_Y	155_V	0.793	0.30
154_H	305_I	0.783	0.29
82_A	145_F	0.782	0.29
106_R	117_M	0.782	0.29
230_G	265_R	0.782	0.29
345_D	349_E	0.780	0.29
13_F	169_R	0.779	0.29
106_R	178_N	0.775	0.29
226_L	289_E	0.773	0.29
254_N	378_V	0.768	0.28
242_D	325_A	0.764	0.28
105_P	112_D	0.764	0.28
163_L	167_E	0.761	0.28
317_L	333_L	0.761	0.28
63_E	78_D	0.760	0.28
303_R	309_G	0.760	0.28
61_F	64_R	0.759	0.28
17_Y	31_R	0.756	0.28
93_S	126_L	0.755	0.28
20_A	69_H	0.752	0.27
18_R	59_T	0.751	0.27
69_H	73_S	0.747	0.27
128_L	313_G	0.745	0.27
217_T	246_E	0.744	0.27
57_S	343_G	0.743	0.27
110_G	231_E	0.741	0.27
21_E	218_R	0.740	0.27
239_T	285_T	0.734	0.27
233_D	331_D	0.732	0.26
369_V	373_P	0.730	0.26
217_T	325_A	0.728	0.26
73_S	77_Y	0.727	0.26
69_H	122_K	0.722	0.26
167_E	307_L	0.720	0.26
204_M	252_I	0.720	0.26
210_G	334_V	0.718	0.26
94_D	103_H	0.718	0.26
143_V	153_V	0.713	0.26
154_H	306_R	0.713	0.26
112_D	290_Q	0.713	0.26
54_D	263_V	0.712	0.25
291_A	303_R	0.709	0.25
62_L	281_Y	0.708	0.25
14_G	18_R	0.707	0.25
34_G	296_P	0.706	0.25
345_D	348_V	0.704	0.25
104_L	306_R	0.704	0.25
21_E	171_I	0.703	0.25
300_D	313_G	0.701	0.25
112_D	120_K	0.700	0.25
50_K	156_R	0.700	0.25
160_V	367_P	0.697	0.25
153_V	201_E	0.695	0.25
374_E	381_M	0.691	0.24
169_R	296_P	0.690	0.24
16_V	206_P	0.689	0.24
372_V	375_Y	0.687	0.24
235_V	253_Y	0.685	0.24
189_E	275_L	0.682	0.24
300_D	368_G	0.681	0.24
26_P	59_T	0.681	0.24
291_A	306_R	0.678	0.24
165_S	301_T	0.678	0.24
27_R	203_R	0.677	0.24
122_K	305_I	0.677	0.24
177_G	296_P	0.676	0.24
366_G	371_T	0.674	0.24
250_R	256_V	0.674	0.24
71_Y	225_D	0.674	0.24
37_P	102_D	0.672	0.24
74_A	83_A	0.671	0.24
44_T	102_D	0.668	0.23
208_D	212_G	0.665	0.23
279_R	283_D	0.664	0.23
77_Y	311_L	0.663	0.23
164_G	171_I	0.660	0.23
110_G	220_E	0.656	0.23
317_L	335_D	0.654	0.23
139_E	261_T	0.653	0.23
53_L	57_S	0.653	0.23
119_S	258_D	0.652	0.23
368_G	373_P	0.649	0.23
117_M	333_L	0.648	0.22
13_F	300_D	0.648	0.22
363_L	379_F	0.647	0.22
53_L	155_V	0.647	0.22
69_H	156_R	0.645	0.22
101_A	113_S	0.643	0.22
48_R	67_P	0.643	0.22
23_D	199_P	0.643	0.22
249_A	343_G	0.640	0.22
77_Y	92_G	0.639	0.22
94_D	112_D	0.638	0.22
174_Y	201_E	0.635	0.22
372_V	377_G	0.634	0.22
197_E	263_V	0.632	0.22
150_G	297_V	0.632	0.22
146_S	297_V	0.632	0.22
33_W	315_S	0.625	0.21
362_S	379_F	0.625	0.21
271_H	278_A	0.624	0.21
260_T	263_V	0.624	0.21
80_P	102_D	0.624	0.21
299_T	317_L	0.623	0.21
52_T	314_G	0.620	0.21
371_T	379_F	0.619	0.21
39_T	58_M	0.618	0.21
77_Y	97_F	0.617	0.21
286_V	321_R	0.617	0.21
16_V	52_T	0.616	0.21
73_S	154_H	0.614	0.21
251_A	270_V	0.614	0.21
294_D	297_V	0.613	0.21
93_S	303_R	0.613	0.21
145_F	188_A	0.613	0.21
175_V	295_E	0.611	0.21
160_V	290_Q	0.611	0.21
247_R	270_V	0.610	0.21
112_D	118_L	0.610	0.21
201_E	204_M	0.607	0.21
298_T	345_D	0.607	0.21
126_L	323_D	0.606	0.21
51_S	76_T	0.604	0.21
73_S	104_L	0.604	0.21
75_G	303_R	0.603	0.21
306_R	313_G	0.602	0.20
73_S	291_A	0.602	0.20
201_E	379_F	0.602	0.20
144_T	157_D	0.602	0.20
80_P	97_F	0.601	0.20
128_L	301_T	0.600	0.20
29_D	172_V	0.599	0.20
14_G	353_E	0.599	0.20
234_A	237_T	0.598	0.20
102_D	128_L	0.597	0.20
117_M	145_F	0.597	0.20
270_V	325_A	0.597	0.20
139_E	237_T	0.597	0.20
309_G	313_G	0.593	0.20
304_L	312_H	0.592	0.20
135_D	173_D	0.591	0.20
35_Y	44_T	0.590	0.20
73_S	309_G	0.590	0.20
103_H	121_C	0.590	0.20
15_D	237_T	0.589	0.20
74_A	153_V	0.588	0.20
210_G	350_L	0.586	0.20
88_K	314_G	0.585	0.20
33_W	94_D	0.583	0.20
198_N	203_R	0.582	0.20
252_I	278_A	0.581	0.20
134_R	378_V	0.581	0.20
209_G	325_A	0.581	0.20
71_Y	306_R	0.581	0.20
28_A	259_N	0.580	0.20
244_V	375_Y	0.580	0.20
45_T	84_T	0.580	0.20
221_A	230_G	0.579	0.20
91_Q	250_R	0.579	0.20
80_P	211_W	0.579	0.20
98_D	297_V	0.577	0.19
100_D	297_V	0.577	0.19
365_V	368_G	0.577	0.19
218_R	289_E	0.576	0.19
135_D	307_L	0.575	0.19
180_L	188_A	0.575	0.19
247_R	253_Y	0.574	0.19
286_V	374_E	0.573	0.19
99_L	118_L	0.573	0.19
261_T	265_R	0.572	0.19
180_L	187_E	0.571	0.19
129_L	151_Y	0.570	0.19
102_D	313_G	0.570	0.19
264_K	273_A	0.569	0.19
342_V	346_I	0.568	0.19
111_E	223_A	0.568	0.19
46_M	148_G	0.567	0.19
367_P	378_V	0.566	0.19
68_R	296_P	0.565	0.19
153_V	185_L	0.565	0.19
263_V	266_G	0.563	0.19
95_L	298_T	0.562	0.19
168_R	297_V	0.560	0.19
104_L	303_R	0.559	0.19
58_M	153_V	0.558	0.19
105_P	309_G	0.557	0.19
372_V	376_A	0.557	0.19
154_H	303_R	0.557	0.19
151_Y	327_L	0.556	0.19
377_G	380_M	0.556	0.19
35_Y	175_V	0.555	0.19
71_Y	156_R	0.555	0.19
291_A	309_G	0.552	0.18
344_H	366_G	0.552	0.18
128_L	377_G	0.551	0.18
104_L	122_K	0.551	0.18
304_L	308_P	0.550	0.18
362_S	368_G	0.550	0.18
154_H	291_A	0.549	0.18
197_E	235_V	0.549	0.18
338_P	341_F	0.548	0.18
209_G	261_T	0.546	0.18
93_S	306_R	0.546	0.18
143_V	309_G	0.543	0.18
343_G	347_T	0.543	0.18
152_H	297_V	0.542	0.18
147_G	297_V	0.542	0.18
74_A	342_V	0.541	0.18
96_V	218_R	0.541	0.18
33_W	56_G	0.540	0.18
241_F	248_S	0.537	0.18
104_L	292_P	0.537	0.18
62_L	325_A	0.536	0.18
53_L	60_S	0.536	0.18
364_T	378_V	0.535	0.18
148_G	154_H	0.535	0.18
71_Y	169_R	0.534	0.18
164_G	217_T	0.534	0.18
122_K	291_A	0.534	0.18
94_D	309_G	0.533	0.18
104_L	154_H	0.532	0.18
39_T	62_L	0.531	0.18
244_V	263_V	0.530	0.18
19_R	34_G	0.529	0.18
248_S	257_A	0.529	0.18
15_D	238_L	0.527	0.18
96_V	235_V	0.527	0.18
249_A	253_Y	0.527	0.18
81_G	165_S	0.527	0.18
135_D	201_E	0.525	0.17
96_V	113_S	0.521	0.17
154_H	309_G	0.521	0.17
71_Y	165_S	0.521	0.17
76_T	333_L	0.520	0.17
90_W	303_R	0.518	0.17
130_D	295_E	0.517	0.17
169_R	284_E	0.517	0.17
208_D	286_V	0.516	0.17
141_L	324_R	0.516	0.17
118_L	125_L	0.516	0.17
244_V	255_V	0.515	0.17
31_R	294_D	0.515	0.17
105_P	118_L	0.514	0.17
69_H	303_R	0.513	0.17
55_L	283_D	0.511	0.17
205_L	276_T	0.510	0.17
93_S	333_L	0.510	0.17
28_A	228_E	0.509	0.17
108_T	315_S	0.509	0.17
62_L	182_L	0.508	0.17
108_T	309_G	0.507	0.17
124_A	214_R	0.507	0.17
302_N	313_G	0.505	0.17
154_H	313_G	0.504	0.17
30_D	62_L	0.503	0.17
101_A	151_Y	0.502	0.17
22_I	226_L	0.501	0.17
107_V	302_N	0.501	0.17
305_I	319_V	0.501	0.17
103_H	112_D	0.500	0.17

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4likA	1	0.89	100	0.23	Contact Map
4mm2A	1	0.9003	100	0.23	Contact Map
1zt2A	3	0.7519	100	0.367	Contact Map
1v33A	1	0.8491	100	0.395	Contact Map
2faoA	1	0.6317	68.9	0.969	Contact Map
2iruA	1	0.5934	52.2	0.972	Contact Map
2d69A	4	0.4783	21.2	0.977	Contact Map
3nwrA	2	0.4578	18.7	0.978	Contact Map
1ls9A	1	0.202	11.6	0.98	Contact Map
4wo7A	2	0.4066	10.1	0.981	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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