GREMLIN Database
Q9HPT9 - Carboxylesterase
UniProt: Q9HPT9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 274 (247)
Sequences: 62056 (50689)
Seq/√Len: 3225.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
24_V58_R4.7171.00
100_V124_A4.2111.00
65_P88_D3.4861.00
49_Q258_N2.9751.00
90_R114_A2.8461.00
253_T256_Q2.6801.00
217_D243_P2.6631.00
240_T260_A2.6581.00
212_F264_F2.6031.00
100_V123_D2.5781.00
129_G219_D2.5591.00
98_A123_D2.4531.00
242_L260_A2.3571.00
128_A257_F2.3491.00
19_S71_D2.2251.00
23_R43_H2.1491.00
114_A118_G2.0941.00
90_R121_E2.0931.00
90_R94_A2.0771.00
90_R118_G2.0401.00
217_D241_T2.0391.00
93_A99_S1.9721.00
101_L111_V1.9661.00
52_R258_N1.8941.00
231_A237_G1.8911.00
32_T60_A1.8431.00
21_A69_D1.8411.00
113_T117_D1.8361.00
94_A121_E1.8351.00
108_G130_C1.8311.00
56_T262_D1.8221.00
31_P100_V1.8221.00
100_V265_L1.8101.00
224_P241_T1.7951.00
22_Y92_V1.7821.00
32_T58_R1.7571.00
24_V60_A1.7481.00
245_A253_T1.7331.00
115_V125_V1.7321.00
31_P123_D1.7201.00
87_A117_D1.7041.00
212_F240_T1.6271.00
21_A43_H1.6141.00
211_V234_V1.6081.00
260_A263_A1.5991.00
100_V126_V1.5861.00
37_H67_H1.5851.00
37_H64_L1.5771.00
57_Y100_V1.5691.00
25_R61_A1.5591.00
86_A113_T1.5391.00
229_F233_H1.5311.00
83_D117_D1.5291.00
41_G45_V1.5041.00
36_V64_L1.5041.00
64_L110_V1.4941.00
16_H91_A1.4921.00
111_V125_V1.4911.00
62_L89_V1.4901.00
36_V89_V1.4871.00
118_G121_E1.4291.00
114_A122_P1.4161.00
89_V114_A1.4121.00
21_A63_D1.3861.00
259_D263_A1.3721.00
43_H63_D1.3711.00
52_R262_D1.3651.00
81_T84_A1.3521.00
203_R206_E1.3231.00
112_L127_L1.3161.00
169_D172_T1.3081.00
256_Q260_A1.2851.00
94_A118_G1.2811.00
36_V111_V1.2721.00
114_A121_E1.2721.00
113_T116_L1.2681.00
126_V261_L1.2651.00
215_T227_H1.2611.00
52_R55_D1.2431.00
104_N250_M1.2391.00
60_A92_V1.2311.00
35_F102_V1.2261.00
127_L130_C1.2241.00
224_P228_E1.2231.00
50_L61_A1.2151.00
102_V128_A1.2141.00
18_R65_P1.2141.00
40_G67_H1.2021.00
20_T88_D1.1791.00
43_H69_D1.1741.00
256_Q259_D1.1731.00
126_V212_F1.1611.00
116_L203_R1.1561.00
105_S247_H1.1551.00
33_V57_Y1.1551.00
35_F59_V1.1451.00
25_R50_L1.1231.00
228_E232_E1.1141.00
231_A239_W1.1131.00
26_G58_R1.1121.00
215_T241_T1.1001.00
31_P57_Y1.0961.00
242_L245_A1.0881.00
92_V96_V1.0881.00
45_V250_M1.0791.00
40_G105_S1.0691.00
234_V237_G1.0651.00
154_A158_L1.0641.00
34_L93_A1.0631.00
43_H61_A1.0631.00
38_G105_S1.0621.00
215_T239_W1.0571.00
99_S122_P1.0521.00
214_L242_L1.0521.00
191_D194_S1.0491.00
56_T266_S1.0411.00
52_R255_D1.0331.00
205_S233_H1.0321.00
212_F238_G1.0281.00
36_V101_L1.0261.00
238_G260_A1.0191.00
57_Y265_L1.0181.00
31_P98_A1.0131.00
257_F261_L1.0111.00
262_D266_S1.0091.00
83_D113_T1.0011.00
102_V261_L0.9951.00
229_F232_E0.9901.00
22_Y96_V0.9841.00
124_A210_P0.9781.00
62_L92_V0.9751.00
246_A252_E0.9741.00
86_A110_V0.9681.00
103_G111_V0.9571.00
215_T224_P0.9521.00
93_A114_A0.9461.00
90_R117_D0.9451.00
255_D259_D0.9351.00
245_A252_E0.9351.00
54_A59_V0.9331.00
242_L256_Q0.9311.00
188_V192_F0.9201.00
228_E239_W0.9181.00
27_S30_A0.9171.00
174_A177_K0.9161.00
240_T263_A0.9161.00
228_E231_A0.9161.00
63_D68_G0.9151.00
18_R71_D0.9111.00
104_N248_L0.9081.00
128_A250_M0.9061.00
190_R193_R0.9061.00
51_A54_A0.9041.00
25_R54_A0.9041.00
99_S121_E0.9011.00
228_E241_T0.9011.00
90_R93_A0.8981.00
217_D244_D0.8891.00
57_Y266_S0.8891.00
84_A87_A0.8821.00
30_A58_R0.8791.00
91_A94_A0.8751.00
150_G153_R0.8711.00
179_A182_D0.8691.00
214_L260_A0.8691.00
47_K61_A0.8681.00
34_L99_S0.8631.00
79_P84_A0.8591.00
128_A249_S0.8551.00
60_A96_V0.8501.00
155_L159_H0.8491.00
187_V190_R0.8441.00
188_V191_D0.8441.00
240_T256_Q0.8411.00
143_W147_D0.8331.00
141_R145_A0.8321.00
245_A249_S0.8311.00
64_L106_L0.8301.00
31_P124_A0.8301.00
91_A95_D0.8261.00
153_R157_F0.8251.00
189_N193_R0.8251.00
33_V102_V0.8241.00
48_A51_A0.8231.00
177_K181_R0.8201.00
190_R194_S0.8141.00
192_F195_C0.8141.00
113_T203_R0.8121.00
33_V59_V0.8081.00
173_L177_K0.8081.00
32_T99_S0.8061.00
140_L143_W0.8061.00
125_V211_V0.8051.00
51_A55_D0.8041.00
20_T70_S0.7981.00
86_A117_D0.7981.00
87_A90_R0.7941.00
115_V122_P0.7931.00
175_L178_D0.7871.00
50_L59_V0.7841.00
170_D174_A0.7781.00
174_A178_D0.7771.00
87_A91_A0.7761.00
35_F46_W0.7731.00
162_G165_F0.7711.00
175_L179_A0.7701.00
36_V62_L0.7661.00
213_A237_G0.7641.00
124_A264_F0.7601.00
85_Y106_L0.7601.00
32_T57_Y0.7481.00
208_D235_Q0.7481.00
103_G108_G0.7481.00
140_L144_L0.7451.00
226_A229_F0.7421.00
23_R47_K0.7371.00
155_L158_L0.7321.00
99_S123_D0.7311.00
186_A190_R0.7301.00
157_F161_S0.7281.00
151_F155_L0.7271.00
34_L89_V0.7261.00
258_N262_D0.7241.00
154_A157_F0.7241.00
163_R166_H0.7231.00
216_G249_S0.7221.00
44_A47_K0.7191.00
183_C186_A0.7181.00
47_K51_A0.7161.00
101_L122_P0.7161.00
227_H239_W0.7131.00
152_E156_A0.7111.00
142_A146_G0.7071.00
104_N129_G0.7061.00
50_L54_A0.7041.00
217_D224_P0.7041.00
144_L147_D0.7031.00
129_G249_S0.7031.00
33_V265_L0.7011.00
168_P172_T0.7001.00
242_L253_T0.7001.00
63_D69_D0.6991.00
57_Y262_D0.6981.00
126_V264_F0.6981.00
164_L167_D0.6981.00
101_L114_A0.6901.00
37_H62_L0.6891.00
225_S228_E0.6881.00
43_H62_L0.6871.00
39_S106_L0.6871.00
86_A114_A0.6871.00
142_A145_A0.6851.00
49_Q52_R0.6851.00
191_D195_C0.6811.00
124_A265_L0.6811.00
40_G106_L0.6801.00
64_L85_Y0.6801.00
27_S58_R0.6741.00
151_F157_F0.6731.00
115_V209_S0.6711.00
141_R144_L0.6701.00
151_F154_A0.6681.00
259_D262_D0.6661.00
170_D173_L0.6651.00
126_V265_L0.6651.00
129_G216_G0.6651.00
157_F160_D0.6591.00
33_V100_V0.6541.00
116_L206_E0.6521.00
104_N128_A0.6521.00
143_W146_G0.6491.00
145_A148_G0.6471.00
109_A131_G0.6451.00
129_G215_T0.6451.00
83_D87_A0.6441.00
184_G187_V0.6391.00
244_D253_T0.6391.00
102_V126_V0.6361.00
187_V191_D0.6351.00
254_P258_N0.6341.00
122_P209_S0.6341.00
156_A159_H0.6341.00
214_L257_F0.6311.00
49_Q257_F0.6291.00
46_W50_L0.6281.00
29_D58_R0.6251.00
144_L149_P0.6241.00
55_D262_D0.6211.00
64_L67_H0.6201.00
166_H169_D0.6181.00
171_R175_L0.6111.00
178_D181_R0.6111.00
202_T205_S0.6101.00
176_S179_A0.6091.00
164_L168_P0.6061.00
21_A70_S0.6061.00
218_H244_D0.6041.00
20_T65_P0.6031.00
65_P85_Y0.6011.00
112_L132_A0.6011.00
176_S180_M0.5981.00
127_L213_A0.5941.00
34_L62_L0.5921.00
34_L101_L0.5901.00
168_P171_R0.5891.00
24_V27_S0.5871.00
24_V96_V0.5861.00
154_A159_H0.5851.00
145_A149_P0.5821.00
46_W49_Q0.5811.00
151_F158_L0.5801.00
103_G107_G0.5781.00
150_G157_F0.5771.00
156_A160_D0.5771.00
144_L148_G0.5711.00
85_Y110_V0.5691.00
16_H87_A0.5671.00
169_D173_L0.5661.00
16_H84_A0.5611.00
25_R51_A0.5601.00
105_S248_L0.5541.00
230_L234_V0.5531.00
219_D247_H0.5531.00
155_L160_D0.5531.00
56_T59_V0.5521.00
201_R233_H0.5511.00
86_A90_R0.5501.00
200_V203_R0.5491.00
261_L265_L0.5471.00
80_E84_A0.5441.00
93_A121_E0.5441.00
82_L113_T0.5431.00
140_L147_D0.5431.00
126_V214_L0.5411.00
188_V194_S0.5391.00
173_L176_S0.5391.00
53_L261_L0.5391.00
238_G263_A0.5381.00
35_F61_A0.5351.00
249_S257_F0.5351.00
23_R61_A0.5341.00
30_A57_Y0.5331.00
108_G127_L0.5311.00
213_A239_W0.5291.00
124_A212_F0.5291.00
227_H231_A0.5291.00
158_L161_S0.5281.00
201_R229_F0.5271.00
153_R156_A0.5251.00
231_A234_V0.5241.00
99_S114_A0.5241.00
196_H199_D0.5201.00
98_A121_E0.5191.00
172_T175_L0.5191.00
189_N192_F0.5171.00
41_G248_L0.5161.00
33_V53_L0.5151.00
44_A69_D0.5111.00
45_V104_N0.5101.00
92_V95_D0.5081.00
213_A227_H0.5071.00
150_G158_L0.5061.00
64_L89_V0.5061.00
109_A112_L0.5061.00
35_F53_L0.5051.00
117_D203_R0.5031.00
250_M257_F0.5021.00
169_D177_K0.5021.00
23_R44_A0.5011.00
112_L130_C0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4inzA 1 0.9343 100 0.188 Contact Map
3om8A 4 0.9453 100 0.192 Contact Map
1ehyA 1 0.938 100 0.2 Contact Map
3oosA 1 0.938 100 0.208 Contact Map
2xuaA 2 0.927 100 0.212 Contact Map
4psuA 1 0.9453 100 0.215 Contact Map
2pujA 4 0.9416 100 0.215 Contact Map
1iupA 2 0.927 100 0.221 Contact Map
1q0rA 1 0.9526 100 0.225 Contact Map
4opmA 2 0.9745 100 0.229 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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