PANB - HALSA - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

PANB - 3-methyl-2-oxobutanoate hydroxymethyltransferase

UniProt:	Q9HPT6	Sequences: MPTVNSVRRAGNTDEETDPVTMLTAYDAPTASVVDDAGVDMILVGDSVGNAKLGYDTTLPVSVDEIASATGAVARATADAVVVADMPFLSFGADETESVRNAGRMLKEEDADAVKLESGPHTVSLTETLTSLGIPVMAHLGLTPQHVNQLGGYFRQGTDQDSAERMLDLARDHEAAGAFALVLEHVPANVAADITDAIDIPTIGIGAGPDTDGQVLVISDVIGMSERSPPFSKQFGDVNREMAAAVDDYVDAVESGSFPAAEHSHVADDVDDVY	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	274 (261)
Sequences:	3104 (1870)
Seq/√Len:	115.7

ECOLI - PANB
BACSU - PANB
HALSA - PANB
SULSO - PANB

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
19_P	256_G	3.398	1.00
89_L	103_G	3.084	1.00
237_D	240_R	2.929	1.00
192_A	196_D	2.867	1.00
126_T	173_H	2.790	1.00
70_T	84_A	2.746	1.00
192_A	210_D	2.666	1.00
235_F	252_A	2.620	1.00
63_V	101_N	2.566	1.00
22_M	215_V	2.553	1.00
174_E	199_D	2.433	1.00
171_R	197_A	2.296	1.00
49_G	61_V	2.226	1.00
104_R	108_E	2.178	1.00
97_E	100_R	2.175	1.00
174_E	198_I	2.153	1.00
53_L	68_S	2.106	1.00
137_M	180_A	2.096	1.00
63_V	90_S	2.081	1.00
241_E	244_A	2.064	1.00
18_D	254_E	2.063	1.00
14_D	212_D	2.017	1.00
21_T	250_V	1.995	1.00
233_K	263_H	1.986	1.00
233_K	252_A	1.983	1.00
93_A	100_R	1.977	1.00
195_T	202_T	1.965	1.00
39_V	250_V	1.933	1.00
12_N	16_E	1.933	1.00
164_E	168_D	1.926	1.00
250_V	254_E	1.890	1.00
127_E	131_S	1.866	1.00
193_D	197_A	1.862	1.00
120_P	168_D	1.848	1.00
65_E	71_G	1.825	1.00
188_A	264_S	1.784	1.00
74_A	82_V	1.770	1.00
251_D	255_S	1.770	1.00
236_G	241_E	1.757	1.00
13_T	20_V	1.738	1.00
244_A	248_D	1.721	1.00
63_V	105_M	1.717	1.00
165_R	169_L	1.688	1.00
137_M	179_F	1.670	1.00
34_V	42_I	1.663	1.00
70_T	111_A	1.656	1.00
34_V	246_V	1.642	1.00
86_M	101_N	1.638	1.00
84_A	105_M	1.633	1.00
93_A	97_E	1.610	1.00
35_D	80_A	1.598	1.00
159_D	162_S	1.592	1.00
57_T	60_P	1.543	1.00
53_L	72_A	1.535	1.00
138_A	173_H	1.522	1.00
70_T	109_E	1.511	1.00
228_S	234_Q	1.511	1.00
41_M	215_V	1.503	1.00
260_A	263_H	1.494	1.00
171_R	174_E	1.489	1.00
42_I	77_T	1.487	1.00
178_A	200_I	1.482	1.00
209_P	264_S	1.480	1.00
105_M	109_E	1.478	1.00
30_T	218_I	1.471	1.00
167_L	193_D	1.470	1.00
98_S	125_L	1.458	1.00
156_Q	162_S	1.455	1.00
252_A	257_S	1.450	1.00
240_R	244_A	1.415	1.00
36_D	243_A	1.402	1.00
234_Q	237_D	1.400	1.00
138_A	178_A	1.380	1.00
10_A	41_M	1.358	1.00
181_L	198_I	1.348	1.00
64_D	104_R	1.343	1.00
86_M	102_A	1.332	1.00
22_M	41_M	1.329	1.00
41_M	137_M	1.327	1.00
173_H	178_A	1.315	1.00
113_A	179_F	1.311	1.00
174_E	200_I	1.300	1.00
222_I	242_M	1.275	0.99
140_L	183_L	1.273	0.99
143_T	150_L	1.269	0.99
84_A	109_E	1.266	0.99
23_L	221_V	1.265	0.99
95_E	125_L	1.264	0.99
35_D	79_D	1.262	0.99
128_T	132_L	1.248	0.99
112_D	148_N	1.238	0.99
138_A	182_V	1.236	0.99
140_L	166_M	1.234	0.99
181_L	202_T	1.218	0.99
67_A	105_M	1.217	0.99
11_G	15_E	1.216	0.99
171_R	198_I	1.213	0.99
160_Q	164_E	1.204	0.99
71_G	75_R	1.204	0.99
34_V	218_I	1.194	0.99
120_P	169_L	1.191	0.99
127_E	175_A	1.179	0.99
83_V	182_V	1.179	0.99
20_V	213_G	1.166	0.99
49_G	55_Y	1.165	0.99
5_N	40_D	1.155	0.99
93_A	96_T	1.150	0.99
13_T	18_D	1.144	0.99
84_A	111_A	1.130	0.99
188_A	210_D	1.121	0.99
183_L	186_V	1.120	0.99
32_S	226_E	1.117	0.99
77_T	82_V	1.117	0.99
121_H	165_R	1.116	0.99
91_F	116_L	1.116	0.99
202_T	211_T	1.105	0.98
97_E	101_N	1.101	0.98
130_T	178_A	1.099	0.98
218_I	222_I	1.098	0.98
95_E	128_T	1.096	0.98
247_D	251_D	1.096	0.98
124_S	127_E	1.095	0.98
21_T	254_E	1.093	0.98
55_Y	60_P	1.088	0.98
243_A	247_D	1.086	0.98
55_Y	75_R	1.085	0.98
181_L	200_I	1.085	0.98
99_V	128_T	1.077	0.98
35_D	78_A	1.072	0.98
83_V	137_M	1.068	0.98
195_T	211_T	1.053	0.98
83_V	113_A	1.043	0.98
41_M	83_V	1.032	0.98
260_A	264_S	1.030	0.98
222_I	238_V	1.024	0.97
185_H	265_H	1.024	0.97
157_G	194_I	1.015	0.97
8_R	154_F	1.003	0.97
188_A	209_P	0.997	0.97
55_Y	65_E	0.990	0.97
48_V	69_A	0.988	0.97
21_T	39_V	0.987	0.97
163_A	190_V	0.983	0.97
9_R	12_N	0.980	0.97
142_L	185_H	0.976	0.97
52_K	219_S	0.968	0.96
86_M	90_S	0.961	0.96
99_V	129_L	0.958	0.96
33_V	246_V	0.953	0.96
168_D	172_D	0.950	0.96
121_H	131_S	0.950	0.96
209_P	256_G	0.950	0.96
5_N	9_R	0.948	0.96
29_P	224_M	0.948	0.96
248_D	251_D	0.943	0.96
49_G	65_E	0.943	0.96
191_A	211_T	0.937	0.96
65_E	68_S	0.937	0.96
123_V	169_L	0.934	0.96
169_L	172_D	0.933	0.96
248_D	252_A	0.929	0.95
91_F	98_S	0.929	0.95
74_A	77_T	0.927	0.95
29_P	52_K	0.924	0.95
193_D	196_D	0.921	0.95
195_T	212_D	0.919	0.95
123_V	172_D	0.919	0.95
96_T	100_R	0.896	0.95
106_L	135_P	0.891	0.94
122_T	125_L	0.888	0.94
239_N	243_A	0.888	0.94
64_D	67_A	0.882	0.94
183_L	194_I	0.879	0.94
244_A	247_D	0.869	0.94
130_T	179_F	0.869	0.94
150_L	185_H	0.869	0.94
20_V	40_D	0.869	0.94
238_V	242_M	0.867	0.93
81_V	113_A	0.863	0.93
23_L	34_V	0.862	0.93
99_V	132_L	0.861	0.93
60_P	107_K	0.857	0.93
120_P	172_D	0.852	0.93
74_A	110_D	0.852	0.93
23_L	39_V	0.848	0.93
63_V	66_I	0.847	0.93
162_S	165_R	0.845	0.93
167_L	197_A	0.839	0.92
32_S	36_D	0.839	0.92
182_V	200_I	0.838	0.92
92_G	107_K	0.837	0.92
48_V	61_V	0.835	0.92
67_A	109_E	0.835	0.92
164_E	193_D	0.834	0.92
40_D	254_E	0.827	0.92
167_L	171_R	0.825	0.92
187_P	207_A	0.816	0.91
29_P	219_S	0.812	0.91
216_L	231_F	0.812	0.91
120_P	165_R	0.811	0.91
95_E	124_S	0.811	0.91
235_F	245_A	0.810	0.91
119_G	123_V	0.808	0.91
82_V	112_D	0.806	0.91
68_S	72_A	0.806	0.91
157_G	166_M	0.805	0.91
53_L	65_E	0.801	0.90
236_G	245_A	0.796	0.90
113_A	137_M	0.795	0.90
5_N	79_D	0.792	0.90
42_I	82_V	0.791	0.90
48_V	53_L	0.785	0.90
62_S	65_E	0.785	0.90
71_G	74_A	0.779	0.89
30_T	219_S	0.779	0.89
13_T	254_E	0.778	0.89
20_V	41_M	0.775	0.89
238_V	241_E	0.775	0.89
37_A	243_A	0.768	0.89
155_R	265_H	0.764	0.88
155_R	230_P	0.764	0.88
99_V	103_G	0.760	0.88
90_S	107_K	0.757	0.88
40_D	213_G	0.751	0.87
231_F	263_H	0.751	0.87
33_V	239_N	0.747	0.87
74_A	112_D	0.742	0.87
237_D	241_E	0.741	0.87
35_D	77_T	0.740	0.87
252_A	255_S	0.740	0.87
28_A	32_S	0.738	0.87
23_L	246_V	0.737	0.86
187_P	190_V	0.735	0.86
60_P	110_D	0.735	0.86
173_H	181_L	0.734	0.86
92_G	98_S	0.732	0.86
235_F	257_S	0.732	0.86
147_V	152_G	0.728	0.86
185_H	230_P	0.727	0.86
218_I	246_V	0.727	0.86
32_S	239_N	0.725	0.86
21_T	40_D	0.725	0.86
66_I	84_A	0.724	0.85
67_A	104_R	0.721	0.85
30_T	242_M	0.719	0.85
96_T	128_T	0.711	0.84
150_L	156_Q	0.705	0.84
172_D	175_A	0.704	0.84
178_A	181_L	0.704	0.84
63_V	67_A	0.704	0.84
232_S	265_H	0.701	0.84
67_A	108_E	0.700	0.83
74_A	109_E	0.685	0.82
163_A	193_D	0.684	0.82
185_H	225_S	0.683	0.82
125_L	128_T	0.682	0.82
59_L	151_G	0.681	0.82
196_D	210_D	0.680	0.82
50_N	229_P	0.679	0.82
10_A	179_F	0.677	0.81
13_T	40_D	0.675	0.81
23_L	218_I	0.675	0.81
5_N	10_A	0.675	0.81
171_R	175_A	0.673	0.81
94_D	125_L	0.672	0.81
59_L	107_K	0.670	0.81
89_L	99_V	0.667	0.80
168_D	171_R	0.666	0.80
142_L	153_Y	0.666	0.80
138_A	181_L	0.664	0.80
48_V	68_S	0.664	0.80
103_G	107_K	0.661	0.80
11_G	199_D	0.657	0.79
233_K	260_A	0.652	0.79
91_F	101_N	0.651	0.79
219_S	224_M	0.650	0.79
86_M	91_F	0.650	0.79
114_V	136_V	0.646	0.78
49_G	62_S	0.645	0.78
95_E	98_S	0.645	0.78
155_R	185_H	0.643	0.78
120_P	123_V	0.642	0.78
183_L	202_T	0.641	0.78
7_V	179_F	0.640	0.78
130_T	149_Q	0.639	0.78
140_L	181_L	0.638	0.77
223_G	228_S	0.638	0.77
229_P	232_S	0.638	0.77
103_G	134_I	0.635	0.77
22_M	31_A	0.633	0.77
233_K	257_S	0.632	0.77
26_Y	52_K	0.631	0.77
14_D	19_P	0.630	0.77
86_M	105_M	0.629	0.76
172_D	176_A	0.627	0.76
198_I	202_T	0.626	0.76
188_A	261_A	0.625	0.76
67_A	70_T	0.623	0.76
71_G	109_E	0.623	0.76
41_M	81_V	0.621	0.76
30_T	222_I	0.620	0.75
116_L	129_L	0.618	0.75
223_G	234_Q	0.616	0.75
27_D	30_T	0.616	0.75
125_L	129_L	0.615	0.75
74_A	78_A	0.611	0.74
118_S	169_L	0.609	0.74
13_T	16_E	0.609	0.74
56_D	60_P	0.598	0.73
258_F	265_H	0.597	0.73
194_I	197_A	0.596	0.73
171_R	199_D	0.596	0.73
95_E	99_V	0.595	0.72
261_A	264_S	0.594	0.72
31_A	42_I	0.594	0.72
166_M	190_V	0.592	0.72
183_L	191_A	0.592	0.72
6_S	142_L	0.592	0.72
37_A	247_D	0.589	0.72
242_M	246_V	0.588	0.72
67_A	71_G	0.588	0.72
120_P	175_A	0.587	0.71
163_A	187_P	0.585	0.71
130_T	176_A	0.583	0.71
7_V	11_G	0.582	0.71
41_M	180_A	0.581	0.71
149_Q	179_F	0.580	0.71
203_I	213_G	0.578	0.70
153_Y	185_H	0.577	0.70
182_V	198_I	0.575	0.70
124_S	131_S	0.575	0.70
116_L	122_T	0.574	0.70
31_A	77_T	0.573	0.70
73_V	82_V	0.570	0.69
52_K	72_A	0.569	0.69
102_A	134_I	0.568	0.69
59_L	146_H	0.565	0.69
83_V	180_A	0.565	0.69
147_V	153_Y	0.563	0.68
140_L	157_G	0.563	0.68
123_V	176_A	0.563	0.68
126_T	138_A	0.563	0.68
152_G	156_Q	0.562	0.68
101_N	105_M	0.562	0.68
153_Y	229_P	0.562	0.68
133_G	149_Q	0.562	0.68
143_T	146_H	0.561	0.68
126_T	178_A	0.559	0.68
20_V	203_I	0.558	0.68
25_A	44_V	0.558	0.68
225_S	228_S	0.558	0.68
129_L	132_L	0.557	0.67
186_V	202_T	0.557	0.67
156_Q	265_H	0.556	0.67
221_V	232_S	0.556	0.67
9_R	13_T	0.553	0.67
28_A	76_A	0.550	0.66
205_I	215_V	0.548	0.66
106_L	129_L	0.546	0.66
195_T	210_D	0.541	0.65
12_N	15_E	0.533	0.64
22_M	83_V	0.533	0.64
57_T	110_D	0.531	0.64
88_F	133_G	0.530	0.64
209_P	261_A	0.530	0.64
63_V	104_R	0.529	0.64
25_A	34_V	0.524	0.63
27_D	219_S	0.522	0.63
119_G	125_L	0.522	0.63
59_L	147_V	0.521	0.62
21_T	213_G	0.521	0.62
235_F	238_V	0.521	0.62
8_R	12_N	0.521	0.62
155_R	187_P	0.519	0.62
25_A	42_I	0.518	0.62
10_A	13_T	0.516	0.62
51_A	219_S	0.515	0.61
61_V	65_E	0.511	0.61
10_A	215_V	0.509	0.61
25_A	31_A	0.509	0.61
218_I	224_M	0.506	0.60
202_T	212_D	0.504	0.60
26_Y	219_S	0.503	0.60
36_D	247_D	0.503	0.60
99_V	125_L	0.502	0.60
100_R	103_G	0.502	0.60
42_I	246_V	0.501	0.59
94_D	97_E	0.501	0.59
36_D	239_N	0.501	0.59
236_G	239_N	0.501	0.59
81_V	179_F	0.500	0.59
235_F	241_E	0.500	0.59

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1o66A	3	0.9088	100	0.247	Contact Map
1oy0A	4	0.9015	100	0.251	Contact Map
1m3uA	4	0.9526	100	0.252	Contact Map
3vavA	4	0.9562	100	0.267	Contact Map
4lsbA	2	0.8978	100	0.551	Contact Map
4mg4A	4	0.865	100	0.606	Contact Map
2qiwA	2	0.8577	100	0.631	Contact Map
3lyeA	4	0.8869	100	0.633	Contact Map
3eooA	4	0.8978	100	0.644	Contact Map
1xg4A	4	0.9015	100	0.645	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0091 seconds.