GREMLIN Database
PANB - 3-methyl-2-oxobutanoate hydroxymethyltransferase
UniProt: Q9HPT6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 274 (261)
Sequences: 3104 (1870)
Seq/√Len: 115.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
19_P256_G3.3981.00
89_L103_G3.0841.00
237_D240_R2.9291.00
192_A196_D2.8671.00
126_T173_H2.7901.00
70_T84_A2.7461.00
192_A210_D2.6661.00
235_F252_A2.6201.00
63_V101_N2.5661.00
22_M215_V2.5531.00
174_E199_D2.4331.00
171_R197_A2.2961.00
49_G61_V2.2261.00
104_R108_E2.1781.00
97_E100_R2.1751.00
174_E198_I2.1531.00
53_L68_S2.1061.00
137_M180_A2.0961.00
63_V90_S2.0811.00
241_E244_A2.0641.00
18_D254_E2.0631.00
14_D212_D2.0171.00
21_T250_V1.9951.00
233_K263_H1.9861.00
233_K252_A1.9831.00
93_A100_R1.9771.00
195_T202_T1.9651.00
39_V250_V1.9331.00
12_N16_E1.9331.00
164_E168_D1.9261.00
250_V254_E1.8901.00
127_E131_S1.8661.00
193_D197_A1.8621.00
120_P168_D1.8481.00
65_E71_G1.8251.00
188_A264_S1.7841.00
74_A82_V1.7701.00
251_D255_S1.7701.00
236_G241_E1.7571.00
13_T20_V1.7381.00
244_A248_D1.7211.00
63_V105_M1.7171.00
165_R169_L1.6881.00
137_M179_F1.6701.00
34_V42_I1.6631.00
70_T111_A1.6561.00
34_V246_V1.6421.00
86_M101_N1.6381.00
84_A105_M1.6331.00
93_A97_E1.6101.00
35_D80_A1.5981.00
159_D162_S1.5921.00
57_T60_P1.5431.00
53_L72_A1.5351.00
138_A173_H1.5221.00
70_T109_E1.5111.00
228_S234_Q1.5111.00
41_M215_V1.5031.00
260_A263_H1.4941.00
171_R174_E1.4891.00
42_I77_T1.4871.00
178_A200_I1.4821.00
209_P264_S1.4801.00
105_M109_E1.4781.00
30_T218_I1.4711.00
167_L193_D1.4701.00
98_S125_L1.4581.00
156_Q162_S1.4551.00
252_A257_S1.4501.00
240_R244_A1.4151.00
36_D243_A1.4021.00
234_Q237_D1.4001.00
138_A178_A1.3801.00
10_A41_M1.3581.00
181_L198_I1.3481.00
64_D104_R1.3431.00
86_M102_A1.3321.00
22_M41_M1.3291.00
41_M137_M1.3271.00
173_H178_A1.3151.00
113_A179_F1.3111.00
174_E200_I1.3001.00
222_I242_M1.2750.99
140_L183_L1.2730.99
143_T150_L1.2690.99
84_A109_E1.2660.99
23_L221_V1.2650.99
95_E125_L1.2640.99
35_D79_D1.2620.99
128_T132_L1.2480.99
112_D148_N1.2380.99
138_A182_V1.2360.99
140_L166_M1.2340.99
181_L202_T1.2180.99
67_A105_M1.2170.99
11_G15_E1.2160.99
171_R198_I1.2130.99
160_Q164_E1.2040.99
71_G75_R1.2040.99
34_V218_I1.1940.99
120_P169_L1.1910.99
127_E175_A1.1790.99
83_V182_V1.1790.99
20_V213_G1.1660.99
49_G55_Y1.1650.99
5_N40_D1.1550.99
93_A96_T1.1500.99
13_T18_D1.1440.99
84_A111_A1.1300.99
188_A210_D1.1210.99
183_L186_V1.1200.99
32_S226_E1.1170.99
77_T82_V1.1170.99
121_H165_R1.1160.99
91_F116_L1.1160.99
202_T211_T1.1050.98
97_E101_N1.1010.98
130_T178_A1.0990.98
218_I222_I1.0980.98
95_E128_T1.0960.98
247_D251_D1.0960.98
124_S127_E1.0950.98
21_T254_E1.0930.98
55_Y60_P1.0880.98
243_A247_D1.0860.98
55_Y75_R1.0850.98
181_L200_I1.0850.98
99_V128_T1.0770.98
35_D78_A1.0720.98
83_V137_M1.0680.98
195_T211_T1.0530.98
83_V113_A1.0430.98
41_M83_V1.0320.98
260_A264_S1.0300.98
222_I238_V1.0240.97
185_H265_H1.0240.97
157_G194_I1.0150.97
8_R154_F1.0030.97
188_A209_P0.9970.97
55_Y65_E0.9900.97
48_V69_A0.9880.97
21_T39_V0.9870.97
163_A190_V0.9830.97
9_R12_N0.9800.97
142_L185_H0.9760.97
52_K219_S0.9680.96
86_M90_S0.9610.96
99_V129_L0.9580.96
33_V246_V0.9530.96
168_D172_D0.9500.96
121_H131_S0.9500.96
209_P256_G0.9500.96
5_N9_R0.9480.96
29_P224_M0.9480.96
248_D251_D0.9430.96
49_G65_E0.9430.96
191_A211_T0.9370.96
65_E68_S0.9370.96
123_V169_L0.9340.96
169_L172_D0.9330.96
248_D252_A0.9290.95
91_F98_S0.9290.95
74_A77_T0.9270.95
29_P52_K0.9240.95
193_D196_D0.9210.95
195_T212_D0.9190.95
123_V172_D0.9190.95
96_T100_R0.8960.95
106_L135_P0.8910.94
122_T125_L0.8880.94
239_N243_A0.8880.94
64_D67_A0.8820.94
183_L194_I0.8790.94
244_A247_D0.8690.94
130_T179_F0.8690.94
150_L185_H0.8690.94
20_V40_D0.8690.94
238_V242_M0.8670.93
81_V113_A0.8630.93
23_L34_V0.8620.93
99_V132_L0.8610.93
60_P107_K0.8570.93
120_P172_D0.8520.93
74_A110_D0.8520.93
23_L39_V0.8480.93
63_V66_I0.8470.93
162_S165_R0.8450.93
167_L197_A0.8390.92
32_S36_D0.8390.92
182_V200_I0.8380.92
92_G107_K0.8370.92
48_V61_V0.8350.92
67_A109_E0.8350.92
164_E193_D0.8340.92
40_D254_E0.8270.92
167_L171_R0.8250.92
187_P207_A0.8160.91
29_P219_S0.8120.91
216_L231_F0.8120.91
120_P165_R0.8110.91
95_E124_S0.8110.91
235_F245_A0.8100.91
119_G123_V0.8080.91
82_V112_D0.8060.91
68_S72_A0.8060.91
157_G166_M0.8050.91
53_L65_E0.8010.90
236_G245_A0.7960.90
113_A137_M0.7950.90
5_N79_D0.7920.90
42_I82_V0.7910.90
48_V53_L0.7850.90
62_S65_E0.7850.90
71_G74_A0.7790.89
30_T219_S0.7790.89
13_T254_E0.7780.89
20_V41_M0.7750.89
238_V241_E0.7750.89
37_A243_A0.7680.89
155_R265_H0.7640.88
155_R230_P0.7640.88
99_V103_G0.7600.88
90_S107_K0.7570.88
40_D213_G0.7510.87
231_F263_H0.7510.87
33_V239_N0.7470.87
74_A112_D0.7420.87
237_D241_E0.7410.87
35_D77_T0.7400.87
252_A255_S0.7400.87
28_A32_S0.7380.87
23_L246_V0.7370.86
187_P190_V0.7350.86
60_P110_D0.7350.86
173_H181_L0.7340.86
92_G98_S0.7320.86
235_F257_S0.7320.86
147_V152_G0.7280.86
185_H230_P0.7270.86
218_I246_V0.7270.86
32_S239_N0.7250.86
21_T40_D0.7250.86
66_I84_A0.7240.85
67_A104_R0.7210.85
30_T242_M0.7190.85
96_T128_T0.7110.84
150_L156_Q0.7050.84
172_D175_A0.7040.84
178_A181_L0.7040.84
63_V67_A0.7040.84
232_S265_H0.7010.84
67_A108_E0.7000.83
74_A109_E0.6850.82
163_A193_D0.6840.82
185_H225_S0.6830.82
125_L128_T0.6820.82
59_L151_G0.6810.82
196_D210_D0.6800.82
50_N229_P0.6790.82
10_A179_F0.6770.81
13_T40_D0.6750.81
23_L218_I0.6750.81
5_N10_A0.6750.81
171_R175_A0.6730.81
94_D125_L0.6720.81
59_L107_K0.6700.81
89_L99_V0.6670.80
168_D171_R0.6660.80
142_L153_Y0.6660.80
138_A181_L0.6640.80
48_V68_S0.6640.80
103_G107_K0.6610.80
11_G199_D0.6570.79
233_K260_A0.6520.79
91_F101_N0.6510.79
219_S224_M0.6500.79
86_M91_F0.6500.79
114_V136_V0.6460.78
49_G62_S0.6450.78
95_E98_S0.6450.78
155_R185_H0.6430.78
120_P123_V0.6420.78
183_L202_T0.6410.78
7_V179_F0.6400.78
130_T149_Q0.6390.78
140_L181_L0.6380.77
223_G228_S0.6380.77
229_P232_S0.6380.77
103_G134_I0.6350.77
22_M31_A0.6330.77
233_K257_S0.6320.77
26_Y52_K0.6310.77
14_D19_P0.6300.77
86_M105_M0.6290.76
172_D176_A0.6270.76
198_I202_T0.6260.76
188_A261_A0.6250.76
67_A70_T0.6230.76
71_G109_E0.6230.76
41_M81_V0.6210.76
30_T222_I0.6200.75
116_L129_L0.6180.75
223_G234_Q0.6160.75
27_D30_T0.6160.75
125_L129_L0.6150.75
74_A78_A0.6110.74
118_S169_L0.6090.74
13_T16_E0.6090.74
56_D60_P0.5980.73
258_F265_H0.5970.73
194_I197_A0.5960.73
171_R199_D0.5960.73
95_E99_V0.5950.72
261_A264_S0.5940.72
31_A42_I0.5940.72
166_M190_V0.5920.72
183_L191_A0.5920.72
6_S142_L0.5920.72
37_A247_D0.5890.72
242_M246_V0.5880.72
67_A71_G0.5880.72
120_P175_A0.5870.71
163_A187_P0.5850.71
130_T176_A0.5830.71
7_V11_G0.5820.71
41_M180_A0.5810.71
149_Q179_F0.5800.71
203_I213_G0.5780.70
153_Y185_H0.5770.70
182_V198_I0.5750.70
124_S131_S0.5750.70
116_L122_T0.5740.70
31_A77_T0.5730.70
73_V82_V0.5700.69
52_K72_A0.5690.69
102_A134_I0.5680.69
59_L146_H0.5650.69
83_V180_A0.5650.69
147_V153_Y0.5630.68
140_L157_G0.5630.68
123_V176_A0.5630.68
126_T138_A0.5630.68
152_G156_Q0.5620.68
101_N105_M0.5620.68
153_Y229_P0.5620.68
133_G149_Q0.5620.68
143_T146_H0.5610.68
126_T178_A0.5590.68
20_V203_I0.5580.68
25_A44_V0.5580.68
225_S228_S0.5580.68
129_L132_L0.5570.67
186_V202_T0.5570.67
156_Q265_H0.5560.67
221_V232_S0.5560.67
9_R13_T0.5530.67
28_A76_A0.5500.66
205_I215_V0.5480.66
106_L129_L0.5460.66
195_T210_D0.5410.65
12_N15_E0.5330.64
22_M83_V0.5330.64
57_T110_D0.5310.64
88_F133_G0.5300.64
209_P261_A0.5300.64
63_V104_R0.5290.64
25_A34_V0.5240.63
27_D219_S0.5220.63
119_G125_L0.5220.63
59_L147_V0.5210.62
21_T213_G0.5210.62
235_F238_V0.5210.62
8_R12_N0.5210.62
155_R187_P0.5190.62
25_A42_I0.5180.62
10_A13_T0.5160.62
51_A219_S0.5150.61
61_V65_E0.5110.61
10_A215_V0.5090.61
25_A31_A0.5090.61
218_I224_M0.5060.60
202_T212_D0.5040.60
26_Y219_S0.5030.60
36_D247_D0.5030.60
99_V125_L0.5020.60
100_R103_G0.5020.60
42_I246_V0.5010.59
94_D97_E0.5010.59
36_D239_N0.5010.59
236_G239_N0.5010.59
81_V179_F0.5000.59
235_F241_E0.5000.59
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1o66A 3 0.9088 100 0.247 Contact Map
1oy0A 4 0.9015 100 0.251 Contact Map
1m3uA 4 0.9526 100 0.252 Contact Map
3vavA 4 0.9562 100 0.267 Contact Map
4lsbA 2 0.8978 100 0.551 Contact Map
4mg4A 4 0.865 100 0.606 Contact Map
2qiwA 2 0.8577 100 0.631 Contact Map
3lyeA 4 0.8869 100 0.633 Contact Map
3eooA 4 0.8978 100 0.644 Contact Map
1xg4A 4 0.9015 100 0.645 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.009 seconds.