GREMLIN Database
Q9HPT3 - Serine acetyltransferase
UniProt: Q9HPT3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 171 (143)
Sequences: 6730 (4211)
Seq/√Len: 352.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
121_R140_A3.3341.00
141_N157_G3.2081.00
77_R97_D3.0151.00
76_R96_D2.8941.00
123_G141_N2.8911.00
86_V92_A2.7301.00
140_A156_A2.5151.00
73_D93_V2.4761.00
106_L118_P2.4301.00
122_A140_A2.4211.00
154_V160_V2.3091.00
97_D123_G2.1801.00
160_V165_A2.1071.00
145_G161_T2.0861.00
133_L146_A2.0291.00
161_T168_V2.0091.00
142_A158_A2.0051.00
95_G122_A1.9631.00
120_V126_L1.9271.00
121_R137_E1.8671.00
75_G96_D1.8431.00
142_A156_A1.7901.00
96_D122_A1.7281.00
93_V119_T1.7041.00
83_G103_G1.6961.00
106_L120_V1.5831.00
136_I153_D1.5821.00
107_G128_A1.5651.00
142_A154_V1.5621.00
49_W53_G1.4881.00
131_T147_A1.4851.00
74_I78_V1.4841.00
119_T137_E1.4841.00
148_S165_A1.4291.00
158_A167_R1.4281.00
155_A167_R1.4031.00
160_V167_R1.4011.00
137_E153_D1.3991.00
98_V122_A1.3841.00
78_V122_A1.3671.00
126_L130_A1.3431.00
42_A46_Y1.3361.00
126_L132_L1.3241.00
44_P48_R1.3211.00
95_G121_R1.2701.00
41_L46_Y1.2611.00
105_T129_N1.2331.00
100_M106_L1.2271.00
43_G46_Y1.1971.00
155_A158_A1.1871.00
121_R156_A1.1801.00
89_G115_D1.1761.00
103_G129_N1.1751.00
143_S159_T1.1541.00
73_D91_T1.1401.00
32_L36_W1.1281.00
100_M126_L1.1141.00
85_G103_G1.0951.00
139_G156_A1.0811.00
78_V96_D1.0781.00
94_V120_V1.0601.00
78_V98_V1.0571.00
100_M104_V1.0541.00
58_Y73_D1.0481.00
42_A45_L1.0301.00
42_A48_R1.0281.00
94_V100_M1.0251.00
34_A38_H1.0131.00
80_I100_M1.0081.00
98_V120_V0.9991.00
138_I144_V0.9941.00
74_I94_V0.9831.00
35_V39_V0.9801.00
144_V154_V0.9791.00
124_V142_A0.9771.00
98_V140_A0.9621.00
105_T128_A0.9481.00
140_A157_G0.9461.00
149_V163_V0.9391.00
50_P53_G0.9301.00
66_I83_G0.9271.00
97_D122_A0.9271.00
123_G140_A0.9171.00
155_A160_V0.9161.00
90_E115_D0.9141.00
44_P47_D0.9101.00
131_T149_V0.9101.00
41_L45_L0.9081.00
138_I142_A0.9061.00
102_H128_A0.9021.00
39_V43_G0.8971.00
43_G47_D0.8881.00
129_N147_A0.8861.00
74_I80_I0.8741.00
104_V130_A0.8711.00
120_V124_V0.8671.00
80_I84_H0.8611.00
43_G48_R0.8531.00
118_P134_G0.8461.00
98_V124_V0.8391.00
110_D114_V0.8231.00
130_A148_S0.8231.00
158_A161_T0.8181.00
37_A60_V0.8181.00
161_T165_A0.8121.00
27_L51_T0.8111.00
147_A163_V0.8091.00
101_Y125_T0.8061.00
38_H42_A0.8061.00
59_W63_L0.7971.00
35_V38_H0.7961.00
94_V106_L0.7931.00
132_L136_I0.7921.00
41_L44_P0.7841.00
110_D116_R0.7811.00
33_H37_A0.7791.00
80_I86_V0.7611.00
51_T55_L0.7601.00
94_V98_V0.7581.00
79_T99_H0.7491.00
124_V156_A0.7431.00
144_V160_V0.7421.00
115_D119_T0.7391.00
78_V94_V0.7371.00
103_G131_T0.7361.00
39_V46_Y0.7331.00
105_T131_T0.7290.99
31_G35_V0.7280.99
61_R79_T0.7220.99
121_R142_A0.7220.99
131_T163_V0.7180.99
66_I72_A0.7120.99
78_V100_M0.7120.99
110_D134_G0.7100.99
65_G82_H0.7040.99
124_V140_A0.7010.99
133_L151_T0.6980.99
138_I154_V0.6830.99
120_V138_I0.6780.99
88_I92_A0.6770.99
39_V42_A0.6770.99
45_L48_R0.6760.99
29_Y32_L0.6680.99
30_P70_P0.6670.99
52_A56_V0.6620.99
71_D90_E0.6610.99
139_G155_A0.6590.99
161_T166_Q0.6470.99
159_T169_D0.6440.99
125_T143_S0.6430.99
93_V135_D0.6430.99
67_E89_G0.6330.99
136_I152_D0.6260.98
137_E156_A0.6240.98
26_A29_Y0.6200.98
31_G34_A0.6150.98
148_S163_V0.6130.98
107_G134_G0.6120.98
119_T135_D0.6070.98
76_R97_D0.6050.98
106_L132_L0.6040.98
104_V126_L0.6030.98
120_V132_L0.6010.98
90_E108_G0.5980.98
29_Y33_H0.5960.98
87_V102_H0.5950.98
36_W39_V0.5900.98
38_H57_A0.5880.98
138_I160_V0.5870.98
141_N156_A0.5830.98
145_G159_T0.5820.98
148_S162_G0.5810.98
95_G119_T0.5800.97
65_G83_G0.5760.97
33_H36_W0.5720.97
28_T51_T0.5720.97
34_A39_V0.5700.97
95_G140_A0.5690.97
93_V117_H0.5680.97
64_T72_A0.5680.97
28_T32_L0.5670.97
45_L49_W0.5670.97
116_R135_D0.5650.97
28_T31_G0.5640.97
147_A151_T0.5620.97
37_A56_V0.5610.97
126_L144_V0.5600.97
102_H105_T0.5590.97
109_N114_V0.5580.97
153_D160_V0.5520.97
60_V63_L0.5510.97
53_G56_V0.5490.97
37_A42_A0.5480.96
28_T55_L0.5460.96
74_I88_I0.5430.96
42_A47_D0.5420.96
121_R139_G0.5380.96
139_G142_A0.5370.96
162_G165_A0.5360.96
150_V162_G0.5360.96
159_T168_V0.5330.96
85_G102_H0.5330.96
41_L48_R0.5300.96
50_P54_R0.5280.96
77_R96_D0.5250.96
154_V165_A0.5230.95
81_D99_H0.5220.95
49_W52_A0.5210.95
91_T117_H0.5210.95
124_V144_V0.5110.95
66_I84_H0.5100.95
128_A131_T0.5070.95
72_A88_I0.5060.95
150_V165_A0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4n6aA 3 0.9825 100 0.264 Contact Map
4h7oA 6 1 100 0.293 Contact Map
1ssqA 6 1 100 0.302 Contact Map
3q1xA 3 0.9415 100 0.304 Contact Map
4hzdA 5 1 100 0.325 Contact Map
3f1xA 6 0.9415 100 0.325 Contact Map
3srtA 3 0.9708 100 0.343 Contact Map
2p2oA 3 0.9591 100 0.345 Contact Map
3hjjA 3 0.9708 100 0.346 Contact Map
3fttA 3 0.9649 100 0.353 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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