GREMLIN Database
Q9HPT2 - Acyl-CoA dehydrogenase
UniProt: Q9HPT2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 374 (363)
Sequences: 33999 (19410)
Seq/√Len: 1018.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
144_E213_R4.1531.00
148_N211_D3.8201.00
286_Q324_D3.4491.00
21_E42_D3.2861.00
140_R216_A2.9411.00
110_E115_R2.9391.00
189_T210_D2.9291.00
101_D105_E2.8301.00
63_D66_T2.7541.00
28_E32_T2.7161.00
141_D213_R2.6921.00
15_R73_Q2.6411.00
177_T219_Q2.6061.00
279_K328_E2.4421.00
258_A262_D2.3801.00
110_E116_P2.3671.00
150_K208_L2.2921.00
250_Q291_R2.2391.00
167_A179_F2.0501.00
222_E225_R2.0481.00
101_D104_Q2.0381.00
269_P272_E2.0321.00
16_E20_E2.0261.00
340_K345_E1.9991.00
141_D144_E1.9851.00
100_D103_Q1.9541.00
345_E349_R1.9051.00
260_A332_I1.9041.00
225_R228_S1.9031.00
163_V183_K1.8731.00
72_E291_R1.8601.00
54_P96_A1.8251.00
253_L287_V1.8151.00
299_R303_A1.8031.00
150_K206_S1.8001.00
41_D45_E1.7991.00
42_D45_E1.7931.00
145_F179_F1.7531.00
320_E361_S1.7501.00
76_Y254_D1.7421.00
146_V213_R1.6941.00
185_A212_C1.6911.00
264_E269_P1.6761.00
250_Q254_D1.6691.00
139_R148_N1.6671.00
73_Q76_Y1.6671.00
119_A163_V1.6601.00
275_T278_H1.6581.00
141_D146_V1.6421.00
255_A343_D1.6121.00
215_P218_N1.6101.00
189_T208_L1.5961.00
260_A276_I1.5961.00
106_R217_S1.5951.00
283_M325_V1.5911.00
146_V211_D1.5891.00
145_F216_A1.5791.00
157_G205_T1.5721.00
268_Q272_E1.5621.00
300_M310_A1.5601.00
106_R110_E1.5541.00
182_P218_N1.5511.00
55_A61_D1.5381.00
289_A317_F1.5331.00
296_D300_M1.5311.00
140_R223_A1.5211.00
8_R11_R1.5101.00
143_D216_A1.5061.00
170_D173_D1.4921.00
143_D213_R1.4911.00
105_E109_P1.4891.00
123_S153_W1.4851.00
148_N210_D1.4841.00
9_R12_E1.4801.00
12_E16_E1.4741.00
124_E151_K1.4691.00
158_K205_T1.4671.00
252_A326_T1.4641.00
336_Y342_F1.4631.00
110_E113_D1.4551.00
290_A318_A1.4541.00
265_Q273_I1.4521.00
216_A219_Q1.4501.00
191_G208_L1.4491.00
219_Q223_A1.4431.00
276_I332_I1.4381.00
191_G206_S1.4371.00
57_Y104_Q1.4331.00
255_A258_A1.4221.00
257_L261_D1.4021.00
102_D106_R1.3981.00
288_Q296_D1.3911.00
251_A255_A1.3891.00
324_D328_E1.3861.00
78_A81_V1.3831.00
323_V355_T1.3811.00
9_R13_S1.3721.00
76_Y250_Q1.3661.00
140_R144_E1.3651.00
138_A179_F1.3601.00
65_L299_R1.3591.00
18_A77_G1.3441.00
37_E41_D1.3391.00
98_F232_H1.3391.00
147_L179_F1.3371.00
283_M328_E1.3351.00
72_E250_Q1.3311.00
316_Y361_S1.3281.00
14_V48_V1.3221.00
327_N352_K1.3161.00
72_E295_R1.3131.00
11_R73_Q1.3131.00
195_D340_K1.3111.00
51_M70_V1.3021.00
103_Q107_W1.2921.00
64_S302_D1.2911.00
182_P185_A1.2901.00
214_I218_N1.2821.00
249_S287_V1.2691.00
102_D217_S1.2631.00
144_E216_A1.2591.00
111_M118_G1.2501.00
256_A329_A1.2491.00
109_P113_D1.2481.00
282_D365_K1.2461.00
121_A154_I1.2421.00
249_S325_V1.2321.00
104_Q108_L1.2151.00
183_K188_L1.2141.00
31_R195_D1.2131.00
140_R145_F1.2121.00
68_S298_A1.2091.00
8_R12_E1.2061.00
63_D302_D1.2041.00
322_A351_S1.2021.00
235_T308_Q1.1991.00
188_L212_C1.1881.00
42_D46_L1.1871.00
237_G358_E1.1871.00
296_D299_R1.1861.00
253_L257_L1.1861.00
41_D44_G1.1851.00
126_D135_S1.1831.00
268_Q273_I1.1791.00
106_R218_N1.1771.00
62_V66_T1.1771.00
25_V29_A1.1761.00
287_V325_V1.1751.00
327_N355_T1.1731.00
284_E288_Q1.1711.00
139_R146_V1.1671.00
243_S294_S1.1621.00
68_S243_S1.1611.00
166_F178_Q1.1601.00
53_T112_A1.1581.00
169_I177_T1.1561.00
251_A347_F1.1521.00
75_A82_A1.1501.00
29_A201_A1.1461.00
255_A333_H1.1441.00
323_V327_N1.1351.00
279_K362_E1.1331.00
11_R69_V1.1331.00
312_A364_Q1.1321.00
13_S46_L1.1311.00
116_P161_G1.1231.00
227_L231_L1.1221.00
329_A344_V1.1211.00
290_A321_A1.1131.00
107_W162_V1.1091.00
183_K190_V1.1081.00
352_K355_T1.1051.00
185_A218_N1.1041.00
300_M305_E1.0931.00
103_Q180_L1.0921.00
137_T148_N1.0881.00
286_Q328_E1.0741.00
121_A163_V1.0741.00
25_V28_E1.0701.00
145_F169_I1.0631.00
41_D115_R1.0611.00
99_G103_Q1.0541.00
136_T147_L1.0531.00
355_T361_S1.0501.00
118_G162_V1.0491.00
44_G49_T1.0471.00
165_V181_V1.0451.00
147_L165_V1.0421.00
246_V287_V1.0411.00
188_L207_L1.0291.00
286_Q321_A1.0261.00
166_F176_I1.0251.00
138_A167_A1.0241.00
187_G212_C1.0241.00
285_T313_K1.0221.00
56_S105_E1.0191.00
139_R211_D1.0161.00
97_E232_H1.0151.00
13_S48_V1.0121.00
91_A118_G1.0121.00
130_N133_Q1.0101.00
38_E41_D1.0051.00
102_D105_E1.0011.00
213_R216_A0.9981.00
320_E324_D0.9951.00
261_D271_S0.9941.00
14_V18_A0.9881.00
316_Y365_K0.9841.00
323_V348_Y0.9831.00
27_A31_R0.9831.00
165_V209_F0.9831.00
121_A209_F0.9791.00
326_T351_S0.9751.00
292_L296_D0.9731.00
145_F223_A0.9701.00
245_A354_T0.9591.00
260_A270_I0.9591.00
103_Q218_N0.9581.00
246_V294_S0.9571.00
199_L353_I0.9531.00
321_A324_D0.9531.00
17_F42_D0.9521.00
163_V188_L0.9471.00
257_L280_L0.9451.00
106_R182_P0.9431.00
282_D286_Q0.9401.00
163_V207_L0.9361.00
179_F219_Q0.9301.00
252_A347_F0.9281.00
91_A164_I0.9281.00
197_L348_Y0.9191.00
260_A271_S0.9141.00
157_G190_V0.9121.00
177_T223_A0.9101.00
153_W336_Y0.9091.00
98_F229_A0.9081.00
361_S365_K0.9071.00
147_L167_A0.9071.00
14_V70_V0.9071.00
320_E355_T0.9041.00
152_Q206_S0.9031.00
297_A314_A0.8941.00
319_S361_S0.8931.00
254_D258_A0.8911.00
53_T92_T0.8901.00
65_L302_D0.8831.00
31_R340_K0.8831.00
162_V182_P0.8751.00
320_E365_K0.8741.00
185_A188_L0.8711.00
353_I357_Y0.8711.00
139_R170_D0.8701.00
147_L214_I0.8691.00
186_D213_R0.8681.00
168_K176_I0.8681.00
330_V348_Y0.8681.00
286_Q317_F0.8671.00
168_K173_D0.8671.00
65_L69_V0.8671.00
30_D349_R0.8661.00
119_A183_K0.8621.00
170_D175_K0.8601.00
119_A160_S0.8591.00
284_E313_K0.8581.00
15_R19_V0.8581.00
122_L234_L0.8581.00
56_S101_D0.8541.00
37_E161_G0.8531.00
100_D104_Q0.8531.00
258_A261_D0.8501.00
17_F46_L0.8471.00
25_V38_E0.8421.00
153_W339_T0.8401.00
354_T357_Y0.8381.00
248_L322_A0.8361.00
323_V352_K0.8351.00
65_L295_R0.8341.00
248_L347_F0.8321.00
54_P57_Y0.8311.00
278_H366_E0.8291.00
129_S363_I0.8281.00
144_E215_P0.8251.00
121_A165_V0.8241.00
277_R366_E0.8241.00
198_G350_D0.8221.00
321_A325_V0.8221.00
142_G213_R0.8181.00
256_A332_I0.8181.00
18_A74_L0.8171.00
278_H282_D0.8171.00
52_T67_Y0.8131.00
116_P162_V0.8121.00
190_V207_L0.8111.00
326_T347_F0.8111.00
69_V73_Q0.8081.00
19_V76_Y0.8081.00
80_S201_A0.8081.00
209_F212_C0.8061.00
11_R15_R0.8011.00
17_F43_L0.8001.00
138_A145_F0.8001.00
256_A333_H0.7991.00
13_S16_E0.7991.00
43_L48_V0.7971.00
288_Q291_R0.7961.00
17_F21_E0.7951.00
164_I178_Q0.7941.00
260_A280_L0.7871.00
162_V180_L0.7851.00
145_F219_Q0.7841.00
197_L345_E0.7841.00
56_S59_G0.7801.00
39_V81_V0.7801.00
249_S321_A0.7791.00
179_F214_I0.7771.00
248_L351_S0.7751.00
288_Q292_L0.7741.00
38_E42_D0.7711.00
327_N348_Y0.7711.00
330_V344_V0.7701.00
27_A346_R0.7651.00
255_A347_F0.7641.00
282_D328_E0.7601.00
242_A314_A0.7591.00
241_I358_E0.7581.00
57_Y101_D0.7581.00
19_V77_G0.7571.00
246_V290_A0.7561.00
138_A169_I0.7561.00
307_H310_A0.7531.00
69_V295_R0.7531.00
326_T348_Y0.7521.00
283_M329_A0.7521.00
134_M166_F0.7511.00
317_F321_A0.7501.00
285_T317_F0.7491.00
253_L284_E0.7491.00
279_K332_I0.7491.00
121_A207_L0.7481.00
348_Y352_K0.7471.00
263_R266_F0.7451.00
161_G183_K0.7451.00
140_R143_D0.7441.00
252_A329_A0.7431.00
144_E217_S0.7391.00
256_A260_A0.7391.00
282_D324_D0.7391.00
259_Y336_Y0.7381.00
293_L314_A0.7321.00
134_M176_I0.7311.00
274_Q278_H0.7281.00
270_I273_I0.7281.00
199_L357_Y0.7271.00
250_Q284_E0.7261.00
366_E370_R0.7251.00
242_A294_S0.7231.00
177_T224_G0.7211.00
92_T111_M0.7211.00
161_G184_D0.7211.00
324_D327_N0.7211.00
177_T221_T0.7171.00
107_W180_L0.7171.00
346_R350_D0.7131.00
285_T316_Y0.7131.00
28_E31_R0.7091.00
219_Q222_E0.7071.00
136_T151_K0.7061.00
76_Y251_A0.7041.00
18_A22_I0.7021.00
170_D224_G0.6991.00
293_L313_K0.6991.00
158_K203_D0.6981.00
289_A293_L0.6981.00
11_R72_E0.6971.00
51_M62_V0.6961.00
225_R229_A0.6951.00
19_V23_R0.6951.00
169_I175_K0.6951.00
120_F230_A0.6941.00
56_S104_Q0.6911.00
99_G104_Q0.6901.00
147_L181_V0.6901.00
107_W218_N0.6891.00
140_R146_V0.6881.00
331_Q352_K0.6871.00
330_V337_G0.6831.00
184_D188_L0.6821.00
124_E136_T0.6811.00
195_D200_R0.6791.00
245_A319_S0.6791.00
168_K175_K0.6771.00
168_K171_G0.6771.00
364_Q367_V0.6761.00
322_A326_T0.6721.00
22_I39_V0.6691.00
134_M168_K0.6681.00
56_S61_D0.6681.00
273_I277_R0.6671.00
326_T344_V0.6641.00
200_R340_K0.6631.00
298_A302_D0.6541.00
122_L131_P0.6541.00
164_I220_L0.6541.00
111_M162_V0.6491.00
291_R295_R0.6491.00
277_R369_A0.6481.00
242_A318_A0.6461.00
53_T57_Y0.6441.00
107_W116_P0.6431.00
333_H344_V0.6421.00
166_F230_A0.6401.00
15_R76_Y0.6391.00
10_M70_V0.6381.00
360_T363_I0.6351.00
94_C233_I0.6321.00
39_V42_D0.6321.00
83_T199_L0.6301.00
286_Q289_A0.6291.00
10_M66_T0.6281.00
198_G338_Y0.6281.00
306_D310_A0.6271.00
23_R26_A0.6241.00
276_I280_L0.6231.00
293_L317_F0.6211.00
16_E19_V0.6211.00
137_T171_G0.6201.00
256_A283_M0.6191.00
294_S318_A0.6191.00
150_K191_G0.6161.00
249_S290_A0.6141.00
154_I207_L0.6131.00
313_K368_I0.6121.00
142_G146_V0.6061.00
136_T209_F0.6021.00
279_K331_Q0.6021.00
169_I223_A0.6021.00
125_P150_K0.6011.00
84_A87_V0.5991.00
279_K282_D0.5991.00
265_Q270_I0.5981.00
251_A254_D0.5971.00
239_I298_A0.5961.00
37_E159_R0.5951.00
316_Y368_I0.5911.00
235_T311_A0.5891.00
246_V250_Q0.5881.00
181_V209_F0.5851.00
286_Q320_E0.5841.00
30_D200_R0.5781.00
136_T149_G0.5771.00
243_S247_G0.5761.00
26_A346_R0.5761.00
249_S252_A0.5751.00
251_A343_D0.5751.00
54_P59_G0.5751.00
92_T108_L0.5741.00
96_A104_Q0.5741.00
67_Y240_G0.5741.00
179_F216_A0.5731.00
288_Q293_L0.5721.00
159_R203_D0.5711.00
27_A343_D0.5711.00
33_Q200_R0.5711.00
276_I279_K0.5681.00
290_A317_F0.5671.00
296_D310_A0.5641.00
37_E117_V0.5641.00
335_G338_Y0.5621.00
266_F273_I0.5621.00
165_V212_C0.5591.00
64_S301_A0.5591.00
285_T289_A0.5581.00
343_D347_F0.5571.00
343_D346_R0.5571.00
196_K204_T0.5561.00
352_K356_I0.5551.00
188_L209_F0.5551.00
15_R77_G0.5531.00
22_I81_V0.5531.00
33_Q195_D0.5531.00
50_A60_L0.5521.00
162_V218_N0.5521.00
43_L81_V0.5511.00
122_L166_F0.5511.00
141_D216_A0.5511.00
216_A223_A0.5501.00
106_R109_P0.5501.00
155_T204_T0.5501.00
222_E229_A0.5491.00
94_C98_F0.5481.00
293_L297_A0.5481.00
323_V351_S0.5461.00
250_Q287_V0.5461.00
57_Y109_P0.5451.00
239_I294_S0.5441.00
282_D320_E0.5441.00
84_A88_H0.5421.00
157_G207_L0.5411.00
179_F218_N0.5381.00
85_L89_C0.5361.00
290_A314_A0.5351.00
50_A112_A0.5341.00
234_L238_R0.5331.00
223_A226_G0.5321.00
319_S354_T0.5321.00
197_L349_R0.5311.00
270_I276_I0.5311.00
20_E24_P0.5311.00
136_T165_V0.5301.00
316_Y320_E0.5291.00
290_A325_V0.5291.00
363_I366_E0.5281.00
10_M14_V0.5271.00
48_V70_V0.5271.00
171_G174_D0.5261.00
273_I276_I0.5251.00
95_I99_G0.5241.00
91_A111_M0.5231.00
259_Y262_D0.5211.00
234_L237_G0.5201.00
283_M332_I0.5201.00
103_Q106_R0.5191.00
282_D285_T0.5181.00
264_E272_E0.5181.00
13_S60_L0.5171.00
259_Y342_F0.5171.00
228_S232_H0.5151.00
94_C229_A0.5151.00
29_A78_A0.5101.00
69_V72_E0.5091.00
193_K206_S0.5091.00
200_R350_D0.5091.00
29_A34_S0.5081.00
79_L248_L0.5071.00
91_A94_C0.5071.00
21_E24_P0.5071.00
184_D187_G0.5061.00
127_A135_S0.5041.00
181_V212_C0.5041.00
136_T167_A0.5021.00
119_A154_I0.5021.00
33_Q192_P0.5011.00
143_D217_S0.5001.00
169_I179_F0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2d29A 4 1 100 0.064 Contact Map
3nf4A 4 0.992 100 0.066 Contact Map
2jifA 4 0.9973 100 0.069 Contact Map
1rx0A 4 1 100 0.07 Contact Map
3pfdA 4 0.9813 100 0.071 Contact Map
1ivhA 4 1 100 0.071 Contact Map
2dvlA 4 0.9866 100 0.072 Contact Map
1ukwA 4 1 100 0.072 Contact Map
4l1fA 4 1 100 0.073 Contact Map
4p13A 4 1 100 0.074 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0118 seconds.