GREMLIN Database
Q9HPS8 - Uncharacterized protein
UniProt: Q9HPS8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 152 (135)
Sequences: 1249 (1048)
Seq/√Len: 90.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
27_S36_A3.5841.00
93_L132_Y3.5651.00
94_T133_E2.9081.00
28_L65_F2.7841.00
94_T135_D2.7731.00
25_V75_V2.6671.00
21_N41_Y2.5781.00
72_V134_C2.5181.00
49_T133_E2.5171.00
25_V77_S2.4721.00
25_V36_A2.4681.00
18_L76_V2.3991.00
28_L72_V2.2501.00
39_I52_L2.2491.00
54_L63_R2.2281.00
24_G74_L2.1241.00
95_E130_Q2.0051.00
93_L134_C1.9941.00
16_A20_R1.8481.00
72_V93_L1.7131.00
33_E71_A1.7101.00
61_E90_Q1.6971.00
63_R132_Y1.6951.00
23_T77_S1.6411.00
29_A69_S1.6331.00
78_E85_R1.5971.00
37_I88_V1.5641.00
41_Y76_V1.5611.00
13_E143_C1.4570.99
42_G112_A1.4460.99
11_R15_D1.4360.99
89_A139_I1.4260.99
101_M133_E1.4020.99
44_D108_Q1.3640.99
106_I129_I1.3510.99
81_P144_I1.3340.99
73_R88_V1.3180.99
90_Q138_T1.3110.99
50_V74_L1.3020.99
103_V107_E1.2730.99
52_L132_Y1.2720.99
42_G105_R1.2590.98
44_D104_E1.2420.98
50_V89_A1.2180.98
14_T87_V1.1980.98
70_P92_T1.1830.98
21_N76_V1.1820.98
117_F121_G1.1760.98
33_E61_E1.1670.97
50_V136_A1.1600.97
73_R90_Q1.1520.97
66_L93_L1.1420.97
22_E80_S1.1300.97
29_A33_E1.1150.97
63_R67_S1.1000.96
41_Y74_L1.0720.96
63_R130_Q1.0600.96
6_Q9_L1.0550.95
24_G89_A1.0540.95
92_T137_T1.0480.95
30_R33_E1.0420.95
15_D46_E1.0320.95
49_T135_D1.0310.95
36_A75_V1.0290.95
64_A67_S1.0010.94
33_E90_Q1.0010.94
95_E132_Y0.9950.94
15_D43_Y0.9950.94
29_A65_F0.9940.94
123_D126_D0.9900.94
30_R61_E0.9850.93
84_Y144_I0.9820.93
27_S88_V0.9740.93
91_G134_C0.9690.93
13_E85_R0.9550.92
65_F90_Q0.9530.92
42_G108_Q0.9360.92
41_Y113_K0.9360.92
71_A92_T0.9200.91
136_A139_I0.9170.91
67_S130_Q0.9150.91
38_P75_V0.9080.90
123_D127_L0.8890.89
107_E122_A0.8850.89
38_P88_V0.8840.89
61_E65_F0.8670.88
9_L143_C0.8630.88
101_M105_R0.8440.87
9_L17_V0.8310.86
85_R143_C0.8310.86
67_S95_E0.8220.85
33_E65_F0.8210.85
26_L39_I0.8130.85
54_L132_Y0.8100.84
53_R142_R0.8090.84
118_E122_A0.7960.83
111_D118_E0.7930.83
89_A136_A0.7900.83
8_E11_R0.7880.83
32_D71_A0.7810.82
110_G114_R0.7780.82
49_T136_A0.7770.82
77_S80_S0.7710.81
122_A126_D0.7700.81
102_T131_L0.7700.81
40_S80_S0.7660.81
14_T141_G0.7650.81
121_G126_D0.7620.81
35_Y61_E0.7520.80
16_A92_T0.7520.80
15_D19_A0.7490.80
52_L134_C0.7420.79
28_L134_C0.7360.78
13_E43_Y0.7340.78
12_A31_G0.7300.78
36_A77_S0.7280.78
74_L89_A0.7190.77
19_A43_Y0.7180.77
102_T106_I0.7180.77
40_S82_P0.7160.76
34_P91_G0.7150.76
10_S13_E0.7150.76
17_V85_R0.7030.75
66_L132_Y0.6930.74
105_R131_L0.6890.74
66_L95_E0.6880.74
106_I131_L0.6830.73
31_G68_S0.6770.72
30_R65_F0.6760.72
83_E144_I0.6740.72
57_T128_R0.6730.72
71_A137_T0.6670.71
29_A32_D0.6660.71
40_S113_K0.6630.71
104_E108_Q0.6610.71
82_P113_K0.6600.70
54_L130_Q0.6600.70
84_Y142_R0.6580.70
12_A16_A0.6580.70
124_K128_R0.6500.69
10_S14_T0.6460.69
100_E104_E0.6430.68
89_A134_C0.6400.68
16_A19_A0.6390.68
24_G76_V0.6380.68
36_A73_R0.6370.68
34_P69_S0.6320.67
28_L37_I0.6270.67
105_R109_F0.6270.67
70_P94_T0.6150.65
81_P84_Y0.6090.64
65_F141_G0.6070.64
51_F101_M0.5980.63
7_T10_S0.5980.63
14_T139_I0.5970.63
24_G112_A0.5960.63
7_T144_I0.5920.62
18_L74_L0.5910.62
42_G82_P0.5890.62
28_L66_L0.5890.62
108_Q111_D0.5880.62
33_E69_S0.5880.62
16_A135_D0.5840.61
33_E137_T0.5820.61
50_V141_G0.5820.61
7_T14_T0.5800.61
21_N78_E0.5780.60
40_S110_G0.5770.60
56_S128_R0.5740.60
107_E111_D0.5680.59
102_T130_Q0.5680.59
13_E16_A0.5660.59
44_D49_T0.5550.57
25_V88_V0.5520.57
60_S106_I0.5470.56
101_M104_E0.5430.56
20_R78_E0.5430.56
18_L43_Y0.5420.55
67_S135_D0.5390.55
120_W124_K0.5390.55
27_S141_G0.5370.55
17_V61_E0.5360.55
63_R95_E0.5350.54
18_L24_G0.5330.54
74_L136_A0.5310.54
42_G49_T0.5280.54
23_T80_S0.5270.53
17_V78_E0.5250.53
32_D104_E0.5170.52
45_A125_P0.5160.52
16_A57_T0.5160.52
103_V123_D0.5160.52
53_R60_S0.5150.52
40_S55_V0.5120.51
56_S130_Q0.5120.51
76_V136_A0.5100.51
99_D103_V0.5070.51
46_E104_E0.5070.51
60_S142_R0.5040.50
23_T36_A0.5040.50
52_L62_K0.5000.50
82_P142_R0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2htiA 2 0.8289 100 0.41 Contact Map
2ol5A 2 0.9276 100 0.413 Contact Map
2vpaA 2 0.9803 100 0.416 Contact Map
2furA 2 0.9408 100 0.419 Contact Map
2fg9A 4 0.9539 100 0.437 Contact Map
3fkhA 2 0.875 99.9 0.477 Contact Map
3cp3A 2 0.8224 99.9 0.483 Contact Map
3u5wA 2 0.8092 99.9 0.483 Contact Map
2hq9A 2 0.8618 99.9 0.49 Contact Map
1rfeA 1 0.9605 99.9 0.507 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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