GREMLIN Database
Q9HPS7 - Bacterio-opsin activator-like protein
UniProt: Q9HPS7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 215 (196)
Sequences: 1824 (1420)
Seq/√Len: 101.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
178_A183_L4.4621.00
172_F202_Q4.4571.00
165_T169_A4.0941.00
169_A183_L3.4161.00
190_A193_T3.4071.00
162_V187_L3.2851.00
87_L92_T3.0441.00
158_R197_H2.9771.00
193_T197_H2.9721.00
167_Y207_G2.8111.00
173_E177_G2.8101.00
169_A186_D2.7891.00
92_T110_G2.7711.00
179_T182_A2.7641.00
165_T183_L2.7241.00
178_A182_A2.6901.00
23_S102_G2.3671.00
158_R162_V2.3491.00
180_A194_F2.3111.00
47_F74_V2.2531.00
174_R195_T2.2281.00
10_S103_E2.2231.00
160_L164_T2.1001.00
158_R161_E2.0051.00
189_I194_F1.9481.00
197_H200_A1.8741.00
77_D132_I1.7721.00
162_V197_H1.7421.00
191_P195_T1.7411.00
180_A195_T1.7251.00
95_N109_H1.6511.00
183_L194_F1.6421.00
163_L206_L1.6391.00
176_R199_L1.5631.00
182_A185_D1.5271.00
169_A178_A1.5101.00
185_D188_G1.4971.00
63_V71_L1.4881.00
112_E115_T1.4731.00
54_V57_D1.4551.00
197_H204_K1.4321.00
170_G177_G1.4131.00
118_A121_G1.4091.00
167_Y210_L1.4021.00
206_L209_A1.3811.00
62_P72_Y1.3770.99
152_R209_A1.3750.99
178_A186_D1.3570.99
196_E200_A1.3560.99
174_R196_E1.3440.99
7_V116_V1.3250.99
162_V189_I1.3160.99
192_S196_E1.3100.99
10_S131_D1.3020.99
22_L26_A1.2900.99
163_L172_F1.2800.99
9_V108_F1.2660.99
184_A194_F1.2250.99
187_L194_F1.2230.99
50_D69_R1.2210.99
61_D178_A1.2130.99
18_P22_L1.2060.99
17_C23_S1.1990.99
33_V48_L1.1980.99
180_A197_H1.1950.99
110_G131_D1.1870.98
193_T196_E1.1590.98
205_L209_A1.1590.98
162_V183_L1.1490.98
10_S133_Q1.1480.98
120_V130_I1.1410.98
162_V201_A1.1400.98
22_L54_V1.1180.98
123_L128_A1.1180.98
171_Y176_R1.1100.98
37_I40_D1.0780.97
164_T168_E1.0770.97
203_R207_G1.0710.97
193_T198_L1.0710.97
17_C20_A1.0700.97
174_R192_S1.0570.97
155_L201_A1.0540.97
174_R199_L1.0440.97
9_V32_N1.0330.96
45_T76_H1.0330.96
32_N35_T1.0180.96
172_F198_L1.0120.96
59_D62_P1.0120.96
23_S103_E1.0080.96
181_Q191_P1.0050.96
96_R172_F0.9930.95
121_G125_A0.9920.95
115_T118_A0.9910.95
21_V26_A0.9880.95
167_Y172_F0.9840.95
193_T201_A0.9750.95
19_I22_L0.9660.95
8_T105_Q0.9650.95
132_I135_L0.9600.95
62_P70_H0.9570.94
162_V194_F0.9560.94
45_T48_L0.9520.94
9_V120_V0.9430.94
198_L202_Q0.9400.94
26_A52_D0.9300.94
172_F201_A0.9290.94
117_Q120_V0.9240.93
48_L69_R0.9170.93
62_P65_T0.9140.93
109_H172_F0.9130.93
131_D139_P0.9110.93
190_A199_L0.9090.93
85_V89_A0.9050.93
103_E149_F0.9030.93
154_Q208_D0.9020.93
180_A191_P0.8910.92
169_A194_F0.8840.92
15_P189_I0.8810.92
25_R210_L0.8750.91
63_V111_R0.8750.91
105_Q133_Q0.8710.91
94_V108_F0.8670.91
174_R181_Q0.8660.91
180_A193_T0.8610.91
174_R203_R0.8600.91
32_N47_F0.8580.91
206_L210_L0.8500.90
98_R105_Q0.8490.90
158_R196_E0.8450.90
14_P17_C0.8410.90
174_R197_H0.8400.90
165_T186_D0.8390.90
171_Y180_A0.8380.89
172_F180_A0.8340.89
22_L56_D0.8320.89
205_L208_D0.8290.89
111_R124_R0.8220.89
25_R53_A0.8070.88
97_Y106_I0.8070.88
45_T74_V0.8020.87
104_L107_V0.7970.87
183_L187_L0.7960.87
161_E164_T0.7900.87
173_E203_R0.7840.86
180_A201_A0.7720.85
7_V10_S0.7710.85
58_Y77_D0.7700.85
91_D112_E0.7680.85
191_P200_A0.7630.85
33_V71_L0.7600.84
30_I49_I0.7580.84
49_I70_H0.7530.84
181_Q199_L0.7530.84
135_L171_Y0.7520.84
76_H84_C0.7450.83
119_I196_E0.7380.83
9_V102_G0.7270.82
118_A177_G0.7250.81
92_T96_R0.7240.81
132_I189_I0.7230.81
90_H122_E0.7190.81
110_G172_F0.7030.79
135_L192_S0.7020.79
88_G183_L0.7000.79
53_A56_D0.7000.79
27_N52_D0.6990.79
91_D122_E0.6950.79
82_C85_V0.6940.79
67_T70_H0.6910.78
35_T161_E0.6890.78
56_D61_D0.6870.78
13_R104_L0.6810.77
30_I119_I0.6790.77
70_H73_R0.6730.76
81_A172_F0.6690.76
200_A203_R0.6640.75
44_V133_Q0.6630.75
178_A194_F0.6630.75
161_E165_T0.6620.75
56_D95_N0.6620.75
24_E112_E0.6600.75
134_R183_L0.6590.75
94_V118_A0.6580.75
116_V161_E0.6560.75
167_Y206_L0.6550.74
71_L200_A0.6550.74
58_Y61_D0.6500.74
37_I106_I0.6490.74
59_D118_A0.6480.74
189_I197_H0.6460.73
32_N109_H0.6430.73
131_D203_R0.6430.73
56_D87_L0.6420.73
99_A104_L0.6380.73
21_V24_E0.6350.72
170_G173_E0.6320.72
40_D43_P0.6300.72
201_A206_L0.6280.71
17_C83_P0.6230.71
69_R72_Y0.6230.71
32_N113_F0.6220.71
119_I191_P0.6200.70
137_R154_Q0.6180.70
44_V93_P0.6180.70
94_V152_R0.6160.70
28_T51_A0.6150.70
165_T187_L0.6130.70
57_D63_V0.6110.69
20_A23_S0.6090.69
86_C126_E0.6040.68
55_P58_Y0.6040.68
96_R187_L0.6030.68
19_I74_V0.6020.68
182_A187_L0.6010.68
96_R202_Q0.5990.68
128_A136_V0.5980.68
7_V135_L0.5980.68
18_P30_I0.5890.66
84_C194_F0.5890.66
95_N179_T0.5880.66
30_I200_A0.5880.66
124_R189_I0.5880.66
57_D62_P0.5880.66
24_E102_G0.5870.66
27_N127_F0.5870.66
175_P199_L0.5820.66
6_R136_V0.5810.65
9_V106_I0.5750.65
42_A53_A0.5740.64
49_I155_L0.5740.64
163_L210_L0.5730.64
69_R179_T0.5730.64
164_T210_L0.5720.64
113_F135_L0.5700.64
170_G195_T0.5690.64
44_V103_E0.5680.64
37_I43_P0.5670.64
20_A57_D0.5650.63
89_A169_A0.5650.63
112_E160_L0.5650.63
93_P109_H0.5590.62
120_V171_Y0.5580.62
26_A51_A0.5560.62
85_V91_D0.5560.62
33_V188_G0.5560.62
167_Y209_A0.5550.62
90_H156_T0.5540.62
156_T204_K0.5530.62
189_I192_S0.5520.61
66_Y209_A0.5520.61
28_T49_I0.5510.61
193_T200_A0.5490.61
159_Q204_K0.5470.61
63_V165_T0.5450.61
193_T209_A0.5450.61
24_E56_D0.5430.60
29_T161_E0.5430.60
69_R157_D0.5430.60
160_L209_A0.5410.60
141_G201_A0.5380.60
161_E194_F0.5370.59
44_V76_H0.5360.59
158_R202_Q0.5360.59
112_E148_A0.5340.59
13_R18_P0.5310.59
7_V113_F0.5310.59
176_R205_L0.5300.58
117_Q193_T0.5290.58
171_Y198_L0.5280.58
113_F190_A0.5270.58
32_N46_E0.5270.58
6_R202_Q0.5250.58
74_V154_Q0.5230.57
152_R160_L0.5200.57
44_V156_T0.5190.57
72_Y115_T0.5170.57
108_F204_K0.5150.56
23_S26_A0.5150.56
24_E31_T0.5130.56
153_G209_A0.5070.55
80_A172_F0.5070.55
13_R17_C0.5070.55
41_G123_L0.5060.55
124_R177_G0.5050.55
87_L106_I0.5050.55
58_Y133_Q0.5040.55
37_I84_C0.5040.55
172_F206_L0.5040.55
112_E149_F0.5030.55
113_F116_V0.5030.55
154_Q207_G0.5030.55
102_G125_A0.5030.55
77_D87_L0.5020.54
92_T97_Y0.5000.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ku3A 1 0.2837 97.6 0.838 Contact Map
1s7oA 3 0.3302 97.5 0.844 Contact Map
4wszA 2 0.2698 97.4 0.846 Contact Map
1je8A 2 0.2744 97.3 0.847 Contact Map
1xsvA 2 0.3256 97.3 0.849 Contact Map
3c57A 2 0.2326 97.2 0.85 Contact Map
2o8xA 7 0.2837 97.2 0.85 Contact Map
3hugA 3 0.3674 97.2 0.851 Contact Map
1x3uA 1 0.3209 97.1 0.852 Contact Map
3t72q 1 0.3302 97.1 0.854 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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