GREMLIN Database
Q9HPS6 - Uncharacterized protein
UniProt: Q9HPS6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 134 (105)
Sequences: 328 (256)
Seq/√Len: 24.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
46_T98_C3.2971.00
38_E70_K3.0891.00
71_I80_L3.0511.00
82_E94_S2.9721.00
51_L59_E2.8591.00
52_T93_V2.3930.98
39_C70_K2.3450.98
63_P70_K2.1680.97
42_I82_E2.0920.96
84_L87_R2.0660.96
63_P67_A1.9670.94
36_D74_L1.9200.94
32_D113_E1.8600.92
36_D92_H1.7140.89
102_D106_S1.7070.89
44_E86_I1.6610.87
85_R95_E1.6250.86
26_L29_R1.6170.86
47_D110_N1.6070.86
83_T95_E1.5880.85
65_S70_K1.5700.84
21_T105_L1.5110.82
67_A70_K1.5000.81
63_P77_A1.4970.81
39_C63_P1.4640.80
71_I75_T1.4540.79
70_K93_V1.4400.78
62_L67_A1.4390.78
75_T80_L1.4250.78
108_S113_E1.4110.77
43_L111_G1.4070.77
28_Q103_V1.4010.77
33_A52_T1.3850.76
87_R91_K1.3100.71
33_A39_C1.2570.68
25_E58_D1.2450.67
46_T95_E1.2220.66
57_A64_S1.2170.66
72_D101_D1.2130.65
30_I116_L1.1620.62
42_I60_C1.1590.62
38_E62_L1.1440.61
26_L106_S1.1330.60
104_T121_T1.1280.60
66_T101_D1.1230.59
67_A111_G1.0870.57
63_P93_V1.0840.57
31_L118_C1.0680.55
86_I123_A1.0260.52
79_L96_Y1.0060.51
78_G110_N1.0010.51
65_S96_Y0.9900.50
53_A94_S0.9860.50
46_T71_I0.9780.49
44_E112_V0.9670.48
35_D54_G0.9650.48
46_T80_L0.9440.46
43_L46_T0.9380.46
55_E101_D0.9320.46
54_G64_S0.9310.46
41_Q103_V0.9220.45
32_D35_D0.8990.43
99_T115_T0.8960.43
35_D42_I0.8930.43
71_I77_A0.8890.43
34_F96_Y0.8880.42
62_L117_S0.8790.42
44_E84_L0.8760.42
26_L30_I0.8700.41
25_E80_L0.8630.41
106_S110_N0.8630.41
37_A73_R0.8600.40
33_A70_K0.8390.39
44_E55_E0.8340.39
19_D22_A0.8250.38
22_A58_D0.8130.37
43_L91_K0.8110.37
66_T97_T0.8070.37
55_E99_T0.8040.37
48_D81_S0.8040.37
67_A123_A0.8010.36
33_A63_P0.7940.36
33_A91_K0.7880.36
22_A78_G0.7840.35
38_E63_P0.7820.35
75_T91_K0.7800.35
40_R79_L0.7610.34
31_L64_S0.7580.34
57_A62_L0.7560.33
35_D122_D0.7530.33
35_D94_S0.7400.32
51_L55_E0.7360.32
66_T69_R0.7340.32
30_I40_R0.7330.32
35_D91_K0.7240.31
41_Q54_G0.7170.31
81_S99_T0.7160.31
43_L56_I0.7090.31
65_S71_I0.7070.30
27_M115_T0.7070.30
34_F56_I0.6900.29
61_D111_G0.6830.29
43_L53_A0.6790.29
42_I68_Y0.6770.29
53_A67_A0.6740.28
64_S94_S0.6730.28
90_G93_V0.6670.28
49_A72_D0.6670.28
33_A62_L0.6630.28
62_L86_I0.6590.28
27_M105_L0.6530.27
44_E109_H0.6530.27
101_D114_A0.6430.27
64_S84_L0.6420.27
64_S97_T0.6390.26
25_E43_L0.6350.26
106_S115_T0.6260.26
64_S122_D0.6190.25
89_S92_H0.6140.25
46_T114_A0.6120.25
63_P86_I0.6100.25
63_P74_L0.6010.24
36_D107_V0.5990.24
63_P80_L0.5980.24
73_R102_D0.5980.24
58_D114_A0.5960.24
49_A118_C0.5950.24
107_V111_G0.5910.24
44_E95_E0.5820.23
84_L111_G0.5820.23
49_A113_E0.5780.23
64_S91_K0.5760.23
20_I99_T0.5750.23
60_C111_G0.5740.23
56_I67_A0.5720.23
89_S112_V0.5700.23
46_T50_A0.5690.23
37_A110_N0.5640.22
41_Q121_T0.5600.22
26_L89_S0.5560.22
31_L87_R0.5520.22
45_S51_L0.5480.22
60_C107_V0.5440.21
54_G77_A0.5360.21
81_S97_T0.5360.21
30_I77_A0.5350.21
41_Q102_D0.5320.21
105_L121_T0.5260.21
42_I46_T0.5260.21
73_R80_L0.5250.21
59_E116_L0.5240.20
47_D123_A0.5230.20
36_D39_C0.5150.20
48_D120_P0.5100.20
81_S92_H0.5100.20
21_T52_T0.5050.20
112_V116_L0.5020.19
94_S112_V0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4g6qA 4 0.8433 98.8 0.745 Contact Map
1q1hA 1 0.6119 98.7 0.755 Contact Map
3f6vA 2 0.6866 98.6 0.759 Contact Map
2qlzA 2 0.791 98.6 0.761 Contact Map
2p4wA 2 0.8209 98.4 0.775 Contact Map
2oqgA 4 0.7687 98.3 0.782 Contact Map
1yyvA 2 0.7687 98.3 0.784 Contact Map
3f6oA 2 0.7164 98.3 0.784 Contact Map
3pqkA 2 0.7164 98.2 0.785 Contact Map
1u2wA 2 0.806 98.2 0.787 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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