Q9HPS6 - HALSA - GREMLIN Contacts

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Q9HPS6 - Uncharacterized protein

UniProt:	Q9HPS6	Sequences: MSQSQLAAPSRTADDDDSDITATGELMQRILDAFDDAECRQILESTDDAALTAGEIADECDLPSSTAYRKIDRLTEAGLLSETLRIRRSGKHVSEYTCTVDDVTLSVSHNGVEATLSCTPTDAGTAGPAQPFAD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	134 (105)
Sequences:	328 (256)
Seq/√Len:	24.9

HALSA - Q9HPS6 Q9HMS0 Q9HQM0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
46_T	98_C	3.297	1.00
38_E	70_K	3.089	1.00
71_I	80_L	3.051	1.00
82_E	94_S	2.972	1.00
51_L	59_E	2.859	1.00
52_T	93_V	2.393	0.98
39_C	70_K	2.345	0.98
63_P	70_K	2.168	0.97
42_I	82_E	2.092	0.96
84_L	87_R	2.066	0.96
63_P	67_A	1.967	0.94
36_D	74_L	1.920	0.94
32_D	113_E	1.860	0.92
36_D	92_H	1.714	0.89
102_D	106_S	1.707	0.89
44_E	86_I	1.661	0.87
85_R	95_E	1.625	0.86
26_L	29_R	1.617	0.86
47_D	110_N	1.607	0.86
83_T	95_E	1.588	0.85
65_S	70_K	1.570	0.84
21_T	105_L	1.511	0.82
67_A	70_K	1.500	0.81
63_P	77_A	1.497	0.81
39_C	63_P	1.464	0.80
71_I	75_T	1.454	0.79
70_K	93_V	1.440	0.78
62_L	67_A	1.439	0.78
75_T	80_L	1.425	0.78
108_S	113_E	1.411	0.77
43_L	111_G	1.407	0.77
28_Q	103_V	1.401	0.77
33_A	52_T	1.385	0.76
87_R	91_K	1.310	0.71
33_A	39_C	1.257	0.68
25_E	58_D	1.245	0.67
46_T	95_E	1.222	0.66
57_A	64_S	1.217	0.66
72_D	101_D	1.213	0.65
30_I	116_L	1.162	0.62
42_I	60_C	1.159	0.62
38_E	62_L	1.144	0.61
26_L	106_S	1.133	0.60
104_T	121_T	1.128	0.60
66_T	101_D	1.123	0.59
67_A	111_G	1.087	0.57
63_P	93_V	1.084	0.57
31_L	118_C	1.068	0.55
86_I	123_A	1.026	0.52
79_L	96_Y	1.006	0.51
78_G	110_N	1.001	0.51
65_S	96_Y	0.990	0.50
53_A	94_S	0.986	0.50
46_T	71_I	0.978	0.49
44_E	112_V	0.967	0.48
35_D	54_G	0.965	0.48
46_T	80_L	0.944	0.46
43_L	46_T	0.938	0.46
55_E	101_D	0.932	0.46
54_G	64_S	0.931	0.46
41_Q	103_V	0.922	0.45
32_D	35_D	0.899	0.43
99_T	115_T	0.896	0.43
35_D	42_I	0.893	0.43
71_I	77_A	0.889	0.43
34_F	96_Y	0.888	0.42
62_L	117_S	0.879	0.42
44_E	84_L	0.876	0.42
26_L	30_I	0.870	0.41
25_E	80_L	0.863	0.41
106_S	110_N	0.863	0.41
37_A	73_R	0.860	0.40
33_A	70_K	0.839	0.39
44_E	55_E	0.834	0.39
19_D	22_A	0.825	0.38
22_A	58_D	0.813	0.37
43_L	91_K	0.811	0.37
66_T	97_T	0.807	0.37
55_E	99_T	0.804	0.37
48_D	81_S	0.804	0.37
67_A	123_A	0.801	0.36
33_A	63_P	0.794	0.36
33_A	91_K	0.788	0.36
22_A	78_G	0.784	0.35
38_E	63_P	0.782	0.35
75_T	91_K	0.780	0.35
40_R	79_L	0.761	0.34
31_L	64_S	0.758	0.34
57_A	62_L	0.756	0.33
35_D	122_D	0.753	0.33
35_D	94_S	0.740	0.32
51_L	55_E	0.736	0.32
66_T	69_R	0.734	0.32
30_I	40_R	0.733	0.32
35_D	91_K	0.724	0.31
41_Q	54_G	0.717	0.31
81_S	99_T	0.716	0.31
43_L	56_I	0.709	0.31
65_S	71_I	0.707	0.30
27_M	115_T	0.707	0.30
34_F	56_I	0.690	0.29
61_D	111_G	0.683	0.29
43_L	53_A	0.679	0.29
42_I	68_Y	0.677	0.29
53_A	67_A	0.674	0.28
64_S	94_S	0.673	0.28
90_G	93_V	0.667	0.28
49_A	72_D	0.667	0.28
33_A	62_L	0.663	0.28
62_L	86_I	0.659	0.28
27_M	105_L	0.653	0.27
44_E	109_H	0.653	0.27
101_D	114_A	0.643	0.27
64_S	84_L	0.642	0.27
64_S	97_T	0.639	0.26
25_E	43_L	0.635	0.26
106_S	115_T	0.626	0.26
64_S	122_D	0.619	0.25
89_S	92_H	0.614	0.25
46_T	114_A	0.612	0.25
63_P	86_I	0.610	0.25
63_P	74_L	0.601	0.24
36_D	107_V	0.599	0.24
63_P	80_L	0.598	0.24
73_R	102_D	0.598	0.24
58_D	114_A	0.596	0.24
49_A	118_C	0.595	0.24
107_V	111_G	0.591	0.24
44_E	95_E	0.582	0.23
84_L	111_G	0.582	0.23
49_A	113_E	0.578	0.23
64_S	91_K	0.576	0.23
20_I	99_T	0.575	0.23
60_C	111_G	0.574	0.23
56_I	67_A	0.572	0.23
89_S	112_V	0.570	0.23
46_T	50_A	0.569	0.23
37_A	110_N	0.564	0.22
41_Q	121_T	0.560	0.22
26_L	89_S	0.556	0.22
31_L	87_R	0.552	0.22
45_S	51_L	0.548	0.22
60_C	107_V	0.544	0.21
54_G	77_A	0.536	0.21
81_S	97_T	0.536	0.21
30_I	77_A	0.535	0.21
41_Q	102_D	0.532	0.21
105_L	121_T	0.526	0.21
42_I	46_T	0.526	0.21
73_R	80_L	0.525	0.21
59_E	116_L	0.524	0.20
47_D	123_A	0.523	0.20
36_D	39_C	0.515	0.20
48_D	120_P	0.510	0.20
81_S	92_H	0.510	0.20
21_T	52_T	0.505	0.20
112_V	116_L	0.502	0.19
94_S	112_V	0.500	0.19

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4g6qA	4	0.8433	98.8	0.745	Contact Map
1q1hA	1	0.6119	98.7	0.755	Contact Map
3f6vA	2	0.6866	98.6	0.759	Contact Map
2qlzA	2	0.791	98.6	0.761	Contact Map
2p4wA	2	0.8209	98.4	0.775	Contact Map
2oqgA	4	0.7687	98.3	0.782	Contact Map
1yyvA	2	0.7687	98.3	0.784	Contact Map
3f6oA	2	0.7164	98.3	0.784	Contact Map
3pqkA	2	0.7164	98.2	0.785	Contact Map
1u2wA	2	0.806	98.2	0.787	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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