GREMLIN Database
Q9HPS5 - Uncharacterized protein
UniProt: Q9HPS5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 189 (171)
Sequences: 437 (308)
Seq/√Len: 23.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
111_F117_V6.7561.00
143_V164_G5.7221.00
22_A26_V3.7721.00
73_I78_V3.3081.00
69_G85_M3.2171.00
118_Y123_L2.9741.00
116_A121_V2.8890.99
18_V22_A2.8600.99
79_A83_A2.5200.99
72_W84_A2.2510.97
147_A152_V2.2300.97
72_W80_K2.2050.97
70_W76_G2.1600.96
65_T91_L2.1050.95
113_T116_A2.0090.94
143_V167_A1.9540.93
164_G167_A1.9150.92
86_A148_G1.8580.91
137_I140_V1.7120.87
12_V23_S1.6940.87
131_G134_I1.6900.87
55_N175_F1.6540.85
30_A35_I1.6260.84
63_I176_A1.6120.84
92_F175_F1.5990.83
116_A120_F1.5840.83
67_L172_L1.5730.82
19_L23_S1.5550.82
109_T185_L1.5020.79
67_L71_R1.4480.77
23_S26_V1.4420.76
24_I27_V1.4240.75
65_T84_A1.4210.75
114_T117_V1.3950.74
16_A20_G1.3750.73
14_G18_V1.3690.73
124_P128_I1.3510.71
85_M147_A1.3350.71
16_A23_S1.3270.70
62_A137_I1.3120.69
69_G87_T1.3080.69
90_L176_A1.2790.67
48_I101_Y1.2780.67
24_I28_V1.2650.66
13_A150_R1.2580.66
146_L164_G1.2570.66
27_V30_A1.2340.64
25_A75_R1.2290.64
17_A20_G1.2270.64
169_S173_V1.2150.63
21_V25_A1.2150.63
93_V97_G1.2120.63
16_A30_A1.2080.63
12_V22_A1.2080.63
77_D80_K1.1940.62
11_H14_G1.1940.62
77_D153_S1.1780.61
117_V121_V1.1730.60
120_F124_P1.1620.60
142_Y147_A1.1600.59
136_C170_L1.1490.59
15_L19_L1.1490.59
92_F168_A1.1470.59
70_W74_R1.1420.58
17_A21_V1.1340.58
53_P57_V1.1210.57
54_L98_L1.1210.57
123_L127_I1.1040.56
142_Y145_L1.0910.55
134_I142_Y1.0580.52
117_V180_V1.0520.52
123_L185_L1.0480.52
111_F184_M1.0330.51
101_Y144_L1.0330.51
26_V29_A1.0300.50
125_V139_L1.0300.50
34_V40_L1.0280.50
139_L170_L1.0270.50
116_A128_I1.0270.50
111_F120_F1.0170.49
82_R86_A1.0140.49
148_G151_P1.0030.49
136_C164_G1.0020.48
102_R185_L0.9950.48
12_V16_A0.9940.48
70_W168_A0.9890.48
55_N98_L0.9890.48
85_M91_L0.9870.47
51_I102_R0.9860.47
18_V23_S0.9760.47
68_A90_L0.9760.47
145_L149_T0.9690.46
15_L22_A0.9650.46
62_A140_V0.9640.46
60_A179_I0.9630.46
45_A48_I0.9600.45
58_I98_L0.9560.45
28_V100_L0.9510.45
12_V19_L0.9460.45
46_W50_A0.9450.44
148_G163_V0.9370.44
102_R109_T0.9370.44
83_A87_T0.9290.43
20_G24_I0.9240.43
115_G124_P0.9230.43
18_V26_V0.9230.43
91_L175_F0.9160.42
59_S66_I0.9070.42
132_L165_R0.9060.42
86_A144_L0.8980.41
36_P40_L0.8860.40
12_V26_V0.8770.40
169_S174_S0.8760.40
52_P181_V0.8710.39
16_A22_A0.8670.39
112_P115_G0.8660.39
159_N162_R0.8640.39
60_A163_V0.8570.38
20_G94_A0.8440.38
67_L176_A0.8380.37
77_D83_A0.8320.37
65_T88_T0.8240.36
74_R78_V0.8220.36
136_C139_L0.8210.36
79_A162_R0.8210.36
134_I149_T0.8100.35
16_A26_V0.8040.35
127_I149_T0.8040.35
45_A111_F0.8030.35
173_V177_L0.8000.35
22_A27_V0.7960.34
63_I92_F0.7930.34
142_Y163_V0.7890.34
54_L58_I0.7870.34
69_G89_T0.7810.34
70_W128_I0.7740.33
16_A24_I0.7740.33
14_G17_A0.7740.33
28_V183_L0.7730.33
57_V88_T0.7720.33
75_R87_T0.7660.33
25_A135_A0.7620.32
83_A86_A0.7590.32
20_G27_V0.7590.32
32_R135_A0.7460.31
92_F138_P0.7410.31
73_I90_L0.7390.31
63_I172_L0.7320.31
109_T186_Y0.7280.30
74_R79_A0.7210.30
55_N133_A0.7200.30
11_H100_L0.7130.29
18_V21_V0.7090.29
171_W178_G0.7040.29
143_V146_L0.7030.29
110_A120_F0.7000.29
10_R22_A0.6980.29
71_R121_V0.6960.28
23_S30_A0.6930.28
110_A135_A0.6890.28
114_T123_L0.6870.28
68_A153_S0.6830.28
29_A100_L0.6820.28
73_I125_V0.6800.28
128_I177_L0.6790.27
53_P143_V0.6700.27
25_A78_V0.6670.27
77_D163_V0.6620.27
168_A172_L0.6550.26
63_I101_Y0.6540.26
147_A150_R0.6540.26
61_A65_T0.6510.26
89_T93_V0.6510.26
15_L23_S0.6510.26
153_S163_V0.6510.26
74_R118_Y0.6510.26
24_I31_V0.6500.26
18_V77_D0.6490.26
174_S177_L0.6470.26
121_V150_R0.6460.26
150_R166_V0.6420.25
22_A90_L0.6420.25
59_S141_Y0.6410.25
115_G127_I0.6380.25
175_F179_I0.6370.25
51_I98_L0.6370.25
127_I131_G0.6340.25
70_W78_V0.6320.25
152_V161_A0.6270.25
93_V144_L0.6270.25
108_T123_L0.6260.25
149_T153_S0.6250.25
108_T185_L0.6250.25
78_V89_T0.6220.24
29_A33_G0.6200.24
135_A170_L0.6180.24
125_V179_I0.6140.24
134_I159_N0.6130.24
13_A23_S0.6040.23
106_H133_A0.6020.23
142_Y151_P0.6020.23
91_L145_L0.5990.23
107_G180_V0.5970.23
56_A84_A0.5950.23
22_A25_A0.5930.23
86_A145_L0.5930.23
102_R105_V0.5880.23
54_L82_R0.5860.23
51_I59_S0.5860.23
85_M90_L0.5860.23
83_A116_A0.5760.22
69_G106_H0.5760.22
16_A25_A0.5760.22
54_L67_L0.5740.22
40_L133_A0.5690.22
27_V31_V0.5640.22
139_L177_L0.5630.21
12_V145_L0.5630.21
22_A32_R0.5600.21
53_P164_G0.5580.21
35_I123_L0.5540.21
64_G180_V0.5540.21
55_N63_I0.5530.21
139_L150_R0.5520.21
29_A32_R0.5510.21
90_L94_A0.5500.21
29_A57_V0.5500.21
14_G21_V0.5480.21
163_V167_A0.5470.21
31_V55_N0.5430.21
29_A36_P0.5420.20
58_I94_A0.5420.20
85_M92_F0.5410.20
46_W133_A0.5400.20
35_I60_A0.5390.20
33_G36_P0.5390.20
59_S92_F0.5370.20
169_S187_V0.5370.20
25_A28_V0.5370.20
88_T139_L0.5310.20
91_L140_V0.5260.20
48_I134_I0.5250.20
68_A116_A0.5240.20
76_G83_A0.5240.20
89_T140_V0.5240.20
161_A172_L0.5230.20
66_I179_I0.5190.19
64_G116_A0.5170.19
114_T120_F0.5160.19
30_A172_L0.5160.19
140_V168_A0.5120.19
84_A87_T0.5120.19
103_L108_T0.5080.19
128_I164_G0.5080.19
21_V131_G0.5030.19
30_A36_P0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1fftC 1 0.9101 94.6 0.912 Contact Map
1v54C 1 0.963 76.9 0.936 Contact Map
1qleC 1 0.963 76.2 0.936 Contact Map
1m56C 2 0.963 75.1 0.937 Contact Map
2yevA 1 0.9524 72.6 0.938 Contact Map
4n6hA 1 0.8466 31.2 0.952 Contact Map
2nwlA 3 0.4921 28.1 0.953 Contact Map
4o6yA 2 0.8783 25.8 0.954 Contact Map
4ev6A 3 0.3757 19.9 0.956 Contact Map
4ldeA 1 0.8201 17.7 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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