GREMLIN Database
Q9HPS4 - Amidophosphoribosyltransferase
UniProt: Q9HPS4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 490 (382)
Sequences: 6892 (3529)
Seq/√Len: 180.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
131_D171_R4.9541.00
135_S154_R4.3831.00
34_T85_A3.7721.00
296_V332_R3.0931.00
160_D163_D3.0061.00
364_Q377_T2.9731.00
244_A248_V2.9281.00
300_V310_G2.8861.00
188_G209_I2.8681.00
39_Y72_F2.8541.00
152_L168_T2.8371.00
155_N167_R2.8201.00
353_K376_G2.7111.00
165_V190_R2.6951.00
280_R284_R2.5861.00
393_E396_V2.5731.00
52_V59_Q2.5351.00
288_H314_A2.4101.00
281_N284_R2.3431.00
155_N171_R2.3421.00
148_I172_I2.2811.00
191_D209_I2.2701.00
64_G99_K2.2321.00
52_V61_Q2.2281.00
185_T188_G2.1751.00
200_L227_V2.1351.00
200_L233_I2.1341.00
65_M97_V2.1251.00
202_T222_D2.1221.00
188_G234_V2.1041.00
191_D233_I2.0741.00
148_I178_L2.0501.00
162_V243_S2.0301.00
137_H154_R2.0251.00
137_H150_H2.0041.00
137_H153_A1.9821.00
53_A82_G1.9691.00
209_I235_L1.9561.00
34_T87_G1.9491.00
64_G74_E1.9481.00
162_V234_V1.9311.00
236_D239_G1.9141.00
161_L190_R1.8991.00
161_L182_H1.8891.00
202_T224_V1.8661.00
21_V37_A1.8471.00
113_A184_D1.8451.00
296_V330_K1.7931.00
69_G73_D1.7921.00
130_A134_A1.7901.00
165_V180_I1.7691.00
358_K362_E1.7611.00
310_G339_I1.7501.00
52_V115_G1.7171.00
207_Y240_T1.7041.00
127_E173_H1.6831.00
203_V206_G1.6761.00
365_S393_E1.6621.00
269_V274_L1.6581.00
36_Y218_T1.6311.00
110_K137_H1.6101.00
107_V111_G1.6061.00
116_L149_A1.5901.00
152_L165_V1.5871.00
152_L180_I1.5811.00
84_A181_M1.5681.00
48_S102_A1.5621.00
113_A183_D1.5611.00
100_S142_D1.5601.00
155_N168_T1.5601.00
354_L357_I1.5501.00
110_K153_A1.5501.00
282_L402_Q1.5471.00
70_D73_D1.5391.00
200_L240_T1.5311.00
222_D254_A1.5131.00
293_E365_S1.5041.00
163_D166_E1.4941.00
227_V233_I1.4891.00
202_T207_Y1.4741.00
129_R133_A1.4701.00
182_H185_T1.4571.00
384_D388_D1.4401.00
200_L209_I1.4361.00
285_Q288_H1.4291.00
65_M98_D1.4111.00
117_S179_T1.4101.00
305_R393_E1.4011.00
330_K334_V1.4011.00
194_G230_G1.3921.00
55_D58_Q1.3901.00
338_F352_L1.3891.00
285_Q383_V1.3861.00
156_L159_A1.3831.00
114_L182_H1.3801.00
255_H259_E1.3751.00
59_Q115_G1.3741.00
295_D335_G1.3741.00
339_I404_Q1.3711.00
130_A133_A1.3631.00
281_N399_G1.3631.00
53_A85_A1.3621.00
179_T209_I1.3571.00
106_S115_G1.3451.00
207_Y239_G1.3411.00
284_R314_A1.3381.00
256_C259_E1.3381.00
336_R360_T1.3171.00
162_V232_A1.3171.00
69_G72_F1.3151.00
107_V137_H1.3151.00
26_S30_A1.3101.00
179_T189_V1.2881.00
63_V99_K1.2841.00
17_K20_V1.2731.00
162_V166_E1.2731.00
54_H181_M1.2651.00
31_A51_I1.2641.00
167_R170_E1.2631.00
169_M172_I1.2591.00
75_A79_A1.2531.00
307_F311_Y1.2511.00
199_V216_I1.2481.00
366_V374_V1.2461.00
210_A215_A1.2431.00
131_D135_S1.2421.00
129_R139_F1.2381.00
202_T240_T1.2301.00
216_I221_G1.2271.00
31_A82_G1.2241.00
35_Y51_I1.2241.00
350_V377_T1.2231.00
187_L237_D1.2111.00
188_G236_D1.2091.00
329_M360_T1.2011.00
23_A33_P1.2001.00
74_E99_K1.1971.00
22_G179_T1.1961.00
116_L145_T1.1951.00
73_D76_D1.1901.00
231_E252_T1.1871.00
126_D130_A1.1801.00
267_D276_Y1.1751.00
191_D200_L1.1741.00
213_S226_D1.1741.00
22_G209_I1.1621.00
292_V397_R1.1611.00
114_L156_L1.1591.00
346_R350_V1.1441.00
364_Q367_T1.1431.00
156_L182_H1.1411.00
199_V213_S1.1381.00
273_E278_V1.1351.00
25_L84_A1.1251.00
106_S112_G1.1241.00
277_E359_S1.1231.00
36_Y39_Y1.1131.00
28_R206_G1.1001.00
374_V380_S1.0931.00
155_N158_D1.0901.00
25_L237_D1.0861.00
336_R355_N1.0821.00
64_G71_A1.0791.00
29_D32_L1.0781.00
53_A80_L1.0771.00
114_L161_L1.0771.00
31_A53_A1.0731.00
23_A30_A1.0691.00
217_D355_N1.0691.00
131_D154_R1.0671.00
383_V399_G1.0641.00
207_Y235_L1.0571.00
18_C119_N1.0561.00
61_Q106_S1.0541.00
62_H79_A1.0441.00
223_V226_D1.0431.00
161_L165_V1.0411.00
163_D167_R1.0401.00
62_H74_E1.0371.00
23_A26_S1.0371.00
297_V330_K1.0371.00
280_R313_D1.0371.00
213_S223_V1.0361.00
164_A168_T1.0331.00
33_P219_I1.0331.00
361_V379_S1.0321.00
254_A257_F1.0321.00
278_V282_L1.0291.00
38_L87_G1.0271.00
236_D240_T1.0271.00
107_V153_A1.0250.99
187_L234_V1.0220.99
294_S367_T1.0170.99
21_V34_T1.0160.99
155_N164_A1.0110.99
338_F377_T1.0090.99
175_S195_N1.0090.99
125_A129_R1.0040.99
374_V382_L1.0020.99
322_V329_M1.0020.99
356_P378_T1.0000.99
168_T172_I1.0000.99
228_R231_E0.9980.99
268_S272_D0.9970.99
323_E350_V0.9970.99
340_M373_I0.9930.99
257_F261_V0.9920.99
369_I382_L0.9890.99
296_V366_V0.9840.99
284_R313_D0.9810.99
362_E377_T0.9800.99
291_G361_V0.9780.99
208_V216_I0.9750.99
209_I233_I0.9700.99
55_D60_H0.9700.99
19_G89_V0.9650.99
166_E232_A0.9600.99
118_H145_T0.9600.99
153_A157_L0.9550.99
200_L224_V0.9540.99
222_D256_C0.9540.99
129_R147_V0.9530.99
176_Y192_P0.9500.99
169_M192_P0.9460.99
158_D167_R0.9460.99
48_S65_M0.9440.99
234_V243_S0.9370.99
67_L264_A0.9370.99
204_E222_D0.9350.99
54_H84_A0.9320.99
254_A259_E0.9270.99
132_L151_D0.9250.99
298_V337_T0.9230.99
132_L139_F0.9230.99
122_L172_I0.9200.99
298_V335_G0.9170.99
113_A153_A0.9170.99
65_M99_K0.9170.99
116_L148_I0.9160.99
150_H153_A0.9110.99
367_T371_D0.9080.99
349_A353_K0.8960.99
156_L160_D0.8940.99
366_V369_I0.8900.99
406_P410_G0.8890.99
65_M96_S0.8870.99
185_T234_V0.8850.99
244_A247_L0.8850.99
58_Q183_D0.8840.98
364_Q373_I0.8820.98
207_Y238_D0.8780.98
252_T257_F0.8780.98
299_P322_V0.8760.98
364_Q368_I0.8740.98
200_L235_L0.8730.98
198_L227_V0.8720.98
269_V272_D0.8720.98
281_N285_Q0.8720.98
176_Y194_G0.8650.98
139_F147_V0.8620.98
133_A138_A0.8610.98
272_D276_Y0.8560.98
236_D243_S0.8550.98
123_V173_H0.8530.98
228_R246_Q0.8480.98
334_V360_T0.8470.98
224_V242_F0.8460.98
151_D172_I0.8440.98
343_Q347_E0.8430.98
301_P336_R0.8420.98
216_I223_V0.8420.98
96_S142_D0.8420.98
308_A311_Y0.8380.98
180_I190_R0.8370.98
390_G397_R0.8340.98
25_L30_A0.8320.98
247_L250_R0.8290.98
201_G220_G0.8280.98
361_V378_T0.8270.98
347_E377_T0.8260.98
105_F141_S0.8260.98
379_S396_V0.8250.98
179_T191_D0.8240.98
203_V207_Y0.8240.98
156_L184_D0.8240.98
177_S195_N0.8230.98
298_V327_G0.8180.98
224_V240_T0.8160.97
327_G354_L0.8160.97
156_L164_A0.8160.97
338_F355_N0.8150.97
295_D361_V0.8150.97
131_D134_A0.8120.97
243_S249_D0.8110.97
40_A218_T0.8110.97
21_V210_A0.8100.97
62_H76_D0.8090.97
63_V100_S0.8080.97
148_I168_T0.8070.97
185_T236_D0.8030.97
159_A167_R0.8030.97
344_E348_R0.8020.97
354_L358_K0.8010.97
337_T349_A0.7980.97
207_Y224_V0.7980.97
214_A217_D0.7960.97
166_E245_H0.7960.97
93_T119_N0.7920.97
338_F362_E0.7870.97
18_C93_T0.7860.97
86_I179_T0.7850.97
32_L36_Y0.7840.97
100_S140_T0.7830.97
178_L189_V0.7820.97
110_K150_H0.7780.97
35_Y72_F0.7740.97
166_E170_E0.7710.96
352_L373_I0.7680.96
291_G294_S0.7680.96
113_A182_H0.7670.96
94_A142_D0.7650.96
27_A237_D0.7620.96
250_R253_T0.7590.96
86_I181_M0.7580.96
188_G233_I0.7540.96
65_M70_D0.7540.96
29_D83_S0.7520.96
287_W314_A0.7520.96
122_L148_I0.7520.96
138_A150_H0.7510.96
83_S237_D0.7500.96
364_Q371_D0.7490.96
252_T259_E0.7480.96
226_D390_G0.7470.96
49_A89_V0.7430.96
208_V219_I0.7430.96
243_S246_Q0.7420.96
166_E243_S0.7420.96
299_P334_V0.7420.96
23_A206_G0.7410.96
365_S392_T0.7410.96
365_S371_D0.7400.96
231_E250_R0.7400.96
280_R325_A0.7390.95
381_Q403_I0.7390.95
64_G70_D0.7380.95
31_A80_L0.7330.95
30_A85_A0.7330.95
278_V398_I0.7320.95
298_V368_I0.7300.95
199_V223_V0.7280.95
84_A189_V0.7270.95
384_D387_R0.7240.95
190_R234_V0.7220.95
23_A208_V0.7200.95
364_Q369_I0.7190.95
92_P97_V0.7190.95
213_S217_D0.7190.95
189_V209_I0.7180.95
203_V208_V0.7180.95
257_F262_Y0.7120.94
34_T53_A0.7120.94
139_F151_D0.7120.94
53_A60_H0.7110.94
252_T255_H0.7110.94
299_P330_K0.7110.94
245_H248_V0.7100.94
115_G181_M0.7090.94
297_V334_V0.7090.94
167_R171_R0.7090.94
47_E92_P0.7070.94
96_S100_S0.7060.94
191_D227_V0.7030.94
353_K372_S0.7010.94
107_V113_A0.6980.94
107_V110_K0.6960.94
372_S376_G0.6950.94
29_D81_H0.6950.94
84_A187_L0.6940.94
296_V334_V0.6930.94
295_D334_V0.6930.94
305_R309_S0.6920.94
257_F260_Y0.6910.94
172_I176_Y0.6860.93
39_Y69_G0.6860.93
133_A136_G0.6850.93
127_E171_R0.6820.93
366_V386_V0.6820.93
19_G41_L0.6820.93
102_A164_A0.6810.93
231_E244_A0.6810.93
383_V400_A0.6800.93
345_A348_R0.6790.93
342_T345_A0.6770.93
305_R326_E0.6770.93
259_E262_Y0.6760.93
232_A243_S0.6750.93
166_E247_L0.6750.93
294_S332_R0.6710.93
291_G397_R0.6710.93
368_I396_V0.6700.92
94_A121_N0.6690.92
181_M189_V0.6690.92
300_V337_T0.6690.92
155_N159_A0.6690.92
165_V169_M0.6680.92
179_T235_L0.6650.92
365_S368_I0.6640.92
188_G191_D0.6610.92
19_G49_A0.6600.92
277_E281_N0.6570.92
39_Y68_V0.6540.92
169_M189_V0.6510.91
222_D252_T0.6500.91
368_I386_V0.6500.91
37_A208_V0.6500.91
200_L207_Y0.6490.91
94_A125_A0.6490.91
90_R93_T0.6490.91
20_V179_T0.6480.91
285_Q403_I0.6460.91
90_R95_G0.6430.91
338_F373_I0.6410.91
255_H271_D0.6390.91
112_G153_A0.6390.91
28_R33_P0.6390.91
340_M345_A0.6380.91
132_L136_G0.6370.91
33_P203_V0.6370.91
349_A372_S0.6340.90
304_G354_L0.6330.90
233_I240_T0.6310.90
55_D82_G0.6310.90
361_V386_V0.6310.90
193_R229_P0.6300.90
379_S382_L0.6290.90
274_L306_A0.6270.90
68_V87_G0.6250.90
312_A320_S0.6240.90
368_I371_D0.6240.90
385_L399_G0.6230.90
165_V168_T0.6230.90
301_P338_F0.6230.90
301_P322_V0.6230.90
235_L240_T0.6190.89
63_V106_S0.6170.89
255_H260_Y0.6160.89
274_L277_E0.6160.89
127_E130_A0.6160.89
182_H190_R0.6140.89
154_R158_D0.6120.89
367_T397_R0.6100.89
111_G157_L0.6100.89
93_T118_H0.6100.89
64_G68_V0.6080.88
139_F146_E0.6080.88
290_T293_E0.6080.88
270_I275_V0.6060.88
152_L164_A0.6060.88
302_D306_A0.6050.88
22_G186_V0.6040.88
366_V371_D0.6040.88
369_I374_V0.6020.88
185_T190_R0.5990.88
305_R324_F0.5960.87
370_D374_V0.5950.87
105_F143_G0.5950.87
34_T86_I0.5940.87
288_H384_D0.5930.87
227_V231_E0.5930.87
229_P353_K0.5920.87
276_Y306_A0.5910.87
399_G402_Q0.5900.87
154_R157_L0.5900.87
158_D163_D0.5900.87
150_H154_R0.5890.87
173_H194_G0.5890.87
124_N128_L0.5840.86
286_L402_Q0.5830.86
63_V66_G0.5830.86
307_F399_G0.5820.86
196_R346_R0.5820.86
302_D332_R0.5810.86
390_G396_V0.5800.86
27_A83_S0.5790.86
306_A309_S0.5790.86
282_L383_V0.5790.86
111_G153_A0.5740.85
273_E281_N0.5720.85
243_S247_L0.5710.85
73_D77_I0.5710.85
267_D272_D0.5700.85
88_H119_N0.5690.85
273_E277_E0.5640.84
162_V190_R0.5640.84
169_M176_Y0.5620.84
62_H78_D0.5590.84
188_G235_L0.5590.84
226_D271_D0.5580.84
107_V112_G0.5580.84
97_V101_C0.5560.84
43_H212_E0.5560.84
54_H57_F0.5560.84
365_S404_Q0.5520.83
165_V232_A0.5500.83
284_R288_H0.5500.83
363_G392_T0.5500.83
28_R208_V0.5490.83
324_F350_V0.5480.83
136_G139_F0.5480.83
255_H258_F0.5470.83
74_E78_D0.5450.82
243_S248_V0.5450.82
72_F76_D0.5430.82
61_Q115_G0.5420.82
290_T294_S0.5410.82
148_I180_I0.5410.82
71_A323_E0.5400.82
344_E347_E0.5400.82
226_D374_V0.5390.82
33_P208_V0.5390.82
21_V208_V0.5370.81
252_T256_C0.5370.81
95_G144_D0.5360.81
339_I374_V0.5360.81
370_D382_L0.5360.81
258_F261_V0.5350.81
25_L187_L0.5320.81
391_A394_V0.5320.81
217_D221_G0.5310.81
101_C142_D0.5310.81
263_F270_I0.5310.81
309_S312_A0.5310.81
227_V240_T0.5310.81
334_V339_I0.5310.81
294_S322_V0.5300.81
329_M334_V0.5300.81
38_L49_A0.5300.81
150_H155_N0.5280.80
131_D155_N0.5270.80
326_E354_L0.5260.80
299_P332_R0.5250.80
356_P376_G0.5250.80
23_A219_I0.5240.80
253_T257_F0.5230.80
254_A261_V0.5220.80
218_T221_G0.5220.80
99_K102_A0.5210.79
112_G140_T0.5200.79
101_C143_G0.5190.79
194_G229_P0.5190.79
294_S361_V0.5180.79
160_D188_G0.5170.79
141_S146_E0.5130.78
76_D79_A0.5130.78
40_A263_F0.5130.78
60_H81_H0.5130.78
175_S346_R0.5120.78
47_E341_P0.5120.78
203_V220_G0.5120.78
260_Y268_S0.5100.78
326_E332_R0.5080.78
179_T188_G0.5080.78
159_A163_D0.5070.78
93_T145_T0.5050.77
187_L236_D0.5050.77
340_M349_A0.5040.77
140_T150_H0.5040.77
95_G119_N0.5030.77
352_L355_N0.5020.77
175_S196_R0.5020.77
299_P336_R0.5010.77
366_V393_E0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ecfA 4 0.949 100 0.381 Contact Map
1ao0A 3 0.9184 100 0.394 Contact Map
4amvA 2 0.9347 100 0.502 Contact Map
1xffA 2 0.4776 100 0.66 Contact Map
1te5A 2 0.4408 100 0.694 Contact Map
3mdnA 4 0.4082 100 0.697 Contact Map
1ofdA 1 0.851 100 0.708 Contact Map
1ea0A 1 0.8653 100 0.713 Contact Map
4zflA 5 0.4245 100 0.729 Contact Map
1ct9A 2 0.8 100 0.733 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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