GREMLIN Database
Q9HPS1 - Endoglucanase
UniProt: Q9HPS1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 353 (332)
Sequences: 2598 (1694)
Seq/√Len: 93.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
143_G147_R4.7791.00
15_V28_V3.4941.00
169_R325_D3.1551.00
250_A253_D2.8061.00
331_A334_D2.7981.00
83_I136_V2.7951.00
18_P86_I2.7001.00
10_D14_A2.6561.00
140_A146_A2.5671.00
267_V308_A2.5471.00
186_E189_R2.5001.00
13_L172_A2.4981.00
102_E157_V2.4781.00
62_T205_T2.4391.00
278_A338_A2.4381.00
59_V340_A2.4021.00
76_T82_R2.4001.00
277_D342_H2.3311.00
30_V34_S2.2901.00
81_V101_I2.2821.00
58_A201_Y2.2291.00
30_V42_T2.1521.00
281_S331_A2.1471.00
67_E173_R2.0931.00
51_V199_T2.0901.00
273_D277_D2.0851.00
19_T86_I2.0741.00
110_G136_V2.0591.00
190_R337_A2.0451.00
271_L308_A2.0291.00
338_A341_A2.0181.00
330_A334_D2.0021.00
194_R341_A1.9891.00
271_L339_F1.9841.00
81_V156_G1.9821.00
144_D148_D1.9691.00
188_F202_A1.9411.00
21_H155_P1.9301.00
77_E143_G1.9241.00
29_W181_L1.9061.00
11_E32_Y1.9021.00
168_G327_A1.9001.00
255_P331_A1.8991.00
31_E34_S1.8951.00
144_D147_R1.8911.00
138_I150_V1.8841.00
11_E28_V1.8741.00
72_V156_G1.8481.00
51_V201_Y1.8031.00
223_D302_G1.7951.00
138_I146_A1.7691.00
53_E199_T1.7381.00
17_S25_A1.7231.00
220_F302_G1.7141.00
99_V136_V1.7071.00
101_I136_V1.7021.00
58_A199_T1.6941.00
63_G184_A1.6871.00
11_E31_E1.6701.00
39_R51_V1.6641.00
324_V329_L1.6381.00
179_T329_L1.6231.00
76_T80_F1.6171.00
115_A124_E1.6121.00
26_Q65_A1.5561.00
103_T106_G1.5281.00
30_V48_A1.5101.00
109_N163_R1.4921.00
37_A50_A1.4841.00
151_S154_D1.4711.00
62_T294_D1.4611.00
6_R164_E1.4601.00
60_A298_F1.4581.00
151_S276_A1.4501.00
47_N217_M1.4481.00
54_G199_T1.4471.00
61_F340_A1.4390.99
17_S178_R1.4330.99
216_R297_A1.4290.99
33_V185_A1.4040.99
274_A278_A1.4010.99
190_R334_D1.3970.99
40_V48_A1.3890.99
7_T10_D1.3870.99
83_I134_Q1.3870.99
270_A342_H1.3850.99
71_A84_A1.3840.99
89_L158_L1.3820.99
83_I156_G1.3760.99
32_Y35_Q1.3730.99
189_R193_E1.3670.99
181_L204_S1.3620.99
7_T11_E1.3590.99
32_Y189_R1.3570.99
164_E326_L1.3560.99
10_D162_P1.3490.99
208_E318_H1.3450.99
60_A218_V1.3450.99
75_I146_A1.3380.99
183_V332_G1.3060.99
272_R282_L1.3050.99
170_L175_L1.3010.99
60_A203_V1.2980.99
314_N317_M1.2930.99
72_V81_V1.2910.99
227_V298_F1.2840.99
147_R151_S1.2770.99
29_W204_S1.2730.99
29_W185_A1.2670.99
270_A339_F1.2540.99
168_G325_D1.2480.99
60_A224_V1.2470.99
27_R31_E1.2450.99
8_F28_V1.2420.98
18_P69_G1.2330.98
261_G296_D1.2310.98
209_E318_H1.2250.98
187_G337_A1.2230.98
187_G336_L1.2180.98
16_H100_R1.2170.98
70_F94_T1.2160.98
229_A295_A1.2040.98
228_V271_L1.1990.98
41_E221_D1.1910.98
19_T69_G1.1880.98
99_V112_I1.1870.98
333_A337_A1.1750.98
60_A222_L1.1730.98
141_A145_D1.1660.98
26_Q42_T1.1560.98
179_T324_V1.1530.98
203_V218_V1.1430.97
81_V138_I1.1380.97
74_E82_R1.1360.97
122_H125_D1.1230.97
13_L162_P1.1200.97
16_H102_E1.1170.97
142_D145_D1.1110.97
187_G333_A1.1100.97
8_F185_A1.1100.97
270_A274_A1.1100.97
295_A307_T1.1060.97
257_V282_L1.1050.97
146_A150_V1.1030.97
101_I156_G1.1000.97
232_V317_M1.0960.97
85_P91_A1.0920.97
272_R284_V1.0910.97
98_Q159_V1.0840.96
8_F32_Y1.0830.96
98_Q163_R1.0760.96
201_Y222_L1.0720.96
33_V50_A1.0630.96
233_T285_A1.0630.96
184_A230_A1.0580.96
104_D269_S1.0570.96
86_I155_P1.0480.96
268_V272_R1.0480.96
15_V24_A1.0460.96
233_T256_V1.0430.96
65_A181_L1.0420.96
255_P310_L1.0300.95
39_R53_E1.0280.95
104_D154_D1.0240.95
310_L332_G1.0200.95
186_E190_R1.0200.95
101_I154_D1.0190.95
49_V203_V1.0150.95
219_G298_F1.0150.95
36_Y189_R1.0140.95
83_I112_I1.0140.95
182_W329_L1.0100.95
229_A298_F1.0080.95
337_A341_A1.0040.95
176_D318_H1.0020.94
280_A335_V0.9990.94
27_R30_V0.9980.94
28_V32_Y0.9960.94
100_R159_V0.9960.94
255_P332_G0.9930.94
276_A282_L0.9920.94
258_M287_H0.9860.94
278_A342_H0.9850.94
233_T311_G0.9840.94
191_A196_V0.9800.94
327_A330_A0.9760.94
126_G130_S0.9740.94
33_V188_F0.9720.94
257_V284_V0.9610.93
264_H306_P0.9600.93
182_W333_A0.9590.93
252_G325_D0.9550.93
266_V306_P0.9530.93
55_G199_T0.9530.93
99_V110_G0.9420.92
29_W65_A0.9360.92
81_V146_A0.9330.92
109_N159_V0.9260.92
223_D303_G0.9210.92
59_V198_A0.9210.92
23_A266_V0.9170.91
269_S273_D0.9160.91
186_E329_L0.9120.91
33_V204_S0.9080.91
257_V268_V0.9070.91
253_D281_S0.9060.91
6_R162_P0.9040.91
170_L326_L0.9020.91
38_D50_A0.8990.91
184_A202_A0.8970.90
176_D208_E0.8970.90
258_M285_A0.8950.90
232_V314_N0.8920.90
43_D47_N0.8890.90
145_D148_D0.8880.90
255_P335_V0.8870.90
171_N323_V0.8860.90
183_V333_A0.8860.90
67_E174_S0.8810.90
123_S127_A0.8800.90
230_A336_L0.8800.90
94_T112_I0.8790.90
50_A204_S0.8790.90
121_D124_E0.8740.89
177_N180_G0.8670.89
56_A199_T0.8670.89
123_S126_G0.8630.89
18_P155_P0.8580.88
24_A107_P0.8580.88
175_L324_V0.8570.88
21_H102_E0.8560.88
26_Q48_A0.8550.88
24_A102_E0.8520.88
296_D299_G0.8520.88
234_H317_M0.8510.88
130_S133_E0.8480.88
46_G206_V0.8480.88
263_N309_D0.8470.88
41_E51_V0.8420.87
212_T297_A0.8400.87
291_T317_M0.8390.87
9_L182_W0.8350.87
40_V50_A0.8340.87
263_N268_V0.8320.87
228_V336_L0.8310.87
14_A162_P0.8300.87
59_V200_V0.8290.87
58_A225_D0.8290.87
65_A204_S0.8280.87
165_L171_N0.8270.87
249_V256_V0.8220.86
23_A27_R0.8200.86
186_E333_A0.8200.86
98_Q321_A0.8190.86
57_P198_A0.8180.86
190_R333_A0.8170.86
207_H212_T0.8110.85
108_V138_I0.8090.85
176_D209_E0.8070.85
88_G318_H0.8050.85
274_A342_H0.8040.85
272_R276_A0.8030.85
212_T296_D0.8030.85
91_A94_T0.8000.85
231_D285_A0.8000.85
63_G177_N0.7970.84
30_V40_V0.7940.84
70_F156_G0.7940.84
162_P172_A0.7920.84
88_G208_E0.7910.84
15_V25_A0.7900.84
334_D338_A0.7870.84
101_I138_I0.7750.83
95_R134_Q0.7740.83
183_V329_L0.7730.83
100_R107_P0.7690.82
177_N232_V0.7660.82
338_A342_H0.7650.82
251_L313_P0.7610.82
64_H208_E0.7570.81
312_I332_G0.7540.81
74_E238_D0.7500.81
103_T149_R0.7490.81
165_L323_V0.7490.81
292_G296_D0.7460.80
51_V58_A0.7460.80
227_V305_V0.7450.80
52_A188_F0.7450.80
108_V150_V0.7430.80
271_L310_L0.7420.80
54_G196_V0.7420.80
237_D315_R0.7410.80
73_A84_A0.7410.80
229_A307_T0.7400.80
6_R10_D0.7400.80
285_A311_G0.7390.80
25_A65_A0.7360.79
327_A331_A0.7360.79
259_R284_V0.7350.79
298_F305_V0.7330.79
9_L175_L0.7320.79
81_V108_V0.7300.79
233_T249_V0.7280.79
10_D164_E0.7280.79
252_G283_Q0.7240.78
183_V230_A0.7240.78
37_A40_V0.7230.78
33_V37_A0.7210.78
96_G320_P0.7200.78
100_R109_N0.7150.77
183_V187_G0.7120.77
15_V32_Y0.7100.77
90_D93_V0.7090.77
200_V340_A0.7090.77
110_G138_I0.7080.77
59_V226_A0.7050.76
88_G292_G0.6990.76
169_R251_L0.6990.76
77_E123_S0.6980.76
228_V308_A0.6970.76
162_P170_L0.6970.76
164_E168_G0.6960.76
301_A305_V0.6950.75
29_W48_A0.6930.75
151_S272_R0.6890.75
182_W186_E0.6870.75
314_N324_V0.6800.74
191_A200_V0.6760.73
317_M322_E0.6750.73
28_V31_E0.6740.73
257_V308_A0.6730.73
236_A248_T0.6730.73
221_D303_G0.6730.73
211_G292_G0.6720.73
195_D279_G0.6680.73
254_G328_D0.6670.72
256_V311_G0.6650.72
103_T108_V0.6650.72
274_A338_A0.6650.72
329_L333_A0.6640.72
252_G328_D0.6630.72
12_L25_A0.6630.72
196_V200_V0.6580.71
219_G301_A0.6580.71
187_G340_A0.6580.71
80_F239_P0.6560.71
250_A257_V0.6540.71
107_P166_A0.6530.71
88_G209_E0.6510.71
190_R194_R0.6500.70
108_V140_A0.6500.70
275_A335_V0.6490.70
261_G291_T0.6480.70
259_R268_V0.6470.70
36_Y192_V0.6470.70
70_F83_I0.6420.70
263_N291_T0.6420.70
274_A280_A0.6420.70
6_R172_A0.6410.69
24_A31_E0.6410.69
33_V40_V0.6380.69
231_D293_T0.6380.69
220_F303_G0.6350.69
103_T154_D0.6350.69
236_A247_S0.6350.69
76_T135_Y0.6330.68
207_H210_I0.6330.68
265_P269_S0.6320.68
42_T48_A0.6310.68
147_R276_A0.6280.68
257_V261_G0.6260.68
273_D276_A0.6250.68
80_F135_Y0.6250.68
265_P306_P0.6240.67
84_A260_G0.6230.67
9_L170_L0.6230.67
232_V285_A0.6220.67
64_H209_E0.6210.67
101_I150_V0.6210.67
270_A273_D0.6200.67
47_N203_V0.6190.67
139_G251_L0.6190.67
38_D192_V0.6180.67
18_P157_V0.6180.67
62_T229_A0.6150.66
121_D125_D0.6150.66
215_A219_G0.6140.66
74_E77_E0.6130.66
38_D52_A0.6130.66
278_A334_D0.6130.66
49_V201_Y0.6090.66
44_A306_P0.6080.65
113_G316_Y0.6060.65
226_A339_F0.6040.65
122_H126_G0.6040.65
291_T309_D0.5990.64
172_A323_V0.5970.64
13_L173_R0.5920.63
104_D273_D0.5900.63
41_E201_Y0.5890.63
177_N231_D0.5890.63
59_V228_V0.5880.63
179_T333_A0.5880.63
177_N208_E0.5880.63
249_V285_A0.5880.63
143_G146_A0.5860.63
21_H24_A0.5860.63
61_F336_L0.5850.62
23_A26_Q0.5840.62
184_A187_G0.5840.62
71_A86_I0.5830.62
276_A279_G0.5820.62
212_T292_G0.5810.62
91_A131_V0.5800.62
229_A336_L0.5780.61
16_H24_A0.5780.61
207_H213_R0.5770.61
68_I322_E0.5770.61
263_N308_A0.5770.61
293_T318_H0.5750.61
309_D317_M0.5720.61
291_T296_D0.5710.61
91_A129_P0.5690.60
34_S40_V0.5660.60
38_D188_F0.5650.60
226_A267_V0.5630.59
64_H318_H0.5600.59
89_L117_V0.5580.59
169_R173_R0.5580.59
102_E156_G0.5580.59
57_P199_T0.5570.59
14_A161_E0.5560.59
6_R326_L0.5560.59
261_G309_D0.5560.59
141_A327_A0.5550.58
37_A188_F0.5500.58
292_G318_H0.5480.57
254_G315_R0.5470.57
85_P131_V0.5460.57
29_W50_A0.5430.57
70_F158_L0.5410.56
234_H285_A0.5410.56
21_H86_I0.5400.56
61_F230_A0.5390.56
234_H261_G0.5380.56
48_A185_A0.5380.56
203_V227_V0.5380.56
192_V195_D0.5380.56
75_I272_R0.5360.56
269_S272_R0.5360.56
140_A145_D0.5350.56
26_Q46_G0.5350.56
60_A219_G0.5340.56
177_N234_H0.5330.55
32_Y185_A0.5320.55
158_L320_P0.5320.55
175_L329_L0.5310.55
38_D51_V0.5300.55
74_E152_V0.5300.55
67_E113_G0.5270.55
179_T312_I0.5260.54
89_L120_R0.5250.54
261_G317_M0.5240.54
16_H157_V0.5240.54
274_A339_F0.5230.54
82_R275_A0.5210.54
172_A175_L0.5200.54
208_E293_T0.5200.54
299_G307_T0.5190.53
73_A83_I0.5190.53
283_Q328_D0.5190.53
56_A198_A0.5180.53
255_P334_D0.5180.53
33_V36_Y0.5160.53
68_I209_E0.5150.53
44_A225_D0.5140.53
280_A338_A0.5130.53
114_Q120_R0.5130.53
62_T267_V0.5120.52
191_A340_A0.5120.52
315_R328_D0.5120.52
49_V218_V0.5110.52
20_G155_P0.5100.52
260_G263_N0.5090.52
218_V298_F0.5090.52
11_E14_A0.5070.52
237_D251_L0.5070.52
69_G86_I0.5060.52
48_A71_A0.5050.51
99_V158_L0.5050.51
185_A189_R0.5040.51
70_F89_L0.5040.51
258_M311_G0.5040.51
89_L320_P0.5030.51
193_E279_G0.5020.51
13_L175_L0.5020.51
258_M309_D0.5010.51
64_H176_D0.5000.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4wwvA 4 0.9773 100 0.412 Contact Map
1y0yA 5 0.932 100 0.421 Contact Map
2wznA 4 0.949 100 0.423 Contact Map
2wyrA 4 0.915 100 0.423 Contact Map
3wt4A 4 0.9462 100 0.431 Contact Map
3vatA 4 0.9915 100 0.431 Contact Map
2fvgA 1 0.8669 100 0.437 Contact Map
2gljA 6 0.9462 100 0.45 Contact Map
2glfA 4 0.9433 100 0.458 Contact Map
1y7eA 4 0.8527 100 0.47 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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