Q9HPS1 - HALSA - GREMLIN Contacts

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Q9HPS1 - Endoglucanase

UniProt:	Q9HPS1	Sequences: MDDARRTFLDELLAVHSPTGHEAAAQRVWVEYVSQYADRVETDAYGNAVAVAEGGAPAVAFTGHADEIGFAVAEITEGGFVRIAPIGGLDASVTRGSQVRIETDDGPVNGVIGQAAVHLRDHSEDGAAPSVTEQYVDIGAADGDDARDRVSVGDPGVLVSEPRELAGGRLNARSLDNRTGLWVAAEGFRRAVERDVDATVYAVSTVHEEIGTRGARMVGFDLDVDAVVAADVTHAADDPMYPAERASTVALGDGPVVMRGGTNHPVVVSALRDAAADAGASLQVAAHRISTGTDADAFGTAGGGVPTADLGIPNRYMHTPAEVVDLADLAAGADVLAAFAAHAGDRDSFGVSV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	353 (332)
Sequences:	2598 (1694)
Seq/√Len:	93.0

ECOLI - SGCX FRVX YPDE
BACSU - YSDC YTOP YHFE
HALSA - Q9HPS1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
143_G	147_R	4.779	1.00
15_V	28_V	3.494	1.00
169_R	325_D	3.155	1.00
250_A	253_D	2.806	1.00
331_A	334_D	2.798	1.00
83_I	136_V	2.795	1.00
18_P	86_I	2.700	1.00
10_D	14_A	2.656	1.00
140_A	146_A	2.567	1.00
267_V	308_A	2.547	1.00
186_E	189_R	2.500	1.00
13_L	172_A	2.498	1.00
102_E	157_V	2.478	1.00
62_T	205_T	2.439	1.00
278_A	338_A	2.438	1.00
59_V	340_A	2.402	1.00
76_T	82_R	2.400	1.00
277_D	342_H	2.331	1.00
30_V	34_S	2.290	1.00
81_V	101_I	2.282	1.00
58_A	201_Y	2.229	1.00
30_V	42_T	2.152	1.00
281_S	331_A	2.147	1.00
67_E	173_R	2.093	1.00
51_V	199_T	2.090	1.00
273_D	277_D	2.085	1.00
19_T	86_I	2.074	1.00
110_G	136_V	2.059	1.00
190_R	337_A	2.045	1.00
271_L	308_A	2.029	1.00
338_A	341_A	2.018	1.00
330_A	334_D	2.002	1.00
194_R	341_A	1.989	1.00
271_L	339_F	1.984	1.00
81_V	156_G	1.982	1.00
144_D	148_D	1.969	1.00
188_F	202_A	1.941	1.00
21_H	155_P	1.930	1.00
77_E	143_G	1.924	1.00
29_W	181_L	1.906	1.00
11_E	32_Y	1.902	1.00
168_G	327_A	1.900	1.00
255_P	331_A	1.899	1.00
31_E	34_S	1.895	1.00
144_D	147_R	1.891	1.00
138_I	150_V	1.884	1.00
11_E	28_V	1.874	1.00
72_V	156_G	1.848	1.00
51_V	201_Y	1.803	1.00
223_D	302_G	1.795	1.00
138_I	146_A	1.769	1.00
53_E	199_T	1.738	1.00
17_S	25_A	1.723	1.00
220_F	302_G	1.714	1.00
99_V	136_V	1.707	1.00
101_I	136_V	1.702	1.00
58_A	199_T	1.694	1.00
63_G	184_A	1.687	1.00
11_E	31_E	1.670	1.00
39_R	51_V	1.664	1.00
324_V	329_L	1.638	1.00
179_T	329_L	1.623	1.00
76_T	80_F	1.617	1.00
115_A	124_E	1.612	1.00
26_Q	65_A	1.556	1.00
103_T	106_G	1.528	1.00
30_V	48_A	1.510	1.00
109_N	163_R	1.492	1.00
37_A	50_A	1.484	1.00
151_S	154_D	1.471	1.00
62_T	294_D	1.461	1.00
6_R	164_E	1.460	1.00
60_A	298_F	1.458	1.00
151_S	276_A	1.450	1.00
47_N	217_M	1.448	1.00
54_G	199_T	1.447	1.00
61_F	340_A	1.439	0.99
17_S	178_R	1.433	0.99
216_R	297_A	1.429	0.99
33_V	185_A	1.404	0.99
274_A	278_A	1.401	0.99
190_R	334_D	1.397	0.99
40_V	48_A	1.389	0.99
7_T	10_D	1.387	0.99
83_I	134_Q	1.387	0.99
270_A	342_H	1.385	0.99
71_A	84_A	1.384	0.99
89_L	158_L	1.382	0.99
83_I	156_G	1.376	0.99
32_Y	35_Q	1.373	0.99
189_R	193_E	1.367	0.99
181_L	204_S	1.362	0.99
7_T	11_E	1.359	0.99
32_Y	189_R	1.357	0.99
164_E	326_L	1.356	0.99
10_D	162_P	1.349	0.99
208_E	318_H	1.345	0.99
60_A	218_V	1.345	0.99
75_I	146_A	1.338	0.99
183_V	332_G	1.306	0.99
272_R	282_L	1.305	0.99
170_L	175_L	1.301	0.99
60_A	203_V	1.298	0.99
314_N	317_M	1.293	0.99
72_V	81_V	1.291	0.99
227_V	298_F	1.284	0.99
147_R	151_S	1.277	0.99
29_W	204_S	1.273	0.99
29_W	185_A	1.267	0.99
270_A	339_F	1.254	0.99
168_G	325_D	1.248	0.99
60_A	224_V	1.247	0.99
27_R	31_E	1.245	0.99
8_F	28_V	1.242	0.98
18_P	69_G	1.233	0.98
261_G	296_D	1.231	0.98
209_E	318_H	1.225	0.98
187_G	337_A	1.223	0.98
187_G	336_L	1.218	0.98
16_H	100_R	1.217	0.98
70_F	94_T	1.216	0.98
229_A	295_A	1.204	0.98
228_V	271_L	1.199	0.98
41_E	221_D	1.191	0.98
19_T	69_G	1.188	0.98
99_V	112_I	1.187	0.98
333_A	337_A	1.175	0.98
60_A	222_L	1.173	0.98
141_A	145_D	1.166	0.98
26_Q	42_T	1.156	0.98
179_T	324_V	1.153	0.98
203_V	218_V	1.143	0.97
81_V	138_I	1.138	0.97
74_E	82_R	1.136	0.97
122_H	125_D	1.123	0.97
13_L	162_P	1.120	0.97
16_H	102_E	1.117	0.97
142_D	145_D	1.111	0.97
187_G	333_A	1.110	0.97
8_F	185_A	1.110	0.97
270_A	274_A	1.110	0.97
295_A	307_T	1.106	0.97
257_V	282_L	1.105	0.97
146_A	150_V	1.103	0.97
101_I	156_G	1.100	0.97
232_V	317_M	1.096	0.97
85_P	91_A	1.092	0.97
272_R	284_V	1.091	0.97
98_Q	159_V	1.084	0.96
8_F	32_Y	1.083	0.96
98_Q	163_R	1.076	0.96
201_Y	222_L	1.072	0.96
33_V	50_A	1.063	0.96
233_T	285_A	1.063	0.96
184_A	230_A	1.058	0.96
104_D	269_S	1.057	0.96
86_I	155_P	1.048	0.96
268_V	272_R	1.048	0.96
15_V	24_A	1.046	0.96
233_T	256_V	1.043	0.96
65_A	181_L	1.042	0.96
255_P	310_L	1.030	0.95
39_R	53_E	1.028	0.95
104_D	154_D	1.024	0.95
310_L	332_G	1.020	0.95
186_E	190_R	1.020	0.95
101_I	154_D	1.019	0.95
49_V	203_V	1.015	0.95
219_G	298_F	1.015	0.95
36_Y	189_R	1.014	0.95
83_I	112_I	1.014	0.95
182_W	329_L	1.010	0.95
229_A	298_F	1.008	0.95
337_A	341_A	1.004	0.95
176_D	318_H	1.002	0.94
280_A	335_V	0.999	0.94
27_R	30_V	0.998	0.94
28_V	32_Y	0.996	0.94
100_R	159_V	0.996	0.94
255_P	332_G	0.993	0.94
276_A	282_L	0.992	0.94
258_M	287_H	0.986	0.94
278_A	342_H	0.985	0.94
233_T	311_G	0.984	0.94
191_A	196_V	0.980	0.94
327_A	330_A	0.976	0.94
126_G	130_S	0.974	0.94
33_V	188_F	0.972	0.94
257_V	284_V	0.961	0.93
264_H	306_P	0.960	0.93
182_W	333_A	0.959	0.93
252_G	325_D	0.955	0.93
266_V	306_P	0.953	0.93
55_G	199_T	0.953	0.93
99_V	110_G	0.942	0.92
29_W	65_A	0.936	0.92
81_V	146_A	0.933	0.92
109_N	159_V	0.926	0.92
223_D	303_G	0.921	0.92
59_V	198_A	0.921	0.92
23_A	266_V	0.917	0.91
269_S	273_D	0.916	0.91
186_E	329_L	0.912	0.91
33_V	204_S	0.908	0.91
257_V	268_V	0.907	0.91
253_D	281_S	0.906	0.91
6_R	162_P	0.904	0.91
170_L	326_L	0.902	0.91
38_D	50_A	0.899	0.91
184_A	202_A	0.897	0.90
176_D	208_E	0.897	0.90
258_M	285_A	0.895	0.90
232_V	314_N	0.892	0.90
43_D	47_N	0.889	0.90
145_D	148_D	0.888	0.90
255_P	335_V	0.887	0.90
171_N	323_V	0.886	0.90
183_V	333_A	0.886	0.90
67_E	174_S	0.881	0.90
123_S	127_A	0.880	0.90
230_A	336_L	0.880	0.90
94_T	112_I	0.879	0.90
50_A	204_S	0.879	0.90
121_D	124_E	0.874	0.89
177_N	180_G	0.867	0.89
56_A	199_T	0.867	0.89
123_S	126_G	0.863	0.89
18_P	155_P	0.858	0.88
24_A	107_P	0.858	0.88
175_L	324_V	0.857	0.88
21_H	102_E	0.856	0.88
26_Q	48_A	0.855	0.88
24_A	102_E	0.852	0.88
296_D	299_G	0.852	0.88
234_H	317_M	0.851	0.88
130_S	133_E	0.848	0.88
46_G	206_V	0.848	0.88
263_N	309_D	0.847	0.88
41_E	51_V	0.842	0.87
212_T	297_A	0.840	0.87
291_T	317_M	0.839	0.87
9_L	182_W	0.835	0.87
40_V	50_A	0.834	0.87
263_N	268_V	0.832	0.87
228_V	336_L	0.831	0.87
14_A	162_P	0.830	0.87
59_V	200_V	0.829	0.87
58_A	225_D	0.829	0.87
65_A	204_S	0.828	0.87
165_L	171_N	0.827	0.87
249_V	256_V	0.822	0.86
23_A	27_R	0.820	0.86
186_E	333_A	0.820	0.86
98_Q	321_A	0.819	0.86
57_P	198_A	0.818	0.86
190_R	333_A	0.817	0.86
207_H	212_T	0.811	0.85
108_V	138_I	0.809	0.85
176_D	209_E	0.807	0.85
88_G	318_H	0.805	0.85
274_A	342_H	0.804	0.85
272_R	276_A	0.803	0.85
212_T	296_D	0.803	0.85
91_A	94_T	0.800	0.85
231_D	285_A	0.800	0.85
63_G	177_N	0.797	0.84
30_V	40_V	0.794	0.84
70_F	156_G	0.794	0.84
162_P	172_A	0.792	0.84
88_G	208_E	0.791	0.84
15_V	25_A	0.790	0.84
334_D	338_A	0.787	0.84
101_I	138_I	0.775	0.83
95_R	134_Q	0.774	0.83
183_V	329_L	0.773	0.83
100_R	107_P	0.769	0.82
177_N	232_V	0.766	0.82
338_A	342_H	0.765	0.82
251_L	313_P	0.761	0.82
64_H	208_E	0.757	0.81
312_I	332_G	0.754	0.81
74_E	238_D	0.750	0.81
103_T	149_R	0.749	0.81
165_L	323_V	0.749	0.81
292_G	296_D	0.746	0.80
51_V	58_A	0.746	0.80
227_V	305_V	0.745	0.80
52_A	188_F	0.745	0.80
108_V	150_V	0.743	0.80
271_L	310_L	0.742	0.80
54_G	196_V	0.742	0.80
237_D	315_R	0.741	0.80
73_A	84_A	0.741	0.80
229_A	307_T	0.740	0.80
6_R	10_D	0.740	0.80
285_A	311_G	0.739	0.80
25_A	65_A	0.736	0.79
327_A	331_A	0.736	0.79
259_R	284_V	0.735	0.79
298_F	305_V	0.733	0.79
9_L	175_L	0.732	0.79
81_V	108_V	0.730	0.79
233_T	249_V	0.728	0.79
10_D	164_E	0.728	0.79
252_G	283_Q	0.724	0.78
183_V	230_A	0.724	0.78
37_A	40_V	0.723	0.78
33_V	37_A	0.721	0.78
96_G	320_P	0.720	0.78
100_R	109_N	0.715	0.77
183_V	187_G	0.712	0.77
15_V	32_Y	0.710	0.77
90_D	93_V	0.709	0.77
200_V	340_A	0.709	0.77
110_G	138_I	0.708	0.77
59_V	226_A	0.705	0.76
88_G	292_G	0.699	0.76
169_R	251_L	0.699	0.76
77_E	123_S	0.698	0.76
228_V	308_A	0.697	0.76
162_P	170_L	0.697	0.76
164_E	168_G	0.696	0.76
301_A	305_V	0.695	0.75
29_W	48_A	0.693	0.75
151_S	272_R	0.689	0.75
182_W	186_E	0.687	0.75
314_N	324_V	0.680	0.74
191_A	200_V	0.676	0.73
317_M	322_E	0.675	0.73
28_V	31_E	0.674	0.73
257_V	308_A	0.673	0.73
236_A	248_T	0.673	0.73
221_D	303_G	0.673	0.73
211_G	292_G	0.672	0.73
195_D	279_G	0.668	0.73
254_G	328_D	0.667	0.72
256_V	311_G	0.665	0.72
103_T	108_V	0.665	0.72
274_A	338_A	0.665	0.72
329_L	333_A	0.664	0.72
252_G	328_D	0.663	0.72
12_L	25_A	0.663	0.72
196_V	200_V	0.658	0.71
219_G	301_A	0.658	0.71
187_G	340_A	0.658	0.71
80_F	239_P	0.656	0.71
250_A	257_V	0.654	0.71
107_P	166_A	0.653	0.71
88_G	209_E	0.651	0.71
190_R	194_R	0.650	0.70
108_V	140_A	0.650	0.70
275_A	335_V	0.649	0.70
261_G	291_T	0.648	0.70
259_R	268_V	0.647	0.70
36_Y	192_V	0.647	0.70
70_F	83_I	0.642	0.70
263_N	291_T	0.642	0.70
274_A	280_A	0.642	0.70
6_R	172_A	0.641	0.69
24_A	31_E	0.641	0.69
33_V	40_V	0.638	0.69
231_D	293_T	0.638	0.69
220_F	303_G	0.635	0.69
103_T	154_D	0.635	0.69
236_A	247_S	0.635	0.69
76_T	135_Y	0.633	0.68
207_H	210_I	0.633	0.68
265_P	269_S	0.632	0.68
42_T	48_A	0.631	0.68
147_R	276_A	0.628	0.68
257_V	261_G	0.626	0.68
273_D	276_A	0.625	0.68
80_F	135_Y	0.625	0.68
265_P	306_P	0.624	0.67
84_A	260_G	0.623	0.67
9_L	170_L	0.623	0.67
232_V	285_A	0.622	0.67
64_H	209_E	0.621	0.67
101_I	150_V	0.621	0.67
270_A	273_D	0.620	0.67
47_N	203_V	0.619	0.67
139_G	251_L	0.619	0.67
38_D	192_V	0.618	0.67
18_P	157_V	0.618	0.67
62_T	229_A	0.615	0.66
121_D	125_D	0.615	0.66
215_A	219_G	0.614	0.66
74_E	77_E	0.613	0.66
38_D	52_A	0.613	0.66
278_A	334_D	0.613	0.66
49_V	201_Y	0.609	0.66
44_A	306_P	0.608	0.65
113_G	316_Y	0.606	0.65
226_A	339_F	0.604	0.65
122_H	126_G	0.604	0.65
291_T	309_D	0.599	0.64
172_A	323_V	0.597	0.64
13_L	173_R	0.592	0.63
104_D	273_D	0.590	0.63
41_E	201_Y	0.589	0.63
177_N	231_D	0.589	0.63
59_V	228_V	0.588	0.63
179_T	333_A	0.588	0.63
177_N	208_E	0.588	0.63
249_V	285_A	0.588	0.63
143_G	146_A	0.586	0.63
21_H	24_A	0.586	0.63
61_F	336_L	0.585	0.62
23_A	26_Q	0.584	0.62
184_A	187_G	0.584	0.62
71_A	86_I	0.583	0.62
276_A	279_G	0.582	0.62
212_T	292_G	0.581	0.62
91_A	131_V	0.580	0.62
229_A	336_L	0.578	0.61
16_H	24_A	0.578	0.61
207_H	213_R	0.577	0.61
68_I	322_E	0.577	0.61
263_N	308_A	0.577	0.61
293_T	318_H	0.575	0.61
309_D	317_M	0.572	0.61
291_T	296_D	0.571	0.61
91_A	129_P	0.569	0.60
34_S	40_V	0.566	0.60
38_D	188_F	0.565	0.60
226_A	267_V	0.563	0.59
64_H	318_H	0.560	0.59
89_L	117_V	0.558	0.59
169_R	173_R	0.558	0.59
102_E	156_G	0.558	0.59
57_P	199_T	0.557	0.59
14_A	161_E	0.556	0.59
6_R	326_L	0.556	0.59
261_G	309_D	0.556	0.59
141_A	327_A	0.555	0.58
37_A	188_F	0.550	0.58
292_G	318_H	0.548	0.57
254_G	315_R	0.547	0.57
85_P	131_V	0.546	0.57
29_W	50_A	0.543	0.57
70_F	158_L	0.541	0.56
234_H	285_A	0.541	0.56
21_H	86_I	0.540	0.56
61_F	230_A	0.539	0.56
234_H	261_G	0.538	0.56
48_A	185_A	0.538	0.56
203_V	227_V	0.538	0.56
192_V	195_D	0.538	0.56
75_I	272_R	0.536	0.56
269_S	272_R	0.536	0.56
140_A	145_D	0.535	0.56
26_Q	46_G	0.535	0.56
60_A	219_G	0.534	0.56
177_N	234_H	0.533	0.55
32_Y	185_A	0.532	0.55
158_L	320_P	0.532	0.55
175_L	329_L	0.531	0.55
38_D	51_V	0.530	0.55
74_E	152_V	0.530	0.55
67_E	113_G	0.527	0.55
179_T	312_I	0.526	0.54
89_L	120_R	0.525	0.54
261_G	317_M	0.524	0.54
16_H	157_V	0.524	0.54
274_A	339_F	0.523	0.54
82_R	275_A	0.521	0.54
172_A	175_L	0.520	0.54
208_E	293_T	0.520	0.54
299_G	307_T	0.519	0.53
73_A	83_I	0.519	0.53
283_Q	328_D	0.519	0.53
56_A	198_A	0.518	0.53
255_P	334_D	0.518	0.53
33_V	36_Y	0.516	0.53
68_I	209_E	0.515	0.53
44_A	225_D	0.514	0.53
280_A	338_A	0.513	0.53
114_Q	120_R	0.513	0.53
62_T	267_V	0.512	0.52
191_A	340_A	0.512	0.52
315_R	328_D	0.512	0.52
49_V	218_V	0.511	0.52
20_G	155_P	0.510	0.52
260_G	263_N	0.509	0.52
218_V	298_F	0.509	0.52
11_E	14_A	0.507	0.52
237_D	251_L	0.507	0.52
69_G	86_I	0.506	0.52
48_A	71_A	0.505	0.51
99_V	158_L	0.505	0.51
185_A	189_R	0.504	0.51
70_F	89_L	0.504	0.51
258_M	311_G	0.504	0.51
89_L	320_P	0.503	0.51
193_E	279_G	0.502	0.51
13_L	175_L	0.502	0.51
258_M	309_D	0.501	0.51
64_H	176_D	0.500	0.51

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4wwvA	4	0.9773	100	0.412	Contact Map
1y0yA	5	0.932	100	0.421	Contact Map
2wznA	4	0.949	100	0.423	Contact Map
2wyrA	4	0.915	100	0.423	Contact Map
3wt4A	4	0.9462	100	0.431	Contact Map
3vatA	4	0.9915	100	0.431	Contact Map
2fvgA	1	0.8669	100	0.437	Contact Map
2gljA	6	0.9462	100	0.45	Contact Map
2glfA	4	0.9433	100	0.458	Contact Map
1y7eA	4	0.8527	100	0.47	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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