GREMLIN Database
Q9HPS0 - Uncharacterized protein
UniProt: Q9HPS0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 317 (297)
Sequences: 812 (505)
Seq/√Len: 29.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
106_A110_N5.9601.00
48_A51_V4.6661.00
170_F232_F4.5351.00
307_V310_R4.2921.00
284_R288_G3.8021.00
188_Y216_A3.6631.00
295_D298_Y3.6361.00
43_T48_A3.3911.00
44_A48_A3.0491.00
175_H179_F3.0061.00
294_D298_Y2.9801.00
226_L274_R2.9581.00
32_T122_A2.7521.00
288_G312_L2.6151.00
29_T82_D2.5850.99
77_R149_N2.4410.99
226_L278_A2.4230.99
45_D49_A2.3530.99
285_G288_G2.2460.99
269_Q272_R2.2400.98
63_G287_A2.1720.98
163_R235_E2.1720.98
154_A161_F2.1060.98
20_D23_S2.0540.97
225_E247_R2.0530.97
274_R278_A2.0370.97
119_V231_A1.9910.97
272_R306_D1.9860.97
238_D242_K1.9820.97
97_Q291_R1.9700.97
245_A248_G1.9550.96
288_G291_R1.9240.96
128_Q175_H1.9120.96
284_R312_L1.8480.95
263_L271_E1.8420.95
53_D57_R1.8380.95
241_R245_A1.8310.95
225_E240_R1.8300.95
72_V189_L1.8190.95
229_D240_R1.7830.94
192_R195_T1.7800.94
276_F280_V1.7780.94
186_S190_E1.7590.93
173_V217_M1.7220.93
128_Q167_W1.6950.92
279_H283_E1.6950.92
32_T81_V1.6770.92
107_R110_N1.6660.91
219_A299_L1.6500.91
85_V89_R1.6280.90
73_A142_A1.5930.89
21_W77_R1.5820.89
43_T49_A1.5720.89
143_L175_H1.5650.89
277_F289_A1.5520.88
153_V157_L1.5430.88
28_A81_V1.5400.88
310_R313_A1.5240.87
192_R212_E1.5240.87
189_L216_A1.5180.87
62_S286_L1.4860.86
244_D248_G1.4780.86
187_D191_T1.4780.86
43_T51_V1.4610.85
296_P303_D1.4420.84
18_A193_L1.4380.84
280_V292_V1.4140.83
84_N88_F1.4000.82
136_D139_D1.3990.82
258_T264_H1.3810.81
218_T271_E1.3670.81
272_R275_E1.3560.80
61_V231_A1.3560.80
263_L267_R1.3540.80
241_R248_G1.3360.79
23_S111_T1.3350.79
150_I164_F1.3330.79
114_T150_I1.3250.79
146_V149_N1.3090.78
236_Y243_L1.3050.77
121_I193_L1.3000.77
203_G241_R1.2970.77
276_F295_D1.2800.76
29_T38_A1.2780.76
119_V312_L1.2710.76
162_P165_R1.2710.76
268_E271_E1.2640.75
36_E39_L1.2580.75
311_W314_R1.2370.74
248_G251_S1.2350.73
49_A52_R1.2320.73
309_P313_A1.2220.73
276_F311_W1.2200.72
178_E223_Y1.2140.72
225_E274_R1.2110.72
206_D260_L1.2080.72
35_G77_R1.2040.71
150_I179_F1.2040.71
25_A29_T1.2030.71
41_E312_L1.2030.71
279_H309_P1.2000.71
128_Q136_D1.1810.70
230_E278_A1.1690.69
55_R59_R1.1660.69
49_A53_D1.1640.69
55_R67_D1.1600.69
84_N125_V1.1410.67
84_N217_M1.1390.67
160_Q163_R1.1320.67
173_V182_A1.1260.66
154_A165_R1.1200.66
32_T78_H1.1100.65
48_A52_R1.1020.64
269_Q306_D1.0840.63
81_V173_V1.0830.63
213_L245_A1.0810.63
75_H144_Y1.0790.63
88_F217_M1.0630.62
187_D190_E1.0600.61
229_D232_F1.0580.61
99_P103_P1.0550.61
27_A115_A1.0510.61
46_A50_D1.0450.60
276_F297_E1.0420.60
226_L281_A1.0350.60
126_L146_V1.0320.59
195_T199_A1.0290.59
128_Q163_R1.0290.59
170_F228_M1.0250.59
88_F218_T1.0230.59
176_A239_L1.0210.58
130_D176_A1.0100.58
291_R294_D1.0070.57
194_R213_L1.0040.57
240_R243_L0.9990.57
127_G176_A0.9920.56
126_L243_L0.9890.56
261_L304_E0.9780.55
179_F189_L0.9770.55
128_Q146_V0.9750.55
47_Y74_L0.9740.55
192_R209_A0.9630.54
127_G130_D0.9580.54
223_Y289_A0.9570.54
88_F247_R0.9530.53
104_G237_D0.9460.53
239_L284_R0.9430.52
119_V123_R0.9410.52
189_L272_R0.9380.52
62_S141_H0.9320.52
21_W146_V0.9300.51
21_W188_Y0.9290.51
58_I174_T0.9240.51
307_V313_A0.9230.51
126_L168_I0.9220.51
145_F219_A0.9190.51
95_M196_G0.9170.50
24_V111_T0.9150.50
111_T115_A0.9130.50
235_E238_D0.9100.50
215_V291_R0.9080.50
55_R111_T0.9080.50
208_A212_E0.9070.50
73_A122_A0.9070.50
210_F268_E0.8990.49
214_Q217_M0.8970.49
209_A254_G0.8940.49
198_D282_G0.8910.48
200_L271_E0.8910.48
211_E303_D0.8880.48
226_L229_D0.8870.48
94_P203_G0.8860.48
127_G240_R0.8840.48
109_L249_Q0.8830.48
41_E158_G0.8830.48
303_D310_R0.8810.48
121_I246_R0.8750.47
119_V130_D0.8740.47
77_R166_R0.8740.47
255_A258_T0.8740.47
229_D236_Y0.8720.47
69_P72_V0.8720.47
203_G206_D0.8710.47
88_F94_P0.8630.46
260_L263_L0.8620.46
87_T189_L0.8600.46
152_A158_G0.8590.46
201_A283_E0.8560.46
18_A28_A0.8530.45
82_D86_A0.8520.45
54_A274_R0.8520.45
225_E232_F0.8520.45
150_I157_L0.8500.45
179_F225_E0.8500.45
149_N301_T0.8490.45
79_H83_A0.8480.45
254_G257_A0.8470.45
89_R114_T0.8440.45
124_N266_K0.8440.45
203_G268_E0.8430.45
178_E289_A0.8420.45
113_T209_A0.8400.44
105_V287_A0.8320.44
47_Y51_V0.8310.44
17_G152_A0.8290.44
25_A83_A0.8270.43
24_V182_A0.8240.43
216_A283_E0.8230.43
40_G76_T0.8220.43
267_R271_E0.8220.43
99_P155_D0.8200.43
247_R250_R0.8200.43
33_P66_F0.8140.42
214_Q218_T0.8140.42
15_G278_A0.8130.42
34_P123_R0.8120.42
160_Q235_E0.8120.42
19_I28_A0.8120.42
174_T241_R0.8100.42
153_V168_I0.8100.42
148_P152_A0.8060.42
59_R173_V0.7990.41
158_G241_R0.7960.41
210_F227_L0.7920.41
57_R289_A0.7920.41
187_D230_E0.7910.41
143_L292_V0.7900.41
67_D143_L0.7890.40
113_T259_R0.7880.40
84_N259_R0.7860.40
130_D187_D0.7830.40
206_D267_R0.7810.40
48_A154_A0.7800.40
236_Y240_R0.7780.40
93_E210_F0.7780.40
193_L212_E0.7770.40
127_G150_I0.7760.40
106_A198_D0.7720.39
28_A140_A0.7710.39
167_W290_S0.7710.39
191_T195_T0.7700.39
164_F257_A0.7700.39
53_D166_R0.7680.39
126_L150_I0.7650.39
60_S234_G0.7650.39
270_Y304_E0.7630.39
115_A119_V0.7590.38
24_V115_A0.7580.38
63_G286_L0.7560.38
164_F242_K0.7550.38
226_L271_E0.7530.38
110_N266_K0.7520.38
86_A139_D0.7520.38
151_V155_D0.7510.38
113_T271_E0.7500.38
271_E274_R0.7480.37
134_L241_R0.7440.37
257_A260_L0.7420.37
89_R93_E0.7420.37
277_F281_A0.7400.37
49_A105_V0.7390.37
218_T247_R0.7340.36
61_V286_L0.7320.36
230_E233_D0.7310.36
46_A150_I0.7250.36
40_G312_L0.7230.36
130_D299_L0.7220.36
68_V291_R0.7220.36
225_E271_E0.7210.35
104_G256_V0.7210.35
125_V175_H0.7180.35
21_W166_R0.7170.35
143_L240_R0.7160.35
217_M259_R0.7130.35
304_E310_R0.7110.35
94_P98_Q0.7100.35
280_V304_E0.7090.35
303_D307_V0.7080.35
16_G112_A0.7070.34
149_N293_W0.7070.34
36_E148_P0.7060.34
82_D305_L0.7060.34
55_R230_E0.7040.34
58_I295_D0.7040.34
118_L141_H0.7020.34
113_T254_G0.7010.34
27_A129_Y0.7010.34
47_Y144_Y0.6950.34
144_Y178_E0.6920.33
197_V312_L0.6900.33
144_Y224_A0.6890.33
44_A47_Y0.6870.33
192_R205_I0.6840.33
25_A82_D0.6830.33
99_P205_I0.6830.33
143_L270_Y0.6810.33
19_I245_A0.6800.33
141_H166_R0.6770.32
45_D48_A0.6760.32
92_F176_A0.6740.32
166_R170_F0.6740.32
180_G264_H0.6730.32
116_G204_T0.6690.32
127_G270_Y0.6680.32
287_A301_T0.6660.32
132_L264_H0.6630.31
61_V132_L0.6620.31
122_A133_L0.6590.31
74_L173_V0.6580.31
38_A145_F0.6550.31
105_V213_L0.6530.31
127_G232_F0.6530.31
200_L210_F0.6500.31
84_N214_Q0.6490.30
233_D236_Y0.6470.30
206_D232_F0.6450.30
272_R310_R0.6450.30
68_V287_A0.6440.30
80_W130_D0.6440.30
287_A303_D0.6440.30
126_L314_R0.6430.30
27_A31_A0.6410.30
67_D259_R0.6400.30
20_D116_G0.6380.30
175_H186_S0.6370.30
60_S312_L0.6370.30
96_N158_G0.6340.29
283_E309_P0.6330.29
77_R170_F0.6310.29
58_I227_L0.6300.29
43_T46_A0.6300.29
167_W273_G0.6290.29
44_A182_A0.6280.29
164_F239_L0.6270.29
217_M221_E0.6260.29
37_L99_P0.6250.29
90_R194_R0.6250.29
73_A272_R0.6250.29
175_H270_Y0.6230.29
266_K270_Y0.6220.29
87_T130_D0.6220.29
162_P188_Y0.6180.28
86_A89_R0.6160.28
180_G240_R0.6150.28
169_A291_R0.6140.28
35_G165_R0.6060.28
118_L176_A0.6040.28
128_Q311_W0.6020.27
155_D207_T0.6020.27
200_L206_D0.6020.27
48_A201_A0.6010.27
284_R292_V0.6000.27
99_P313_A0.5990.27
211_E302_D0.5960.27
273_G289_A0.5950.27
57_R217_M0.5940.27
37_L204_T0.5920.27
126_L149_N0.5890.27
57_R209_A0.5880.27
175_H188_Y0.5880.27
78_H112_A0.5870.27
167_W276_F0.5850.26
148_P163_R0.5850.26
158_G309_P0.5840.26
176_A212_E0.5840.26
50_D197_V0.5840.26
177_A197_V0.5820.26
182_A295_D0.5820.26
53_D66_F0.5820.26
24_V265_R0.5810.26
105_V306_D0.5810.26
24_V119_V0.5780.26
19_I307_V0.5780.26
254_G266_K0.5770.26
283_E296_P0.5760.26
176_A228_M0.5750.26
244_D254_G0.5740.26
59_R168_I0.5700.25
177_A214_Q0.5690.25
145_F169_A0.5690.25
27_A170_F0.5660.25
134_L248_G0.5660.25
57_R119_V0.5650.25
263_L266_K0.5640.25
59_R67_D0.5630.25
245_A260_L0.5630.25
277_F312_L0.5600.25
79_H113_T0.5590.25
99_P297_E0.5580.25
150_I286_L0.5580.25
117_A239_L0.5580.25
161_F165_R0.5570.25
49_A93_E0.5560.25
171_H223_Y0.5540.25
78_H279_H0.5540.25
27_A292_V0.5520.24
115_A239_L0.5520.24
92_F113_T0.5510.24
178_E273_G0.5490.24
52_R282_G0.5490.24
58_I62_S0.5490.24
45_D201_A0.5450.24
126_L175_H0.5430.24
60_S114_T0.5390.24
225_E307_V0.5370.24
164_F240_R0.5370.24
25_A85_V0.5360.24
169_A176_A0.5340.23
43_T50_D0.5330.23
220_V224_A0.5310.23
163_R281_A0.5310.23
21_W89_R0.5300.23
230_E281_A0.5290.23
151_V154_A0.5270.23
52_R68_V0.5250.23
273_G311_W0.5230.23
52_R280_V0.5230.23
62_S86_A0.5220.23
82_D242_K0.5220.23
74_L243_L0.5210.23
97_Q198_D0.5210.23
39_L207_T0.5200.23
220_V265_R0.5180.23
291_R313_A0.5180.23
156_S215_V0.5150.22
189_L259_R0.5150.22
78_H207_T0.5150.22
117_A218_T0.5140.22
65_S71_T0.5130.22
19_I111_T0.5110.22
47_Y50_D0.5110.22
193_L298_Y0.5110.22
16_G23_S0.5110.22
59_R177_A0.5100.22
95_M297_E0.5090.22
127_G175_H0.5090.22
29_T78_H0.5090.22
44_A303_D0.5060.22
44_A79_H0.5050.22
46_A162_P0.5040.22
38_A151_V0.5030.22
44_A167_W0.5030.22
132_L141_H0.5020.22
132_L277_F0.5000.22
175_H299_L0.5000.22
189_L242_K0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3cmnA 1 0.8959 100 0.085 Contact Map
4jixA 2 0.3375 50.9 0.965 Contact Map
4jiuA 1 0.3155 25.4 0.971 Contact Map
2ztdA 4 0.5615 17.4 0.973 Contact Map
1cg5A 2 0.4196 16.3 0.973 Contact Map
1ixrA 4 0.5552 15.3 0.973 Contact Map
2aa1B 1 0.4164 14.4 0.974 Contact Map
1lhsA 1 0.4416 13.4 0.974 Contact Map
3mkbA 1 0.4006 13.4 0.974 Contact Map
3bomA 2 0.4196 13.4 0.974 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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