Q9HPS0 - HALSA - GREMLIN Contacts

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Q9HPS0 - Uncharacterized protein

UniProt:	Q9HPS0	Sequences: MSIFESARAVVSADGGGAIDWDSVADAATSATPPGELALGEDTADAYAADVRDARARIRSVSGLSFDVPETVALHTRHHWVDANVATFRRAFEPMNQQPSRLPGVARTLNTATTAGALVFIARNVLGQYDPLLLADASDAHALYFVHPNIVAVADSLGVQFPRFRRWIAFHEVTHAAEFGAAGWLSDYLETRLRTGVDALADGTIDTAAFEELQVAMTAVEGYAELLMDEAFDGEYDDLRRKLDARRGQRSPIGAVATRLLGLHRKREQYERGREFFAHVAGERGLAGASRVWDDPEYLPTDDELDVPPRWLARVPA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	317 (297)
Sequences:	812 (505)
Seq/√Len:	29.3

HALSA - Q9HPS0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
106_A	110_N	5.960	1.00
48_A	51_V	4.666	1.00
170_F	232_F	4.535	1.00
307_V	310_R	4.292	1.00
284_R	288_G	3.802	1.00
188_Y	216_A	3.663	1.00
295_D	298_Y	3.636	1.00
43_T	48_A	3.391	1.00
44_A	48_A	3.049	1.00
175_H	179_F	3.006	1.00
294_D	298_Y	2.980	1.00
226_L	274_R	2.958	1.00
32_T	122_A	2.752	1.00
288_G	312_L	2.615	1.00
29_T	82_D	2.585	0.99
77_R	149_N	2.441	0.99
226_L	278_A	2.423	0.99
45_D	49_A	2.353	0.99
285_G	288_G	2.246	0.99
269_Q	272_R	2.240	0.98
63_G	287_A	2.172	0.98
163_R	235_E	2.172	0.98
154_A	161_F	2.106	0.98
20_D	23_S	2.054	0.97
225_E	247_R	2.053	0.97
274_R	278_A	2.037	0.97
119_V	231_A	1.991	0.97
272_R	306_D	1.986	0.97
238_D	242_K	1.982	0.97
97_Q	291_R	1.970	0.97
245_A	248_G	1.955	0.96
288_G	291_R	1.924	0.96
128_Q	175_H	1.912	0.96
284_R	312_L	1.848	0.95
263_L	271_E	1.842	0.95
53_D	57_R	1.838	0.95
241_R	245_A	1.831	0.95
225_E	240_R	1.830	0.95
72_V	189_L	1.819	0.95
229_D	240_R	1.783	0.94
192_R	195_T	1.780	0.94
276_F	280_V	1.778	0.94
186_S	190_E	1.759	0.93
173_V	217_M	1.722	0.93
128_Q	167_W	1.695	0.92
279_H	283_E	1.695	0.92
32_T	81_V	1.677	0.92
107_R	110_N	1.666	0.91
219_A	299_L	1.650	0.91
85_V	89_R	1.628	0.90
73_A	142_A	1.593	0.89
21_W	77_R	1.582	0.89
43_T	49_A	1.572	0.89
143_L	175_H	1.565	0.89
277_F	289_A	1.552	0.88
153_V	157_L	1.543	0.88
28_A	81_V	1.540	0.88
310_R	313_A	1.524	0.87
192_R	212_E	1.524	0.87
189_L	216_A	1.518	0.87
62_S	286_L	1.486	0.86
244_D	248_G	1.478	0.86
187_D	191_T	1.478	0.86
43_T	51_V	1.461	0.85
296_P	303_D	1.442	0.84
18_A	193_L	1.438	0.84
280_V	292_V	1.414	0.83
84_N	88_F	1.400	0.82
136_D	139_D	1.399	0.82
258_T	264_H	1.381	0.81
218_T	271_E	1.367	0.81
272_R	275_E	1.356	0.80
61_V	231_A	1.356	0.80
263_L	267_R	1.354	0.80
241_R	248_G	1.336	0.79
23_S	111_T	1.335	0.79
150_I	164_F	1.333	0.79
114_T	150_I	1.325	0.79
146_V	149_N	1.309	0.78
236_Y	243_L	1.305	0.77
121_I	193_L	1.300	0.77
203_G	241_R	1.297	0.77
276_F	295_D	1.280	0.76
29_T	38_A	1.278	0.76
119_V	312_L	1.271	0.76
162_P	165_R	1.271	0.76
268_E	271_E	1.264	0.75
36_E	39_L	1.258	0.75
311_W	314_R	1.237	0.74
248_G	251_S	1.235	0.73
49_A	52_R	1.232	0.73
309_P	313_A	1.222	0.73
276_F	311_W	1.220	0.72
178_E	223_Y	1.214	0.72
225_E	274_R	1.211	0.72
206_D	260_L	1.208	0.72
35_G	77_R	1.204	0.71
150_I	179_F	1.204	0.71
25_A	29_T	1.203	0.71
41_E	312_L	1.203	0.71
279_H	309_P	1.200	0.71
128_Q	136_D	1.181	0.70
230_E	278_A	1.169	0.69
55_R	59_R	1.166	0.69
49_A	53_D	1.164	0.69
55_R	67_D	1.160	0.69
84_N	125_V	1.141	0.67
84_N	217_M	1.139	0.67
160_Q	163_R	1.132	0.67
173_V	182_A	1.126	0.66
154_A	165_R	1.120	0.66
32_T	78_H	1.110	0.65
48_A	52_R	1.102	0.64
269_Q	306_D	1.084	0.63
81_V	173_V	1.083	0.63
213_L	245_A	1.081	0.63
75_H	144_Y	1.079	0.63
88_F	217_M	1.063	0.62
187_D	190_E	1.060	0.61
229_D	232_F	1.058	0.61
99_P	103_P	1.055	0.61
27_A	115_A	1.051	0.61
46_A	50_D	1.045	0.60
276_F	297_E	1.042	0.60
226_L	281_A	1.035	0.60
126_L	146_V	1.032	0.59
195_T	199_A	1.029	0.59
128_Q	163_R	1.029	0.59
170_F	228_M	1.025	0.59
88_F	218_T	1.023	0.59
176_A	239_L	1.021	0.58
130_D	176_A	1.010	0.58
291_R	294_D	1.007	0.57
194_R	213_L	1.004	0.57
240_R	243_L	0.999	0.57
127_G	176_A	0.992	0.56
126_L	243_L	0.989	0.56
261_L	304_E	0.978	0.55
179_F	189_L	0.977	0.55
128_Q	146_V	0.975	0.55
47_Y	74_L	0.974	0.55
192_R	209_A	0.963	0.54
127_G	130_D	0.958	0.54
223_Y	289_A	0.957	0.54
88_F	247_R	0.953	0.53
104_G	237_D	0.946	0.53
239_L	284_R	0.943	0.52
119_V	123_R	0.941	0.52
189_L	272_R	0.938	0.52
62_S	141_H	0.932	0.52
21_W	146_V	0.930	0.51
21_W	188_Y	0.929	0.51
58_I	174_T	0.924	0.51
307_V	313_A	0.923	0.51
126_L	168_I	0.922	0.51
145_F	219_A	0.919	0.51
95_M	196_G	0.917	0.50
24_V	111_T	0.915	0.50
111_T	115_A	0.913	0.50
235_E	238_D	0.910	0.50
215_V	291_R	0.908	0.50
55_R	111_T	0.908	0.50
208_A	212_E	0.907	0.50
73_A	122_A	0.907	0.50
210_F	268_E	0.899	0.49
214_Q	217_M	0.897	0.49
209_A	254_G	0.894	0.49
198_D	282_G	0.891	0.48
200_L	271_E	0.891	0.48
211_E	303_D	0.888	0.48
226_L	229_D	0.887	0.48
94_P	203_G	0.886	0.48
127_G	240_R	0.884	0.48
109_L	249_Q	0.883	0.48
41_E	158_G	0.883	0.48
303_D	310_R	0.881	0.48
121_I	246_R	0.875	0.47
119_V	130_D	0.874	0.47
77_R	166_R	0.874	0.47
255_A	258_T	0.874	0.47
229_D	236_Y	0.872	0.47
69_P	72_V	0.872	0.47
203_G	206_D	0.871	0.47
88_F	94_P	0.863	0.46
260_L	263_L	0.862	0.46
87_T	189_L	0.860	0.46
152_A	158_G	0.859	0.46
201_A	283_E	0.856	0.46
18_A	28_A	0.853	0.45
82_D	86_A	0.852	0.45
54_A	274_R	0.852	0.45
225_E	232_F	0.852	0.45
150_I	157_L	0.850	0.45
179_F	225_E	0.850	0.45
149_N	301_T	0.849	0.45
79_H	83_A	0.848	0.45
254_G	257_A	0.847	0.45
89_R	114_T	0.844	0.45
124_N	266_K	0.844	0.45
203_G	268_E	0.843	0.45
178_E	289_A	0.842	0.45
113_T	209_A	0.840	0.44
105_V	287_A	0.832	0.44
47_Y	51_V	0.831	0.44
17_G	152_A	0.829	0.44
25_A	83_A	0.827	0.43
24_V	182_A	0.824	0.43
216_A	283_E	0.823	0.43
40_G	76_T	0.822	0.43
267_R	271_E	0.822	0.43
99_P	155_D	0.820	0.43
247_R	250_R	0.820	0.43
33_P	66_F	0.814	0.42
214_Q	218_T	0.814	0.42
15_G	278_A	0.813	0.42
34_P	123_R	0.812	0.42
160_Q	235_E	0.812	0.42
19_I	28_A	0.812	0.42
174_T	241_R	0.810	0.42
153_V	168_I	0.810	0.42
148_P	152_A	0.806	0.42
59_R	173_V	0.799	0.41
158_G	241_R	0.796	0.41
210_F	227_L	0.792	0.41
57_R	289_A	0.792	0.41
187_D	230_E	0.791	0.41
143_L	292_V	0.790	0.41
67_D	143_L	0.789	0.40
113_T	259_R	0.788	0.40
84_N	259_R	0.786	0.40
130_D	187_D	0.783	0.40
206_D	267_R	0.781	0.40
48_A	154_A	0.780	0.40
236_Y	240_R	0.778	0.40
93_E	210_F	0.778	0.40
193_L	212_E	0.777	0.40
127_G	150_I	0.776	0.40
106_A	198_D	0.772	0.39
28_A	140_A	0.771	0.39
167_W	290_S	0.771	0.39
191_T	195_T	0.770	0.39
164_F	257_A	0.770	0.39
53_D	166_R	0.768	0.39
126_L	150_I	0.765	0.39
60_S	234_G	0.765	0.39
270_Y	304_E	0.763	0.39
115_A	119_V	0.759	0.38
24_V	115_A	0.758	0.38
63_G	286_L	0.756	0.38
164_F	242_K	0.755	0.38
226_L	271_E	0.753	0.38
110_N	266_K	0.752	0.38
86_A	139_D	0.752	0.38
151_V	155_D	0.751	0.38
113_T	271_E	0.750	0.38
271_E	274_R	0.748	0.37
134_L	241_R	0.744	0.37
257_A	260_L	0.742	0.37
89_R	93_E	0.742	0.37
277_F	281_A	0.740	0.37
49_A	105_V	0.739	0.37
218_T	247_R	0.734	0.36
61_V	286_L	0.732	0.36
230_E	233_D	0.731	0.36
46_A	150_I	0.725	0.36
40_G	312_L	0.723	0.36
130_D	299_L	0.722	0.36
68_V	291_R	0.722	0.36
225_E	271_E	0.721	0.35
104_G	256_V	0.721	0.35
125_V	175_H	0.718	0.35
21_W	166_R	0.717	0.35
143_L	240_R	0.716	0.35
217_M	259_R	0.713	0.35
304_E	310_R	0.711	0.35
94_P	98_Q	0.710	0.35
280_V	304_E	0.709	0.35
303_D	307_V	0.708	0.35
16_G	112_A	0.707	0.34
149_N	293_W	0.707	0.34
36_E	148_P	0.706	0.34
82_D	305_L	0.706	0.34
55_R	230_E	0.704	0.34
58_I	295_D	0.704	0.34
118_L	141_H	0.702	0.34
113_T	254_G	0.701	0.34
27_A	129_Y	0.701	0.34
47_Y	144_Y	0.695	0.34
144_Y	178_E	0.692	0.33
197_V	312_L	0.690	0.33
144_Y	224_A	0.689	0.33
44_A	47_Y	0.687	0.33
192_R	205_I	0.684	0.33
25_A	82_D	0.683	0.33
99_P	205_I	0.683	0.33
143_L	270_Y	0.681	0.33
19_I	245_A	0.680	0.33
141_H	166_R	0.677	0.32
45_D	48_A	0.676	0.32
92_F	176_A	0.674	0.32
166_R	170_F	0.674	0.32
180_G	264_H	0.673	0.32
116_G	204_T	0.669	0.32
127_G	270_Y	0.668	0.32
287_A	301_T	0.666	0.32
132_L	264_H	0.663	0.31
61_V	132_L	0.662	0.31
122_A	133_L	0.659	0.31
74_L	173_V	0.658	0.31
38_A	145_F	0.655	0.31
105_V	213_L	0.653	0.31
127_G	232_F	0.653	0.31
200_L	210_F	0.650	0.31
84_N	214_Q	0.649	0.30
233_D	236_Y	0.647	0.30
206_D	232_F	0.645	0.30
272_R	310_R	0.645	0.30
68_V	287_A	0.644	0.30
80_W	130_D	0.644	0.30
287_A	303_D	0.644	0.30
126_L	314_R	0.643	0.30
27_A	31_A	0.641	0.30
67_D	259_R	0.640	0.30
20_D	116_G	0.638	0.30
175_H	186_S	0.637	0.30
60_S	312_L	0.637	0.30
96_N	158_G	0.634	0.29
283_E	309_P	0.633	0.29
77_R	170_F	0.631	0.29
58_I	227_L	0.630	0.29
43_T	46_A	0.630	0.29
167_W	273_G	0.629	0.29
44_A	182_A	0.628	0.29
164_F	239_L	0.627	0.29
217_M	221_E	0.626	0.29
37_L	99_P	0.625	0.29
90_R	194_R	0.625	0.29
73_A	272_R	0.625	0.29
175_H	270_Y	0.623	0.29
266_K	270_Y	0.622	0.29
87_T	130_D	0.622	0.29
162_P	188_Y	0.618	0.28
86_A	89_R	0.616	0.28
180_G	240_R	0.615	0.28
169_A	291_R	0.614	0.28
35_G	165_R	0.606	0.28
118_L	176_A	0.604	0.28
128_Q	311_W	0.602	0.27
155_D	207_T	0.602	0.27
200_L	206_D	0.602	0.27
48_A	201_A	0.601	0.27
284_R	292_V	0.600	0.27
99_P	313_A	0.599	0.27
211_E	302_D	0.596	0.27
273_G	289_A	0.595	0.27
57_R	217_M	0.594	0.27
37_L	204_T	0.592	0.27
126_L	149_N	0.589	0.27
57_R	209_A	0.588	0.27
175_H	188_Y	0.588	0.27
78_H	112_A	0.587	0.27
167_W	276_F	0.585	0.26
148_P	163_R	0.585	0.26
158_G	309_P	0.584	0.26
176_A	212_E	0.584	0.26
50_D	197_V	0.584	0.26
177_A	197_V	0.582	0.26
182_A	295_D	0.582	0.26
53_D	66_F	0.582	0.26
24_V	265_R	0.581	0.26
105_V	306_D	0.581	0.26
24_V	119_V	0.578	0.26
19_I	307_V	0.578	0.26
254_G	266_K	0.577	0.26
283_E	296_P	0.576	0.26
176_A	228_M	0.575	0.26
244_D	254_G	0.574	0.26
59_R	168_I	0.570	0.25
177_A	214_Q	0.569	0.25
145_F	169_A	0.569	0.25
27_A	170_F	0.566	0.25
134_L	248_G	0.566	0.25
57_R	119_V	0.565	0.25
263_L	266_K	0.564	0.25
59_R	67_D	0.563	0.25
245_A	260_L	0.563	0.25
277_F	312_L	0.560	0.25
79_H	113_T	0.559	0.25
99_P	297_E	0.558	0.25
150_I	286_L	0.558	0.25
117_A	239_L	0.558	0.25
161_F	165_R	0.557	0.25
49_A	93_E	0.556	0.25
171_H	223_Y	0.554	0.25
78_H	279_H	0.554	0.25
27_A	292_V	0.552	0.24
115_A	239_L	0.552	0.24
92_F	113_T	0.551	0.24
178_E	273_G	0.549	0.24
52_R	282_G	0.549	0.24
58_I	62_S	0.549	0.24
45_D	201_A	0.545	0.24
126_L	175_H	0.543	0.24
60_S	114_T	0.539	0.24
225_E	307_V	0.537	0.24
164_F	240_R	0.537	0.24
25_A	85_V	0.536	0.24
169_A	176_A	0.534	0.23
43_T	50_D	0.533	0.23
220_V	224_A	0.531	0.23
163_R	281_A	0.531	0.23
21_W	89_R	0.530	0.23
230_E	281_A	0.529	0.23
151_V	154_A	0.527	0.23
52_R	68_V	0.525	0.23
273_G	311_W	0.523	0.23
52_R	280_V	0.523	0.23
62_S	86_A	0.522	0.23
82_D	242_K	0.522	0.23
74_L	243_L	0.521	0.23
97_Q	198_D	0.521	0.23
39_L	207_T	0.520	0.23
220_V	265_R	0.518	0.23
291_R	313_A	0.518	0.23
156_S	215_V	0.515	0.22
189_L	259_R	0.515	0.22
78_H	207_T	0.515	0.22
117_A	218_T	0.514	0.22
65_S	71_T	0.513	0.22
19_I	111_T	0.511	0.22
47_Y	50_D	0.511	0.22
193_L	298_Y	0.511	0.22
16_G	23_S	0.511	0.22
59_R	177_A	0.510	0.22
95_M	297_E	0.509	0.22
127_G	175_H	0.509	0.22
29_T	78_H	0.509	0.22
44_A	303_D	0.506	0.22
44_A	79_H	0.505	0.22
46_A	162_P	0.504	0.22
38_A	151_V	0.503	0.22
44_A	167_W	0.503	0.22
132_L	141_H	0.502	0.22
132_L	277_F	0.500	0.22
175_H	299_L	0.500	0.22
189_L	242_K	0.500	0.22

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3cmnA	1	0.8959	100	0.085	Contact Map
4jixA	2	0.3375	50.9	0.965	Contact Map
4jiuA	1	0.3155	25.4	0.971	Contact Map
2ztdA	4	0.5615	17.4	0.973	Contact Map
1cg5A	2	0.4196	16.3	0.973	Contact Map
1ixrA	4	0.5552	15.3	0.973	Contact Map
2aa1B	1	0.4164	14.4	0.974	Contact Map
1lhsA	1	0.4416	13.4	0.974	Contact Map
3mkbA	1	0.4006	13.4	0.974	Contact Map
3bomA	2	0.4196	13.4	0.974	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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