GREMLIN Database
Q9HPR7 - Uncharacterized protein
UniProt: Q9HPR7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 247 (231)
Sequences: 8925 (6569)
Seq/√Len: 432.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
153_V171_A4.6321.00
144_R151_D3.5261.00
172_S205_D3.3511.00
5_F8_T3.1591.00
165_G201_G3.1091.00
206_D237_H2.8331.00
85_T115_R2.7341.00
25_E30_R2.6661.00
5_F239_A2.3241.00
33_V145_F2.2701.00
199_L207_L2.2491.00
173_V208_Y2.2401.00
182_D193_T2.2351.00
134_T142_A2.1441.00
123_G128_D2.1131.00
85_T113_T2.1051.00
42_T45_R2.0621.00
29_S54_D2.0591.00
93_D97_T2.0491.00
55_T85_T2.0141.00
23_L30_R1.9931.00
132_I167_F1.9911.00
224_T228_H1.9811.00
175_V210_T1.9801.00
153_V168_A1.9711.00
134_T140_G1.9671.00
176_H190_P1.9301.00
197_A201_G1.9141.00
166_A169_D1.8121.00
57_L129_V1.8031.00
206_D235_E1.7281.00
170_G203_D1.7241.00
152_L175_V1.6371.00
151_D171_A1.5831.00
57_L143_Y1.5721.00
194_Q197_A1.5541.00
168_A171_A1.5491.00
31_L55_T1.5461.00
130_T146_G1.5371.00
38_G41_H1.5321.00
4_T25_E1.5241.00
128_D146_G1.4961.00
140_G156_A1.4631.00
146_G151_D1.4521.00
144_R153_V1.4501.00
151_D172_S1.4461.00
55_T87_V1.4261.00
35_C58_L1.4251.00
199_L204_V1.4071.00
155_S176_H1.4041.00
208_Y237_H1.4031.00
162_D165_G1.3971.00
58_L69_L1.3921.00
118_D121_S1.3861.00
134_T155_S1.3771.00
29_S125_A1.3711.00
144_R171_A1.3641.00
162_D201_G1.3611.00
133_E139_P1.3341.00
135_E159_E1.3331.00
5_F208_Y1.3311.00
222_A225_A1.3291.00
21_G39_V1.3171.00
208_Y239_A1.3141.00
26_D126_G1.3061.00
88_G93_D1.3041.00
31_L127_F1.2991.00
8_T17_R1.2721.00
89_P141_L1.2641.00
169_D203_D1.2611.00
90_A116_E1.2561.00
225_A228_H1.2561.00
20_T154_F1.2551.00
178_C209_L1.2501.00
83_T113_T1.2201.00
39_V43_L1.2191.00
165_G169_D1.2181.00
65_H211_H1.2131.00
193_T197_A1.2101.00
5_F175_V1.2091.00
95_L99_L1.2031.00
59_S143_Y1.1811.00
38_G42_T1.1771.00
5_F22_L1.1761.00
93_D116_E1.1671.00
168_A202_V1.1661.00
165_G198_S1.1631.00
131_A143_Y1.1551.00
221_D224_T1.1521.00
159_E194_Q1.1501.00
63_L67_S1.1411.00
192_P196_G1.1331.00
196_G231_G1.1311.00
49_G52_G1.1271.00
30_R52_G1.1271.00
88_G92_T1.1211.00
155_S158_T1.1131.00
23_L32_L1.1041.00
33_V57_L1.1021.00
176_H195_L1.0941.00
173_V206_D1.0931.00
204_V207_L1.0911.00
87_V115_R1.0861.00
197_A200_A1.0811.00
191_T194_Q1.0811.00
158_T164_M1.0781.00
57_L122_V1.0781.00
3_L22_L1.0691.00
142_A155_S1.0371.00
129_V145_F1.0361.00
178_C195_L1.0341.00
54_D82_E1.0311.00
123_G126_G1.0301.00
83_T111_D1.0301.00
56_V69_L1.0251.00
147_G150_G1.0241.00
30_R54_D1.0211.00
150_G172_S1.0181.00
163_G166_A1.0181.00
8_T241_D1.0151.00
132_I164_M1.0101.00
221_D225_A1.0081.00
41_H45_R1.0041.00
22_L210_T1.0011.00
210_T239_A1.0001.00
26_D29_S1.0001.00
90_A94_A0.9991.00
119_V133_E0.9901.00
23_L48_V0.9881.00
32_L39_V0.9871.00
3_L152_L0.9871.00
37_S40_L0.9851.00
161_F164_M0.9761.00
18_M41_H0.9741.00
29_S126_G0.9661.00
3_L173_V0.9621.00
98_D101_G0.9551.00
178_C192_P0.9431.00
70_L74_K0.9401.00
24_V145_F0.9401.00
17_R241_D0.9331.00
94_A101_G0.9271.00
197_A231_G0.9261.00
29_S124_V0.9251.00
61_H91_G0.9231.00
3_L24_V0.9221.00
6_L21_G0.9201.00
137_S188_N0.9151.00
32_L35_C0.9051.00
169_D201_G0.9051.00
130_T167_F0.9041.00
162_D166_A0.9011.00
29_S127_F0.9011.00
35_C39_V0.8971.00
224_T238_I0.8961.00
94_A97_T0.8951.00
176_H198_S0.8891.00
212_L238_I0.8881.00
164_M167_F0.8861.00
159_E190_P0.8791.00
193_T230_A0.8761.00
26_D127_F0.8751.00
31_L129_V0.8731.00
171_A204_V0.8731.00
24_V33_V0.8671.00
222_A226_S0.8671.00
146_G149_D0.8631.00
94_A98_D0.8611.00
181_P192_P0.8591.00
18_M45_R0.8531.00
117_V143_Y0.8511.00
61_H92_T0.8451.00
223_M226_S0.8411.00
33_V154_F0.8361.00
97_T101_G0.8341.00
159_E188_N0.8241.00
174_L199_L0.8221.00
132_I142_A0.8181.00
91_G139_P0.8151.00
165_G202_V0.8121.00
195_L199_L0.8121.00
89_P92_T0.8111.00
24_V152_L0.8081.00
196_G199_L0.8071.00
196_G200_A0.8051.00
232_F236_V0.8041.00
9_G17_R0.8021.00
57_L87_V0.8011.00
200_A233_D0.8011.00
22_L33_V0.8001.00
134_T156_A0.7971.00
100_L103_H0.7951.00
193_T231_G0.7941.00
31_L57_L0.7891.00
33_V143_Y0.7851.00
58_L92_T0.7781.00
90_A118_D0.7731.00
228_H237_H0.7691.00
29_S55_T0.7691.00
3_L175_V0.7651.00
135_E161_F0.7641.00
104_D107_Q0.7631.00
18_M42_T0.7621.00
224_T236_V0.7601.00
181_P184_V0.7591.00
191_T195_L0.7581.00
181_P231_G0.7571.00
121_S131_A0.7541.00
50_Y72_L0.7511.00
155_S164_M0.7441.00
91_G116_E0.7431.00
179_S213_Y0.7421.00
9_G16_Q0.7411.00
31_L145_F0.7391.00
176_H207_L0.7371.00
180_F187_S0.7361.00
200_A231_G0.7241.00
61_H66_V0.7221.00
177_D190_P0.7201.00
134_T158_T0.7181.00
56_V84_L0.7181.00
163_G167_F0.7161.00
160_A194_Q0.7161.00
40_L44_A0.7121.00
22_L154_F0.7091.00
55_T124_V0.7081.00
99_L102_V0.7071.00
93_D114_L0.7061.00
154_F210_T0.7041.00
42_T46_T0.7031.00
22_L175_V0.7011.00
227_I232_F0.7001.00
212_L216_T0.6981.00
154_F175_V0.6951.00
161_F165_G0.6941.00
144_R167_F0.6921.00
35_C56_V0.6911.00
193_T226_S0.6911.00
76_R80_G0.6871.00
223_M227_I0.6801.00
70_L99_L0.6801.00
153_V174_L0.6781.00
31_L124_V0.6771.00
117_V141_L0.6751.00
117_V131_A0.6751.00
56_V72_L0.6691.00
92_T99_L0.6691.00
43_L50_Y0.6661.00
113_T116_E0.6641.00
152_L173_V0.6641.00
21_G32_L0.6591.00
19_Q37_S0.6550.99
168_A174_L0.6530.99
37_S42_T0.6520.99
69_L86_V0.6520.99
130_T144_R0.6510.99
73_L84_L0.6490.99
37_S71_A0.6490.99
132_I168_A0.6440.99
209_L212_L0.6390.99
192_P216_T0.6370.99
225_A230_A0.6370.99
155_S174_L0.6360.99
32_L53_V0.6320.99
199_L209_L0.6310.99
33_V59_S0.6290.99
59_S154_F0.6280.99
58_L96_V0.6240.99
129_V143_Y0.6240.99
132_I144_R0.6230.99
48_V52_G0.6220.99
174_L204_V0.6220.99
135_E188_N0.6170.99
142_A153_V0.6150.99
40_L71_A0.6140.99
209_L236_V0.6140.99
10_S179_S0.6130.99
160_A197_A0.6100.99
37_S68_D0.6060.99
26_D147_G0.6050.99
62_H136_H0.6050.99
190_P198_S0.6040.99
233_D236_V0.6040.99
54_D125_A0.6010.99
155_S177_D0.5960.99
227_I236_V0.5930.99
4_T46_T0.5920.99
232_F235_E0.5910.99
196_G227_I0.5900.99
195_L207_L0.5890.99
199_L202_V0.5880.99
158_T190_P0.5870.99
131_A141_L0.5860.99
195_L204_V0.5860.99
198_S202_V0.5850.99
61_H95_L0.5810.99
30_R48_V0.5810.99
20_T210_T0.5770.99
127_F145_F0.5760.99
96_V99_L0.5720.99
181_P223_M0.5720.99
95_L98_D0.5680.99
9_G14_T0.5670.99
60_H65_H0.5660.99
60_H64_D0.5650.98
61_H89_P0.5630.98
62_H65_H0.5630.98
199_L203_D0.5620.98
76_R82_E0.5590.98
96_V100_L0.5580.98
119_V141_L0.5570.98
17_R21_G0.5550.98
96_V103_H0.5550.98
171_A174_L0.5550.98
15_G217_N0.5510.98
21_G35_C0.5440.98
142_A158_T0.5400.98
87_V117_V0.5400.98
178_C191_T0.5390.98
170_G205_D0.5350.98
135_E158_T0.5340.98
43_L53_V0.5330.98
19_Q22_L0.5310.98
177_D189_H0.5300.98
4_T23_L0.5270.98
25_E28_D0.5260.98
182_D185_D0.5240.98
174_L207_L0.5240.98
156_A211_H0.5220.97
192_P227_I0.5190.97
226_S230_A0.5160.97
228_H236_V0.5160.97
153_V167_F0.5160.97
37_S41_H0.5140.97
10_S19_Q0.5100.97
196_G236_V0.5090.97
25_E48_V0.5090.97
155_S168_A0.5090.97
89_P139_P0.5080.97
209_L227_I0.5060.97
89_P133_E0.5050.97
199_L227_I0.5050.97
180_F191_T0.5010.97
158_T177_D0.5000.97
95_L103_H0.5000.97
76_R84_L0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zwfA 2 0.9271 100 0.208 Contact Map
2cbnA 2 0.9879 100 0.244 Contact Map
1y44A 2 0.9879 100 0.25 Contact Map
1zkpA 2 0.9555 100 0.323 Contact Map
3jxpA 2 0.9595 100 0.346 Contact Map
3g1pA 2 0.915 100 0.375 Contact Map
2e7yA 2 0.9312 100 0.376 Contact Map
4ojvA 2 0.9879 100 0.38 Contact Map
3md7A 2 0.9352 100 0.384 Contact Map
3bk2A 2 0.9433 100 0.485 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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