GREMLIN Database
HMAT - Heme-based aerotactic transducer HemAT
UniProt: Q9HPR6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 489 (438)
Sequences: 16273 (13473)
Seq/√Len: 643.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
197_L202_D3.9191.00
183_Q188_T3.1421.00
183_Q191_D2.5581.00
69_Y86_T2.4481.00
312_Q386_E2.3731.00
192_S216_E2.2971.00
315_E318_A2.2181.00
209_N212_A2.1941.00
168_V172_L2.1661.00
182_Q203_S2.1531.00
178_L203_S2.1251.00
316_R382_Q2.1071.00
178_L207_L2.1021.00
177_L205_Q2.0991.00
146_D150_D2.0711.00
316_R386_E2.0701.00
182_Q210_A1.9651.00
167_L171_F1.9471.00
199_D202_D1.9181.00
319_D322_S1.9071.00
325_G329_D1.9031.00
302_A396_E1.8991.00
59_A63_A1.8871.00
263_E266_S1.8791.00
182_Q186_M1.8581.00
287_A291_D1.8431.00
284_Q287_A1.8391.00
143_G147_A1.8361.00
124_D128_L1.8181.00
409_E413_E1.8071.00
181_D208_A1.8021.00
149_A153_V1.7971.00
128_L132_V1.7931.00
410_E413_E1.7691.00
209_N213_S1.7531.00
388_E392_D1.7491.00
299_I404_G1.7371.00
310_V390_T1.7331.00
301_E305_G1.7191.00
273_R276_E1.7041.00
192_S209_N1.6871.00
322_S325_G1.6771.00
181_D211_V1.6631.00
245_D248_A1.6601.00
192_S213_S1.6591.00
277_D280_A1.6441.00
80_D84_N1.6411.00
62_D66_T1.6211.00
293_L412_M1.6181.00
117_A121_K1.6181.00
243_Q250_V1.6131.00
184_I212_A1.6111.00
395_D399_Q1.6071.00
311_E395_D1.6061.00
402_G406_E1.6011.00
314_R391_V1.5971.00
145_L149_A1.5951.00
83_A87_K1.5941.00
97_A101_L1.5891.00
79_Q83_A1.5781.00
466_D469_D1.5761.00
399_Q403_E1.5731.00
184_I211_V1.5721.00
131_D135_G1.5701.00
308_A312_Q1.5691.00
309_G389_E1.5661.00
182_Q207_L1.5631.00
84_N88_T1.5621.00
203_S206_E1.5571.00
321_E384_Q1.5551.00
216_E220_S1.5461.00
377_E381_E1.5421.00
392_D396_E1.5361.00
150_D154_A1.5261.00
181_D207_L1.5191.00
120_G124_D1.5121.00
309_G390_T1.5121.00
106_G110_T1.5071.00
163_A167_L1.5061.00
101_L105_R1.5051.00
369_S373_S1.5021.00
192_S212_A1.5001.00
142_T146_D1.4971.00
280_A284_Q1.4891.00
217_A221_S1.4871.00
177_L208_A1.4811.00
60_T63_A1.4781.00
141_Y145_L1.4761.00
364_A367_E1.4701.00
406_E410_E1.4641.00
316_R319_D1.4611.00
76_E79_Q1.4581.00
90_E94_E1.4561.00
262_E266_S1.4551.00
77_R80_D1.4441.00
146_D149_A1.4421.00
311_E315_E1.4351.00
367_E371_E1.4341.00
55_P59_A1.4281.00
273_R277_D1.4261.00
465_D469_D1.4251.00
188_T191_D1.4251.00
51_A104_G1.4221.00
177_L204_R1.4211.00
312_Q315_E1.4171.00
371_E375_R1.4151.00
459_E462_A1.4061.00
473_Q476_R1.4011.00
221_S480_E1.4011.00
98_E101_L1.4011.00
63_A67_D1.4001.00
276_E280_A1.3991.00
142_T145_L1.3981.00
445_E448_E1.3921.00
305_G308_A1.3861.00
399_Q402_G1.3851.00
175_L178_L1.3781.00
319_D375_R1.3761.00
52_A56_L1.3741.00
83_A86_T1.3731.00
304_D308_A1.3711.00
48_A52_A1.3691.00
308_A311_E1.3641.00
195_Q209_N1.3631.00
86_T90_E1.3571.00
342_S360_D1.3481.00
302_A400_R1.3481.00
236_M240_T1.3451.00
269_D273_R1.3451.00
403_E406_E1.3381.00
261_V264_V1.3371.00
317_A387_T1.3351.00
328_D377_E1.3301.00
108_Y112_Y1.3161.00
301_E304_D1.3151.00
310_V394_L1.3121.00
75_Y78_T1.3101.00
413_E417_E1.3071.00
315_E319_D1.3071.00
51_A55_P1.3071.00
135_G139_R1.3001.00
462_A465_D1.2991.00
401_I404_G1.2961.00
360_D363_K1.2911.00
438_E441_V1.2911.00
252_R256_S1.2911.00
374_T378_E1.2861.00
458_G462_A1.2841.00
451_D455_D1.2831.00
126_L129_G1.2791.00
178_L182_Q1.2761.00
118_R121_K1.2711.00
462_A466_D1.2701.00
231_E235_T1.2681.00
270_D273_R1.2681.00
417_E420_D1.2661.00
176_K194_A1.2651.00
423_E427_S1.2611.00
326_V372_Q1.2541.00
298_D400_R1.2481.00
283_Q287_A1.2451.00
314_R388_E1.2441.00
291_D294_A1.2411.00
214_D217_A1.2391.00
306_V394_L1.2321.00
309_G393_Q1.2311.00
113_A117_A1.2311.00
281_L417_E1.2291.00
256_S259_A1.2261.00
455_D459_E1.2241.00
107_E110_T1.2191.00
318_A388_E1.2141.00
476_R480_E1.2141.00
249_D252_R1.2061.00
392_D395_D1.2041.00
223_E227_Q1.2041.00
300_D405_V1.2041.00
84_N87_K1.2031.00
114_A117_A1.1981.00
58_E62_D1.1951.00
381_E385_A1.1891.00
109_D113_A1.1861.00
159_E163_A1.1841.00
94_E98_E1.1831.00
444_E448_E1.1801.00
482_R486_G1.1781.00
271_V429_M1.1761.00
280_A283_Q1.1741.00
396_E399_Q1.1721.00
319_D382_Q1.1601.00
179_T182_Q1.1591.00
282_A419_T1.1561.00
307_T398_N1.1501.00
76_E80_D1.1501.00
95_T98_E1.1461.00
161_A165_D1.1461.00
224_A227_Q1.1431.00
279_E283_Q1.1401.00
213_S217_A1.1391.00
98_E102_G1.1361.00
238_A242_D1.1311.00
306_V397_V1.1291.00
452_D455_D1.1281.00
87_K91_Q1.1221.00
342_S363_K1.1091.00
290_D294_A1.1061.00
245_D249_D1.1061.00
68_F78_T1.1021.00
56_L60_T1.0981.00
186_M210_A1.0971.00
310_V391_V1.0961.00
174_M201_I1.0941.00
314_R318_A1.0931.00
371_E374_T1.0931.00
176_K179_T1.0921.00
297_T301_E1.0921.00
291_D407_R1.0911.00
441_V445_E1.0891.00
455_D458_G1.0881.00
385_A389_E1.0811.00
431_E434_T1.0791.00
125_V128_L1.0791.00
177_L181_D1.0791.00
180_F193_Y1.0771.00
224_A228_D1.0771.00
241_D245_D1.0711.00
77_R81_L1.0661.00
195_Q205_Q1.0621.00
259_A263_E1.0611.00
164_V168_V1.0571.00
328_D373_S1.0561.00
472_D476_R1.0491.00
170_R173_P1.0491.00
193_Y209_N1.0491.00
246_R452_D1.0491.00
424_D427_S1.0471.00
305_G396_E1.0461.00
129_G132_V1.0461.00
121_K124_D1.0441.00
413_E416_Q1.0441.00
243_Q246_R1.0411.00
378_E382_Q1.0411.00
64_L67_D1.0411.00
52_A55_P1.0401.00
134_L138_T1.0351.00
92_L96_Q1.0331.00
212_A216_E1.0311.00
94_E97_A1.0311.00
313_L390_T1.0301.00
236_M239_A1.0291.00
89_V93_K1.0281.00
430_Q434_T1.0281.00
132_V136_A1.0281.00
227_Q231_E1.0271.00
253_E256_S1.0271.00
286_E290_D1.0241.00
480_E483_E1.0211.00
437_D441_V1.0191.00
456_R460_I1.0171.00
139_R143_G1.0161.00
129_G133_Y1.0161.00
114_A118_R1.0161.00
206_E209_N1.0151.00
176_K180_F1.0151.00
416_Q420_D1.0131.00
101_L104_G1.0131.00
50_L54_Q1.0121.00
195_Q206_E1.0111.00
56_L59_A1.0111.00
374_T377_E1.0081.00
173_P200_E1.0081.00
80_D83_A1.0041.00
178_L204_R1.0041.00
88_T118_R1.0041.00
175_L179_T1.0031.00
155_D159_E1.0001.00
469_D473_Q0.9991.00
98_E107_E0.9961.00
147_A150_D0.9961.00
303_T401_I0.9951.00
57_F61_A0.9931.00
179_T183_Q0.9921.00
58_E97_A0.9921.00
183_Q186_M0.9921.00
126_L133_Y0.9911.00
294_A297_T0.9841.00
382_Q386_E0.9841.00
286_E416_Q0.9821.00
479_E483_E0.9811.00
61_A65_V0.9811.00
153_V157_G0.9801.00
93_K97_A0.9791.00
448_E451_D0.9741.00
63_A66_T0.9721.00
304_D402_G0.9711.00
87_K90_E0.9701.00
120_G123_H0.9681.00
294_A298_D0.9681.00
53_E56_L0.9671.00
292_A404_G0.9661.00
173_P197_L0.9651.00
205_Q209_N0.9611.00
434_T438_E0.9611.00
88_T91_Q0.9601.00
122_I126_L0.9571.00
121_K125_V0.9551.00
138_T142_T0.9551.00
62_D93_K0.9551.00
323_V379_L0.9541.00
210_A213_S0.9531.00
169_A173_P0.9501.00
49_A52_A0.9501.00
127_G131_D0.9501.00
54_Q58_E0.9491.00
287_A290_D0.9481.00
252_R259_A0.9471.00
313_L383_M0.9451.00
370_R374_T0.9411.00
181_D204_R0.9351.00
266_S270_D0.9351.00
368_E375_R0.9341.00
375_R378_E0.9311.00
420_D424_D0.9311.00
160_A164_V0.9301.00
111_E114_A0.9271.00
299_I401_I0.9271.00
174_M204_R0.9271.00
255_S259_A0.9251.00
66_T69_Y0.9251.00
221_S484_T0.9231.00
81_L84_N0.9211.00
165_D168_V0.9151.00
47_M51_A0.9151.00
60_T64_L0.9151.00
193_Y205_Q0.9131.00
296_M404_G0.9121.00
100_L104_G0.9041.00
194_A209_N0.9011.00
291_D410_E0.9001.00
448_E452_D0.8971.00
427_S430_Q0.8911.00
130_P133_Y0.8891.00
235_T238_A0.8871.00
172_L176_K0.8851.00
288_A410_E0.8851.00
210_A214_D0.8841.00
123_H126_L0.8831.00
184_I208_A0.8821.00
54_Q57_F0.8811.00
378_E381_E0.8801.00
250_V253_E0.8801.00
201_I205_Q0.8801.00
302_A305_G0.8791.00
109_D112_Y0.8751.00
305_G393_Q0.8751.00
389_E392_D0.8731.00
133_Y136_A0.8711.00
463_A466_D0.8701.00
469_D472_D0.8691.00
406_E409_E0.8661.00
454_D458_G0.8661.00
311_E314_R0.8651.00
434_T437_D0.8631.00
474_Q478_V0.8631.00
312_Q389_E0.8621.00
48_A51_A0.8621.00
243_Q247_M0.8571.00
53_E57_F0.8561.00
128_L131_D0.8541.00
220_S224_A0.8541.00
58_E93_K0.8541.00
91_Q95_T0.8511.00
180_F191_D0.8451.00
382_Q385_A0.8451.00
137_Y141_Y0.8441.00
112_Y116_R0.8431.00
78_T81_L0.8431.00
183_Q211_V0.8421.00
65_V69_Y0.8391.00
474_Q481_V0.8361.00
319_D379_L0.8321.00
191_D212_A0.8321.00
242_D245_D0.8271.00
306_V393_Q0.8261.00
304_D398_N0.8251.00
460_I474_Q0.8241.00
300_D304_D0.8191.00
195_Q202_D0.8191.00
59_A62_D0.8161.00
282_A285_G0.8141.00
180_F183_Q0.8141.00
100_L103_L0.8131.00
110_T114_A0.8121.00
215_V219_L0.8121.00
234_D238_A0.8101.00
291_D403_E0.8101.00
328_D332_E0.8091.00
47_M50_L0.8061.00
312_Q316_R0.8031.00
281_L284_Q0.8031.00
147_A151_D0.8031.00
50_L57_F0.8021.00
136_A140_Y0.8021.00
96_Q100_L0.8001.00
91_Q94_E0.8001.00
483_E486_G0.7991.00
57_F65_V0.7971.00
297_T409_E0.7971.00
307_T395_D0.7961.00
329_D368_E0.7961.00
445_E449_M0.7961.00
298_D301_E0.7941.00
180_F208_A0.7941.00
295_T403_E0.7911.00
171_F175_L0.7901.00
424_D428_G0.7891.00
198_H202_D0.7821.00
62_D65_V0.7771.00
61_A64_L0.7761.00
247_M251_S0.7751.00
138_T141_Y0.7751.00
329_D332_E0.7701.00
173_P201_I0.7691.00
175_L203_S0.7681.00
318_A322_S0.7671.00
238_A241_D0.7641.00
447_A451_D0.7611.00
366_A369_S0.7601.00
266_S269_D0.7571.00
197_L200_E0.7561.00
85_S115_Q0.7531.00
324_T377_E0.7511.00
58_E96_Q0.7491.00
131_D134_L0.7441.00
284_Q288_A0.7441.00
292_A411_A0.7431.00
317_A383_M0.7421.00
427_S431_E0.7411.00
157_G161_A0.7401.00
57_F60_T0.7391.00
476_R479_E0.7361.00
252_R255_S0.7351.00
115_Q122_I0.7321.00
117_A120_G0.7321.00
407_R410_E0.7311.00
387_T390_T0.7301.00
323_V380_V0.7301.00
278_A422_V0.7301.00
208_A211_V0.7291.00
474_Q485_V0.7281.00
303_T397_V0.7271.00
181_D184_I0.7271.00
96_Q99_Y0.7271.00
65_V68_F0.7241.00
55_P58_E0.7221.00
171_F201_I0.7201.00
285_G415_L0.7181.00
69_Y83_A0.7161.00
368_E371_E0.7141.00
221_S224_A0.7141.00
140_Y144_L0.7131.00
143_G146_D0.7111.00
479_E482_R0.7071.00
303_T394_L0.7071.00
191_D195_Q0.7071.00
286_E412_M0.7061.00
135_G138_T0.7051.00
271_V422_V0.7001.00
233_T471_T0.6991.00
409_E412_M0.6981.00
115_Q119_I0.6971.00
126_L130_P0.6971.00
208_A212_A0.6961.00
265_A268_A0.6951.00
400_R403_E0.6941.00
81_L125_V0.6911.00
102_G105_R0.6911.00
222_L485_V0.6911.00
54_Q61_A0.6861.00
447_A450_V0.6851.00
78_T126_L0.6801.00
307_T311_E0.6801.00
481_V485_V0.6791.00
220_S223_E0.6781.00
215_V218_P0.6781.00
49_A53_E0.6751.00
248_A252_R0.6741.00
51_A54_Q0.6741.00
397_V404_G0.6731.00
419_T423_E0.6711.00
58_E61_A0.6701.00
84_N118_R0.6681.00
412_M416_Q0.6661.00
323_V372_Q0.6661.00
189_Y215_V0.6641.00
274_T424_D0.6641.00
85_S89_V0.6621.00
441_V444_E0.6581.00
67_D71_H0.6561.00
50_L53_E0.6561.00
279_E423_E0.6561.00
385_A388_E0.6541.00
439_Q446_V0.6501.00
255_S447_A0.6481.00
185_A210_A0.6471.00
61_A89_V0.6451.00
180_F205_Q0.6451.00
397_V401_I0.6441.00
305_G309_G0.6441.00
186_M214_D0.6431.00
116_R120_G0.6421.00
322_S326_V0.6411.00
420_D423_E0.6411.00
320_V380_V0.6401.00
65_V86_T0.6401.00
284_Q410_E0.6401.00
251_S256_S0.6371.00
296_M405_V0.6361.00
288_A291_D0.6341.00
150_D153_V0.6341.00
237_R241_D0.6341.00
384_Q388_E0.6331.00
119_I122_I0.6301.00
115_Q118_R0.6261.00
64_L68_F0.6241.00
184_I189_Y0.6231.00
243_Q257_V0.6231.00
219_L222_L0.6221.00
246_R249_D0.6221.00
226_S230_A0.6221.00
68_F126_L0.6211.00
49_A54_Q0.6201.00
257_V260_S0.6171.00
69_Y82_F0.6171.00
78_T125_V0.6161.00
123_H127_G0.6161.00
309_G386_E0.6151.00
127_G130_P0.6141.00
172_L175_L0.6111.00
335_N363_K0.6111.00
442_S446_V0.6081.00
296_M299_I0.6081.00
161_A164_V0.6081.00
462_A469_D0.6051.00
211_V214_D0.6031.00
295_T407_R0.6011.00
228_D231_E0.6001.00
96_Q103_L0.6001.00
99_Y103_L0.6001.00
118_R122_I0.5991.00
178_L201_I0.5981.00
324_T328_D0.5921.00
360_D364_A0.5921.00
185_A207_L0.5901.00
229_V233_T0.5901.00
95_T108_Y0.5901.00
322_S375_R0.5901.00
227_Q482_R0.5891.00
276_E279_E0.5881.00
89_V115_Q0.5861.00
300_D402_G0.5851.00
444_E447_A0.5851.00
68_F82_F0.5851.00
302_A393_Q0.5841.00
440_A443_T0.5841.00
108_Y116_R0.5841.00
92_L112_Y0.5841.00
110_T113_A0.5821.00
239_A456_R0.5821.00
398_N402_G0.5811.00
230_A235_T0.5781.00
467_I470_A0.5771.00
124_D127_G0.5761.00
90_E93_K0.5761.00
211_V215_V0.5761.00
108_Y115_Q0.5761.00
75_Y125_V0.5741.00
82_F86_T0.5731.00
130_P134_L0.5731.00
243_Q264_V0.5721.00
338_A363_K0.5721.00
180_F184_I0.5721.00
390_T397_V0.5661.00
363_K367_E0.5661.00
231_E234_D0.5651.00
381_E384_Q0.5641.00
270_D428_G0.5641.00
187_D211_V0.5631.00
272_R276_E0.5631.00
107_E111_E0.5621.00
204_R208_A0.5621.00
478_V481_V0.5611.00
351_A362_V0.5601.00
47_M103_L0.5591.00
92_L115_Q0.5591.00
75_Y79_Q0.5541.00
145_L148_L0.5541.00
184_I215_V0.5541.00
244_V247_M0.5531.00
134_L137_Y0.5531.00
218_P222_L0.5521.00
332_E370_R0.5511.00
136_A139_R0.5491.00
109_D116_R0.5471.00
88_T114_A0.5471.00
303_T306_V0.5451.00
128_L133_Y0.5411.00
256_S260_S0.5411.00
112_Y115_Q0.5401.00
438_E442_S0.5391.00
82_F85_S0.5381.00
81_L121_K0.5381.00
247_M254_I0.5340.99
292_A299_I0.5340.99
187_D204_R0.5330.99
202_D206_E0.5330.99
339_L347_R0.5300.99
250_V264_V0.5290.99
257_V443_T0.5280.99
411_A414_T0.5280.99
458_G461_A0.5280.99
477_T480_E0.5260.99
236_M242_D0.5250.99
230_A234_D0.5250.99
468_A472_D0.5250.99
205_Q208_A0.5250.99
259_A262_E0.5230.99
328_D374_T0.5230.99
204_R207_L0.5230.99
274_T277_D0.5220.99
307_T394_L0.5220.99
271_V275_S0.5220.99
89_V92_L0.5190.99
217_A220_S0.5190.99
275_S278_A0.5180.99
254_I450_V0.5160.99
480_E484_T0.5160.99
113_A116_R0.5150.99
284_Q417_E0.5130.99
258_S261_V0.5120.99
400_R404_G0.5110.99
171_F178_L0.5110.99
446_V450_V0.5110.99
218_P221_S0.5100.99
108_Y111_E0.5080.99
84_N121_K0.5070.99
380_V384_Q0.5060.99
293_L297_T0.5060.99
275_S279_E0.5050.99
387_T391_V0.5040.99
475_V479_E0.5040.99
277_D281_L0.5040.99
173_P202_D0.5040.99
91_Q111_E0.5030.99
390_T393_Q0.5020.99
71_H74_S0.5010.99
257_V264_V0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zx6A 2 0.6155 100 0.335 Contact Map
2ch7A 2 0.6033 100 0.48 Contact Map
1qu7A 2 0.456 100 0.485 Contact Map
3g67A 2 0.4274 100 0.551 Contact Map
4i3mA 2 0.3006 99.9 0.718 Contact Map
2f95B 2 0.1084 99.3 0.841 Contact Map
4cq4A 4 0.1759 99.1 0.853 Contact Map
4gycB 2 0.1227 99.1 0.855 Contact Map
3zccA 2 0.2229 98.8 0.868 Contact Map
4i5sA 2 0.5767 98.5 0.881 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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