PELO - HALSA - GREMLIN Contacts

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PELO - Protein pelota homolog

UniProt:	Q9HPR5	Sequences: MQLKDRHTVEGGRERITLVPESLDDLWHLAYVLEPGDFVAGDTHRRIQRNDDQMRDTGGEREHMFVTIDVGDVEFHKFSNRLRVSGTIEDCSREDQLGLHHTLNVAEREELEVEKHWQPDQLNRLNEAVEATDQPDVAIATVEEGEAHIHVVQQYGVDEQGSFTATTGKGEQNDRGRDELFGTLADALARMQADAIILAGPGFTKQDALDHITEEYPDLQETITMVDTSAVGGRGVHEVLKRGAVEDVQEETRIAEESELIDELTTQMATDGKAAYGIDEVQKAVEFGAVEDLLILDERLRLERAGEGDWVDVDVNDLVRTVEQQGGSVTVFSHEFAPGEQLRNLGGIGAVLRYRLD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	357 (316)
Sequences:	869 (569)
Seq/√Len:	32.0

HALSA - PELO
SULSO - PELO RF1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
322_V	327_G	7.108	1.00
285_V	290_V	4.524	1.00
140_A	149_I	4.291	1.00
77_K	80_N	3.992	1.00
181_F	208_A	3.713	1.00
199_A	239_V	3.314	1.00
71_G	100_H	3.300	1.00
77_K	81_R	3.087	1.00
283_K	286_E	2.773	1.00
198_L	209_L	2.701	1.00
291_E	353_R	2.600	1.00
342_L	349_G	2.568	1.00
54_M	57_T	2.512	1.00
215_E	218_D	2.499	1.00
275_A	350_A	2.478	0.99
76_H	80_N	2.477	0.99
76_H	79_S	2.472	0.99
58_G	62_E	2.451	0.99
39_V	68_I	2.419	0.99
279_D	283_K	2.413	0.99
140_A	188_L	2.307	0.99
281_V	350_A	2.259	0.99
290_V	293_L	2.169	0.99
150_H	236_V	2.139	0.98
321_T	324_Q	2.121	0.98
230_A	354_Y	2.070	0.98
147_A	180_L	2.039	0.98
211_H	214_E	2.037	0.98
43_T	101_H	1.996	0.98
267_Q	351_V	1.990	0.98
147_A	184_L	1.953	0.97
150_H	159_E	1.941	0.97
208_A	211_H	1.908	0.97
290_V	350_A	1.884	0.97
292_D	330_T	1.880	0.96
317_D	321_T	1.879	0.96
226_V	239_V	1.859	0.96
59_G	62_E	1.837	0.96
256_E	328_S	1.798	0.95
58_G	61_R	1.783	0.95
53_Q	61_R	1.755	0.95
263_E	267_Q	1.713	0.94
54_M	58_G	1.690	0.94
264_L	345_L	1.674	0.93
207_D	210_D	1.669	0.93
138_A	193_A	1.668	0.93
39_V	84_V	1.633	0.92
143_E	231_V	1.628	0.92
142_V	200_G	1.622	0.92
56_D	62_E	1.613	0.92
142_V	208_A	1.610	0.92
57_T	62_E	1.601	0.92
40_A	67_T	1.593	0.91
48_Q	51_D	1.576	0.91
287_F	356_L	1.572	0.91
205_K	225_M	1.555	0.90
78_F	81_R	1.552	0.90
53_Q	57_T	1.527	0.90
48_Q	57_T	1.522	0.89
139_I	150_H	1.517	0.89
211_H	215_E	1.508	0.89
45_R	101_H	1.508	0.89
272_G	355_R	1.502	0.89
29_L	34_E	1.490	0.88
87_T	100_H	1.484	0.88
69_D	89_E	1.483	0.88
38_F	69_D	1.455	0.87
75_F	79_S	1.449	0.87
37_D	102_T	1.446	0.87
29_L	105_V	1.442	0.87
76_H	81_R	1.430	0.86
38_F	89_E	1.418	0.86
139_I	199_A	1.412	0.86
54_M	62_E	1.409	0.85
53_Q	59_G	1.401	0.85
142_V	152_V	1.389	0.85
55_R	59_G	1.387	0.85
181_F	211_H	1.386	0.84
292_D	328_S	1.382	0.84
57_T	60_E	1.382	0.84
291_E	328_S	1.370	0.84
257_E	333_S	1.366	0.84
201_P	238_E	1.349	0.83
42_D	63_H	1.345	0.83
55_R	61_R	1.311	0.81
56_D	59_G	1.300	0.80
47_I	51_D	1.298	0.80
209_L	223_I	1.298	0.80
111_L	223_I	1.297	0.80
82_L	98_G	1.297	0.80
193_A	196_I	1.286	0.80
57_T	61_R	1.283	0.80
106_A	109_E	1.279	0.79
260_L	330_T	1.275	0.79
56_D	60_E	1.275	0.79
51_D	55_R	1.274	0.79
198_L	223_I	1.265	0.79
150_H	158_D	1.263	0.78
202_G	238_E	1.256	0.78
88_I	256_E	1.253	0.78
75_F	80_N	1.237	0.77
261_I	332_F	1.236	0.77
212_I	215_E	1.234	0.77
241_K	262_D	1.224	0.76
284_A	356_L	1.218	0.76
159_E	212_I	1.208	0.75
180_L	208_A	1.208	0.75
32_V	37_D	1.180	0.73
51_D	56_D	1.178	0.73
200_G	231_V	1.174	0.73
141_T	231_V	1.165	0.73
219_L	223_I	1.158	0.72
271_D	355_R	1.157	0.72
182_G	186_D	1.156	0.72
53_Q	56_D	1.146	0.71
197_I	248_V	1.141	0.71
266_T	270_T	1.141	0.71
298_E	306_G	1.139	0.71
339_G	346_G	1.113	0.69
136_D	194_D	1.111	0.69
247_D	306_G	1.106	0.68
39_V	123_N	1.106	0.68
44_H	63_H	1.104	0.68
313_V	317_D	1.104	0.68
293_L	349_G	1.097	0.68
267_Q	273_K	1.096	0.68
288_G	337_A	1.095	0.68
46_R	50_N	1.088	0.67
264_L	268_M	1.085	0.67
47_I	55_R	1.081	0.67
181_F	193_A	1.066	0.66
36_G	356_L	1.065	0.66
34_E	38_F	1.063	0.65
33_L	123_N	1.057	0.65
143_E	180_L	1.057	0.65
33_L	111_L	1.057	0.65
264_L	271_D	1.055	0.65
162_S	232_G	1.052	0.65
263_E	340_E	1.048	0.64
206_Q	225_M	1.046	0.64
276_Y	350_A	1.039	0.64
44_H	61_R	1.037	0.63
227_D	230_A	1.036	0.63
53_Q	62_E	1.031	0.63
60_E	64_M	1.029	0.63
55_R	60_E	1.024	0.62
196_I	223_I	1.023	0.62
55_R	62_E	1.022	0.62
125_L	266_T	1.021	0.62
145_G	180_L	1.019	0.62
125_L	178_D	1.019	0.62
232_G	235_G	1.014	0.62
267_Q	272_G	1.010	0.61
149_I	298_E	1.008	0.61
101_H	115_K	1.002	0.61
50_N	53_Q	1.002	0.61
301_R	336_F	0.991	0.60
72_D	85_S	0.991	0.60
45_R	49_R	0.988	0.60
185_A	208_A	0.987	0.60
212_I	220_Q	0.985	0.59
47_I	53_Q	0.982	0.59
56_D	61_R	0.980	0.59
57_T	63_H	0.979	0.59
54_M	59_G	0.978	0.59
202_G	205_K	0.974	0.58
50_N	55_R	0.974	0.58
196_I	222_T	0.970	0.58
205_K	227_D	0.968	0.58
46_R	55_R	0.960	0.57
230_A	234_R	0.959	0.57
128_A	203_F	0.953	0.57
200_G	205_K	0.950	0.57
244_A	250_E	0.941	0.56
192_Q	247_D	0.939	0.56
50_N	208_A	0.933	0.55
53_Q	58_G	0.931	0.55
141_T	236_V	0.918	0.54
182_G	213_T	0.912	0.53
160_Q	165_A	0.910	0.53
163_F	334_H	0.908	0.53
264_L	304_R	0.907	0.53
263_E	292_D	0.907	0.53
122_L	126_N	0.902	0.53
283_K	287_F	0.895	0.52
29_L	330_T	0.890	0.52
47_I	54_M	0.888	0.52
218_D	356_L	0.885	0.51
339_G	349_G	0.884	0.51
45_R	103_L	0.884	0.51
50_N	59_G	0.881	0.51
37_D	115_K	0.879	0.51
70_V	114_E	0.878	0.51
46_R	114_E	0.878	0.51
263_E	266_T	0.875	0.50
102_T	115_K	0.875	0.50
201_P	205_K	0.874	0.50
105_V	111_L	0.872	0.50
188_L	196_I	0.870	0.50
333_S	349_G	0.869	0.50
29_L	32_V	0.868	0.50
162_S	191_M	0.867	0.50
139_I	236_V	0.864	0.50
32_V	215_E	0.862	0.49
69_D	73_V	0.862	0.49
139_I	197_I	0.862	0.49
75_F	78_F	0.861	0.49
149_I	187_A	0.857	0.49
43_T	60_E	0.854	0.49
296_L	343_R	0.853	0.49
64_M	100_H	0.847	0.48
117_W	122_L	0.846	0.48
74_E	78_F	0.845	0.48
143_E	200_G	0.845	0.48
103_L	290_V	0.838	0.47
250_E	256_E	0.837	0.47
180_L	184_L	0.835	0.47
37_D	41_G	0.828	0.47
321_T	325_Q	0.828	0.47
263_E	328_S	0.826	0.46
105_V	293_L	0.826	0.46
44_H	47_I	0.825	0.46
225_M	262_D	0.825	0.46
47_I	50_N	0.822	0.46
196_I	218_D	0.822	0.46
318_L	333_S	0.819	0.46
198_L	271_D	0.819	0.46
83_R	102_T	0.815	0.46
41_G	84_V	0.812	0.45
34_E	40_A	0.812	0.45
38_F	67_T	0.809	0.45
104_N	109_E	0.804	0.45
34_E	37_D	0.804	0.45
343_R	351_V	0.802	0.44
256_E	279_D	0.799	0.44
48_Q	55_R	0.797	0.44
148_H	232_G	0.797	0.44
289_A	293_L	0.795	0.44
87_T	285_V	0.794	0.44
295_I	319_V	0.792	0.44
268_M	346_G	0.792	0.44
139_I	240_L	0.790	0.44
179_E	183_T	0.788	0.43
157_V	240_L	0.787	0.43
228_T	318_L	0.787	0.43
54_M	60_E	0.786	0.43
89_E	295_I	0.785	0.43
261_I	297_D	0.783	0.43
54_M	61_R	0.783	0.43
200_G	227_D	0.780	0.43
229_S	238_E	0.779	0.43
294_L	332_F	0.779	0.43
66_V	101_H	0.779	0.43
139_I	239_V	0.776	0.42
135_P	194_D	0.771	0.42
58_G	235_G	0.768	0.42
193_A	268_M	0.767	0.42
88_I	136_D	0.762	0.41
45_R	304_R	0.760	0.41
269_A	329_V	0.759	0.41
106_A	257_E	0.756	0.41
139_I	233_G	0.751	0.40
45_R	51_D	0.750	0.40
167_T	173_N	0.750	0.40
271_D	348_I	0.747	0.40
292_D	320_R	0.746	0.40
209_L	213_T	0.743	0.40
274_A	351_V	0.741	0.40
148_H	162_S	0.739	0.39
150_H	200_G	0.735	0.39
146_E	231_V	0.734	0.39
55_R	58_G	0.733	0.39
209_L	225_M	0.733	0.39
256_E	351_V	0.733	0.39
39_V	108_R	0.729	0.39
108_R	206_Q	0.722	0.38
68_I	163_F	0.722	0.38
106_A	147_A	0.722	0.38
180_L	336_F	0.718	0.38
249_Q	252_T	0.717	0.38
45_R	102_T	0.714	0.38
225_M	350_A	0.711	0.37
314_D	318_L	0.711	0.37
48_Q	53_Q	0.711	0.37
51_D	57_T	0.708	0.37
50_N	57_T	0.707	0.37
75_F	115_K	0.705	0.37
214_E	218_D	0.705	0.37
183_T	187_A	0.704	0.37
35_P	346_G	0.702	0.37
123_N	323_E	0.702	0.37
85_S	102_T	0.701	0.37
97_L	331_V	0.701	0.37
179_E	329_V	0.701	0.37
208_A	212_I	0.698	0.36
75_F	82_L	0.696	0.36
191_M	334_H	0.696	0.36
159_E	233_G	0.694	0.36
261_I	265_T	0.694	0.36
34_E	121_Q	0.693	0.36
244_A	273_K	0.692	0.36
294_L	342_L	0.691	0.36
304_R	308_G	0.690	0.36
265_T	323_E	0.687	0.35
71_G	85_S	0.686	0.35
196_I	323_E	0.685	0.35
178_D	182_G	0.685	0.35
201_P	276_Y	0.684	0.35
281_V	299_R	0.684	0.35
279_D	282_Q	0.683	0.35
149_I	272_G	0.682	0.35
257_E	339_G	0.681	0.35
199_A	236_V	0.678	0.35
318_L	334_H	0.674	0.34
282_Q	295_I	0.673	0.34
145_G	252_T	0.672	0.34
229_S	250_E	0.670	0.34
56_D	63_H	0.668	0.34
71_G	87_T	0.664	0.34
211_H	348_I	0.664	0.34
195_A	249_Q	0.664	0.34
72_D	354_Y	0.664	0.34
284_A	293_L	0.664	0.34
153_Q	315_V	0.662	0.34
273_K	295_I	0.662	0.34
308_G	355_R	0.662	0.34
56_D	65_F	0.662	0.34
265_T	341_Q	0.661	0.34
298_E	343_R	0.660	0.33
274_A	327_G	0.660	0.33
34_E	263_E	0.660	0.33
147_A	163_F	0.660	0.33
87_T	98_G	0.659	0.33
308_G	313_V	0.657	0.33
326_G	329_V	0.657	0.33
236_V	338_P	0.657	0.33
96_Q	99_L	0.655	0.33
278_I	282_Q	0.654	0.33
51_D	61_R	0.654	0.33
283_K	302_L	0.654	0.33
56_D	66_V	0.653	0.33
125_L	188_L	0.652	0.33
160_Q	191_M	0.649	0.33
125_L	244_A	0.649	0.33
45_R	61_R	0.648	0.33
275_A	280_E	0.645	0.32
113_V	184_L	0.644	0.32
39_V	43_T	0.643	0.32
285_V	321_T	0.643	0.32
127_E	326_G	0.642	0.32
85_S	100_H	0.641	0.32
142_V	231_V	0.640	0.32
197_I	355_R	0.637	0.32
149_I	297_D	0.632	0.31
197_I	247_D	0.632	0.31
62_E	164_T	0.632	0.31
178_D	270_T	0.631	0.31
70_V	84_V	0.629	0.31
178_D	279_D	0.628	0.31
327_G	350_A	0.625	0.31
190_R	225_M	0.625	0.31
49_R	53_Q	0.623	0.31
122_L	315_V	0.622	0.31
145_G	332_F	0.619	0.31
74_E	83_R	0.617	0.30
134_Q	279_D	0.617	0.30
118_Q	150_H	0.617	0.30
83_R	353_R	0.616	0.30
198_L	205_K	0.614	0.30
249_Q	348_I	0.613	0.30
89_E	209_L	0.610	0.30
203_F	238_E	0.609	0.30
88_I	99_L	0.608	0.30
41_G	354_Y	0.608	0.30
181_F	203_F	0.606	0.30
33_L	351_V	0.605	0.30
47_I	62_E	0.605	0.30
179_E	182_G	0.604	0.29
188_L	212_I	0.604	0.29
47_I	58_G	0.604	0.29
197_I	216_Y	0.604	0.29
264_L	351_V	0.603	0.29
147_A	181_F	0.603	0.29
292_D	298_E	0.601	0.29
333_S	339_G	0.600	0.29
257_E	274_A	0.598	0.29
215_E	356_L	0.597	0.29
169_K	336_F	0.596	0.29
336_F	339_G	0.596	0.29
34_E	298_E	0.591	0.29
254_I	353_R	0.590	0.29
73_V	355_R	0.590	0.29
38_F	154_Q	0.588	0.28
88_I	346_G	0.587	0.28
135_P	348_I	0.586	0.28
152_V	256_E	0.584	0.28
316_N	320_R	0.584	0.28
261_I	281_V	0.582	0.28
72_D	152_V	0.581	0.28
170_G	298_E	0.581	0.28
129_V	143_E	0.580	0.28
110_E	169_K	0.579	0.28
187_A	299_R	0.578	0.28
145_G	202_G	0.577	0.28
197_I	261_I	0.575	0.28
137_V	229_S	0.574	0.27
70_V	328_S	0.574	0.27
43_T	61_R	0.573	0.27
252_T	332_F	0.573	0.27
267_Q	274_A	0.573	0.27
281_V	348_I	0.571	0.27
36_G	90_D	0.571	0.27
142_V	280_E	0.571	0.27
232_G	346_G	0.570	0.27
29_L	111_L	0.569	0.27
36_G	39_V	0.569	0.27
263_E	343_R	0.567	0.27
140_A	217_P	0.566	0.27
144_E	239_V	0.564	0.27
199_A	257_E	0.563	0.27
149_I	228_T	0.563	0.27
164_T	176_G	0.562	0.27
292_D	354_Y	0.562	0.27
258_S	321_T	0.561	0.27
181_F	188_L	0.560	0.27
157_V	216_Y	0.559	0.27
278_I	281_V	0.559	0.27
263_E	307_E	0.559	0.27
82_L	156_G	0.557	0.26
29_L	208_A	0.555	0.26
239_V	335_E	0.553	0.26
97_L	356_L	0.553	0.26
235_G	238_E	0.551	0.26
220_Q	223_I	0.549	0.26
185_A	216_Y	0.547	0.26
313_V	320_R	0.546	0.26
195_A	208_A	0.546	0.26
71_G	298_E	0.543	0.26
220_Q	261_I	0.542	0.25
84_V	195_A	0.539	0.25
283_K	295_I	0.538	0.25
168_G	172_Q	0.538	0.25
58_G	64_M	0.535	0.25
33_L	36_G	0.534	0.25
266_T	343_R	0.532	0.25
46_R	51_D	0.532	0.25
197_I	243_G	0.530	0.25
145_G	165_A	0.527	0.25
68_I	212_I	0.527	0.25
197_I	278_I	0.526	0.24
102_T	157_V	0.524	0.24
44_H	54_M	0.524	0.24
332_F	341_Q	0.523	0.24
36_G	45_R	0.522	0.24
37_D	351_V	0.522	0.24
198_L	317_D	0.522	0.24
60_E	65_F	0.520	0.24
107_E	123_N	0.519	0.24
224_T	328_S	0.518	0.24
337_A	340_E	0.517	0.24
138_A	213_T	0.517	0.24
278_I	285_V	0.516	0.24
110_E	164_T	0.515	0.24
149_I	161_G	0.515	0.24
48_Q	59_G	0.513	0.24
80_N	107_E	0.513	0.24
261_I	337_A	0.509	0.23
90_D	225_M	0.508	0.23
68_I	103_L	0.505	0.23
176_G	204_T	0.503	0.23
198_L	219_L	0.503	0.23
143_E	235_G	0.501	0.23
206_Q	350_A	0.500	0.23
261_I	280_E	0.500	0.23

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3mcaB	1	0.8796	100	0.166	Contact Map
3obyA	1	0.8824	100	0.176	Contact Map
2qi2A	1	0.8627	100	0.179	Contact Map
2vgnA	1	0.9216	100	0.196	Contact Map
3j15A	1	0.9692	100	0.233	Contact Map
3wxmB	1	0.9468	100	0.263	Contact Map
3obwA	2	0.8796	100	0.268	Contact Map
3e20C	1	0.591	100	0.434	Contact Map
4crnX	1	0.9692	100	0.44	Contact Map
4af1A	1	0.9496	100	0.461	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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