GREMLIN Database
PELO - Protein pelota homolog
UniProt: Q9HPR5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 357 (316)
Sequences: 869 (569)
Seq/√Len: 32.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
322_V327_G7.1081.00
285_V290_V4.5241.00
140_A149_I4.2911.00
77_K80_N3.9921.00
181_F208_A3.7131.00
199_A239_V3.3141.00
71_G100_H3.3001.00
77_K81_R3.0871.00
283_K286_E2.7731.00
198_L209_L2.7011.00
291_E353_R2.6001.00
342_L349_G2.5681.00
54_M57_T2.5121.00
215_E218_D2.4991.00
275_A350_A2.4780.99
76_H80_N2.4770.99
76_H79_S2.4720.99
58_G62_E2.4510.99
39_V68_I2.4190.99
279_D283_K2.4130.99
140_A188_L2.3070.99
281_V350_A2.2590.99
290_V293_L2.1690.99
150_H236_V2.1390.98
321_T324_Q2.1210.98
230_A354_Y2.0700.98
147_A180_L2.0390.98
211_H214_E2.0370.98
43_T101_H1.9960.98
267_Q351_V1.9900.98
147_A184_L1.9530.97
150_H159_E1.9410.97
208_A211_H1.9080.97
290_V350_A1.8840.97
292_D330_T1.8800.96
317_D321_T1.8790.96
226_V239_V1.8590.96
59_G62_E1.8370.96
256_E328_S1.7980.95
58_G61_R1.7830.95
53_Q61_R1.7550.95
263_E267_Q1.7130.94
54_M58_G1.6900.94
264_L345_L1.6740.93
207_D210_D1.6690.93
138_A193_A1.6680.93
39_V84_V1.6330.92
143_E231_V1.6280.92
142_V200_G1.6220.92
56_D62_E1.6130.92
142_V208_A1.6100.92
57_T62_E1.6010.92
40_A67_T1.5930.91
48_Q51_D1.5760.91
287_F356_L1.5720.91
205_K225_M1.5550.90
78_F81_R1.5520.90
53_Q57_T1.5270.90
48_Q57_T1.5220.89
139_I150_H1.5170.89
211_H215_E1.5080.89
45_R101_H1.5080.89
272_G355_R1.5020.89
29_L34_E1.4900.88
87_T100_H1.4840.88
69_D89_E1.4830.88
38_F69_D1.4550.87
75_F79_S1.4490.87
37_D102_T1.4460.87
29_L105_V1.4420.87
76_H81_R1.4300.86
38_F89_E1.4180.86
139_I199_A1.4120.86
54_M62_E1.4090.85
53_Q59_G1.4010.85
142_V152_V1.3890.85
55_R59_G1.3870.85
181_F211_H1.3860.84
292_D328_S1.3820.84
57_T60_E1.3820.84
291_E328_S1.3700.84
257_E333_S1.3660.84
201_P238_E1.3490.83
42_D63_H1.3450.83
55_R61_R1.3110.81
56_D59_G1.3000.80
47_I51_D1.2980.80
209_L223_I1.2980.80
111_L223_I1.2970.80
82_L98_G1.2970.80
193_A196_I1.2860.80
57_T61_R1.2830.80
106_A109_E1.2790.79
260_L330_T1.2750.79
56_D60_E1.2750.79
51_D55_R1.2740.79
198_L223_I1.2650.79
150_H158_D1.2630.78
202_G238_E1.2560.78
88_I256_E1.2530.78
75_F80_N1.2370.77
261_I332_F1.2360.77
212_I215_E1.2340.77
241_K262_D1.2240.76
284_A356_L1.2180.76
159_E212_I1.2080.75
180_L208_A1.2080.75
32_V37_D1.1800.73
51_D56_D1.1780.73
200_G231_V1.1740.73
141_T231_V1.1650.73
219_L223_I1.1580.72
271_D355_R1.1570.72
182_G186_D1.1560.72
53_Q56_D1.1460.71
197_I248_V1.1410.71
266_T270_T1.1410.71
298_E306_G1.1390.71
339_G346_G1.1130.69
136_D194_D1.1110.69
247_D306_G1.1060.68
39_V123_N1.1060.68
44_H63_H1.1040.68
313_V317_D1.1040.68
293_L349_G1.0970.68
267_Q273_K1.0960.68
288_G337_A1.0950.68
46_R50_N1.0880.67
264_L268_M1.0850.67
47_I55_R1.0810.67
181_F193_A1.0660.66
36_G356_L1.0650.66
34_E38_F1.0630.65
33_L123_N1.0570.65
143_E180_L1.0570.65
33_L111_L1.0570.65
264_L271_D1.0550.65
162_S232_G1.0520.65
263_E340_E1.0480.64
206_Q225_M1.0460.64
276_Y350_A1.0390.64
44_H61_R1.0370.63
227_D230_A1.0360.63
53_Q62_E1.0310.63
60_E64_M1.0290.63
55_R60_E1.0240.62
196_I223_I1.0230.62
55_R62_E1.0220.62
125_L266_T1.0210.62
145_G180_L1.0190.62
125_L178_D1.0190.62
232_G235_G1.0140.62
267_Q272_G1.0100.61
149_I298_E1.0080.61
101_H115_K1.0020.61
50_N53_Q1.0020.61
301_R336_F0.9910.60
72_D85_S0.9910.60
45_R49_R0.9880.60
185_A208_A0.9870.60
212_I220_Q0.9850.59
47_I53_Q0.9820.59
56_D61_R0.9800.59
57_T63_H0.9790.59
54_M59_G0.9780.59
202_G205_K0.9740.58
50_N55_R0.9740.58
196_I222_T0.9700.58
205_K227_D0.9680.58
46_R55_R0.9600.57
230_A234_R0.9590.57
128_A203_F0.9530.57
200_G205_K0.9500.57
244_A250_E0.9410.56
192_Q247_D0.9390.56
50_N208_A0.9330.55
53_Q58_G0.9310.55
141_T236_V0.9180.54
182_G213_T0.9120.53
160_Q165_A0.9100.53
163_F334_H0.9080.53
264_L304_R0.9070.53
263_E292_D0.9070.53
122_L126_N0.9020.53
283_K287_F0.8950.52
29_L330_T0.8900.52
47_I54_M0.8880.52
218_D356_L0.8850.51
339_G349_G0.8840.51
45_R103_L0.8840.51
50_N59_G0.8810.51
37_D115_K0.8790.51
70_V114_E0.8780.51
46_R114_E0.8780.51
263_E266_T0.8750.50
102_T115_K0.8750.50
201_P205_K0.8740.50
105_V111_L0.8720.50
188_L196_I0.8700.50
333_S349_G0.8690.50
29_L32_V0.8680.50
162_S191_M0.8670.50
139_I236_V0.8640.50
32_V215_E0.8620.49
69_D73_V0.8620.49
139_I197_I0.8620.49
75_F78_F0.8610.49
149_I187_A0.8570.49
43_T60_E0.8540.49
296_L343_R0.8530.49
64_M100_H0.8470.48
117_W122_L0.8460.48
74_E78_F0.8450.48
143_E200_G0.8450.48
103_L290_V0.8380.47
250_E256_E0.8370.47
180_L184_L0.8350.47
37_D41_G0.8280.47
321_T325_Q0.8280.47
263_E328_S0.8260.46
105_V293_L0.8260.46
44_H47_I0.8250.46
225_M262_D0.8250.46
47_I50_N0.8220.46
196_I218_D0.8220.46
318_L333_S0.8190.46
198_L271_D0.8190.46
83_R102_T0.8150.46
41_G84_V0.8120.45
34_E40_A0.8120.45
38_F67_T0.8090.45
104_N109_E0.8040.45
34_E37_D0.8040.45
343_R351_V0.8020.44
256_E279_D0.7990.44
48_Q55_R0.7970.44
148_H232_G0.7970.44
289_A293_L0.7950.44
87_T285_V0.7940.44
295_I319_V0.7920.44
268_M346_G0.7920.44
139_I240_L0.7900.44
179_E183_T0.7880.43
157_V240_L0.7870.43
228_T318_L0.7870.43
54_M60_E0.7860.43
89_E295_I0.7850.43
261_I297_D0.7830.43
54_M61_R0.7830.43
200_G227_D0.7800.43
229_S238_E0.7790.43
294_L332_F0.7790.43
66_V101_H0.7790.43
139_I239_V0.7760.42
135_P194_D0.7710.42
58_G235_G0.7680.42
193_A268_M0.7670.42
88_I136_D0.7620.41
45_R304_R0.7600.41
269_A329_V0.7590.41
106_A257_E0.7560.41
139_I233_G0.7510.40
45_R51_D0.7500.40
167_T173_N0.7500.40
271_D348_I0.7470.40
292_D320_R0.7460.40
209_L213_T0.7430.40
274_A351_V0.7410.40
148_H162_S0.7390.39
150_H200_G0.7350.39
146_E231_V0.7340.39
55_R58_G0.7330.39
209_L225_M0.7330.39
256_E351_V0.7330.39
39_V108_R0.7290.39
108_R206_Q0.7220.38
68_I163_F0.7220.38
106_A147_A0.7220.38
180_L336_F0.7180.38
249_Q252_T0.7170.38
45_R102_T0.7140.38
225_M350_A0.7110.37
314_D318_L0.7110.37
48_Q53_Q0.7110.37
51_D57_T0.7080.37
50_N57_T0.7070.37
75_F115_K0.7050.37
214_E218_D0.7050.37
183_T187_A0.7040.37
35_P346_G0.7020.37
123_N323_E0.7020.37
85_S102_T0.7010.37
97_L331_V0.7010.37
179_E329_V0.7010.37
208_A212_I0.6980.36
75_F82_L0.6960.36
191_M334_H0.6960.36
159_E233_G0.6940.36
261_I265_T0.6940.36
34_E121_Q0.6930.36
244_A273_K0.6920.36
294_L342_L0.6910.36
304_R308_G0.6900.36
265_T323_E0.6870.35
71_G85_S0.6860.35
196_I323_E0.6850.35
178_D182_G0.6850.35
201_P276_Y0.6840.35
281_V299_R0.6840.35
279_D282_Q0.6830.35
149_I272_G0.6820.35
257_E339_G0.6810.35
199_A236_V0.6780.35
318_L334_H0.6740.34
282_Q295_I0.6730.34
145_G252_T0.6720.34
229_S250_E0.6700.34
56_D63_H0.6680.34
71_G87_T0.6640.34
211_H348_I0.6640.34
195_A249_Q0.6640.34
72_D354_Y0.6640.34
284_A293_L0.6640.34
153_Q315_V0.6620.34
273_K295_I0.6620.34
308_G355_R0.6620.34
56_D65_F0.6620.34
265_T341_Q0.6610.34
298_E343_R0.6600.33
274_A327_G0.6600.33
34_E263_E0.6600.33
147_A163_F0.6600.33
87_T98_G0.6590.33
308_G313_V0.6570.33
326_G329_V0.6570.33
236_V338_P0.6570.33
96_Q99_L0.6550.33
278_I282_Q0.6540.33
51_D61_R0.6540.33
283_K302_L0.6540.33
56_D66_V0.6530.33
125_L188_L0.6520.33
160_Q191_M0.6490.33
125_L244_A0.6490.33
45_R61_R0.6480.33
275_A280_E0.6450.32
113_V184_L0.6440.32
39_V43_T0.6430.32
285_V321_T0.6430.32
127_E326_G0.6420.32
85_S100_H0.6410.32
142_V231_V0.6400.32
197_I355_R0.6370.32
149_I297_D0.6320.31
197_I247_D0.6320.31
62_E164_T0.6320.31
178_D270_T0.6310.31
70_V84_V0.6290.31
178_D279_D0.6280.31
327_G350_A0.6250.31
190_R225_M0.6250.31
49_R53_Q0.6230.31
122_L315_V0.6220.31
145_G332_F0.6190.31
74_E83_R0.6170.30
134_Q279_D0.6170.30
118_Q150_H0.6170.30
83_R353_R0.6160.30
198_L205_K0.6140.30
249_Q348_I0.6130.30
89_E209_L0.6100.30
203_F238_E0.6090.30
88_I99_L0.6080.30
41_G354_Y0.6080.30
181_F203_F0.6060.30
33_L351_V0.6050.30
47_I62_E0.6050.30
179_E182_G0.6040.29
188_L212_I0.6040.29
47_I58_G0.6040.29
197_I216_Y0.6040.29
264_L351_V0.6030.29
147_A181_F0.6030.29
292_D298_E0.6010.29
333_S339_G0.6000.29
257_E274_A0.5980.29
215_E356_L0.5970.29
169_K336_F0.5960.29
336_F339_G0.5960.29
34_E298_E0.5910.29
254_I353_R0.5900.29
73_V355_R0.5900.29
38_F154_Q0.5880.28
88_I346_G0.5870.28
135_P348_I0.5860.28
152_V256_E0.5840.28
316_N320_R0.5840.28
261_I281_V0.5820.28
72_D152_V0.5810.28
170_G298_E0.5810.28
129_V143_E0.5800.28
110_E169_K0.5790.28
187_A299_R0.5780.28
145_G202_G0.5770.28
197_I261_I0.5750.28
137_V229_S0.5740.27
70_V328_S0.5740.27
43_T61_R0.5730.27
252_T332_F0.5730.27
267_Q274_A0.5730.27
281_V348_I0.5710.27
36_G90_D0.5710.27
142_V280_E0.5710.27
232_G346_G0.5700.27
29_L111_L0.5690.27
36_G39_V0.5690.27
263_E343_R0.5670.27
140_A217_P0.5660.27
144_E239_V0.5640.27
199_A257_E0.5630.27
149_I228_T0.5630.27
164_T176_G0.5620.27
292_D354_Y0.5620.27
258_S321_T0.5610.27
181_F188_L0.5600.27
157_V216_Y0.5590.27
278_I281_V0.5590.27
263_E307_E0.5590.27
82_L156_G0.5570.26
29_L208_A0.5550.26
239_V335_E0.5530.26
97_L356_L0.5530.26
235_G238_E0.5510.26
220_Q223_I0.5490.26
185_A216_Y0.5470.26
313_V320_R0.5460.26
195_A208_A0.5460.26
71_G298_E0.5430.26
220_Q261_I0.5420.25
84_V195_A0.5390.25
283_K295_I0.5380.25
168_G172_Q0.5380.25
58_G64_M0.5350.25
33_L36_G0.5340.25
266_T343_R0.5320.25
46_R51_D0.5320.25
197_I243_G0.5300.25
145_G165_A0.5270.25
68_I212_I0.5270.25
197_I278_I0.5260.24
102_T157_V0.5240.24
44_H54_M0.5240.24
332_F341_Q0.5230.24
36_G45_R0.5220.24
37_D351_V0.5220.24
198_L317_D0.5220.24
60_E65_F0.5200.24
107_E123_N0.5190.24
224_T328_S0.5180.24
337_A340_E0.5170.24
138_A213_T0.5170.24
278_I285_V0.5160.24
110_E164_T0.5150.24
149_I161_G0.5150.24
48_Q59_G0.5130.24
80_N107_E0.5130.24
261_I337_A0.5090.23
90_D225_M0.5080.23
68_I103_L0.5050.23
176_G204_T0.5030.23
198_L219_L0.5030.23
143_E235_G0.5010.23
206_Q350_A0.5000.23
261_I280_E0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mcaB 1 0.8796 100 0.166 Contact Map
3obyA 1 0.8824 100 0.176 Contact Map
2qi2A 1 0.8627 100 0.179 Contact Map
2vgnA 1 0.9216 100 0.196 Contact Map
3j15A 1 0.9692 100 0.233 Contact Map
3wxmB 1 0.9468 100 0.263 Contact Map
3obwA 2 0.8796 100 0.268 Contact Map
3e20C 1 0.591 100 0.434 Contact Map
4crnX 1 0.9692 100 0.44 Contact Map
4af1A 1 0.9496 100 0.461 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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