GREMLIN Database
KITH - Thymidine kinase
UniProt: Q9HPQ9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 195 (181)
Sequences: 2083 (1111)
Seq/√Len: 82.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
151_C186_C3.9911.00
159_Q185_R3.1351.00
186_C189_C2.9551.00
9_W140_Y2.7671.00
33_E63_W2.7561.00
151_C189_C2.6411.00
175_M181_T2.4481.00
54_T62_S2.3801.00
102_D133_Q2.3631.00
41_A55_L2.3211.00
51_G54_T2.2611.00
10_V108_A2.2341.00
29_L39_V2.2181.00
73_E76_A2.2131.00
23_E27_R2.1461.00
122_T173_T2.1261.00
93_A116_L2.1111.00
24_E27_R2.0351.00
29_L89_A2.0141.00
45_A69_E1.9881.00
26_L41_A1.9171.00
49_R177_G1.9141.00
104_C116_L1.9011.00
42_V77_S1.9011.00
106_E110_D1.8891.00
109_A187_R1.8281.00
105_Q137_I1.7651.00
78_I107_L1.7611.00
75_V106_E1.7531.00
25_L89_A1.7471.00
15_G19_S1.7421.00
98_A129_E1.7081.00
13_I142_D1.6691.00
90_I104_C1.6571.00
150_Q189_C1.6431.00
93_A100_L1.6291.00
98_A133_Q1.6211.00
48_D52_E1.6041.00
105_Q187_R1.5931.00
106_E191_V1.5651.00
132_P136_A1.5611.00
20_G27_R1.5541.00
72_A77_S1.5451.00
20_G23_E1.5250.99
50_Y56_G1.5230.99
13_I115_V1.4710.99
120_D143_K1.4410.99
71_T97_P1.4380.99
162_I166_P1.4230.99
71_T99_E1.4220.99
73_E103_V1.3880.99
129_E132_P1.3780.99
159_Q167_A1.3640.99
28_R115_V1.3570.99
105_Q191_V1.3390.99
99_E103_V1.3370.99
43_T47_D1.3250.99
54_T64_A1.3170.98
50_Y58_H1.3010.98
126_E133_Q1.2670.98
40_A85_E1.2610.98
13_I28_R1.2550.98
11_E113_R1.2460.98
188_N192_V1.2400.98
105_Q109_A1.2200.97
102_D137_I1.2060.97
125_G190_H1.2000.97
87_V115_V1.1910.97
150_Q183_E1.1900.97
40_A66_T1.1860.97
19_S145_R1.1780.97
42_V66_T1.1700.97
98_A126_E1.1660.97
161_L181_T1.1600.97
29_L63_W1.1460.96
93_A134_L1.1380.96
51_G56_G1.1220.96
108_A187_R1.1180.96
38_D86_Q1.1170.96
125_G157_R1.1140.96
90_I96_F1.1120.96
43_T53_A1.1050.95
146_A155_A1.1030.95
38_D84_G1.0860.95
58_H178_A1.0790.95
26_L63_W1.0710.95
85_E112_R1.0580.94
148_C151_C1.0430.94
41_A63_W1.0180.93
120_D135_M1.0160.93
16_S158_N1.0090.93
56_G62_S1.0050.93
27_R31_R1.0040.93
129_E173_T1.0010.92
172_P175_M0.9950.92
38_D85_E0.9880.92
22_T58_H0.9820.92
32_A37_Q0.9680.91
26_L59_A0.9660.91
13_I24_E0.9640.91
93_A118_G0.9610.91
108_A139_E0.9370.90
11_E28_R0.9320.89
24_E144_M0.9320.89
74_G77_S0.9300.89
123_F160_R0.9280.89
160_R175_M0.9220.89
69_E73_E0.9180.89
31_R34_I0.9140.89
29_L33_E0.8930.87
12_V138_A0.8920.87
69_E72_A0.8800.87
150_Q185_R0.8750.86
22_T65_A0.8740.86
127_P132_P0.8670.86
148_C186_C0.8650.86
139_E187_R0.8640.86
31_R147_I0.8640.86
83_N86_Q0.8590.85
71_T75_V0.8590.85
32_A87_V0.8520.85
35_A147_I0.8440.84
17_M21_K0.8420.84
116_L131_V0.8380.84
116_L134_L0.8320.83
32_A113_R0.8310.83
55_L161_L0.8260.83
133_Q136_A0.8220.83
126_E169_Y0.8160.82
69_E76_A0.8090.82
20_G24_E0.8070.81
145_R154_P0.8020.81
70_P97_P0.7890.80
121_Q136_A0.7880.80
32_A39_V0.7870.80
178_A181_T0.7790.79
133_Q137_I0.7780.79
19_S34_I0.7730.79
31_R146_A0.7700.78
125_G136_A0.7680.78
122_T126_E0.7680.78
37_Q113_R0.7660.78
46_V174_V0.7650.78
161_L183_E0.7600.77
43_T50_Y0.7600.77
71_T103_V0.7580.77
160_R173_T0.7560.77
137_I191_V0.7520.77
24_E28_R0.7520.77
28_R89_A0.7490.76
167_A172_P0.7450.76
123_F173_T0.7430.76
40_A77_S0.7380.75
62_S153_E0.7370.75
142_D145_R0.7350.75
16_S146_A0.7320.75
87_V113_R0.7270.74
78_I112_R0.7220.74
16_S145_R0.7220.74
111_G188_N0.7200.74
75_V103_V0.7150.73
53_A64_A0.7140.73
109_A139_E0.7080.72
104_C130_P0.7050.72
88_V112_R0.7030.72
17_M20_G0.6980.71
83_N110_D0.6930.71
38_D83_N0.6860.70
82_L85_E0.6840.70
66_T77_S0.6830.70
43_T65_A0.6790.69
10_V104_C0.6760.69
18_F22_T0.6740.69
139_E156_T0.6720.68
77_S111_G0.6700.68
16_S22_T0.6680.68
146_A184_A0.6650.68
57_S154_P0.6650.68
20_G25_L0.6620.67
129_E133_Q0.6610.67
52_E67_V0.6580.67
16_S121_Q0.6570.67
88_V114_V0.6540.66
115_V155_A0.6540.66
70_P74_G0.6480.66
62_S99_E0.6450.65
103_V107_L0.6440.65
124_R171_D0.6410.65
48_D176_V0.6400.65
87_V112_R0.6370.64
104_C108_A0.6350.64
26_L117_S0.6330.64
23_E57_S0.6320.64
31_R35_A0.6290.63
38_D163_E0.6290.63
22_T178_A0.6260.63
101_V134_L0.6250.63
52_E64_A0.6210.62
167_A185_R0.6180.62
14_T184_A0.6170.62
89_A115_V0.6160.62
140_Y145_R0.6140.61
144_M156_T0.6110.61
18_F34_I0.6090.61
11_E143_K0.6080.61
50_Y54_T0.6050.60
14_T135_M0.6040.60
77_S82_L0.6000.60
75_V110_D0.5970.59
76_A81_L0.5970.59
8_G108_A0.5960.59
68_V74_G0.5960.59
45_A48_D0.5940.59
177_G187_R0.5920.59
8_G11_E0.5920.59
100_L130_P0.5910.58
25_L117_S0.5900.58
18_F25_L0.5890.58
48_D51_G0.5890.58
15_G68_V0.5860.58
23_E58_H0.5860.58
98_A132_P0.5850.58
93_A131_V0.5850.58
121_Q158_N0.5830.57
44_P68_V0.5800.57
175_M180_E0.5790.57
34_I179_E0.5760.57
113_R143_K0.5750.56
124_R170_D0.5730.56
34_I184_A0.5660.55
164_G167_A0.5650.55
32_A147_I0.5640.55
155_A184_A0.5640.55
123_F190_H0.5620.55
164_G181_T0.5610.55
19_S37_Q0.5580.54
84_G98_A0.5550.54
145_R156_T0.5540.54
33_E38_D0.5540.54
147_I154_P0.5530.54
11_E57_S0.5530.54
10_V130_P0.5530.54
13_I144_M0.5480.53
26_L57_S0.5460.53
19_S32_A0.5450.52
49_R178_A0.5420.52
111_G153_E0.5380.52
94_N174_V0.5360.51
18_F58_H0.5320.51
101_V130_P0.5310.51
114_V147_I0.5310.51
36_G152_G0.5300.50
94_N176_V0.5270.50
71_T106_E0.5270.50
185_R190_H0.5270.50
189_C192_V0.5270.50
44_P174_V0.5260.50
121_Q145_R0.5250.50
19_S177_G0.5240.50
110_D192_V0.5240.50
60_G171_D0.5220.49
43_T48_D0.5210.49
162_I181_T0.5160.49
153_E188_N0.5110.48
22_T41_A0.5100.48
113_R154_P0.5090.48
15_G146_A0.5080.48
109_A191_V0.5070.47
156_T174_V0.5060.47
18_F184_A0.5060.47
45_A67_V0.5040.47
9_W139_E0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1w4rA 3 0.8923 100 0.181 Contact Map
2orvA 3 0.8359 100 0.238 Contact Map
2j9rA 3 0.8974 100 0.379 Contact Map
3e2iA 3 0.8974 100 0.39 Contact Map
2b8tA 3 0.9641 100 0.411 Contact Map
1xx6A 4 0.9128 100 0.448 Contact Map
2orwA 3 0.8923 100 0.56 Contact Map
4uxhA 3 0.8872 100 0.584 Contact Map
3upuA 1 0.9692 98.5 0.84 Contact Map
3e1sA 1 0.9282 98.5 0.841 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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