GREMLIN Database
Q9HPQ8 - Uncharacterized protein
UniProt: Q9HPQ8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 146 (130)
Sequences: 21418 (17348)
Seq/√Len: 1521.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
34_H82_V3.2001.00
6_L101_I2.8451.00
4_D34_H2.8161.00
89_F125_R2.8161.00
32_T80_M2.5331.00
95_Y99_E2.5151.00
21_N135_L2.4881.00
4_D32_T2.3861.00
82_V95_Y2.3461.00
103_T135_L2.2711.00
34_H99_E2.1031.00
104_V132_V2.0721.00
34_H80_M1.9671.00
84_L91_T1.9391.00
124_E128_R1.9251.00
106_M126_V1.9161.00
69_V81_G1.9161.00
96_V104_V1.8481.00
34_H101_I1.8341.00
108_T138_R1.8261.00
86_G91_T1.8211.00
34_H95_Y1.7751.00
8_P92_I1.7271.00
38_V91_T1.6991.00
36_L95_Y1.6891.00
7_L22_A1.6151.00
8_P106_M1.5271.00
91_T94_A1.5121.00
25_L29_Y1.4901.00
69_V73_E1.4471.00
37_Y61_G1.4461.00
93_Q129_T1.4411.00
20_A71_R1.4361.00
16_D71_R1.4001.00
31_A102_D1.3721.00
58_E62_E1.3651.00
32_T78_V1.3231.00
125_R129_T1.3121.00
82_V99_E1.2931.00
97_D131_D1.2891.00
104_V130_S1.2771.00
84_L95_Y1.2661.00
62_E66_D1.2651.00
7_L19_V1.2651.00
22_A26_A1.1961.00
61_G64_V1.1861.00
36_L84_L1.1851.00
71_R75_A1.1811.00
88_V122_V1.1801.00
96_V131_D1.1461.00
104_V126_V1.1351.00
4_D102_D1.0861.00
66_D69_V1.0761.00
96_V132_V1.0741.00
38_V88_V1.0721.00
93_Q96_V1.0391.00
21_N137_V1.0361.00
114_L118_L1.0271.00
39_A85_H1.0251.00
5_I103_T1.0191.00
9_T68_A1.0171.00
130_S134_V1.0161.00
64_V68_A0.9801.00
21_N25_L0.9631.00
71_R74_D0.9591.00
22_A105_V0.9591.00
57_L60_E0.9581.00
108_T136_T0.9571.00
68_A71_R0.9471.00
106_M123_T0.9441.00
19_V35_V0.9421.00
39_A83_V0.9341.00
4_D99_E0.9341.00
113_G116_R0.9271.00
66_D81_G0.9261.00
4_D101_I0.9211.00
127_V136_T0.9211.00
36_L92_I0.9161.00
65_V81_G0.9011.00
64_V67_D0.8981.00
19_V68_A0.8971.00
54_T58_E0.8961.00
11_G37_Y0.8941.00
68_A72_A0.8931.00
108_T123_T0.8821.00
61_G65_V0.8811.00
6_L36_L0.8641.00
21_N24_D0.8431.00
37_Y64_V0.8411.00
23_I77_V0.8341.00
95_Y101_I0.8321.00
111_R115_G0.8301.00
66_D70_A0.8281.00
35_V79_A0.8271.00
60_E64_V0.8171.00
24_D28_K0.8101.00
16_D20_A0.8081.00
116_R124_E0.8031.00
23_I75_A0.8031.00
35_V68_A0.8011.00
67_D71_R0.7901.00
26_A33_L0.7771.00
23_I72_A0.7751.00
29_Y102_D0.7751.00
17_A20_A0.7731.00
96_V101_I0.7711.00
22_A33_L0.7691.00
9_T16_D0.7691.00
26_A31_A0.7601.00
6_L95_Y0.7571.00
12_S15_A0.7551.00
55_D59_R0.7531.00
15_A18_A0.7531.00
59_R63_R0.7531.00
9_T35_V0.7271.00
72_A79_A0.7271.00
87_G90_E0.7251.00
39_A61_G0.7241.00
105_V135_L0.7231.00
123_T136_T0.7191.00
51_D55_D0.7171.00
52_A56_P0.7171.00
56_P59_R0.7141.00
6_L104_V0.7141.00
93_Q130_S0.7121.00
16_D67_D0.7101.00
61_G83_V0.6971.00
9_T19_V0.6931.00
80_M99_E0.6911.00
20_A75_A0.6901.00
27_S76_G0.6861.00
93_Q126_V0.6801.00
51_D54_T0.6741.00
113_G117_A0.6721.00
21_N133_P0.6701.00
91_T95_Y0.6681.00
8_P107_G0.6681.00
9_T18_A0.6661.00
9_T15_A0.6661.00
55_D58_E0.6631.00
56_P60_E0.6621.00
14_A139_E0.6581.00
92_I126_V0.6481.00
105_V137_V0.6471.00
67_D70_A0.6461.00
60_E63_R0.6461.00
63_R67_D0.6411.00
70_A74_D0.6401.00
53_V56_P0.6371.00
39_A58_E0.6291.00
16_D68_A0.6261.00
7_L33_L0.6231.00
25_L28_K0.6211.00
72_A75_A0.6211.00
89_F93_Q0.6201.00
57_L61_G0.6201.00
114_L117_A0.6141.00
65_V69_V0.6111.00
26_A29_Y0.6101.00
14_A17_A0.6051.00
23_I27_S0.6011.00
11_G68_A0.6011.00
110_G119_L0.6001.00
62_E81_G0.6001.00
86_G94_A0.5981.00
106_M136_T0.5971.00
5_I26_A0.5961.00
59_R62_E0.5941.00
36_L91_T0.5931.00
89_F122_V0.5861.00
22_A31_A0.5791.00
82_V85_H0.5731.00
58_E85_H0.5711.00
54_T85_H0.5671.00
70_A73_E0.5631.00
19_V23_I0.5621.00
11_G64_V0.5591.00
24_D27_S0.5591.00
107_G137_V0.5471.00
35_V72_A0.5441.00
89_F129_T0.5431.00
5_I105_V0.5401.00
69_V79_A0.5381.00
17_A21_N0.5351.00
97_D132_V0.5331.00
44_Y50_E0.5281.00
17_A139_E0.5281.00
7_L18_A0.5281.00
12_S110_G0.5261.00
126_V134_V0.5191.00
53_V57_L0.5191.00
119_L123_T0.5141.00
100_G132_V0.5131.00
38_V86_G0.5011.00
90_E94_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1mjhA 2 0.9658 99.9 0.145 Contact Map
4wnyA 2 0.8493 99.9 0.153 Contact Map
5ahwA 4 0.9589 99.9 0.156 Contact Map
3s3tA 4 0.9452 99.9 0.156 Contact Map
3hgmA 2 0.9384 99.9 0.166 Contact Map
2gm3A 2 0.8904 99.9 0.166 Contact Map
2dumA 2 0.9589 99.9 0.17 Contact Map
1tq8A 4 0.8425 99.9 0.187 Contact Map
3tnjA 2 0.8288 99.9 0.193 Contact Map
3loqA 1 0.9795 99.9 0.193 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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