GREMLIN Database
Q9HPQ6 - A/G specific adenine glycosylase, repair protein
UniProt: Q9HPQ6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 312 (256)
Sequences: 1908 (1401)
Seq/√Len: 87.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_S40_E4.3341.00
123_T126_E4.3111.00
75_T78_A4.2601.00
30_T188_T3.5601.00
72_R86_D3.4351.00
106_H110_Q3.3321.00
122_R148_A2.5721.00
111_Q131_M2.5211.00
209_R214_E2.4591.00
116_Y129_E2.3721.00
211_D214_E2.3351.00
41_T47_I2.2221.00
30_T191_V2.2201.00
111_Q115_D2.2161.00
24_A220_W2.1981.00
253_R257_E2.1861.00
72_R90_F2.1721.00
49_V105_L2.1561.00
67_R71_D2.1511.00
29_Y194_N2.1501.00
259_D272_V2.1281.00
218_R224_Y2.0881.00
119_A122_R2.0851.00
188_T191_V2.0701.00
135_P177_R2.0541.00
222_H226_T2.0501.00
73_W90_F2.0361.00
77_A113_E2.0171.00
54_S59_L1.9881.00
43_D46_E1.9851.00
46_E70_L1.9541.00
126_E129_E1.9241.00
48_L141_V1.8621.00
127_L142_A1.8581.00
174_P178_P1.8561.00
164_A217_L1.8471.00
107_E131_M1.8421.00
66_W70_L1.8101.00
83_D86_D1.8101.00
89_G92_S1.7911.00
210_C221_C1.7801.00
84_R106_H1.7631.00
49_V70_L1.7571.00
41_T46_E1.7011.00
166_E222_H1.6921.00
128_S135_P1.6811.00
108_A130_L1.6421.00
102_A105_L1.6281.00
174_P177_R1.6271.00
87_V106_H1.6141.00
26_V30_T1.6091.00
46_E66_W1.5851.00
124_P128_S1.5821.00
82_A87_V1.5681.00
198_E202_V1.5621.00
68_A90_F1.5521.00
104_H107_E1.5471.00
77_A81_A1.5351.00
143_S193_N1.4931.00
210_C215_C1.4921.00
73_W82_A1.4730.99
119_A146_F1.4580.99
26_V191_V1.4540.99
204_C210_C1.4540.99
224_Y228_D1.4460.99
205_Q209_R1.4330.99
33_H198_E1.4310.99
113_E118_G1.4200.99
215_C221_C1.4120.99
176_Y180_A1.4110.99
116_Y126_E1.4110.99
21_L217_L1.4020.99
127_L141_V1.3940.99
228_D232_P1.3830.99
60_S63_I1.3780.99
204_C221_C1.3740.99
124_P150_N1.3710.99
120_I127_L1.3650.99
166_E226_T1.3620.99
112_V120_I1.3540.99
22_Q185_P1.3410.99
265_A268_H1.3120.99
124_P142_A1.3090.99
29_Y33_H1.3080.99
115_D126_E1.2990.99
204_C215_C1.2900.99
261_M265_A1.2810.98
64_D67_R1.2680.98
142_A150_N1.2640.98
150_N181_N1.2550.98
228_D231_A1.2520.98
139_N151_A1.2280.98
43_D47_I1.2240.98
48_L52_V1.2190.98
166_E228_D1.2180.98
53_M62_V1.2080.98
139_N152_V1.2070.98
190_R195_A1.2060.98
58_Q61_R1.1780.97
262_E265_A1.1760.97
161_L180_A1.1640.97
272_V275_T1.1630.97
165_F179_L1.1400.97
33_H191_V1.1380.97
84_R88_V1.1380.97
83_D106_H1.1200.96
224_Y229_F1.1170.96
153_V176_Y1.1140.96
177_R181_N1.1120.96
232_P235_P1.1060.96
63_I67_R1.1010.96
149_G190_R1.0930.96
92_S95_S1.0930.96
25_L195_A1.0890.96
110_Q114_T1.0840.96
107_E110_Q1.0790.96
142_A148_A1.0630.95
152_V177_R1.0600.95
253_R256_G1.0560.95
111_Q116_Y1.0530.95
144_F190_R1.0510.95
164_A220_W1.0480.95
271_R274_Y1.0450.95
20_A24_A1.0420.95
77_A118_G1.0240.94
142_A146_F1.0030.94
36_F59_L0.9870.93
185_P189_S0.9850.93
223_A229_F0.9830.93
79_L87_V0.9820.93
151_A181_N0.9790.93
161_L164_A0.9710.92
26_V195_A0.9680.92
44_P146_F0.9670.92
136_Y140_A0.9620.92
177_R180_A0.9420.91
39_R136_Y0.9360.91
254_L257_E0.9240.90
175_D179_L0.9170.90
52_V141_V0.9160.90
220_W224_Y0.9140.90
260_E269_R0.9100.90
41_T70_L0.9080.90
238_P243_S0.9010.89
270_V275_T0.9010.89
108_A112_V0.8990.89
275_T278_G0.8970.89
82_A88_V0.8970.89
124_P138_A0.8960.89
42_T47_I0.8960.89
100_N104_H0.8940.89
29_Y191_V0.8880.89
143_S150_N0.8870.89
42_T54_S0.8820.88
36_F39_R0.8720.88
180_A183_L0.8710.88
267_G271_R0.8630.87
73_W86_D0.8630.87
170_D235_P0.8600.87
127_L150_N0.8600.87
113_E116_Y0.8550.87
82_A86_D0.8520.86
262_E268_H0.8500.86
153_V161_L0.8450.86
84_R110_Q0.8390.86
163_R208_P0.8380.86
169_R175_D0.8330.85
261_M267_G0.8310.85
84_R103_T0.8300.85
27_D31_D0.8260.85
166_E232_P0.8200.84
124_P139_N0.8190.84
29_Y39_R0.8190.84
244_R248_R0.8130.84
222_H225_Q0.8070.83
270_V273_D0.8050.83
180_A184_L0.8000.83
261_M264_D0.8000.83
261_M270_V0.7960.83
95_S253_R0.7960.83
52_V133_V0.7950.82
189_S193_N0.7940.82
85_S106_H0.7810.81
136_Y198_E0.7800.81
161_L196_V0.7790.81
270_V274_Y0.7770.81
127_L133_V0.7740.81
199_L203_A0.7700.80
49_V145_A0.7700.80
263_L266_L0.7640.80
264_D268_H0.7630.80
115_D129_E0.7620.80
199_L216_P0.7600.80
85_S88_V0.7540.79
179_L182_E0.7540.79
251_I267_G0.7530.79
54_S63_I0.7510.79
168_I232_P0.7500.79
136_Y152_V0.7490.79
198_E201_A0.7490.79
171_D177_R0.7480.78
100_N103_T0.7450.78
76_T120_I0.7450.78
157_V198_E0.7430.78
151_A192_W0.7430.78
65_A92_S0.7400.78
246_Q249_G0.7380.77
21_L164_A0.7380.77
149_G186_D0.7380.77
260_E264_D0.7380.77
53_M61_R0.7310.77
260_E270_V0.7300.77
127_L138_A0.7290.77
112_V127_L0.7290.77
26_V188_T0.7280.77
25_L196_V0.7270.76
259_D275_T0.7240.76
247_F250_R0.7200.76
149_G189_S0.7160.75
25_L199_L0.7150.75
42_T46_E0.7150.75
139_N150_N0.7140.75
151_A193_N0.7130.75
20_A220_W0.7130.75
147_N190_R0.7130.75
242_G245_R0.7120.75
245_R248_R0.7110.75
24_A219_E0.7100.75
128_S138_A0.7090.75
124_P143_S0.7060.74
193_N196_V0.7060.74
23_T115_D0.7000.74
149_G185_P0.7000.74
22_Q186_D0.6980.73
264_D269_R0.6980.73
271_R276_P0.6970.73
108_A193_N0.6950.73
272_V276_P0.6920.73
167_G179_L0.6890.73
104_H238_P0.6890.73
110_Q113_E0.6880.72
59_L62_V0.6870.72
125_A129_E0.6860.72
192_W196_V0.6810.72
49_V108_A0.6790.71
19_T23_T0.6790.71
208_P221_C0.6790.71
87_V102_A0.6750.71
124_P148_A0.6740.71
178_P181_N0.6670.70
152_V158_K0.6660.70
68_A72_R0.6650.70
82_A106_H0.6640.70
78_A81_A0.6640.70
158_K176_Y0.6630.70
169_R172_D0.6620.69
73_W87_V0.6610.69
120_I146_F0.6600.69
109_A116_Y0.6600.69
145_A189_S0.6590.69
101_R156_N0.6590.69
47_I145_A0.6560.69
48_L76_T0.6560.69
211_D218_R0.6550.69
53_M96_L0.6500.68
153_V170_D0.6450.68
241_E246_Q0.6420.67
270_V277_D0.6410.67
168_I234_V0.6390.67
253_R258_H0.6380.67
102_A106_H0.6380.67
199_L217_L0.6350.66
27_D30_T0.6350.66
229_F232_P0.6320.66
22_Q192_W0.6310.66
48_L108_A0.6290.66
208_P229_F0.6240.65
260_E265_A0.6230.65
157_V193_N0.6220.65
123_T142_A0.6210.65
273_D276_P0.6200.64
123_T148_A0.6200.64
261_M268_H0.6190.64
47_I66_W0.6180.64
61_R158_K0.6180.64
165_F183_L0.6160.64
184_L193_N0.6120.63
163_R204_C0.6090.63
108_A111_Q0.6090.63
95_S99_N0.6080.63
86_D89_G0.6070.63
136_Y153_V0.6060.63
244_R249_G0.6040.62
267_G270_V0.6030.62
108_A133_V0.6000.62
208_P215_C0.6000.62
160_V198_E0.5940.61
99_N155_T0.5930.61
252_V255_L0.5890.61
58_Q206_Q0.5880.60
157_V196_V0.5880.60
241_E250_R0.5870.60
42_T147_N0.5860.60
52_V127_L0.5860.60
139_N196_V0.5850.60
65_A68_A0.5850.60
22_Q189_S0.5820.60
91_W101_R0.5810.59
207_T230_T0.5810.59
261_M266_L0.5780.59
91_W156_N0.5780.59
24_A31_D0.5770.59
240_F252_V0.5770.59
139_N157_V0.5770.59
79_L102_A0.5760.59
128_S139_N0.5750.59
65_A194_N0.5730.58
268_H277_D0.5710.58
202_V205_Q0.5680.58
139_N142_A0.5680.58
59_L194_N0.5680.58
172_D176_Y0.5670.58
242_G249_G0.5630.57
246_Q250_R0.5630.57
173_D177_R0.5630.57
135_P170_D0.5610.57
21_L165_F0.5590.57
262_E266_L0.5580.56
109_A112_V0.5570.56
125_A148_A0.5570.56
252_V257_E0.5570.56
154_D157_V0.5560.56
65_A95_S0.5560.56
117_D209_R0.5550.56
143_S149_G0.5520.56
175_D178_P0.5500.55
92_S104_H0.5490.55
29_Y195_A0.5490.55
139_N177_R0.5480.55
26_V144_F0.5460.55
171_D180_A0.5460.55
250_R254_L0.5460.55
248_R255_L0.5450.55
168_I182_E0.5440.55
242_G248_R0.5420.54
88_V106_H0.5420.54
44_P47_I0.5410.54
139_N192_W0.5410.54
112_V118_G0.5400.54
84_R107_E0.5390.54
69_F232_P0.5360.53
196_V203_A0.5360.53
76_T109_A0.5350.53
243_S248_R0.5350.53
51_E55_Q0.5350.53
58_Q158_K0.5340.53
40_E46_E0.5320.53
147_N188_T0.5310.53
98_Y101_R0.5300.53
177_R184_L0.5300.53
259_D262_E0.5290.53
50_S54_S0.5280.52
91_W98_Y0.5240.52
264_D277_D0.5230.52
23_T27_D0.5230.52
225_Q228_D0.5210.51
81_A113_E0.5200.51
30_T195_A0.5200.51
249_G252_V0.5170.51
54_S106_H0.5160.51
27_D209_R0.5160.51
47_I70_L0.5150.51
116_Y119_A0.5130.50
68_A92_S0.5110.50
159_R163_R0.5110.50
266_L270_V0.5100.50
129_E186_D0.5090.50
266_L269_R0.5060.49
28_W34_R0.5060.49
98_Y156_N0.5050.49
181_N184_L0.5040.49
111_Q117_D0.5010.49
168_I228_D0.5000.49
107_E111_Q0.5000.49
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fspA 1 0.9359 100 0.34 Contact Map
3n5nX 1 0.8109 100 0.38 Contact Map
1kg2A 1 0.6987 100 0.393 Contact Map
1keaA 2 0.6795 100 0.43 Contact Map
1ornA 1 0.6795 100 0.435 Contact Map
4unfA 1 0.7019 100 0.44 Contact Map
4uobA 1 0.7147 100 0.447 Contact Map
2abkA 1 0.6699 100 0.463 Contact Map
1pu6A 1 0.6058 100 0.556 Contact Map
3n0uA 1 0.6314 100 0.612 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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