GREMLIN Database
Q9HPQ4 - Uncharacterized protein
UniProt: Q9HPQ4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 458 (377)
Sequences: 20936 (12475)
Seq/√Len: 642.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
83_E89_D4.3911.00
260_A264_R3.9551.00
403_R437_E3.9061.00
50_F58_V3.5761.00
360_Q429_D3.2031.00
45_D52_T3.1041.00
120_R343_D2.9501.00
360_Q425_E2.9051.00
284_E290_H2.8561.00
349_G352_D2.8001.00
353_H357_R2.7121.00
424_T427_E2.6551.00
77_K347_S2.6001.00
80_D84_S2.5001.00
62_F431_A2.4781.00
77_K344_A2.3651.00
340_A343_D2.3541.00
120_R346_T2.3431.00
50_F427_E2.3311.00
219_A258_D2.3261.00
258_D261_D2.3061.00
364_R432_V2.2871.00
399_A441_D2.2641.00
44_E54_V2.2341.00
403_R441_D2.2331.00
75_N344_A2.2091.00
369_D436_L2.2051.00
261_D265_T2.1971.00
52_T58_V2.1391.00
399_A402_K2.1261.00
364_R429_D2.1191.00
77_K340_A2.1161.00
157_R233_E2.0531.00
356_A425_E2.0381.00
79_M83_E1.9971.00
120_R339_V1.9901.00
430_I434_I1.9901.00
117_L338_G1.9641.00
223_H265_T1.9561.00
196_P221_K1.9201.00
53_D57_N1.8821.00
362_T366_H1.8781.00
57_N404_G1.8501.00
131_D313_E1.8461.00
359_E363_D1.8331.00
399_A403_R1.8201.00
132_T313_E1.8041.00
405_L434_I1.8011.00
362_T378_G1.7941.00
344_A348_D1.7901.00
364_R367_D1.7681.00
50_F430_I1.7671.00
157_R193_V1.7391.00
238_I271_I1.7331.00
313_E317_P1.6931.00
44_E90_P1.6871.00
222_L259_I1.6821.00
143_V299_T1.6631.00
374_T388_D1.6391.00
284_E355_V1.6211.00
82_L337_Q1.6191.00
119_D123_D1.6161.00
370_P440_D1.6151.00
370_P436_L1.6071.00
116_Q339_V1.6001.00
162_D196_P1.5901.00
362_T383_L1.5871.00
399_A438_A1.5801.00
82_L88_V1.5791.00
47_I76_P1.5791.00
49_P427_E1.5651.00
124_I346_T1.5651.00
120_R123_D1.5551.00
272_S288_I1.5361.00
239_M259_I1.5311.00
357_R360_Q1.5291.00
226_R268_I1.5091.00
436_L440_D1.5041.00
357_R428_I1.4921.00
237_L263_Q1.4831.00
159_L234_V1.4701.00
300_S308_A1.4621.00
400_C407_V1.4541.00
84_S90_P1.4461.00
49_P422_D1.4451.00
254_D257_A1.4381.00
368_A436_L1.4361.00
260_A263_Q1.4321.00
76_P80_D1.4311.00
145_N309_T1.4311.00
260_A270_V1.4211.00
58_V430_I1.4191.00
200_C258_D1.4101.00
353_H356_A1.4081.00
158_A236_Y1.3991.00
160_T194_S1.3901.00
122_T133_V1.3841.00
285_L289_D1.3811.00
357_R425_E1.3791.00
198_C252_N1.3781.00
339_V343_D1.3631.00
352_D356_A1.3631.00
290_H379_R1.3561.00
80_D83_E1.3561.00
147_I158_A1.3561.00
300_S310_V1.3541.00
125_T310_V1.3531.00
403_R438_A1.3501.00
133_V310_V1.3451.00
284_E289_D1.3341.00
340_A344_A1.3271.00
161_F255_F1.3271.00
220_D224_H1.3191.00
79_M89_D1.3151.00
364_R433_D1.3141.00
360_Q364_R1.3141.00
47_I74_N1.3131.00
364_R436_L1.3121.00
368_A432_V1.3121.00
157_R231_P1.3091.00
123_D346_T1.3021.00
239_M256_I1.2991.00
143_V238_I1.2941.00
53_D59_L1.2941.00
288_I298_I1.2901.00
223_H258_D1.2811.00
146_A299_T1.2781.00
118_L135_L1.2731.00
423_V428_I1.2711.00
237_L259_I1.2651.00
150_C271_I1.2611.00
74_N79_M1.2571.00
81_R340_A1.2551.00
71_F344_A1.2481.00
75_N348_D1.2481.00
45_D90_P1.2431.00
297_V311_A1.2351.00
291_T379_R1.2301.00
427_E430_I1.2241.00
294_E312_N1.2221.00
254_D291_T1.2191.00
223_H262_I1.2181.00
355_V359_E1.2151.00
343_D347_S1.2101.00
43_T51_C1.2051.00
82_L333_V1.2041.00
257_A261_D1.1971.00
132_T317_P1.1761.00
269_P315_L1.1711.00
116_Q343_D1.1701.00
135_L335_A1.1701.00
280_G351_L1.1681.00
221_K224_H1.1661.00
136_S309_T1.1651.00
433_D437_E1.1641.00
79_M88_V1.1571.00
286_W300_S1.1401.00
195_V225_D1.1321.00
83_E88_V1.1291.00
257_A292_E1.1251.00
344_A347_S1.1221.00
403_R434_I1.1101.00
175_L192_V1.1101.00
405_L431_A1.1051.00
50_F60_M1.0951.00
430_I433_D1.0921.00
129_D294_E1.0921.00
49_P60_M1.0911.00
400_C434_I1.0851.00
175_L238_I1.0821.00
297_V309_T1.0631.00
304_L308_A1.0591.00
272_S293_I1.0581.00
44_E52_T1.0541.00
130_L310_V1.0541.00
142_A299_T1.0531.00
429_D433_D1.0501.00
117_L339_V1.0481.00
400_C438_A1.0481.00
201_E374_T1.0451.00
120_R124_I1.0431.00
395_A399_A1.0421.00
47_I52_T1.0381.00
425_E429_D1.0351.00
42_I54_V1.0311.00
77_K343_D1.0311.00
363_D367_D1.0171.00
97_D100_A1.0151.00
263_Q268_I1.0141.00
224_H229_I1.0131.00
253_D257_A1.0131.00
156_H233_E1.0121.00
47_I58_V1.0111.00
140_A172_A1.0091.00
196_P199_T1.0061.00
352_D355_V1.0031.00
261_D264_R1.0011.00
236_Y271_I0.9971.00
306_V341_T0.9951.00
241_P272_S0.9911.00
44_E56_G0.9871.00
400_C405_L0.9871.00
223_H261_D0.9851.00
398_N402_K0.9701.00
155_G267_D0.9701.00
279_L345_I0.9671.00
283_G289_D0.9661.00
124_I285_L0.9641.00
223_H266_H0.9641.00
84_S336_A0.9641.00
70_P303_G0.9611.00
71_F341_T0.9601.00
80_D89_D0.9591.00
149_I309_T0.9531.00
116_Q120_R0.9521.00
77_K80_D0.9521.00
358_G362_T0.9441.00
250_V379_R0.9421.00
160_T238_I0.9381.00
60_M427_E0.9371.00
256_I291_T0.9351.00
319_E322_R0.9331.00
254_D258_D0.9301.00
374_T386_E0.9301.00
351_L354_V0.9301.00
386_E413_K0.9291.00
426_R429_D0.9261.00
396_V442_P0.9241.00
161_F251_P0.9201.00
146_A271_I0.9161.00
147_I175_L0.9131.00
353_H425_E0.9061.00
226_R234_V0.9051.00
259_I270_V0.9011.00
174_S189_I0.9001.00
71_F78_I0.9001.00
60_M430_I0.8991.00
62_F423_V0.8971.00
345_I351_L0.8931.00
290_H355_V0.8911.00
149_I311_A0.8901.00
157_R234_V0.8891.00
363_D366_H0.8861.00
336_A340_A0.8841.00
262_I266_H0.8831.00
124_I342_I0.8821.00
96_Q99_Y0.8811.00
231_P266_H0.8791.00
345_I350_L0.8751.00
264_R294_E0.8741.00
197_Y251_P0.8681.00
367_D436_L0.8671.00
285_L351_L0.8641.00
87_L90_P0.8641.00
126_A288_I0.8641.00
150_C236_Y0.8631.00
78_I337_Q0.8631.00
161_F197_Y0.8591.00
200_C218_A0.8591.00
115_T119_D0.8591.00
140_A169_T0.8591.00
277_A382_M0.8551.00
218_A221_K0.8521.00
69_A306_V0.8511.00
193_V225_D0.8511.00
49_P424_T0.8491.00
156_H191_G0.8491.00
129_D298_I0.8391.00
258_D262_I0.8381.00
351_L355_V0.8301.00
77_K81_R0.8301.00
219_A262_I0.8291.00
360_Q363_D0.8281.00
152_N322_R0.8271.00
350_L354_V0.8221.00
150_C269_P0.8221.00
437_E441_D0.8191.00
136_S142_A0.8191.00
84_S89_D0.8171.00
242_Q379_R0.8151.00
117_L335_A0.8141.00
42_I115_T0.8111.00
375_D386_E0.8091.00
122_T130_L0.8061.00
356_A360_Q0.8011.00
60_M431_A0.8011.00
263_Q270_V0.8001.00
381_L423_V0.7991.00
423_V431_A0.7981.00
221_K225_D0.7971.00
384_A414_T0.7941.00
220_D223_H0.7911.00
376_V383_L0.7881.00
382_M418_L0.7881.00
288_I293_I0.7871.00
286_W298_I0.7861.00
417_L435_L0.7851.00
87_L91_L0.7841.00
244_G276_Q0.7841.00
279_L342_I0.7821.00
397_V409_G0.7801.00
241_P256_I0.7791.00
357_R381_L0.7771.00
257_A291_T0.7761.00
325_S328_G0.7751.00
377_R386_E0.7751.00
28_H122_T0.7701.00
48_G422_D0.7681.00
399_A442_P0.7641.00
438_A442_P0.7631.00
364_R428_I0.7631.00
239_M270_V0.7601.00
285_L346_T0.7601.00
230_D233_E0.7531.00
279_L300_S0.7521.00
67_A418_L0.7521.00
171_G189_I0.7521.00
60_M405_L0.7501.00
234_V268_I0.7491.00
154_G233_E0.7481.00
314_D317_P0.7451.00
150_C297_V0.7441.00
130_L298_I0.7431.00
81_R337_Q0.7431.00
201_E223_H0.7411.00
260_A293_I0.7401.00
312_N315_L0.7391.00
146_A297_V0.7381.00
121_L310_V0.7381.00
378_G383_L0.7361.00
237_L268_I0.7351.00
396_V435_L0.7341.00
193_V196_P0.7341.00
395_A398_N0.7331.00
179_K183_R0.7331.00
195_V199_T0.7311.00
133_V308_A0.7281.00
49_P420_P0.7261.00
280_G345_I0.7261.00
354_V358_G0.7251.00
267_D314_D0.7231.00
28_H119_D0.7211.00
300_S304_L0.7161.00
282_T290_H0.7151.00
147_I238_I0.7131.00
279_L285_L0.7111.00
195_V198_C0.7091.00
279_L304_L0.7071.00
63_T408_L0.7051.00
51_C406_L0.7011.00
242_Q282_T0.7011.00
137_N141_E0.7011.00
356_A359_E0.6991.00
387_F396_V0.6981.00
288_I295_P0.6971.00
143_V172_A0.6971.00
386_E414_T0.6941.00
431_A434_I0.6911.00
426_R430_I0.6891.00
387_F439_L0.6861.00
96_Q100_A0.6861.00
423_V427_E0.6841.00
62_F405_L0.6841.00
226_R262_I0.6821.00
358_G378_G0.6791.00
390_K393_R0.6771.00
271_I297_V0.6761.00
253_D291_T0.6751.00
270_V293_I0.6751.00
398_N401_V0.6741.00
311_A316_F0.6741.00
262_I265_T0.6721.00
359_E362_T0.6711.00
81_R84_S0.6681.00
78_I306_V0.6671.00
360_Q428_I0.6661.00
417_L431_A0.6651.00
256_I272_S0.6651.00
315_L318_S0.6651.00
253_D379_R0.6641.00
49_P423_V0.6631.00
396_V438_A0.6621.00
149_I297_V0.6621.00
405_L430_I0.6611.00
162_D194_S0.6601.00
353_H424_T0.6591.00
243_Q249_R0.6591.00
400_C435_L0.6581.00
57_N402_K0.6581.00
250_V378_G0.6581.00
222_L237_L0.6541.00
138_T141_E0.6541.00
275_I299_T0.6521.00
43_T46_A0.6521.00
136_S141_E0.6511.00
76_P89_D0.6501.00
220_D258_D0.6501.00
354_V381_L0.6491.00
397_V401_V0.6471.00
125_T298_I0.6461.00
64_S420_P0.6451.00
391_K394_E0.6451.00
242_Q382_M0.6431.00
148_K323_L0.6431.00
264_R270_V0.6431.00
88_V333_V0.6421.00
364_R368_A0.6401.00
58_V434_I0.6391.00
226_R266_H0.6391.00
71_F350_L0.6381.00
124_I284_E0.6371.00
369_D440_D0.6361.00
129_D312_N0.6361.00
432_V436_L0.6351.00
114_A118_L0.6341.00
155_G268_I0.6341.00
64_S418_L0.6331.00
32_S35_V0.6331.00
438_A441_D0.6321.00
157_R230_D0.6311.00
415_V435_L0.6311.00
376_V385_V0.6281.00
396_V400_C0.6271.00
157_R191_G0.6271.00
145_N323_L0.6251.00
81_R343_D0.6251.00
139_G275_I0.6241.00
368_A433_D0.6241.00
243_Q246_G0.6241.00
434_I438_A0.6231.00
223_H228_V0.6231.00
372_F388_D0.6221.00
354_V421_L0.6211.00
337_Q340_A0.6191.00
161_F195_V0.6181.00
126_A130_L0.6181.00
29_A32_S0.6181.00
251_P254_D0.6171.00
396_V415_V0.6171.00
155_G233_E0.6161.00
385_V435_L0.6131.00
120_R342_I0.6121.00
125_T286_W0.6101.00
225_D228_V0.6091.00
151_Y187_P0.6081.00
41_D44_E0.6061.00
159_L225_D0.6051.00
355_V358_G0.6051.00
88_V337_Q0.6051.00
47_I50_F0.6041.00
201_E394_E0.6011.00
74_N88_V0.6011.00
147_I171_G0.6011.00
361_T432_V0.6011.00
434_I437_E0.5981.00
194_S198_C0.5951.00
46_A91_L0.5931.00
117_L135_L0.5911.00
241_P277_A0.5901.00
60_M423_V0.5881.00
257_A260_A0.5871.00
63_T406_L0.5871.00
179_K182_H0.5861.00
195_V222_L0.5851.00
361_T383_L0.5851.00
151_Y170_L0.5851.00
377_R414_T0.5841.00
70_P421_L0.5831.00
304_L338_G0.5831.00
129_D288_I0.5821.00
124_I286_W0.5801.00
357_R423_V0.5801.00
264_R314_D0.5791.00
132_T316_F0.5781.00
373_V439_L0.5781.00
195_V221_K0.5771.00
182_H186_F0.5771.00
122_T131_D0.5761.00
161_F239_M0.5761.00
244_G382_M0.5741.00
361_T428_I0.5741.00
331_D334_A0.5731.00
116_Q119_D0.5731.00
165_F168_R0.5721.00
276_Q382_M0.5691.00
279_L286_W0.5691.00
297_V315_L0.5691.00
46_A51_C0.5681.00
377_R384_A0.5681.00
429_D432_V0.5661.00
360_Q432_V0.5631.00
70_P345_I0.5611.00
125_T300_S0.5611.00
193_V200_C0.5601.00
402_K441_D0.5591.00
269_P297_V0.5581.00
159_L222_L0.5571.00
84_S340_A0.5571.00
388_D391_K0.5571.00
183_R186_F0.5571.00
198_C201_E0.5541.00
428_I432_V0.5541.00
435_L439_L0.5541.00
157_R229_I0.5531.00
153_N235_A0.5521.00
431_A435_L0.5521.00
285_L345_I0.5501.00
373_V385_V0.5501.00
122_T310_V0.5481.00
251_P256_I0.5471.00
405_L438_A0.5461.00
348_D353_H0.5461.00
224_H228_V0.5441.00
44_E47_I0.5421.00
346_T349_G0.5411.00
357_R424_T0.5401.00
39_V401_V0.5391.00
298_I310_V0.5381.00
253_D292_E0.5381.00
428_I431_A0.5360.99
368_A439_L0.5350.99
43_T91_L0.5350.99
163_G246_G0.5340.99
41_D401_V0.5330.99
390_K394_E0.5320.99
232_E266_H0.5320.99
177_R194_S0.5310.99
78_I341_T0.5310.99
250_V291_T0.5310.99
255_F259_I0.5310.99
239_M272_S0.5290.99
29_A35_V0.5260.99
420_P423_V0.5260.99
260_A294_E0.5250.99
274_E287_G0.5240.99
180_A183_R0.5230.99
389_T392_R0.5210.99
366_H376_V0.5200.99
350_L421_L0.5200.99
178_S181_I0.5200.99
159_L195_V0.5200.99
218_A226_R0.5190.99
259_I268_I0.5190.99
161_F259_I0.5190.99
287_G290_H0.5190.99
401_V406_L0.5190.99
222_L258_D0.5190.99
160_T192_V0.5150.99
222_L262_I0.5140.99
260_A272_S0.5130.99
201_E224_H0.5130.99
126_A289_D0.5120.99
295_P298_I0.5110.99
282_T287_G0.5110.99
236_Y269_P0.5090.99
396_V439_L0.5080.99
372_F439_L0.5070.99
353_H428_I0.5070.99
385_V417_L0.5060.99
76_P79_M0.5060.99
437_E440_D0.5050.99
223_H226_R0.5050.99
193_V199_T0.5040.99
361_T364_R0.5040.99
79_M306_V0.5020.99
408_L411_G0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4uoxA 3 0.9061 100 0.419 Contact Map
3oksA 2 0.9279 100 0.426 Contact Map
4atqA 7 0.9148 100 0.427 Contact Map
4e3qA 3 0.9083 100 0.434 Contact Map
1z7dA 2 0.7904 100 0.436 Contact Map
4ffcA 4 0.9192 100 0.437 Contact Map
3hmuA 2 0.9367 100 0.439 Contact Map
4a0gA 2 0.9279 100 0.442 Contact Map
3i5tA 2 0.8974 100 0.444 Contact Map
4nogA 2 0.8799 100 0.446 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0124 seconds.