GREMLIN Database
Q9HPQ2 - Transporter
UniProt: Q9HPQ2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 447 (422)
Sequences: 4629 (3070)
Seq/√Len: 149.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
194_E198_S4.4271.00
191_A194_E4.1221.00
150_A349_G3.9921.00
200_D203_F3.9141.00
143_G353_F3.7661.00
302_A305_V3.5711.00
68_A75_A3.1081.00
113_L308_V3.0351.00
327_E341_R3.0121.00
203_F206_D2.9431.00
288_L314_V2.8381.00
64_I75_A2.8181.00
193_Y263_L2.7941.00
239_D403_K2.7811.00
113_L312_G2.7411.00
70_L78_R2.7251.00
340_S343_A2.6871.00
197_L263_L2.6201.00
58_I230_M2.6141.00
77_D85_T2.5441.00
182_Y185_T2.4561.00
184_S193_Y2.3821.00
69_N239_D2.3541.00
394_G397_A2.2661.00
149_T322_A2.2361.00
29_Q218_Q2.1941.00
133_S136_W2.1921.00
182_Y306_L2.1591.00
18_V253_L2.1111.00
159_D163_K2.0991.00
177_V260_L2.0871.00
173_L257_V2.0661.00
177_V181_V2.0511.00
127_A131_S2.0471.00
111_R115_G2.0451.00
26_N254_N2.0361.00
190_G193_Y2.0291.00
20_S224_S1.9871.00
196_Y262_G1.9711.00
416_L420_R1.9631.00
109_V315_L1.9631.00
4_R235_S1.9621.00
190_G194_E1.9281.00
151_G155_F1.9181.00
197_L259_L1.9031.00
135_G142_H1.8741.00
370_D374_Y1.8521.00
70_L74_E1.8451.00
55_L251_V1.8381.00
54_G223_L1.8351.00
387_V392_V1.8341.00
11_L15_L1.8331.00
116_S307_G1.8211.00
180_A264_V1.8061.00
254_N258_G1.7951.00
147_A151_G1.7881.00
414_A418_S1.7771.00
110_T315_L1.7671.00
106_G318_A1.7581.00
6_T69_N1.7481.00
49_A216_V1.7431.00
115_G128_Y1.7311.00
113_L315_L1.7141.00
71_N335_D1.6921.00
117_A308_V1.6781.00
339_Y347_S1.6631.00
196_Y263_L1.6551.00
182_Y186_L1.6491.00
143_G147_A1.6351.00
346_F350_G1.6201.00
138_A142_H1.6191.00
133_S142_H1.6131.00
127_A130_G1.5981.00
180_A260_L1.5941.00
232_T328_V1.5861.00
18_V22_V1.5851.00
380_L429_V1.5801.00
415_W419_V1.5681.00
355_L358_L1.5641.00
155_F163_K1.5621.00
359_S365_W1.5551.00
59_L247_G1.5441.00
20_S324_S1.5411.00
312_G316_V1.5061.00
43_V259_L1.4941.00
98_I373_A1.4941.00
45_V212_V1.4941.00
268_L295_A1.4931.00
196_Y259_L1.4911.00
233_Y324_S1.4901.00
174_V178_G1.4901.00
62_F234_A1.4851.00
74_E336_N1.4711.00
139_V142_H1.4671.00
176_L264_V1.4601.00
84_W388_F1.4591.00
181_V185_T1.4171.00
339_Y344_T1.4141.00
183_A268_L1.4051.00
59_L243_L1.3991.00
143_G357_T1.3831.00
136_W142_H1.3821.00
383_L426_G1.3821.00
83_A86_I1.3761.00
331_A335_D1.3731.00
133_S138_A1.3661.00
41_A201_F1.3651.00
204_I211_I1.3631.00
98_I227_M1.3631.00
106_G145_F1.3591.00
224_S229_A1.3551.00
67_R400_E1.3531.00
72_A75_A1.3511.00
99_L322_A1.3481.00
12_G162_E1.3471.00
226_G382_V1.3471.00
137_E141_F1.3311.00
76_F231_I1.3241.00
396_A414_A1.3201.00
288_L291_S1.3171.00
390_G418_S1.3161.00
363_T367_D1.3091.00
82_P85_T1.2971.00
71_N74_E1.2971.00
142_H356_G1.2961.00
37_E211_I1.2911.00
135_G141_F1.2851.00
359_S369_F1.2701.00
90_M381_S1.2551.00
101_Y370_D1.2521.00
100_S355_L1.2491.00
402_K408_G1.2431.00
4_R335_D1.2431.00
36_T210_S1.2401.00
45_V204_I1.2261.00
396_A418_S1.2251.00
252_V256_S1.2251.00
139_V360_A1.2191.00
350_G354_A1.2141.00
182_Y300_G1.2081.00
368_W372_L1.2081.00
62_F230_M1.2001.00
133_S141_F1.2001.00
8_A11_L1.1991.00
286_G290_I1.1961.00
135_G138_A1.1931.00
202_G205_A1.1921.00
62_F250_I1.1911.00
66_R400_E1.1881.00
400_E403_K1.1881.00
269_L275_T1.1861.00
135_G139_V1.1791.00
63_V401_I1.1781.00
364_A367_D1.1751.00
100_S359_S1.1751.00
52_L56_P1.1721.00
411_F414_A1.1701.00
393_Y397_A1.1701.00
154_A342_P1.1691.00
136_W139_V1.1681.00
219_A254_N1.1681.00
229_A325_L1.1661.00
62_F247_G1.1641.00
99_L352_L1.1641.00
147_A353_F1.1641.00
19_G320_S1.1611.00
334_V344_T1.1591.00
366_L370_D1.1561.00
415_W420_R1.1481.00
184_S189_V1.1481.00
153_V330_T1.1391.00
137_E140_A1.1361.00
33_K214_Y1.1351.00
60_G413_T1.1341.00
94_T377_L1.1300.99
320_S323_I1.1270.99
393_Y400_E1.1240.99
154_A346_F1.1180.99
92_L332_Y1.1180.99
7_W16_A1.1180.99
354_A358_L1.1090.99
308_V312_G1.1030.99
383_L429_V1.1000.99
37_E214_Y1.0970.99
138_A141_F1.0930.99
219_A255_T1.0920.99
35_A277_P1.0920.99
343_A347_S1.0880.99
13_F17_A1.0800.99
255_T259_L1.0800.99
72_A228_G1.0800.99
244_F247_G1.0780.99
178_G306_L1.0750.99
363_T368_W1.0750.99
133_S137_E1.0740.99
139_V143_G1.0680.99
412_A416_L1.0600.99
241_D246_D1.0550.99
97_W373_A1.0520.99
129_F132_V1.0460.99
29_Q33_K1.0430.99
178_G182_Y1.0400.99
27_I314_V1.0400.99
6_T238_G1.0400.99
187_N271_V1.0380.99
59_L63_V1.0370.99
14_I18_V1.0350.99
136_W141_F1.0300.99
29_Q370_D1.0280.99
255_T258_G1.0260.99
114_L148_A1.0250.99
133_S139_V1.0250.99
45_V211_I1.0240.99
178_G181_V1.0220.99
141_F144_A1.0200.99
427_V431_L1.0180.99
66_R404_G1.0110.99
409_T412_A1.0100.99
50_A219_A1.0090.99
9_S12_G1.0080.99
99_L326_L1.0050.99
402_K405_S1.0040.99
50_A255_T1.0010.99
52_L216_V0.9990.99
330_T345_A0.9980.99
106_G322_A0.9890.99
8_A12_G0.9890.99
146_M150_A0.9890.99
57_A425_I0.9830.99
189_V192_A0.9800.99
344_T347_S0.9800.99
35_A269_L0.9730.98
164_A168_M0.9700.98
175_M309_L0.9610.98
114_L117_A0.9540.98
207_N210_S0.9510.98
187_N192_A0.9490.98
118_T121_Y0.9450.98
140_A144_A0.9450.98
68_A78_R0.9430.98
150_A345_A0.9420.98
134_M137_E0.9420.98
122_F125_P0.9410.98
177_V180_A0.9410.98
37_E210_S0.9400.98
206_D210_S0.9400.98
285_A288_L0.9360.98
270_F277_P0.9350.98
132_V138_A0.9340.98
27_I317_A0.9310.98
67_R399_D0.9280.98
411_F415_W0.9270.98
33_K218_Q0.9220.98
180_A184_S0.9190.98
134_M142_H0.9160.98
390_G417_W0.9140.98
99_L325_L0.9140.98
206_D211_I0.9130.98
124_A127_A0.9130.98
376_V433_L0.9120.98
186_L189_V0.9120.98
165_T320_S0.9120.98
182_Y299_L0.9120.98
85_T89_A0.9120.98
121_Y124_A0.9100.98
41_A204_I0.9100.98
423_V426_G0.9020.98
248_G252_V0.9020.98
179_L264_V0.9010.97
72_A91_G0.8970.97
132_V135_G0.8960.97
86_I89_A0.8940.97
138_A360_A0.8920.97
35_A270_F0.8910.97
423_V427_V0.8910.97
228_G328_V0.8900.97
34_T262_G0.8890.97
98_I325_L0.8880.97
146_M352_L0.8850.97
28_W32_F0.8830.97
229_A324_S0.8830.97
412_A415_W0.8800.97
5_E158_E0.8790.97
333_V344_T0.8780.97
87_V384_L0.8760.97
340_S344_T0.8730.97
59_L401_I0.8680.97
17_A20_S0.8620.97
33_K37_E0.8620.97
134_M141_F0.8590.97
151_G154_A0.8590.97
85_T336_N0.8530.97
60_G389_V0.8510.96
63_V398_V0.8490.96
104_V360_A0.8490.96
105_V108_W0.8460.96
349_G353_F0.8460.96
299_L306_L0.8460.96
227_M325_L0.8430.96
296_F307_G0.8420.96
358_L365_W0.8390.96
178_G309_L0.8360.96
323_I327_E0.8350.96
48_V52_L0.8320.96
35_A195_F0.8310.96
276_V283_G0.8310.96
152_I319_L0.8280.96
383_L387_V0.8270.96
18_V320_S0.8240.96
101_Y374_Y0.8210.96
96_L351_V0.8210.96
419_V423_V0.8170.96
103_S146_M0.8140.95
53_L424_L0.8130.95
274_G277_P0.8110.95
71_N331_A0.8080.95
238_G241_D0.8070.95
109_V314_V0.8070.95
48_V51_L0.8060.95
333_V339_Y0.8010.95
227_M378_L0.7990.95
266_I271_V0.7980.95
34_T196_Y0.7960.95
47_L255_T0.7960.95
146_M353_F0.7950.95
26_N46_Y0.7950.95
193_Y197_L0.7950.95
206_D212_V0.7910.95
77_D336_N0.7900.95
16_A233_Y0.7860.95
144_A148_A0.7820.94
333_V337_Y0.7810.94
144_A147_A0.7800.94
124_A297_A0.7800.94
171_S316_V0.7770.94
234_A254_N0.7750.94
55_L230_M0.7720.94
225_L229_A0.7720.94
207_N212_V0.7710.94
111_R132_V0.7680.94
74_E77_D0.7670.94
72_A231_I0.7670.94
136_W140_A0.7660.94
20_S229_A0.7650.94
25_G29_Q0.7650.94
371_S376_V0.7650.94
7_W13_F0.7630.94
149_T319_L0.7630.94
168_M320_S0.7620.94
22_V26_N0.7610.94
271_V277_P0.7600.93
294_Q298_T0.7600.93
396_A399_D0.7580.93
193_Y199_P0.7570.93
299_L303_G0.7540.93
326_L345_A0.7510.93
148_A319_L0.7510.93
16_A20_S0.7500.93
17_A250_I0.7500.93
284_G287_A0.7470.93
204_I212_V0.7470.93
380_L384_L0.7450.93
95_G329_V0.7440.93
218_Q222_S0.7430.93
226_G378_L0.7420.93
304_R308_V0.7410.93
183_A267_P0.7390.93
10_R245_A0.7340.92
77_D88_G0.7340.92
110_T149_T0.7330.92
13_F62_F0.7320.92
155_F158_E0.7300.92
58_I62_F0.7290.92
402_K410_T0.7290.92
333_V351_V0.7290.92
326_L348_F0.7280.92
111_R137_E0.7280.92
14_I250_I0.7280.92
79_L393_Y0.7260.92
34_T40_A0.7260.92
34_T43_V0.7250.92
329_V348_F0.7230.92
103_S149_T0.7220.92
73_V332_Y0.7180.91
33_K36_T0.7150.91
383_L386_V0.7150.91
421_T424_L0.7120.91
155_F159_D0.7110.91
161_I323_I0.7100.91
384_L387_V0.7090.91
153_V322_A0.7070.91
123_A126_A0.7060.91
163_K167_L0.7060.91
72_A92_L0.7040.91
111_R114_L0.7030.91
364_A368_W0.7020.90
168_M316_V0.7000.90
345_A349_G0.6990.90
363_T371_S0.6980.90
114_L141_F0.6970.90
20_S98_I0.6960.90
374_Y378_L0.6940.90
249_L253_L0.6940.90
36_T214_Y0.6930.90
95_G328_V0.6890.90
220_F382_V0.6890.90
33_K211_I0.6890.90
49_A52_L0.6880.90
68_A79_L0.6870.90
100_S322_A0.6860.89
103_S322_A0.6850.89
273_F277_P0.6840.89
386_V390_G0.6840.89
128_Y131_S0.6810.89
294_Q297_A0.6790.89
265_V293_A0.6790.89
236_Y327_E0.6770.89
94_T381_S0.6770.89
217_S375_G0.6770.89
416_L421_T0.6760.89
92_L328_V0.6750.89
96_L352_L0.6740.89
327_E334_V0.6740.89
86_I90_M0.6720.88
88_G101_Y0.6700.88
413_T417_W0.6690.88
395_P414_A0.6690.88
171_S178_G0.6690.88
35_A273_F0.6670.88
12_G165_T0.6670.88
55_L247_G0.6650.88
95_G228_G0.6650.88
285_A290_I0.6620.88
429_V433_L0.6610.88
325_L329_V0.6590.88
113_L117_A0.6550.87
76_F385_G0.6540.87
41_A45_V0.6540.87
194_E197_L0.6530.87
95_G229_A0.6530.87
26_N258_G0.6510.87
173_L177_V0.6490.87
81_H84_W0.6490.87
11_L18_V0.6490.87
22_V173_L0.6480.87
233_Y321_S0.6470.87
31_P38_G0.6460.86
57_A421_T0.6460.86
34_T204_I0.6430.86
339_Y343_A0.6420.86
115_G120_A0.6410.86
96_L348_F0.6410.86
396_A419_V0.6410.86
90_M384_L0.6410.86
10_R246_D0.6410.86
410_T413_T0.6400.86
57_A386_V0.6400.86
72_A332_Y0.6370.86
119_G304_R0.6370.86
64_I79_L0.6360.86
59_L244_F0.6350.86
23_G30_F0.6350.86
75_A231_I0.6340.85
245_A249_L0.6320.85
7_W413_T0.6290.85
59_L319_L0.6270.85
184_S187_N0.6270.85
29_Q105_V0.6260.85
211_I214_Y0.6250.85
307_G311_F0.6250.85
74_E78_R0.6250.85
58_I251_V0.6240.85
388_F392_V0.6230.84
132_V137_E0.6230.84
29_Q374_Y0.6230.84
391_W418_S0.6220.84
337_Y344_T0.6220.84
73_V88_G0.6210.84
242_S405_S0.6210.84
100_S369_F0.6210.84
58_I225_L0.6200.84
399_D408_G0.6190.84
182_Y187_N0.6190.84
427_V430_T0.6180.84
172_I313_V0.6170.84
188_G191_A0.6170.84
28_W285_A0.6160.84
117_A120_A0.6160.84
300_G304_R0.6150.84
57_A219_A0.6140.84
192_A306_L0.6130.83
103_S145_F0.6130.83
148_A155_F0.6120.83
187_N270_F0.6120.83
408_G411_F0.6110.83
93_L97_W0.6110.83
106_G149_T0.6100.83
185_T188_G0.6100.83
145_F148_A0.6080.83
156_G323_I0.6080.83
317_A320_S0.6070.83
106_G315_L0.6070.83
183_A266_I0.6050.83
11_L14_I0.6040.83
13_F413_T0.6040.83
329_V350_G0.6040.83
426_G430_T0.6040.83
49_A219_A0.6030.82
103_S142_H0.6010.82
188_G192_A0.6010.82
82_P86_I0.6010.82
389_V393_Y0.5990.82
114_L118_T0.5990.82
202_G206_D0.5990.82
350_G389_V0.5930.81
183_A264_V0.5920.81
414_A419_V0.5900.81
26_N255_T0.5900.81
46_Y222_S0.5890.81
232_T324_S0.5880.81
189_V193_Y0.5880.81
310_F327_E0.5860.81
17_A230_M0.5860.81
152_I164_A0.5850.81
67_R393_Y0.5850.81
101_Y227_M0.5850.81
60_G417_W0.5840.80
62_F243_L0.5840.80
224_S324_S0.5820.80
273_F298_T0.5820.80
363_T366_L0.5790.80
91_G381_S0.5770.80
163_K166_K0.5770.80
224_S325_L0.5760.80
15_L19_G0.5760.80
247_G251_V0.5750.79
188_G271_V0.5750.79
187_N190_G0.5750.79
334_V341_R0.5740.79
236_Y331_A0.5740.79
330_T348_F0.5740.79
148_A151_G0.5730.79
383_L425_I0.5720.79
32_F285_A0.5720.79
226_G328_V0.5710.79
180_A193_Y0.5700.79
26_N50_A0.5690.79
150_A346_F0.5680.79
237_L241_D0.5670.78
229_A386_V0.5670.78
17_A58_I0.5670.78
110_T148_A0.5650.78
171_S174_V0.5650.78
132_V139_V0.5640.78
222_S254_N0.5610.78
343_A346_F0.5610.78
61_E65_G0.5600.78
216_V428_F0.5600.78
322_A356_G0.5580.77
92_L329_V0.5570.77
13_F237_L0.5570.77
284_G289_F0.5560.77
351_V355_L0.5520.77
98_I374_Y0.5520.77
60_G63_V0.5520.77
422_Y425_I0.5500.76
289_F310_F0.5500.76
178_G184_S0.5490.76
358_L369_F0.5490.76
96_L329_V0.5490.76
239_D400_E0.5490.76
25_G28_W0.5460.76
40_A199_P0.5400.75
235_S335_D0.5380.75
186_L192_A0.5370.75
224_S230_M0.5360.75
67_R397_A0.5360.75
43_V196_Y0.5360.75
351_V358_L0.5360.75
122_F126_A0.5350.74
289_F311_F0.5330.74
7_W54_G0.5320.74
35_A278_D0.5310.74
87_V388_F0.5310.74
84_W87_V0.5290.74
369_F373_A0.5270.73
102_Y105_V0.5270.73
7_W268_L0.5270.73
242_S246_D0.5260.73
50_A251_V0.5250.73
334_V339_Y0.5240.73
176_L261_A0.5240.73
330_T334_V0.5240.73
32_F287_A0.5230.73
264_V269_L0.5230.73
47_L51_L0.5230.73
14_I249_L0.5210.72
197_L201_F0.5200.72
101_Y366_L0.5200.72
46_Y255_T0.5190.72
28_W38_G0.5190.72
98_I224_S0.5170.72
228_G335_D0.5150.72
291_S294_Q0.5150.72
146_M356_G0.5150.72
242_S245_A0.5150.72
107_G149_T0.5140.71
182_Y192_A0.5140.71
54_G219_A0.5130.71
121_Y297_A0.5130.71
223_L255_T0.5120.71
239_D404_G0.5120.71
203_F211_I0.5120.71
211_I218_Q0.5120.71
242_S247_G0.5120.71
51_L54_G0.5110.71
64_I389_V0.5090.71
153_V345_A0.5090.71
366_L369_F0.5090.71
169_V172_I0.5090.71
261_A265_V0.5080.71
135_G140_A0.5080.71
128_Y132_V0.5080.71
347_S351_V0.5070.70
389_V398_V0.5070.70
51_L415_W0.5070.70
400_E404_G0.5060.70
28_W31_P0.5050.70
234_A255_T0.5050.70
137_E142_H0.5020.70
99_L153_V0.5020.70
72_A229_A0.5000.69
265_V292_V0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4xp4A 1 0.9888 100 0.033 Contact Map
4us3A 1 0.9441 100 0.061 Contact Map
2a65A 2 0.9843 100 0.062 Contact Map
3giaA 1 0.8702 98.2 0.917 Contact Map
4djkA 2 0.8658 97.3 0.932 Contact Map
3l1lA 2 0.8322 97 0.935 Contact Map
2jlnA 1 0.8725 89 0.955 Contact Map
2wswA 3 0.8143 86.2 0.957 Contact Map
4wgvA 2 0.8166 85.7 0.957 Contact Map
3dh4A 3 0.8546 76.1 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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