GREMLIN Database
Q9HPQ1 - Transporter
UniProt: Q9HPQ1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 477 (420)
Sequences: 4658 (3051)
Seq/√Len: 148.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
194_A198_S4.3821.00
191_A194_A4.0741.00
150_G344_V3.8831.00
200_D203_L3.7511.00
297_Y300_A3.5131.00
67_S74_A3.0361.00
133_S136_L3.0111.00
132_V135_G2.9651.00
322_E336_R2.8931.00
113_F303_A2.8801.00
143_L348_T2.8471.00
203_L206_A2.8361.00
63_I74_A2.8011.00
335_S338_R2.7541.00
113_F307_A2.7441.00
284_L309_V2.7381.00
193_L263_L2.6951.00
69_R77_S2.6131.00
239_E398_L2.6051.00
57_L230_M2.5631.00
197_L263_L2.5291.00
76_S85_R2.4881.00
135_G138_A2.4721.00
182_W185_T2.3761.00
149_T317_S2.3311.00
68_R239_E2.2981.00
184_S193_L2.2811.00
126_G129_F2.2211.00
182_W301_V2.1551.00
134_Y138_A2.1401.00
428_V432_A2.1201.00
28_R218_Q2.0991.00
159_R163_N2.0861.00
25_N254_N2.0661.00
389_G392_A2.0481.00
173_V257_I2.0471.00
17_V253_L2.0131.00
177_I181_A2.0041.00
177_I260_L2.0031.00
196_Y262_G1.9741.00
111_R115_A1.9631.00
190_G193_L1.9571.00
109_I310_S1.9571.00
414_A418_V1.9311.00
19_S224_S1.9281.00
3_R235_S1.9161.00
132_V138_A1.9071.00
69_R73_G1.8511.00
147_A151_L1.8501.00
190_G194_A1.8421.00
151_L155_R1.8241.00
365_A369_V1.8221.00
116_S302_G1.8191.00
131_T134_Y1.8171.00
54_V251_A1.8161.00
382_L387_V1.8131.00
131_T135_G1.8121.00
10_L14_M1.7981.00
53_G223_L1.7691.00
254_N258_G1.7451.00
180_A264_V1.7311.00
334_V339_A1.7221.00
117_L303_A1.7151.00
110_L310_S1.7131.00
48_V216_A1.7071.00
142_H351_G1.7041.00
139_V355_A1.7041.00
412_L416_G1.6911.00
132_V136_L1.6891.00
79_S83_L1.6891.00
139_V142_H1.6851.00
182_W186_L1.6851.00
106_G313_A1.6731.00
113_F310_S1.6691.00
70_S330_D1.6421.00
197_L259_V1.6361.00
187_D271_A1.6321.00
232_T323_L1.6261.00
334_V342_L1.6221.00
341_A345_G1.6151.00
274_G277_G1.6061.00
5_V68_R1.6011.00
352_S356_L1.5771.00
155_R163_N1.5621.00
115_A128_Y1.5591.00
180_A260_L1.5561.00
19_S319_S1.5551.00
17_V21_V1.5541.00
66_R395_E1.5531.00
350_T353_A1.5491.00
375_A427_L1.5471.00
98_L368_L1.5451.00
84_W383_F1.5431.00
196_Y263_L1.5431.00
307_A311_L1.5291.00
395_E398_L1.5291.00
354_T360_L1.5251.00
233_Y319_S1.5241.00
58_L247_G1.5171.00
139_V143_L1.4741.00
61_F234_A1.4601.00
174_V178_V1.4491.00
83_L86_V1.4471.00
44_V212_L1.4461.00
131_T138_A1.4331.00
73_G331_E1.4331.00
413_Y417_V1.4291.00
356_L359_G1.4271.00
34_S277_G1.4191.00
106_G145_F1.4001.00
378_I424_I1.3941.00
176_L264_V1.3921.00
204_L211_I1.3891.00
11_G162_E1.3871.00
183_A268_L1.3851.00
181_A185_T1.3851.00
226_G377_L1.3771.00
42_L259_V1.3641.00
58_L243_L1.3591.00
130_A133_S1.3591.00
326_S330_D1.3491.00
385_G416_G1.3401.00
391_N412_L1.3341.00
75_F231_I1.3281.00
196_Y259_V1.3251.00
268_L291_A1.3241.00
154_V337_R1.3241.00
224_S229_T1.3111.00
99_L317_S1.3091.00
90_L376_G1.2871.00
70_S73_G1.2741.00
363_F367_T1.2691.00
182_W296_P1.2681.00
40_A201_V1.2671.00
361_F365_A1.2651.00
354_T364_V1.2601.00
98_L227_S1.2591.00
147_A348_T1.2581.00
133_S138_A1.2491.00
71_P74_A1.2471.00
345_G349_V1.2441.00
36_N211_I1.2421.00
7_H10_L1.2411.00
388_V392_A1.2381.00
101_F365_A1.2341.00
252_V256_C1.2241.00
44_V204_L1.2241.00
202_E205_E1.2241.00
92_V327_F1.2131.00
100_S350_T1.2121.00
229_T320_M1.2101.00
3_R330_D1.1811.00
329_V339_A1.1741.00
18_G315_S1.1701.00
51_C55_P1.1541.00
409_T412_L1.1531.00
284_L287_G1.1511.00
282_G286_V1.1411.00
32_M214_A1.1391.00
61_F250_I1.1391.00
134_Y137_D1.1391.00
61_F230_M1.1310.99
410_P414_A1.1300.99
140_G144_L1.1260.99
349_V353_A1.1260.99
184_S189_A1.1220.99
71_P228_G1.1220.99
391_N416_G1.1200.99
99_L347_F1.1190.99
141_F144_L1.1180.99
270_F277_G1.1160.99
338_R342_L1.1090.99
124_N127_Q1.1090.99
421_V425_F1.1070.99
6_W15_A1.1060.99
153_V325_V1.1060.99
378_I427_L1.1040.99
28_R365_A1.0970.99
59_A411_W1.0960.99
100_S354_T1.0860.99
255_T259_V1.0790.99
36_N214_A1.0790.99
154_V341_A1.0780.99
121_Y124_N1.0770.99
61_F247_G1.0740.99
219_A254_N1.0740.99
58_L62_V1.0630.99
303_A307_A1.0630.99
315_S318_I1.0590.99
44_V211_I1.0560.99
179_L264_V1.0550.99
99_L321_L1.0510.99
206_A211_I1.0500.99
219_A255_T1.0470.99
97_V368_L1.0460.99
12_F16_A1.0440.99
413_Y418_V1.0440.99
425_F429_S1.0430.99
94_I372_L1.0410.99
132_V137_D1.0400.99
133_S137_D1.0400.99
178_V182_W1.0390.99
5_V238_D1.0370.99
28_R32_M1.0370.99
62_V396_Y1.0260.99
175_L304_V1.0230.99
150_G340_T1.0220.99
187_D192_G1.0170.99
178_V301_V1.0160.99
7_H11_G1.0150.99
114_G148_I1.0100.99
241_R246_D1.0080.99
131_T136_L1.0080.99
358_P361_F1.0070.99
26_L312_A1.0060.99
244_A247_G1.0030.99
130_A134_Y0.9980.99
177_I180_A0.9920.99
96_V346_V0.9920.99
8_S11_G0.9850.99
51_C216_A0.9840.99
26_L309_V0.9840.99
228_G323_L0.9840.99
106_G317_S0.9830.99
49_V219_A0.9810.99
278_T282_G0.9770.99
146_L150_G0.9750.98
40_A204_L0.9740.98
328_L334_V0.9710.98
255_T258_G0.9690.98
56_G423_L0.9690.98
99_L320_M0.9660.98
13_I17_V0.9530.98
325_V340_T0.9520.98
409_T413_Y0.9490.98
32_M218_Q0.9480.98
164_A168_M0.9480.98
85_R331_E0.9430.98
142_H146_L0.9380.98
355_A359_G0.9360.98
103_S142_H0.9310.98
104_V355_A0.9290.98
114_G117_L0.9270.98
165_T315_S0.9260.98
27_W31_W0.9250.98
4_D158_K0.9230.98
49_V255_T0.9150.98
86_V89_H0.9140.98
371_L431_I0.9080.98
410_P413_Y0.9040.98
229_T319_S0.9040.98
178_V304_V0.9030.98
124_N293_V0.9020.97
204_L212_L0.9010.97
281_P284_L0.8990.97
391_N394_T0.8950.97
186_L189_A0.8940.97
292_F302_G0.8910.97
98_L320_M0.8910.97
178_V181_A0.8900.97
47_G50_L0.8900.97
85_R89_H0.8900.97
71_P91_S0.8880.97
152_I314_I0.8860.97
33_T196_Y0.8860.97
328_L339_A0.8830.97
276_A279_G0.8780.97
189_A192_G0.8770.97
146_L347_F0.8750.97
101_F369_V0.8740.97
385_G415_V0.8740.97
67_S77_S0.8730.97
87_F379_G0.8720.97
335_S339_A0.8710.97
129_F133_S0.8700.97
421_V424_I0.8700.97
70_S326_S0.8690.97
362_D365_A0.8680.97
16_A19_S0.8680.97
32_M36_N0.8610.97
397_E406_A0.8550.97
62_V393_V0.8540.97
182_W295_V0.8540.97
193_L197_L0.8510.96
131_T137_D0.8500.96
295_V301_V0.8490.96
52_V422_F0.8490.96
34_S195_F0.8470.96
180_A184_S0.8430.96
34_S274_G0.8420.96
226_G373_M0.8370.96
366_G371_L0.8360.96
227_S373_M0.8350.96
227_S320_M0.8290.96
47_G51_C0.8280.96
318_I322_E0.8260.96
407_L410_P0.8250.96
357_S361_F0.8240.96
295_V298_G0.8240.96
59_A384_T0.8220.96
105_V108_W0.8170.96
71_P231_I0.8170.96
13_I250_I0.8160.95
78_L388_V0.8140.95
183_A267_P0.8130.95
238_D241_R0.8090.95
148_I314_I0.8080.95
419_I422_F0.8030.95
118_T121_Y0.8020.95
328_L332_Y0.8010.95
17_V315_S0.8000.95
34_S269_L0.7970.95
128_Y133_S0.7970.95
171_A311_L0.7960.95
72_V327_F0.7940.95
25_N45_Y0.7930.95
6_W12_F0.7920.95
95_A324_P0.7900.95
19_S229_T0.7900.95
33_T262_G0.7900.95
206_A212_L0.7890.95
290_N294_A0.7880.95
150_G341_A0.7860.94
339_A342_L0.7860.94
353_A360_L0.7830.94
46_L255_T0.7820.94
265_V289_A0.7810.94
272_L294_A0.7780.94
168_M311_L0.7750.94
73_G76_S0.7740.94
114_G141_F0.7710.94
24_G28_R0.7700.94
225_L229_T0.7700.94
149_T314_I0.7690.94
15_A233_Y0.7670.94
66_R394_T0.7670.94
278_T287_G0.7660.94
388_V395_E0.7650.94
152_I164_A0.7650.94
344_V348_T0.7640.94
79_S84_W0.7610.93
267_P271_A0.7580.93
151_L154_V0.7560.93
15_A19_S0.7550.93
57_L61_F0.7550.93
378_I382_L0.7530.93
207_D212_L0.7500.93
324_P343_F0.7490.93
161_I318_I0.7480.93
249_A253_L0.7460.93
234_A254_N0.7440.93
168_M315_S0.7430.93
394_T406_A0.7400.92
76_S88_G0.7380.92
218_Q222_T0.7380.92
109_I309_V0.7370.92
21_V25_N0.7370.92
103_S317_S0.7350.92
220_L377_L0.7350.92
100_S317_S0.7350.92
375_A379_G0.7330.92
76_S331_E0.7330.92
129_F136_L0.7330.92
113_F117_L0.7320.92
299_R303_A0.7320.92
417_V421_V0.7320.92
381_L385_G0.7300.92
144_L148_I0.7300.92
248_A252_V0.7300.92
16_A250_I0.7290.92
6_W411_W0.7290.92
33_T42_L0.7290.92
427_L431_I0.7290.92
163_N167_L0.7280.92
414_A419_I0.7260.92
334_V338_R0.7240.92
19_S98_L0.7230.92
72_V88_G0.7210.92
34_S270_F0.7200.91
397_E408_S0.7190.91
275_D287_G0.7170.91
406_A409_T0.7150.91
32_M211_I0.7120.91
386_W416_G0.7110.91
103_S149_T0.7100.91
321_L340_T0.7070.91
332_Y339_A0.7060.91
290_N293_V0.7050.91
71_P327_F0.7050.91
32_M35_E0.7040.91
56_G381_L0.7020.90
281_P286_V0.7020.90
155_R158_K0.7020.90
9_R246_D0.7000.90
346_V350_T0.6990.90
329_V336_R0.6970.90
33_T39_A0.6960.90
328_L346_V0.6960.90
110_L148_I0.6950.90
54_V230_M0.6940.90
266_F271_A0.6930.90
79_S383_F0.6920.90
88_G101_F0.6910.90
12_F61_F0.6900.90
9_R245_A0.6900.90
146_L348_T0.6890.90
340_T344_V0.6890.90
390_Q412_L0.6850.89
95_A229_T0.6820.89
95_A228_G0.6820.89
57_L225_L0.6810.89
48_V51_C0.6800.89
173_V177_I0.6790.89
364_V368_L0.6790.89
271_A294_A0.6780.89
131_T140_G0.6770.89
144_L147_A0.6760.89
378_I381_L0.6750.89
236_Y326_S0.6740.89
236_Y322_E0.6730.88
35_E214_A0.6710.88
408_S411_W0.6700.88
56_G219_A0.6690.88
11_G165_T0.6670.88
74_A231_I0.6660.88
172_V308_V0.6660.88
403_V407_L0.6630.88
361_F364_V0.6620.88
46_L50_L0.6610.88
126_G286_V0.6580.87
67_S78_L0.6580.87
63_I78_L0.6560.87
280_G283_A0.6560.87
95_A323_L0.6550.87
320_M324_P0.6520.87
27_W281_P0.6520.87
211_I214_A0.6510.87
92_V323_L0.6510.87
56_G419_I0.6510.87
245_A249_A0.6510.87
224_S319_S0.6500.87
180_A193_L0.6470.86
34_S276_A0.6470.86
321_L343_F0.6460.86
75_F380_F0.6440.86
61_F243_L0.6430.86
110_L149_T0.6420.86
183_A266_F0.6420.86
40_A44_V0.6400.86
383_F387_V0.6380.86
54_V247_G0.6370.86
71_P92_V0.6360.86
93_V97_V0.6320.85
33_T204_L0.6320.85
411_W415_V0.6300.85
65_R395_E0.6280.85
269_L277_G0.6280.85
58_L244_A0.6280.85
58_L396_Y0.6270.85
103_S146_L0.6270.85
25_N255_T0.6260.85
379_G382_L0.6250.85
94_I376_G0.6210.84
22_G29_F0.6210.84
45_Y222_T0.6180.84
86_V90_L0.6170.84
130_A135_G0.6160.84
103_S145_F0.6160.84
146_L351_G0.6140.83
194_A197_L0.6130.83
193_L199_P0.6130.83
28_R105_V0.6120.83
28_R369_V0.6110.83
122_F125_P0.6090.83
25_N258_G0.6090.83
322_E329_V0.6060.83
338_R341_A0.6060.83
155_R159_R0.6050.83
73_G77_S0.6050.83
302_G306_F0.6040.82
106_G310_S0.6040.82
10_L17_V0.6030.82
96_V347_F0.6030.82
412_L417_V0.6020.82
425_F428_V0.6020.82
115_A120_A0.6020.82
31_W277_G0.6020.82
202_E206_A0.6010.82
153_V317_S0.6000.82
187_D190_G0.5990.82
404_A407_L0.5980.82
111_R114_G0.5980.82
148_I155_R0.5970.82
12_F237_L0.5960.82
57_L251_A0.5940.81
114_G118_T0.5940.81
328_L343_F0.5930.81
100_S364_V0.5930.81
188_G192_G0.5930.81
235_S330_D0.5910.81
233_Y316_S0.5910.81
224_S320_M0.5900.81
10_L13_I0.5900.81
59_A415_V0.5900.81
14_M18_G0.5890.81
153_V340_T0.5850.80
96_V343_F0.5840.80
247_G251_A0.5840.80
66_R388_V0.5830.80
90_L379_G0.5830.80
202_E207_D0.5820.80
203_L211_I0.5820.80
362_D366_G0.5810.80
312_A315_S0.5810.80
185_T188_G0.5800.80
391_N417_V0.5800.80
50_L53_G0.5790.80
110_L347_F0.5770.80
101_F361_F0.5770.80
232_T319_S0.5760.79
229_T381_L0.5760.79
25_N49_V0.5750.79
269_L287_G0.5740.79
31_W281_P0.5740.79
97_V364_V0.5730.79
99_L153_V0.5730.79
119_G122_F0.5720.79
58_L314_I0.5710.79
163_N166_K0.5710.79
211_I218_Q0.5700.79
12_F411_W0.5700.79
16_A57_L0.5690.79
182_W187_D0.5690.79
87_F383_F0.5680.78
24_G27_W0.5680.78
98_L369_V0.5660.78
16_A230_M0.5660.78
111_R141_F0.5650.78
267_P270_F0.5650.78
66_R392_A0.5600.78
237_L241_R0.5590.77
171_A178_V0.5590.77
222_T254_N0.5590.77
101_F227_S0.5580.77
394_T398_L0.5580.77
91_S376_G0.5570.77
59_A62_V0.5570.77
119_G299_R0.5560.77
192_G301_V0.5550.77
117_L120_A0.5540.77
13_I249_A0.5530.77
184_S187_D0.5520.77
60_E64_G0.5510.76
66_R83_L0.5510.76
30_P37_G0.5510.76
27_W30_P0.5500.76
110_L114_G0.5490.76
324_P345_G0.5460.76
182_W192_G0.5460.76
330_D334_V0.5450.76
161_I170_P0.5450.76
283_A289_A0.5450.76
397_E403_V0.5450.76
224_S230_M0.5440.75
408_S412_L0.5420.75
339_A343_F0.5410.75
48_V219_A0.5410.75
221_F233_Y0.5400.75
186_L192_G0.5400.75
223_L255_T0.5400.75
239_E395_E0.5400.75
126_G130_A0.5390.75
153_V318_I0.5380.75
234_A423_L0.5380.75
127_Q130_A0.5380.75
120_A124_N0.5370.75
189_A193_L0.5370.75
342_L346_V0.5370.75
226_G323_L0.5360.74
243_L247_G0.5350.74
305_F322_E0.5350.74
39_A56_G0.5340.74
96_V324_P0.5340.74
353_A364_V0.5340.74
188_G191_A0.5340.74
244_A248_A0.5330.74
228_G318_I0.5330.74
176_L261_A0.5310.74
63_I384_T0.5310.74
317_S351_G0.5270.73
382_L386_W0.5260.73
108_W112_Y0.5250.73
49_V251_A0.5240.73
285_F305_F0.5230.73
105_V354_T0.5200.72
37_G41_F0.5200.72
17_V316_S0.5190.72
221_F225_L0.5180.72
156_G318_I0.5170.72
68_R419_I0.5170.72
125_P128_Y0.5160.72
84_W87_F0.5160.72
39_A199_P0.5160.72
25_N222_T0.5160.72
325_V329_V0.5150.71
53_G219_A0.5150.71
183_A264_V0.5150.71
393_V408_S0.5130.71
188_G271_A0.5130.71
86_V165_T0.5130.71
195_F270_F0.5120.71
120_A299_R0.5120.71
405_S408_S0.5120.71
66_R78_L0.5120.71
105_V281_P0.5110.71
180_A267_P0.5100.71
376_G380_F0.5090.71
386_W417_V0.5090.71
228_G330_D0.5090.71
329_V332_Y0.5090.71
92_V324_P0.5080.70
341_A344_V0.5060.70
316_S319_S0.5050.70
27_W37_G0.5050.70
71_P229_T0.5030.70
403_V406_A0.5030.70
272_L291_A0.5020.70
116_S121_Y0.5010.69
178_V184_S0.5010.69
6_W53_G0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4xp4A 1 0.9811 100 0.038 Contact Map
2a65A 2 0.9769 100 0.075 Contact Map
4us3A 1 0.8889 100 0.082 Contact Map
3giaA 1 0.8491 98.2 0.919 Contact Map
4djkA 2 0.8616 97.7 0.926 Contact Map
3l1lA 2 0.8281 97.4 0.931 Contact Map
2jlnA 1 0.8491 95.3 0.945 Contact Map
2xq2A 2 0.8931 88.6 0.956 Contact Map
4wgvA 2 0.761 87.4 0.956 Contact Map
3dh4A 3 0.8658 86.5 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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