Q9HPP8 - HALSA - GREMLIN Contacts

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Q9HPP8 - Biotin carboxylase

UniProt:	Q9HPP8	Sequences: MFEKVLVANRGEIAVRVMRACDDLGVDTVAVYSDADAHAGHVRYADEAYNVGPARAADSYLDHDAIIDAATRAGADAIHPGYGFLAENAEFAGKVEDTDGVTWVGPSADSMRQLGEKTSARKTMREADVPIVPGTTDPVESVADIHEFGEEHGYPIAIKAEGGGGGRGMKIVRSADEAEDQLESAEREGEAYFDNANVYLERYLENPRHIEVQILADHHGNVRHLGERDCSLQRRHQKVIEEGPSPALTDELREEIGTAARRGADAAGYYNAGTFEFLVEEDTEREPGDLLGPETEFYFLEVNTRIQVEHTVTEALTGVDIVKWQLKIASDDELTFEQDDVALDGHAVEYRINAENAADDFAPATGGELETYDPPGGIGVRVDDGLRQGDDLVTDYDSMVAKLIVHGSDREECLARSRRALAEYDIEGIPTIIPFHRLMLTDDAFVGGTHTTKYLDRDIEESRISDAQAEWGTTTASESSADENVVERDFTVEVNGKRFEVNLEERGAAQFAAPEADTGGGGPPEPAGGADDGETVVEGDGETVTAEMQGTILDVAVSEGDAVDAGDVLVVLEAMKMENDVVASHGGTVTQVAVSEDDSVDMDDVLVVID	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	610 (572)
Sequences:	5148 (2669)
Seq/√Len:	111.6

BACSU - PYC
HALSA - Q9HPP8
SULSO - Q97VY6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
93_G	97_D	4.685	1.00
34_D	50_N	4.488	1.00
68_D	72_R	4.358	1.00
5_V	104_V	4.346	1.00
93_G	112_R	4.241	1.00
564_D	586_G	4.184	1.00
558_S	561_D	3.994	1.00
150_E	175_A	3.649	1.00
174_S	177_E	3.421	1.00
4_K	27_D	3.245	1.00
173_R	205_E	3.202	1.00
3_E	76_D	3.171	1.00
104_V	326_L	3.122	1.00
70_A	78_I	3.077	1.00
186_E	196_A	3.012	1.00
561_D	567_D	2.965	1.00
7_V	18_M	2.921	1.00
4_K	29_V	2.907	1.00
353_N	398_S	2.845	1.00
451_T	457_R	2.828	1.00
94_K	99_D	2.812	1.00
254_E	258_T	2.781	1.00
4_K	47_E	2.761	1.00
190_E	196_A	2.749	1.00
327_K	332_D	2.728	1.00
124_M	263_G	2.691	1.00
2_F	76_D	2.672	1.00
23_D	323_K	2.664	1.00
568_V	580_D	2.642	1.00
95_V	101_V	2.607	1.00
409_D	412_E	2.594	1.00
216_A	222_V	2.559	1.00
2_F	102_T	2.554	1.00
148_F	151_E	2.552	1.00
259_A	297_F	2.528	1.00
564_D	567_D	2.505	1.00
212_V	256_I	2.476	1.00
218_H	270_Y	2.475	1.00
240_I	350_Y	2.412	1.00
444_A	449_T	2.379	1.00
67_I	71_T	2.348	1.00
146_H	179_E	2.339	1.00
43_R	387_R	2.336	1.00
559_E	591_Q	2.303	1.00
78_I	95_V	2.287	1.00
49_Y	73_A	2.225	1.00
31_V	51_V	2.223	1.00
107_S	110_S	2.216	1.00
49_Y	69_A	2.215	1.00
154_Y	175_A	2.193	1.00
5_V	21_C	2.179	1.00
5_V	326_L	2.142	1.00
408_S	412_E	2.090	1.00
258_T	262_R	2.086	1.00
229_D	245_S	2.080	1.00
226_G	341_V	2.079	1.00
95_V	103_W	2.044	1.00
316_L	343_L	2.044	1.00
350_Y	417_S	2.030	1.00
142_V	186_E	2.024	1.00
324_W	335_T	2.021	1.00
249_T	252_L	2.008	1.00
126_E	266_A	2.008	1.00
107_S	270_Y	1.994	1.00
380_V	405_V	1.968	1.00
96_E	108_A	1.935	1.00
590_T	608_V	1.926	1.00
215_L	324_W	1.912	1.00
141_S	144_D	1.908	1.00
414_L	446_V	1.908	1.00
52_G	59_S	1.875	1.00
18_M	45_A	1.862	1.00
33_S	396_Y	1.859	1.00
50_N	54_A	1.857	1.00
171_I	203_Y	1.849	1.00
18_M	44_Y	1.838	1.00
2_F	330_S	1.829	1.00
93_G	109_D	1.827	1.00
119_S	122_K	1.807	1.00
418_R	441_T	1.803	1.00
369_L	386_L	1.797	1.00
223_R	341_V	1.791	1.00
15_V	44_Y	1.787	1.00
591_Q	608_V	1.779	1.00
215_L	328_I	1.770	1.00
114_L	302_V	1.770	1.00
62_D	65_A	1.766	1.00
139_V	144_D	1.756	1.00
557_V	589_V	1.745	1.00
562_A	588_T	1.729	1.00
442_D	454_Y	1.719	1.00
63_H	94_K	1.717	1.00
261_R	265_D	1.711	1.00
352_I	433_I	1.709	1.00
565_A	586_G	1.704	1.00
323_K	327_K	1.693	1.00
595_S	598_D	1.687	1.00
214_I	264_A	1.687	1.00
173_R	177_E	1.671	1.00
348_V	414_L	1.665	1.00
373_D	388_Q	1.665	1.00
112_R	119_S	1.664	1.00
415_A	446_V	1.661	1.00
243_G	316_L	1.659	1.00
21_C	28_T	1.657	1.00
435_F	455_L	1.642	1.00
407_G	412_E	1.639	1.00
250_D	254_E	1.626	1.00
442_D	458_D	1.625	1.00
252_L	255_E	1.608	1.00
150_E	154_Y	1.607	1.00
380_V	420_A	1.581	1.00
569_L	607_V	1.569	1.00
223_R	336_F	1.566	1.00
184_S	187_R	1.566	1.00
552_I	570_V	1.565	1.00
280_E	296_E	1.560	1.00
414_L	440_L	1.553	1.00
315_A	406_H	1.545	1.00
559_E	592_V	1.531	1.00
96_E	270_Y	1.529	1.00
31_V	66_I	1.525	1.00
443_D	447_G	1.521	1.00
414_L	418_R	1.520	1.00
122_K	126_E	1.515	1.00
158_I	198_V	1.509	1.00
156_I	200_L	1.503	1.00
144_D	148_F	1.502	1.00
262_R	265_D	1.492	1.00
53_P	56_A	1.487	1.00
374_P	424_Y	1.476	1.00
417_S	440_L	1.473	1.00
67_I	78_I	1.465	1.00
371_T	388_Q	1.464	1.00
20_A	323_K	1.457	1.00
347_A	406_H	1.456	1.00
64_D	94_K	1.450	1.00
422_A	437_R	1.449	1.00
69_A	73_A	1.448	1.00
546_A	572_L	1.447	1.00
65_A	68_D	1.440	1.00
30_A	45_A	1.438	1.00
600_V	606_L	1.434	1.00
70_A	95_V	1.431	1.00
31_V	69_A	1.430	1.00
356_N	430_P	1.419	1.00
556_A	568_V	1.415	1.00
70_A	101_V	1.406	1.00
592_V	607_V	1.406	1.00
128_D	262_R	1.405	1.00
156_I	202_R	1.398	1.00
170_K	188_E	1.391	1.00
113_Q	123_T	1.388	1.00
2_F	5_V	1.383	1.00
226_G	342_A	1.383	1.00
215_L	272_A	1.383	1.00
133_P	202_R	1.372	1.00
167_R	398_S	1.371	1.00
107_S	216_A	1.368	1.00
67_I	101_V	1.368	1.00
383_D	404_I	1.365	1.00
109_D	113_Q	1.364	1.00
352_I	403_L	1.362	1.00
444_A	458_D	1.359	1.00
424_Y	433_I	1.353	1.00
139_V	145_I	1.346	1.00
55_R	58_D	1.344	1.00
26_V	326_L	1.336	1.00
226_G	316_L	1.332	1.00
585_H	609_I	1.323	1.00
411_E	414_L	1.323	1.00
148_F	152_H	1.321	1.00
570_V	606_L	1.316	1.00
172_V	181_Q	1.311	0.99
252_L	279_V	1.297	0.99
405_V	417_S	1.296	0.99
187_R	578_E	1.292	0.99
555_V	592_V	1.279	0.99
162_G	195_N	1.274	0.99
282_D	296_E	1.274	0.99
226_G	343_L	1.271	0.99
439_M	445_F	1.270	0.99
146_H	150_E	1.269	0.99
426_I	431_T	1.269	0.99
337_E	340_D	1.268	0.99
71_T	99_D	1.267	0.99
371_T	425_D	1.266	0.99
348_V	440_L	1.265	0.99
222_V	261_R	1.263	0.99
540_D	543_T	1.250	0.99
178_A	182_L	1.244	0.99
206_N	281_E	1.238	0.99
491_T	498_R	1.236	0.99
107_S	268_G	1.234	0.99
53_P	58_D	1.233	0.99
58_D	62_D	1.218	0.99
203_Y	236_H	1.210	0.99
554_D	596_E	1.209	0.99
96_E	109_D	1.208	0.99
418_R	437_R	1.205	0.99
145_I	200_L	1.204	0.99
373_D	425_D	1.200	0.99
40_G	384_D	1.189	0.99
212_V	257_G	1.188	0.99
239_V	455_L	1.187	0.99
344_D	406_H	1.183	0.99
93_G	108_A	1.182	0.99
19_R	40_G	1.181	0.99
435_F	439_M	1.181	0.99
15_V	40_G	1.181	0.99
419_R	423_E	1.180	0.99
542_E	609_I	1.179	0.99
54_A	59_S	1.178	0.99
179_E	183_E	1.178	0.99
232_L	439_M	1.174	0.99
27_D	47_E	1.173	0.99
232_L	450_H	1.171	0.99
69_A	75_A	1.171	0.99
5_V	26_V	1.171	0.99
453_K	457_R	1.169	0.99
306_I	321_I	1.167	0.99
202_R	298_Y	1.166	0.99
454_Y	458_D	1.164	0.99
51_V	69_A	1.161	0.99
248_L	252_L	1.158	0.99
180_D	183_E	1.153	0.99
379_G	416_R	1.152	0.99
319_V	324_W	1.152	0.99
493_E	496_G	1.151	0.99
256_I	297_F	1.151	0.99
368_E	391_D	1.148	0.99
118_T	161_E	1.144	0.99
102_T	218_H	1.140	0.99
143_A	179_E	1.139	0.99
178_A	198_V	1.138	0.99
40_G	44_Y	1.134	0.99
247_A	279_V	1.128	0.98
147_E	150_E	1.126	0.98
496_G	499_F	1.125	0.98
405_V	440_L	1.117	0.98
338_Q	341_V	1.116	0.98
403_L	424_Y	1.113	0.98
222_V	265_D	1.113	0.98
54_A	395_D	1.113	0.98
249_T	295_T	1.111	0.98
170_K	184_S	1.110	0.98
145_I	178_A	1.108	0.98
40_G	387_R	1.104	0.98
242_E	410_R	1.104	0.98
51_V	65_A	1.102	0.98
493_E	498_R	1.099	0.98
120_A	161_E	1.094	0.98
264_A	302_V	1.092	0.98
40_G	390_D	1.087	0.98
374_P	384_D	1.085	0.98
219_H	333_E	1.084	0.98
311_T	349_E	1.080	0.98
96_E	103_W	1.080	0.98
422_A	441_T	1.078	0.98
118_T	199_Y	1.078	0.98
542_E	585_H	1.076	0.98
407_G	416_R	1.076	0.98
20_A	23_D	1.073	0.98
53_P	59_S	1.069	0.98
552_I	572_L	1.066	0.98
146_H	175_A	1.060	0.98
240_I	440_L	1.058	0.98
147_E	151_E	1.055	0.98
497_K	501_V	1.055	0.98
66_I	78_I	1.055	0.98
453_K	456_D	1.054	0.98
22_D	28_T	1.053	0.98
95_V	99_D	1.050	0.98
593_A	608_V	1.045	0.97
68_D	71_T	1.037	0.97
63_H	91_F	1.034	0.97
317_T	343_L	1.031	0.97
315_A	404_I	1.027	0.97
94_K	97_D	1.026	0.97
175_A	179_E	1.022	0.97
336_F	340_D	1.021	0.97
140_E	144_D	1.020	0.97
239_V	353_N	1.019	0.97
601_D	604_D	1.015	0.97
7_V	17_V	1.010	0.97
143_A	147_E	1.006	0.97
52_G	65_A	1.005	0.97
496_G	501_V	1.000	0.97
255_E	258_T	0.998	0.97
224_H	257_G	0.997	0.97
182_L	198_V	0.997	0.97
202_R	296_E	0.994	0.97
92_A	108_A	0.983	0.96
158_I	178_A	0.982	0.96
184_S	578_E	0.977	0.96
587_G	609_I	0.976	0.96
21_C	326_L	0.976	0.96
89_A	112_R	0.976	0.96
215_L	335_T	0.974	0.96
142_V	179_E	0.970	0.96
24_L	323_K	0.967	0.96
30_A	48_A	0.967	0.96
552_I	594_V	0.964	0.96
104_V	329_A	0.963	0.96
224_H	254_E	0.962	0.96
2_F	77_A	0.959	0.96
142_V	178_A	0.958	0.96
107_S	218_H	0.957	0.96
348_V	413_C	0.957	0.96
224_H	258_T	0.951	0.96
361_F	435_F	0.949	0.96
34_D	54_A	0.948	0.96
225_L	317_T	0.945	0.95
418_R	440_L	0.941	0.95
490_F	499_F	0.938	0.95
35_A	396_Y	0.938	0.95
319_V	336_F	0.938	0.95
259_A	277_F	0.937	0.95
392_L	400_V	0.936	0.95
34_D	53_P	0.935	0.95
224_H	338_Q	0.935	0.95
519_G	523_P	0.934	0.95
142_V	183_E	0.934	0.95
224_H	261_R	0.933	0.95
139_V	148_F	0.933	0.95
33_S	58_D	0.932	0.95
372_Y	424_Y	0.929	0.95
232_L	445_F	0.923	0.95
4_K	74_G	0.919	0.95
315_A	347_A	0.918	0.95
336_F	341_V	0.918	0.95
210_I	245_S	0.915	0.95
214_I	275_F	0.915	0.95
253_R	257_G	0.911	0.94
581_V	594_V	0.909	0.94
63_H	67_I	0.907	0.94
51_V	59_S	0.904	0.94
158_I	172_V	0.902	0.94
121_R	199_Y	0.900	0.94
352_I	424_Y	0.896	0.94
15_V	41_H	0.895	0.94
227_E	253_R	0.891	0.94
90_E	112_R	0.889	0.94
177_E	181_Q	0.888	0.94
315_A	383_D	0.887	0.94
240_I	439_M	0.886	0.94
29_V	75_A	0.882	0.93
324_W	336_F	0.878	0.93
125_R	136_T	0.878	0.93
13_I	82_Y	0.874	0.93
245_S	248_L	0.871	0.93
2_F	26_V	0.870	0.93
346_H	410_R	0.868	0.93
125_R	131_I	0.864	0.93
24_L	326_L	0.861	0.93
382_V	424_Y	0.861	0.93
210_I	278_L	0.856	0.92
418_R	446_V	0.856	0.92
110_S	268_G	0.854	0.92
324_W	328_I	0.852	0.92
19_R	23_D	0.850	0.92
386_L	390_D	0.847	0.92
109_D	268_G	0.846	0.92
123_T	267_A	0.843	0.92
281_E	295_T	0.842	0.92
483_E	492_V	0.842	0.92
86_A	306_I	0.841	0.92
160_A	188_E	0.840	0.92
326_L	330_S	0.836	0.91
459_I	463_R	0.834	0.91
42_V	48_A	0.831	0.91
145_I	182_L	0.830	0.91
158_I	200_L	0.830	0.91
492_V	499_F	0.829	0.91
251_E	255_E	0.829	0.91
152_H	156_I	0.828	0.91
145_I	148_F	0.827	0.91
411_E	446_V	0.824	0.91
17_V	79_H	0.821	0.91
189_G	192_Y	0.821	0.91
455_L	462_S	0.821	0.91
387_R	390_D	0.819	0.91
22_D	46_D	0.818	0.91
122_K	125_R	0.816	0.90
152_H	202_R	0.815	0.90
167_R	192_Y	0.814	0.90
63_H	78_I	0.812	0.90
93_G	96_E	0.811	0.90
229_D	450_H	0.810	0.90
421_L	433_I	0.806	0.90
216_A	264_A	0.805	0.90
437_R	441_T	0.805	0.90
171_I	205_E	0.805	0.90
441_T	446_V	0.803	0.90
258_T	265_D	0.801	0.90
251_E	254_E	0.800	0.90
137_D	140_E	0.799	0.90
418_R	422_A	0.799	0.90
124_M	127_A	0.797	0.89
492_V	501_V	0.796	0.89
32_Y	48_A	0.795	0.89
245_S	249_T	0.793	0.89
210_I	279_V	0.792	0.89
598_D	604_D	0.789	0.89
135_T	140_E	0.789	0.89
114_L	263_G	0.788	0.89
206_N	451_T	0.786	0.89
484_N	487_E	0.786	0.89
160_A	170_K	0.784	0.89
40_G	43_R	0.784	0.89
568_V	582_V	0.784	0.89
2_F	104_V	0.784	0.89
497_K	500_E	0.782	0.89
229_D	445_F	0.782	0.89
221_N	265_D	0.781	0.88
385_G	390_D	0.780	0.88
20_A	24_L	0.779	0.88
21_C	24_L	0.779	0.88
113_Q	119_S	0.765	0.87
324_W	327_K	0.759	0.87
216_A	226_G	0.758	0.87
495_N	499_F	0.758	0.87
114_L	267_A	0.756	0.87
4_K	76_D	0.755	0.87
221_N	333_E	0.754	0.87
15_V	18_M	0.752	0.87
502_N	505_E	0.752	0.87
489_D	502_N	0.750	0.86
214_I	222_V	0.749	0.86
33_S	59_S	0.748	0.86
555_V	570_V	0.747	0.86
212_V	260_A	0.747	0.86
245_S	257_G	0.746	0.86
501_V	505_E	0.746	0.86
174_S	179_E	0.745	0.86
490_F	497_K	0.745	0.86
497_K	502_N	0.744	0.86
278_L	300_L	0.743	0.86
348_V	405_V	0.742	0.86
562_A	586_G	0.741	0.86
232_L	414_L	0.741	0.86
563_V	569_L	0.740	0.86
312_V	404_I	0.740	0.86
73_A	76_D	0.740	0.86
360_D	456_D	0.739	0.86
130_P	259_A	0.738	0.85
216_A	261_R	0.737	0.85
182_L	186_E	0.736	0.85
488_R	501_V	0.735	0.85
20_A	319_V	0.735	0.85
483_E	486_V	0.734	0.85
487_E	505_E	0.734	0.85
239_V	432_I	0.734	0.85
488_R	495_N	0.734	0.85
414_L	445_F	0.733	0.85
487_E	490_F	0.733	0.85
138_P	197_N	0.732	0.85
63_H	90_E	0.732	0.85
67_I	95_V	0.731	0.85
590_T	609_I	0.731	0.85
146_H	154_Y	0.729	0.85
186_E	190_E	0.729	0.85
111_M	114_L	0.728	0.85
433_I	437_R	0.727	0.85
66_I	69_A	0.726	0.85
442_D	447_G	0.724	0.84
227_E	245_S	0.724	0.84
483_E	498_R	0.723	0.84
484_N	490_F	0.723	0.84
76_D	102_T	0.721	0.84
344_D	408_S	0.721	0.84
323_K	332_D	0.721	0.84
375_P	403_L	0.720	0.84
589_V	609_I	0.719	0.84
206_N	449_T	0.718	0.84
501_V	504_E	0.717	0.84
229_D	247_A	0.715	0.84
110_S	270_Y	0.714	0.84
422_A	425_D	0.713	0.83
3_E	27_D	0.710	0.83
494_V	497_K	0.710	0.83
177_E	180_D	0.708	0.83
111_M	304_T	0.708	0.83
432_I	436_H	0.706	0.83
490_F	501_V	0.706	0.83
26_V	330_S	0.705	0.83
35_A	53_P	0.704	0.83
30_A	41_H	0.704	0.83
50_N	53_P	0.703	0.83
33_S	53_P	0.702	0.83
551_T	599_S	0.701	0.82
487_E	502_N	0.701	0.82
135_T	148_F	0.701	0.82
118_T	121_R	0.698	0.82
255_E	296_E	0.698	0.82
76_D	330_S	0.696	0.82
379_G	406_H	0.695	0.82
271_N	325_Q	0.694	0.82
483_E	487_E	0.694	0.82
496_G	502_N	0.693	0.82
365_T	393_V	0.692	0.82
492_V	496_G	0.692	0.82
123_T	126_E	0.691	0.82
260_A	275_F	0.689	0.81
353_N	436_H	0.689	0.81
483_E	505_E	0.688	0.81
71_T	101_V	0.688	0.81
281_E	296_E	0.683	0.81
219_H	328_I	0.682	0.81
18_M	28_T	0.681	0.81
519_G	522_G	0.679	0.80
523_P	526_P	0.679	0.80
550_G	572_L	0.678	0.80
490_F	505_E	0.676	0.80
394_T	398_S	0.675	0.80
24_L	327_K	0.675	0.80
144_D	147_E	0.675	0.80
269_Y	273_G	0.673	0.80
33_S	36_D	0.672	0.80
59_S	62_D	0.671	0.80
411_E	418_R	0.671	0.80
372_Y	388_Q	0.670	0.80
589_V	607_V	0.670	0.80
149_G	154_Y	0.669	0.79
374_P	382_V	0.668	0.79
278_L	454_Y	0.667	0.79
279_V	295_T	0.667	0.79
328_I	334_L	0.667	0.79
66_I	88_N	0.667	0.79
557_V	561_D	0.665	0.79
556_A	567_D	0.664	0.79
264_A	267_A	0.661	0.79
17_V	86_A	0.661	0.79
232_L	454_Y	0.659	0.78
52_G	55_R	0.659	0.78
493_E	497_K	0.655	0.78
552_I	606_L	0.655	0.78
311_T	404_I	0.654	0.78
444_A	457_R	0.653	0.78
407_G	414_L	0.653	0.78
63_H	66_I	0.652	0.78
142_V	146_H	0.652	0.78
488_R	497_K	0.651	0.78
544_V	569_L	0.651	0.78
55_R	59_S	0.650	0.77
490_F	498_R	0.649	0.77
496_G	505_E	0.648	0.77
492_V	495_N	0.648	0.77
483_E	501_V	0.647	0.77
487_E	497_K	0.647	0.77
62_D	68_D	0.646	0.77
459_I	462_S	0.645	0.77
123_T	266_A	0.645	0.77
158_I	182_L	0.645	0.77
537_V	540_D	0.644	0.77
393_V	400_V	0.643	0.77
491_T	500_E	0.643	0.77
183_E	187_R	0.642	0.77
559_E	590_T	0.641	0.76
350_Y	403_L	0.641	0.76
216_A	270_Y	0.638	0.76
222_V	264_A	0.637	0.76
492_V	497_K	0.637	0.76
216_A	334_L	0.637	0.76
18_M	30_A	0.637	0.76
91_F	95_V	0.637	0.76
223_R	226_G	0.637	0.76
492_V	502_N	0.636	0.76
489_D	495_N	0.635	0.76
128_D	207_P	0.635	0.76
323_K	412_E	0.633	0.76
252_L	295_T	0.632	0.75
554_D	570_V	0.632	0.75
216_A	278_L	0.630	0.75
495_N	498_R	0.629	0.75
497_K	504_E	0.627	0.75
352_I	426_I	0.625	0.75
347_A	405_V	0.625	0.75
12_E	16_R	0.625	0.75
456_D	459_I	0.625	0.75
377_G	380_V	0.624	0.75
139_V	142_V	0.624	0.75
242_E	346_H	0.623	0.74
497_K	505_E	0.623	0.74
438_L	462_S	0.622	0.74
379_G	407_G	0.622	0.74
212_V	224_H	0.622	0.74
18_M	22_D	0.620	0.74
275_F	302_V	0.618	0.74
108_A	111_M	0.617	0.74
260_A	264_A	0.617	0.74
490_F	500_E	0.615	0.73
140_E	182_L	0.614	0.73
226_G	336_F	0.614	0.73
348_V	417_S	0.614	0.73
205_E	281_E	0.612	0.73
487_E	492_V	0.612	0.73
167_R	188_E	0.612	0.73
62_D	239_V	0.611	0.73
490_F	502_N	0.611	0.73
149_G	153_G	0.611	0.73
492_V	504_E	0.610	0.73
215_L	223_R	0.609	0.73
167_R	199_Y	0.609	0.73
4_K	75_A	0.608	0.73
32_Y	41_H	0.607	0.73
483_E	488_R	0.607	0.73
4_K	28_T	0.607	0.73
21_C	26_V	0.606	0.72
210_I	227_E	0.606	0.72
300_L	462_S	0.605	0.72
157_A	203_Y	0.605	0.72
223_R	335_T	0.604	0.72
57_A	190_E	0.603	0.72
319_V	341_V	0.603	0.72
30_A	42_V	0.603	0.72
145_I	278_L	0.602	0.72
279_V	297_F	0.602	0.72
5_V	17_V	0.602	0.72
335_T	340_D	0.602	0.72
543_T	605_V	0.601	0.72
493_E	502_N	0.601	0.72
143_A	146_H	0.601	0.72
490_F	496_G	0.600	0.72
242_E	312_V	0.600	0.72
494_V	499_F	0.600	0.72
239_V	436_H	0.599	0.72
487_E	491_T	0.598	0.71
243_G	343_L	0.597	0.71
483_E	489_D	0.596	0.71
490_F	494_V	0.595	0.71
487_E	493_E	0.595	0.71
146_H	178_A	0.595	0.71
272_A	574_A	0.594	0.71
135_T	199_Y	0.594	0.71
542_E	584_S	0.593	0.71
154_Y	185_A	0.592	0.71
369_L	390_D	0.591	0.71
544_V	563_V	0.591	0.71
401_A	424_Y	0.591	0.71
340_D	343_L	0.590	0.70
370_E	427_E	0.590	0.70
557_V	567_D	0.588	0.70
490_F	493_E	0.586	0.70
92_A	96_E	0.586	0.70
372_Y	384_D	0.585	0.70
185_A	236_H	0.584	0.70
214_I	302_V	0.584	0.70
257_G	261_R	0.583	0.69
145_I	152_H	0.583	0.69
486_V	494_V	0.583	0.69
114_L	264_A	0.583	0.69
433_I	440_L	0.583	0.69
96_E	107_S	0.582	0.69
365_T	394_T	0.581	0.69
556_A	559_E	0.581	0.69
89_A	108_A	0.580	0.69
232_L	459_I	0.579	0.69
167_R	353_N	0.579	0.69
544_V	608_V	0.579	0.69
132_V	278_L	0.578	0.69
34_D	59_S	0.577	0.69
97_D	108_A	0.576	0.69
489_D	500_E	0.575	0.68
526_P	530_A	0.575	0.68
124_M	266_A	0.574	0.68
458_D	462_S	0.574	0.68
574_A	579_N	0.574	0.68
565_A	585_H	0.573	0.68
522_G	526_P	0.573	0.68
118_T	124_M	0.573	0.68
499_F	505_E	0.572	0.68
487_E	504_E	0.572	0.68
559_E	593_A	0.572	0.68
350_Y	440_L	0.570	0.68
257_G	343_L	0.570	0.68
86_A	353_N	0.570	0.68
187_R	191_A	0.570	0.68
369_L	426_I	0.570	0.68
484_N	499_F	0.569	0.68
483_E	497_K	0.568	0.68
382_V	401_A	0.568	0.68
35_A	54_A	0.568	0.68
488_R	498_R	0.568	0.68
167_R	207_P	0.567	0.67
566_G	582_V	0.567	0.67
258_T	261_R	0.567	0.67
412_E	416_R	0.567	0.67
541_G	545_T	0.565	0.67
255_E	262_R	0.563	0.67
371_T	427_E	0.563	0.67
409_D	415_A	0.563	0.67
58_D	65_A	0.562	0.67
161_E	195_N	0.562	0.67
359_D	603_D	0.561	0.67
357_A	430_P	0.561	0.67
325_Q	606_L	0.561	0.67
317_T	341_V	0.561	0.67
555_V	596_E	0.560	0.66
486_V	489_D	0.559	0.66
491_T	499_F	0.559	0.66
384_D	401_A	0.559	0.66
5_V	102_T	0.558	0.66
135_T	139_V	0.558	0.66
306_I	322_V	0.558	0.66
555_V	607_V	0.557	0.66
483_E	502_N	0.557	0.66
227_E	297_F	0.556	0.66
146_H	172_V	0.556	0.66
499_F	502_N	0.556	0.66
26_V	77_A	0.556	0.66
199_Y	321_I	0.556	0.66
492_V	500_E	0.555	0.66
256_I	259_A	0.554	0.66
546_A	599_S	0.554	0.66
345_G	406_H	0.553	0.65
375_P	424_Y	0.552	0.65
444_A	450_H	0.552	0.65
157_A	171_I	0.550	0.65
280_E	295_T	0.550	0.65
15_V	20_A	0.550	0.65
215_L	319_V	0.550	0.65
375_P	420_A	0.550	0.65
494_V	506_R	0.549	0.65
256_I	260_A	0.549	0.65
486_V	498_R	0.548	0.65
496_G	500_E	0.548	0.65
225_L	321_I	0.548	0.65
405_V	420_A	0.548	0.65
484_N	488_R	0.548	0.65
111_M	115_G	0.548	0.65
161_E	549_Q	0.547	0.65
27_D	46_D	0.547	0.65
487_E	501_V	0.547	0.65
488_R	499_F	0.547	0.65
82_Y	85_L	0.546	0.64
356_N	379_G	0.546	0.64
350_Y	404_I	0.546	0.64
526_P	529_G	0.546	0.64
207_P	453_K	0.546	0.64
50_N	65_A	0.545	0.64
378_I	416_R	0.545	0.64
486_V	501_V	0.544	0.64
142_V	182_L	0.544	0.64
63_H	95_V	0.544	0.64
570_V	592_V	0.544	0.64
485_V	497_K	0.543	0.64
160_A	198_V	0.542	0.64
86_A	311_T	0.542	0.64
483_E	503_L	0.542	0.64
35_A	55_R	0.541	0.64
124_M	300_L	0.541	0.64
15_V	387_R	0.540	0.64
63_H	86_A	0.540	0.64
572_L	600_V	0.540	0.64
65_A	69_A	0.540	0.64
90_E	94_K	0.540	0.64
245_S	450_H	0.539	0.63
15_V	384_D	0.539	0.63
56_A	59_S	0.539	0.63
76_D	101_V	0.538	0.63
570_V	607_V	0.538	0.63
556_A	571_V	0.537	0.63
256_I	550_G	0.537	0.63
120_A	267_A	0.537	0.63
493_E	504_E	0.536	0.63
64_D	68_D	0.536	0.63
543_T	608_V	0.536	0.63
90_E	97_D	0.536	0.63
114_L	304_T	0.535	0.63
59_S	396_Y	0.535	0.63
161_E	199_Y	0.534	0.63
491_T	502_N	0.533	0.63
408_S	411_E	0.533	0.63
132_V	204_L	0.531	0.62
485_V	507_G	0.531	0.62
216_A	257_G	0.531	0.62
135_T	138_P	0.531	0.62
369_L	372_Y	0.531	0.62
495_N	502_N	0.531	0.62
124_M	267_A	0.530	0.62
525_E	530_A	0.530	0.62
359_D	362_A	0.530	0.62
158_I	181_Q	0.529	0.62
252_L	297_F	0.529	0.62
12_E	402_K	0.528	0.62
331_D	334_L	0.527	0.62
487_E	496_G	0.527	0.62
54_A	58_D	0.527	0.62
239_V	398_S	0.526	0.62
491_T	495_N	0.526	0.62
135_T	144_D	0.526	0.62
78_I	101_V	0.526	0.62
523_P	527_A	0.526	0.62
456_D	462_S	0.524	0.61
131_I	161_E	0.524	0.61
149_G	178_A	0.523	0.61
232_L	444_A	0.522	0.61
56_A	191_A	0.522	0.61
500_E	505_E	0.521	0.61
212_V	226_G	0.519	0.61
502_N	506_R	0.519	0.61
352_I	380_V	0.519	0.61
488_R	492_V	0.518	0.60
227_E	316_L	0.518	0.60
486_V	505_E	0.518	0.60
443_D	446_V	0.518	0.60
224_H	227_E	0.517	0.60
556_A	580_D	0.517	0.60
324_W	340_D	0.517	0.60
563_V	583_A	0.517	0.60
364_A	430_P	0.517	0.60
485_V	492_V	0.517	0.60
553_L	596_E	0.516	0.60
554_D	578_E	0.516	0.60
212_V	275_F	0.515	0.60
9_N	12_E	0.515	0.60
205_E	282_D	0.515	0.60
119_S	126_E	0.515	0.60
487_E	498_R	0.514	0.60
225_L	319_V	0.514	0.60
103_W	108_A	0.513	0.60
120_A	302_V	0.513	0.60
594_V	604_D	0.513	0.60
172_V	177_E	0.513	0.60
44_Y	47_E	0.513	0.60
324_W	332_D	0.513	0.60
412_E	415_A	0.512	0.60
353_N	432_I	0.512	0.60
487_E	499_F	0.512	0.60
149_G	200_L	0.512	0.60
32_Y	35_A	0.511	0.59
486_V	499_F	0.511	0.59
519_G	526_P	0.511	0.59
593_A	605_V	0.511	0.59
492_V	505_E	0.511	0.59
32_Y	37_A	0.510	0.59
520_G	523_P	0.510	0.59
67_I	99_D	0.510	0.59
38_H	391_D	0.510	0.59
361_F	455_L	0.509	0.59
138_P	144_D	0.509	0.59
121_R	135_T	0.507	0.59
255_E	259_A	0.507	0.59
7_V	21_C	0.507	0.59
121_R	385_G	0.507	0.59
23_D	419_R	0.506	0.59
210_I	248_L	0.506	0.59
10_R	16_R	0.506	0.59
348_V	445_F	0.505	0.59
116_E	119_S	0.505	0.59
218_H	331_D	0.503	0.58
594_V	598_D	0.503	0.58
32_Y	50_N	0.503	0.58
113_Q	126_E	0.501	0.58
501_V	506_R	0.501	0.58
178_A	400_V	0.500	0.58
469_A	482_D	0.500	0.58

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3n6rA	1	0.8607	100	0.36	Contact Map
3u9tA	3	0.8311	100	0.375	Contact Map
4rcnA	6	0.8033	100	0.403	Contact Map
2qf7A	4	0.8361	100	0.467	Contact Map
3jrxA	1	0.6869	100	0.468	Contact Map
3hblA	4	0.9016	100	0.475	Contact Map
3va7A	1	0.8377	100	0.482	Contact Map
4qshA	4	0.8361	100	0.482	Contact Map
1w96A	1	0.7246	100	0.519	Contact Map
3glkA	1	0.6443	100	0.522	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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