GREMLIN Database
Q9HPP8 - Biotin carboxylase
UniProt: Q9HPP8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 610 (572)
Sequences: 5148 (2669)
Seq/√Len: 111.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
93_G97_D4.6851.00
34_D50_N4.4881.00
68_D72_R4.3581.00
5_V104_V4.3461.00
93_G112_R4.2411.00
564_D586_G4.1841.00
558_S561_D3.9941.00
150_E175_A3.6491.00
174_S177_E3.4211.00
4_K27_D3.2451.00
173_R205_E3.2021.00
3_E76_D3.1711.00
104_V326_L3.1221.00
70_A78_I3.0771.00
186_E196_A3.0121.00
561_D567_D2.9651.00
7_V18_M2.9211.00
4_K29_V2.9071.00
353_N398_S2.8451.00
451_T457_R2.8281.00
94_K99_D2.8121.00
254_E258_T2.7811.00
4_K47_E2.7611.00
190_E196_A2.7491.00
327_K332_D2.7281.00
124_M263_G2.6911.00
2_F76_D2.6721.00
23_D323_K2.6641.00
568_V580_D2.6421.00
95_V101_V2.6071.00
409_D412_E2.5941.00
216_A222_V2.5591.00
2_F102_T2.5541.00
148_F151_E2.5521.00
259_A297_F2.5281.00
564_D567_D2.5051.00
212_V256_I2.4761.00
218_H270_Y2.4751.00
240_I350_Y2.4121.00
444_A449_T2.3791.00
67_I71_T2.3481.00
146_H179_E2.3391.00
43_R387_R2.3361.00
559_E591_Q2.3031.00
78_I95_V2.2871.00
49_Y73_A2.2251.00
31_V51_V2.2231.00
107_S110_S2.2161.00
49_Y69_A2.2151.00
154_Y175_A2.1931.00
5_V21_C2.1791.00
5_V326_L2.1421.00
408_S412_E2.0901.00
258_T262_R2.0861.00
229_D245_S2.0801.00
226_G341_V2.0791.00
95_V103_W2.0441.00
316_L343_L2.0441.00
350_Y417_S2.0301.00
142_V186_E2.0241.00
324_W335_T2.0211.00
249_T252_L2.0081.00
126_E266_A2.0081.00
107_S270_Y1.9941.00
380_V405_V1.9681.00
96_E108_A1.9351.00
590_T608_V1.9261.00
215_L324_W1.9121.00
141_S144_D1.9081.00
414_L446_V1.9081.00
52_G59_S1.8751.00
18_M45_A1.8621.00
33_S396_Y1.8591.00
50_N54_A1.8571.00
171_I203_Y1.8491.00
18_M44_Y1.8381.00
2_F330_S1.8291.00
93_G109_D1.8271.00
119_S122_K1.8071.00
418_R441_T1.8031.00
369_L386_L1.7971.00
223_R341_V1.7911.00
15_V44_Y1.7871.00
591_Q608_V1.7791.00
215_L328_I1.7701.00
114_L302_V1.7701.00
62_D65_A1.7661.00
139_V144_D1.7561.00
557_V589_V1.7451.00
562_A588_T1.7291.00
442_D454_Y1.7191.00
63_H94_K1.7171.00
261_R265_D1.7111.00
352_I433_I1.7091.00
565_A586_G1.7041.00
323_K327_K1.6931.00
595_S598_D1.6871.00
214_I264_A1.6871.00
173_R177_E1.6711.00
348_V414_L1.6651.00
373_D388_Q1.6651.00
112_R119_S1.6641.00
415_A446_V1.6611.00
243_G316_L1.6591.00
21_C28_T1.6571.00
435_F455_L1.6421.00
407_G412_E1.6391.00
250_D254_E1.6261.00
442_D458_D1.6251.00
252_L255_E1.6081.00
150_E154_Y1.6071.00
380_V420_A1.5811.00
569_L607_V1.5691.00
223_R336_F1.5661.00
184_S187_R1.5661.00
552_I570_V1.5651.00
280_E296_E1.5601.00
414_L440_L1.5531.00
315_A406_H1.5451.00
559_E592_V1.5311.00
96_E270_Y1.5291.00
31_V66_I1.5251.00
443_D447_G1.5211.00
414_L418_R1.5201.00
122_K126_E1.5151.00
158_I198_V1.5091.00
156_I200_L1.5031.00
144_D148_F1.5021.00
262_R265_D1.4921.00
53_P56_A1.4871.00
374_P424_Y1.4761.00
417_S440_L1.4731.00
67_I78_I1.4651.00
371_T388_Q1.4641.00
20_A323_K1.4571.00
347_A406_H1.4561.00
64_D94_K1.4501.00
422_A437_R1.4491.00
69_A73_A1.4481.00
546_A572_L1.4471.00
65_A68_D1.4401.00
30_A45_A1.4381.00
600_V606_L1.4341.00
70_A95_V1.4311.00
31_V69_A1.4301.00
356_N430_P1.4191.00
556_A568_V1.4151.00
70_A101_V1.4061.00
592_V607_V1.4061.00
128_D262_R1.4051.00
156_I202_R1.3981.00
170_K188_E1.3911.00
113_Q123_T1.3881.00
2_F5_V1.3831.00
226_G342_A1.3831.00
215_L272_A1.3831.00
133_P202_R1.3721.00
167_R398_S1.3711.00
107_S216_A1.3681.00
67_I101_V1.3681.00
383_D404_I1.3651.00
109_D113_Q1.3641.00
352_I403_L1.3621.00
444_A458_D1.3591.00
424_Y433_I1.3531.00
139_V145_I1.3461.00
55_R58_D1.3441.00
26_V326_L1.3361.00
226_G316_L1.3321.00
585_H609_I1.3231.00
411_E414_L1.3231.00
148_F152_H1.3211.00
570_V606_L1.3161.00
172_V181_Q1.3110.99
252_L279_V1.2970.99
405_V417_S1.2960.99
187_R578_E1.2920.99
555_V592_V1.2790.99
162_G195_N1.2740.99
282_D296_E1.2740.99
226_G343_L1.2710.99
439_M445_F1.2700.99
146_H150_E1.2690.99
426_I431_T1.2690.99
337_E340_D1.2680.99
71_T99_D1.2670.99
371_T425_D1.2660.99
348_V440_L1.2650.99
222_V261_R1.2630.99
540_D543_T1.2500.99
178_A182_L1.2440.99
206_N281_E1.2380.99
491_T498_R1.2360.99
107_S268_G1.2340.99
53_P58_D1.2330.99
58_D62_D1.2180.99
203_Y236_H1.2100.99
554_D596_E1.2090.99
96_E109_D1.2080.99
418_R437_R1.2050.99
145_I200_L1.2040.99
373_D425_D1.2000.99
40_G384_D1.1890.99
212_V257_G1.1880.99
239_V455_L1.1870.99
344_D406_H1.1830.99
93_G108_A1.1820.99
19_R40_G1.1810.99
435_F439_M1.1810.99
15_V40_G1.1810.99
419_R423_E1.1800.99
542_E609_I1.1790.99
54_A59_S1.1780.99
179_E183_E1.1780.99
232_L439_M1.1740.99
27_D47_E1.1730.99
232_L450_H1.1710.99
69_A75_A1.1710.99
5_V26_V1.1710.99
453_K457_R1.1690.99
306_I321_I1.1670.99
202_R298_Y1.1660.99
454_Y458_D1.1640.99
51_V69_A1.1610.99
248_L252_L1.1580.99
180_D183_E1.1530.99
379_G416_R1.1520.99
319_V324_W1.1520.99
493_E496_G1.1510.99
256_I297_F1.1510.99
368_E391_D1.1480.99
118_T161_E1.1440.99
102_T218_H1.1400.99
143_A179_E1.1390.99
178_A198_V1.1380.99
40_G44_Y1.1340.99
247_A279_V1.1280.98
147_E150_E1.1260.98
496_G499_F1.1250.98
405_V440_L1.1170.98
338_Q341_V1.1160.98
403_L424_Y1.1130.98
222_V265_D1.1130.98
54_A395_D1.1130.98
249_T295_T1.1110.98
170_K184_S1.1100.98
145_I178_A1.1080.98
40_G387_R1.1040.98
242_E410_R1.1040.98
51_V65_A1.1020.98
493_E498_R1.0990.98
120_A161_E1.0940.98
264_A302_V1.0920.98
40_G390_D1.0870.98
374_P384_D1.0850.98
219_H333_E1.0840.98
311_T349_E1.0800.98
96_E103_W1.0800.98
422_A441_T1.0780.98
118_T199_Y1.0780.98
542_E585_H1.0760.98
407_G416_R1.0760.98
20_A23_D1.0730.98
53_P59_S1.0690.98
552_I572_L1.0660.98
146_H175_A1.0600.98
240_I440_L1.0580.98
147_E151_E1.0550.98
497_K501_V1.0550.98
66_I78_I1.0550.98
453_K456_D1.0540.98
22_D28_T1.0530.98
95_V99_D1.0500.98
593_A608_V1.0450.97
68_D71_T1.0370.97
63_H91_F1.0340.97
317_T343_L1.0310.97
315_A404_I1.0270.97
94_K97_D1.0260.97
175_A179_E1.0220.97
336_F340_D1.0210.97
140_E144_D1.0200.97
239_V353_N1.0190.97
601_D604_D1.0150.97
7_V17_V1.0100.97
143_A147_E1.0060.97
52_G65_A1.0050.97
496_G501_V1.0000.97
255_E258_T0.9980.97
224_H257_G0.9970.97
182_L198_V0.9970.97
202_R296_E0.9940.97
92_A108_A0.9830.96
158_I178_A0.9820.96
184_S578_E0.9770.96
587_G609_I0.9760.96
21_C326_L0.9760.96
89_A112_R0.9760.96
215_L335_T0.9740.96
142_V179_E0.9700.96
24_L323_K0.9670.96
30_A48_A0.9670.96
552_I594_V0.9640.96
104_V329_A0.9630.96
224_H254_E0.9620.96
2_F77_A0.9590.96
142_V178_A0.9580.96
107_S218_H0.9570.96
348_V413_C0.9570.96
224_H258_T0.9510.96
361_F435_F0.9490.96
34_D54_A0.9480.96
225_L317_T0.9450.95
418_R440_L0.9410.95
490_F499_F0.9380.95
35_A396_Y0.9380.95
319_V336_F0.9380.95
259_A277_F0.9370.95
392_L400_V0.9360.95
34_D53_P0.9350.95
224_H338_Q0.9350.95
519_G523_P0.9340.95
142_V183_E0.9340.95
224_H261_R0.9330.95
139_V148_F0.9330.95
33_S58_D0.9320.95
372_Y424_Y0.9290.95
232_L445_F0.9230.95
4_K74_G0.9190.95
315_A347_A0.9180.95
336_F341_V0.9180.95
210_I245_S0.9150.95
214_I275_F0.9150.95
253_R257_G0.9110.94
581_V594_V0.9090.94
63_H67_I0.9070.94
51_V59_S0.9040.94
158_I172_V0.9020.94
121_R199_Y0.9000.94
352_I424_Y0.8960.94
15_V41_H0.8950.94
227_E253_R0.8910.94
90_E112_R0.8890.94
177_E181_Q0.8880.94
315_A383_D0.8870.94
240_I439_M0.8860.94
29_V75_A0.8820.93
324_W336_F0.8780.93
125_R136_T0.8780.93
13_I82_Y0.8740.93
245_S248_L0.8710.93
2_F26_V0.8700.93
346_H410_R0.8680.93
125_R131_I0.8640.93
24_L326_L0.8610.93
382_V424_Y0.8610.93
210_I278_L0.8560.92
418_R446_V0.8560.92
110_S268_G0.8540.92
324_W328_I0.8520.92
19_R23_D0.8500.92
386_L390_D0.8470.92
109_D268_G0.8460.92
123_T267_A0.8430.92
281_E295_T0.8420.92
483_E492_V0.8420.92
86_A306_I0.8410.92
160_A188_E0.8400.92
326_L330_S0.8360.91
459_I463_R0.8340.91
42_V48_A0.8310.91
145_I182_L0.8300.91
158_I200_L0.8300.91
492_V499_F0.8290.91
251_E255_E0.8290.91
152_H156_I0.8280.91
145_I148_F0.8270.91
411_E446_V0.8240.91
17_V79_H0.8210.91
189_G192_Y0.8210.91
455_L462_S0.8210.91
387_R390_D0.8190.91
22_D46_D0.8180.91
122_K125_R0.8160.90
152_H202_R0.8150.90
167_R192_Y0.8140.90
63_H78_I0.8120.90
93_G96_E0.8110.90
229_D450_H0.8100.90
421_L433_I0.8060.90
216_A264_A0.8050.90
437_R441_T0.8050.90
171_I205_E0.8050.90
441_T446_V0.8030.90
258_T265_D0.8010.90
251_E254_E0.8000.90
137_D140_E0.7990.90
418_R422_A0.7990.90
124_M127_A0.7970.89
492_V501_V0.7960.89
32_Y48_A0.7950.89
245_S249_T0.7930.89
210_I279_V0.7920.89
598_D604_D0.7890.89
135_T140_E0.7890.89
114_L263_G0.7880.89
206_N451_T0.7860.89
484_N487_E0.7860.89
160_A170_K0.7840.89
40_G43_R0.7840.89
568_V582_V0.7840.89
2_F104_V0.7840.89
497_K500_E0.7820.89
229_D445_F0.7820.89
221_N265_D0.7810.88
385_G390_D0.7800.88
20_A24_L0.7790.88
21_C24_L0.7790.88
113_Q119_S0.7650.87
324_W327_K0.7590.87
216_A226_G0.7580.87
495_N499_F0.7580.87
114_L267_A0.7560.87
4_K76_D0.7550.87
221_N333_E0.7540.87
15_V18_M0.7520.87
502_N505_E0.7520.87
489_D502_N0.7500.86
214_I222_V0.7490.86
33_S59_S0.7480.86
555_V570_V0.7470.86
212_V260_A0.7470.86
245_S257_G0.7460.86
501_V505_E0.7460.86
174_S179_E0.7450.86
490_F497_K0.7450.86
497_K502_N0.7440.86
278_L300_L0.7430.86
348_V405_V0.7420.86
562_A586_G0.7410.86
232_L414_L0.7410.86
563_V569_L0.7400.86
312_V404_I0.7400.86
73_A76_D0.7400.86
360_D456_D0.7390.86
130_P259_A0.7380.85
216_A261_R0.7370.85
182_L186_E0.7360.85
488_R501_V0.7350.85
20_A319_V0.7350.85
483_E486_V0.7340.85
487_E505_E0.7340.85
239_V432_I0.7340.85
488_R495_N0.7340.85
414_L445_F0.7330.85
487_E490_F0.7330.85
138_P197_N0.7320.85
63_H90_E0.7320.85
67_I95_V0.7310.85
590_T609_I0.7310.85
146_H154_Y0.7290.85
186_E190_E0.7290.85
111_M114_L0.7280.85
433_I437_R0.7270.85
66_I69_A0.7260.85
442_D447_G0.7240.84
227_E245_S0.7240.84
483_E498_R0.7230.84
484_N490_F0.7230.84
76_D102_T0.7210.84
344_D408_S0.7210.84
323_K332_D0.7210.84
375_P403_L0.7200.84
589_V609_I0.7190.84
206_N449_T0.7180.84
501_V504_E0.7170.84
229_D247_A0.7150.84
110_S270_Y0.7140.84
422_A425_D0.7130.83
3_E27_D0.7100.83
494_V497_K0.7100.83
177_E180_D0.7080.83
111_M304_T0.7080.83
432_I436_H0.7060.83
490_F501_V0.7060.83
26_V330_S0.7050.83
35_A53_P0.7040.83
30_A41_H0.7040.83
50_N53_P0.7030.83
33_S53_P0.7020.83
551_T599_S0.7010.82
487_E502_N0.7010.82
135_T148_F0.7010.82
118_T121_R0.6980.82
255_E296_E0.6980.82
76_D330_S0.6960.82
379_G406_H0.6950.82
271_N325_Q0.6940.82
483_E487_E0.6940.82
496_G502_N0.6930.82
365_T393_V0.6920.82
492_V496_G0.6920.82
123_T126_E0.6910.82
260_A275_F0.6890.81
353_N436_H0.6890.81
483_E505_E0.6880.81
71_T101_V0.6880.81
281_E296_E0.6830.81
219_H328_I0.6820.81
18_M28_T0.6810.81
519_G522_G0.6790.80
523_P526_P0.6790.80
550_G572_L0.6780.80
490_F505_E0.6760.80
394_T398_S0.6750.80
24_L327_K0.6750.80
144_D147_E0.6750.80
269_Y273_G0.6730.80
33_S36_D0.6720.80
59_S62_D0.6710.80
411_E418_R0.6710.80
372_Y388_Q0.6700.80
589_V607_V0.6700.80
149_G154_Y0.6690.79
374_P382_V0.6680.79
278_L454_Y0.6670.79
279_V295_T0.6670.79
328_I334_L0.6670.79
66_I88_N0.6670.79
557_V561_D0.6650.79
556_A567_D0.6640.79
264_A267_A0.6610.79
17_V86_A0.6610.79
232_L454_Y0.6590.78
52_G55_R0.6590.78
493_E497_K0.6550.78
552_I606_L0.6550.78
311_T404_I0.6540.78
444_A457_R0.6530.78
407_G414_L0.6530.78
63_H66_I0.6520.78
142_V146_H0.6520.78
488_R497_K0.6510.78
544_V569_L0.6510.78
55_R59_S0.6500.77
490_F498_R0.6490.77
496_G505_E0.6480.77
492_V495_N0.6480.77
483_E501_V0.6470.77
487_E497_K0.6470.77
62_D68_D0.6460.77
459_I462_S0.6450.77
123_T266_A0.6450.77
158_I182_L0.6450.77
537_V540_D0.6440.77
393_V400_V0.6430.77
491_T500_E0.6430.77
183_E187_R0.6420.77
559_E590_T0.6410.76
350_Y403_L0.6410.76
216_A270_Y0.6380.76
222_V264_A0.6370.76
492_V497_K0.6370.76
216_A334_L0.6370.76
18_M30_A0.6370.76
91_F95_V0.6370.76
223_R226_G0.6370.76
492_V502_N0.6360.76
489_D495_N0.6350.76
128_D207_P0.6350.76
323_K412_E0.6330.76
252_L295_T0.6320.75
554_D570_V0.6320.75
216_A278_L0.6300.75
495_N498_R0.6290.75
497_K504_E0.6270.75
352_I426_I0.6250.75
347_A405_V0.6250.75
12_E16_R0.6250.75
456_D459_I0.6250.75
377_G380_V0.6240.75
139_V142_V0.6240.75
242_E346_H0.6230.74
497_K505_E0.6230.74
438_L462_S0.6220.74
379_G407_G0.6220.74
212_V224_H0.6220.74
18_M22_D0.6200.74
275_F302_V0.6180.74
108_A111_M0.6170.74
260_A264_A0.6170.74
490_F500_E0.6150.73
140_E182_L0.6140.73
226_G336_F0.6140.73
348_V417_S0.6140.73
205_E281_E0.6120.73
487_E492_V0.6120.73
167_R188_E0.6120.73
62_D239_V0.6110.73
490_F502_N0.6110.73
149_G153_G0.6110.73
492_V504_E0.6100.73
215_L223_R0.6090.73
167_R199_Y0.6090.73
4_K75_A0.6080.73
32_Y41_H0.6070.73
483_E488_R0.6070.73
4_K28_T0.6070.73
21_C26_V0.6060.72
210_I227_E0.6060.72
300_L462_S0.6050.72
157_A203_Y0.6050.72
223_R335_T0.6040.72
57_A190_E0.6030.72
319_V341_V0.6030.72
30_A42_V0.6030.72
145_I278_L0.6020.72
279_V297_F0.6020.72
5_V17_V0.6020.72
335_T340_D0.6020.72
543_T605_V0.6010.72
493_E502_N0.6010.72
143_A146_H0.6010.72
490_F496_G0.6000.72
242_E312_V0.6000.72
494_V499_F0.6000.72
239_V436_H0.5990.72
487_E491_T0.5980.71
243_G343_L0.5970.71
483_E489_D0.5960.71
490_F494_V0.5950.71
487_E493_E0.5950.71
146_H178_A0.5950.71
272_A574_A0.5940.71
135_T199_Y0.5940.71
542_E584_S0.5930.71
154_Y185_A0.5920.71
369_L390_D0.5910.71
544_V563_V0.5910.71
401_A424_Y0.5910.71
340_D343_L0.5900.70
370_E427_E0.5900.70
557_V567_D0.5880.70
490_F493_E0.5860.70
92_A96_E0.5860.70
372_Y384_D0.5850.70
185_A236_H0.5840.70
214_I302_V0.5840.70
257_G261_R0.5830.69
145_I152_H0.5830.69
486_V494_V0.5830.69
114_L264_A0.5830.69
433_I440_L0.5830.69
96_E107_S0.5820.69
365_T394_T0.5810.69
556_A559_E0.5810.69
89_A108_A0.5800.69
232_L459_I0.5790.69
167_R353_N0.5790.69
544_V608_V0.5790.69
132_V278_L0.5780.69
34_D59_S0.5770.69
97_D108_A0.5760.69
489_D500_E0.5750.68
526_P530_A0.5750.68
124_M266_A0.5740.68
458_D462_S0.5740.68
574_A579_N0.5740.68
565_A585_H0.5730.68
522_G526_P0.5730.68
118_T124_M0.5730.68
499_F505_E0.5720.68
487_E504_E0.5720.68
559_E593_A0.5720.68
350_Y440_L0.5700.68
257_G343_L0.5700.68
86_A353_N0.5700.68
187_R191_A0.5700.68
369_L426_I0.5700.68
484_N499_F0.5690.68
483_E497_K0.5680.68
382_V401_A0.5680.68
35_A54_A0.5680.68
488_R498_R0.5680.68
167_R207_P0.5670.67
566_G582_V0.5670.67
258_T261_R0.5670.67
412_E416_R0.5670.67
541_G545_T0.5650.67
255_E262_R0.5630.67
371_T427_E0.5630.67
409_D415_A0.5630.67
58_D65_A0.5620.67
161_E195_N0.5620.67
359_D603_D0.5610.67
357_A430_P0.5610.67
325_Q606_L0.5610.67
317_T341_V0.5610.67
555_V596_E0.5600.66
486_V489_D0.5590.66
491_T499_F0.5590.66
384_D401_A0.5590.66
5_V102_T0.5580.66
135_T139_V0.5580.66
306_I322_V0.5580.66
555_V607_V0.5570.66
483_E502_N0.5570.66
227_E297_F0.5560.66
146_H172_V0.5560.66
499_F502_N0.5560.66
26_V77_A0.5560.66
199_Y321_I0.5560.66
492_V500_E0.5550.66
256_I259_A0.5540.66
546_A599_S0.5540.66
345_G406_H0.5530.65
375_P424_Y0.5520.65
444_A450_H0.5520.65
157_A171_I0.5500.65
280_E295_T0.5500.65
15_V20_A0.5500.65
215_L319_V0.5500.65
375_P420_A0.5500.65
494_V506_R0.5490.65
256_I260_A0.5490.65
486_V498_R0.5480.65
496_G500_E0.5480.65
225_L321_I0.5480.65
405_V420_A0.5480.65
484_N488_R0.5480.65
111_M115_G0.5480.65
161_E549_Q0.5470.65
27_D46_D0.5470.65
487_E501_V0.5470.65
488_R499_F0.5470.65
82_Y85_L0.5460.64
356_N379_G0.5460.64
350_Y404_I0.5460.64
526_P529_G0.5460.64
207_P453_K0.5460.64
50_N65_A0.5450.64
378_I416_R0.5450.64
486_V501_V0.5440.64
142_V182_L0.5440.64
63_H95_V0.5440.64
570_V592_V0.5440.64
485_V497_K0.5430.64
160_A198_V0.5420.64
86_A311_T0.5420.64
483_E503_L0.5420.64
35_A55_R0.5410.64
124_M300_L0.5410.64
15_V387_R0.5400.64
63_H86_A0.5400.64
572_L600_V0.5400.64
65_A69_A0.5400.64
90_E94_K0.5400.64
245_S450_H0.5390.63
15_V384_D0.5390.63
56_A59_S0.5390.63
76_D101_V0.5380.63
570_V607_V0.5380.63
556_A571_V0.5370.63
256_I550_G0.5370.63
120_A267_A0.5370.63
493_E504_E0.5360.63
64_D68_D0.5360.63
543_T608_V0.5360.63
90_E97_D0.5360.63
114_L304_T0.5350.63
59_S396_Y0.5350.63
161_E199_Y0.5340.63
491_T502_N0.5330.63
408_S411_E0.5330.63
132_V204_L0.5310.62
485_V507_G0.5310.62
216_A257_G0.5310.62
135_T138_P0.5310.62
369_L372_Y0.5310.62
495_N502_N0.5310.62
124_M267_A0.5300.62
525_E530_A0.5300.62
359_D362_A0.5300.62
158_I181_Q0.5290.62
252_L297_F0.5290.62
12_E402_K0.5280.62
331_D334_L0.5270.62
487_E496_G0.5270.62
54_A58_D0.5270.62
239_V398_S0.5260.62
491_T495_N0.5260.62
135_T144_D0.5260.62
78_I101_V0.5260.62
523_P527_A0.5260.62
456_D462_S0.5240.61
131_I161_E0.5240.61
149_G178_A0.5230.61
232_L444_A0.5220.61
56_A191_A0.5220.61
500_E505_E0.5210.61
212_V226_G0.5190.61
502_N506_R0.5190.61
352_I380_V0.5190.61
488_R492_V0.5180.60
227_E316_L0.5180.60
486_V505_E0.5180.60
443_D446_V0.5180.60
224_H227_E0.5170.60
556_A580_D0.5170.60
324_W340_D0.5170.60
563_V583_A0.5170.60
364_A430_P0.5170.60
485_V492_V0.5170.60
553_L596_E0.5160.60
554_D578_E0.5160.60
212_V275_F0.5150.60
9_N12_E0.5150.60
205_E282_D0.5150.60
119_S126_E0.5150.60
487_E498_R0.5140.60
225_L319_V0.5140.60
103_W108_A0.5130.60
120_A302_V0.5130.60
594_V604_D0.5130.60
172_V177_E0.5130.60
44_Y47_E0.5130.60
324_W332_D0.5130.60
412_E415_A0.5120.60
353_N432_I0.5120.60
487_E499_F0.5120.60
149_G200_L0.5120.60
32_Y35_A0.5110.59
486_V499_F0.5110.59
519_G526_P0.5110.59
593_A605_V0.5110.59
492_V505_E0.5110.59
32_Y37_A0.5100.59
520_G523_P0.5100.59
67_I99_D0.5100.59
38_H391_D0.5100.59
361_F455_L0.5090.59
138_P144_D0.5090.59
121_R135_T0.5070.59
255_E259_A0.5070.59
7_V21_C0.5070.59
121_R385_G0.5070.59
23_D419_R0.5060.59
210_I248_L0.5060.59
10_R16_R0.5060.59
348_V445_F0.5050.59
116_E119_S0.5050.59
218_H331_D0.5030.58
594_V598_D0.5030.58
32_Y50_N0.5030.58
113_Q126_E0.5010.58
501_V506_R0.5010.58
178_A400_V0.5000.58
469_A482_D0.5000.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3n6rA 1 0.8607 100 0.36 Contact Map
3u9tA 3 0.8311 100 0.375 Contact Map
4rcnA 6 0.8033 100 0.403 Contact Map
2qf7A 4 0.8361 100 0.467 Contact Map
3jrxA 1 0.6869 100 0.468 Contact Map
3hblA 4 0.9016 100 0.475 Contact Map
3va7A 1 0.8377 100 0.482 Contact Map
4qshA 4 0.8361 100 0.482 Contact Map
1w96A 1 0.7246 100 0.519 Contact Map
3glkA 1 0.6443 100 0.522 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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