Q9HPP5 - HALSA - GREMLIN Contacts

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Q9HPP5 - Uncharacterized protein

UniProt:	Q9HPP5	Sequences: MGRYERILVPTDGSNASQDAVAHAVDLAVEHDATVHALYVVDTASYAGLPMDSSWESVSAMLSSEGTSALDTVTAAANDRGVATERELRDGNPAMEIVTYADNAGCDLIVMGTHGRGGIDRLLLGSVTEKVVRSSSVPVLTVSGGDE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	147 (135)
Sequences:	20408 (16633)
Seq/√Len:	1431.5

ECOLI - USPE USPF USPG USPC USPD USPA
BACSU - NHAX YXIE
HALSA - Q9HPP5 Q9HRP5 Q9HPQ8 Q9HPF7 Q9HP90 Q9HRD8 Q9HMJ0 Q9HNX9 Q9HMI9 Q9HHV8 Q9HHX5 Q9HHY0 Q9HMU1
SULSO - Q97X90 Q97V57 Q7LXW4 Q97U40

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
36_H	87_E	3.151	1.00
6_R	36_H	2.813	1.00
8_L	106_C	2.739	1.00
94_A	130_K	2.695	1.00
34_T	85_E	2.599	1.00
23_H	140_L	2.501	1.00
6_R	34_T	2.466	1.00
108_L	140_L	2.356	1.00
87_E	100_Y	2.333	1.00
111_M	131_V	1.978	1.00
109_I	137_V	1.974	1.00
91_G	96_E	1.970	1.00
36_H	85_E	1.969	1.00
100_Y	104_A	1.890	1.00
74_T	86_R	1.882	1.00
129_E	133_R	1.864	1.00
36_H	106_C	1.853	1.00
89_R	96_E	1.798	1.00
101_A	109_I	1.766	1.00
9_V	24_A	1.759	1.00
113_T	143_S	1.757	1.00
36_H	100_Y	1.734	1.00
36_H	104_A	1.704	1.00
38_L	100_Y	1.703	1.00
10_P	111_M	1.695	1.00
40_V	96_E	1.662	1.00
10_P	97_I	1.631	1.00
74_T	78_N	1.624	1.00
22_A	76_A	1.602	1.00
6_R	107_D	1.515	1.00
96_E	99_T	1.470	1.00
27_L	31_H	1.453	1.00
98_V	134_S	1.420	1.00
67_T	71_D	1.410	1.00
130_K	134_S	1.402	1.00
109_I	135_S	1.388	1.00
63_S	67_T	1.363	1.00
24_A	28_A	1.359	1.00
34_T	83_A	1.341	1.00
39_Y	66_G	1.323	1.00
18_Q	76_A	1.303	1.00
33_A	107_D	1.303	1.00
89_R	100_Y	1.300	1.00
9_V	21_V	1.293	1.00
101_A	136_S	1.289	1.00
109_I	131_V	1.222	1.00
38_L	89_R	1.220	1.00
69_A	73_V	1.176	1.00
71_D	74_T	1.174	1.00
93_P	127_V	1.158	1.00
62_L	65_E	1.143	1.00
40_V	93_P	1.112	1.00
135_S	139_V	1.105	1.00
66_G	69_A	1.100	1.00
119_I	123_L	1.079	1.00
73_V	77_A	1.075	1.00
101_A	137_V	1.071	1.00
66_G	70_L	1.071	1.00
11_T	73_V	1.063	1.00
23_H	142_V	1.053	1.00
23_H	27_L	1.038	1.00
71_D	75_A	1.024	1.00
59_S	63_S	1.013	1.00
64_S	68_S	1.009	1.00
101_A	106_C	1.009	1.00
111_M	128_T	0.991	1.00
29_V	80_R	0.991	1.00
6_R	106_C	0.980	1.00
7_I	108_L	0.978	1.00
121_R	129_E	0.969	1.00
17_S	20_A	0.968	1.00
98_V	101_A	0.964	1.00
24_A	110_V	0.963	1.00
113_T	141_T	0.959	1.00
13_G	39_Y	0.957	1.00
76_A	79_D	0.955	1.00
132_V	141_T	0.954	1.00
38_L	97_I	0.947	1.00
18_Q	72_T	0.940	1.00
73_V	76_A	0.940	1.00
21_V	37_A	0.927	1.00
71_D	86_R	0.923	1.00
100_Y	106_C	0.922	1.00
69_A	72_T	0.918	1.00
37_A	84_T	0.907	1.00
26_D	30_E	0.906	1.00
6_R	104_A	0.906	1.00
72_T	76_A	0.904	1.00
128_T	141_T	0.898	1.00
87_E	104_A	0.893	1.00
41_V	90_D	0.886	1.00
25_V	82_V	0.878	1.00
23_H	26_D	0.877	1.00
23_H	138_P	0.872	1.00
65_E	69_A	0.865	1.00
31_H	107_D	0.859	1.00
21_V	73_V	0.856	1.00
28_A	35_V	0.843	1.00
66_G	88_L	0.842	1.00
60_A	64_S	0.841	1.00
11_T	37_A	0.838	1.00
70_L	86_R	0.835	1.00
116_R	120_D	0.820	1.00
25_V	80_R	0.819	1.00
8_L	38_L	0.812	1.00
41_V	88_L	0.811	1.00
113_T	128_T	0.809	1.00
18_Q	22_A	0.794	1.00
11_T	20_A	0.794	1.00
24_A	35_V	0.792	1.00
25_V	77_A	0.792	1.00
8_L	109_I	0.792	1.00
92_N	95_M	0.787	1.00
14_S	17_S	0.785	1.00
11_T	21_V	0.783	1.00
118_G	121_R	0.776	1.00
10_P	112_G	0.774	1.00
19_D	22_A	0.770	1.00
28_A	31_H	0.766	1.00
98_V	131_V	0.763	1.00
54_S	57_S	0.759	1.00
56_E	60_A	0.756	1.00
21_V	25_V	0.752	1.00
75_A	79_D	0.737	1.00
62_L	66_G	0.732	1.00
98_V	135_S	0.729	1.00
110_V	140_L	0.729	1.00
11_T	18_Q	0.728	1.00
29_V	81_G	0.725	1.00
65_E	68_S	0.723	1.00
119_I	122_L	0.720	1.00
57_S	60_A	0.720	1.00
39_Y	69_A	0.711	1.00
75_A	78_N	0.707	1.00
9_V	35_V	0.702	1.00
28_A	33_A	0.700	1.00
8_L	100_Y	0.697	1.00
118_G	122_L	0.696	1.00
37_A	77_A	0.691	1.00
72_T	75_A	0.685	1.00
26_D	29_V	0.677	1.00
115_G	124_L	0.669	1.00
51_M	54_S	0.667	1.00
37_A	73_V	0.664	1.00
96_E	100_Y	0.663	1.00
97_I	131_V	0.660	1.00
27_L	30_E	0.659	1.00
64_S	67_T	0.650	1.00
105_G	137_V	0.646	1.00
111_M	141_T	0.645	1.00
94_A	127_V	0.643	1.00
11_T	17_S	0.635	1.00
7_I	28_A	0.634	1.00
61_M	64_S	0.632	1.00
41_V	66_G	0.632	1.00
5_E	107_D	0.631	1.00
14_S	115_G	0.631	1.00
68_S	72_T	0.630	1.00
25_V	29_V	0.627	1.00
52_D	55_W	0.624	1.00
74_T	77_A	0.624	1.00
61_M	65_E	0.615	1.00
77_A	84_T	0.612	1.00
5_E	33_A	0.611	1.00
38_L	96_E	0.605	1.00
112_G	142_V	0.603	1.00
51_M	55_W	0.600	1.00
95_M	99_T	0.594	1.00
110_V	142_V	0.594	1.00
94_A	131_V	0.594	1.00
13_G	69_A	0.592	1.00
60_A	63_S	0.587	1.00
57_S	61_M	0.583	1.00
94_A	98_V	0.578	1.00
47_A	50_P	0.571	1.00
16_A	19_D	0.564	1.00
9_V	20_A	0.558	1.00
15_N	18_Q	0.556	1.00
114_H	128_T	0.554	1.00
124_L	128_T	0.554	1.00
55_W	58_V	0.549	1.00
131_V	139_V	0.547	1.00
91_G	99_T	0.544	1.00
59_S	90_D	0.543	1.00
70_L	74_T	0.542	1.00
70_L	88_L	0.540	1.00
67_T	86_R	0.535	1.00
98_V	130_K	0.533	1.00
7_I	110_V	0.533	1.00
13_G	73_V	0.532	1.00
6_R	33_A	0.531	1.00
132_V	139_V	0.518	1.00
63_S	90_D	0.515	1.00
43_T	90_D	0.513	1.00
68_S	71_D	0.512	1.00
74_T	84_T	0.510	1.00
24_A	33_A	0.510	1.00
94_A	134_S	0.508	1.00
20_A	110_V	0.507	1.00
53_S	57_S	0.505	1.00
115_G	125_G	0.501	1.00
27_L	110_V	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
5ahwA	4	0.9796	99.9	0.138	Contact Map
4wnyA	2	0.8776	99.9	0.148	Contact Map
1mjhA	2	0.966	99.9	0.155	Contact Map
2dumA	2	0.9592	99.9	0.159	Contact Map
2gm3A	2	0.8776	99.9	0.162	Contact Map
3loqA	1	0.9592	99.9	0.168	Contact Map
3s3tA	4	0.9728	99.9	0.17	Contact Map
3tnjA	2	0.8639	99.9	0.173	Contact Map
3hgmA	2	0.9524	99.9	0.18	Contact Map
1tq8A	4	0.8503	99.9	0.185	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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