GREMLIN Database
Q9HPP5 - Uncharacterized protein
UniProt: Q9HPP5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 147 (135)
Sequences: 20408 (16633)
Seq/√Len: 1431.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
36_H87_E3.1511.00
6_R36_H2.8131.00
8_L106_C2.7391.00
94_A130_K2.6951.00
34_T85_E2.5991.00
23_H140_L2.5011.00
6_R34_T2.4661.00
108_L140_L2.3561.00
87_E100_Y2.3331.00
111_M131_V1.9781.00
109_I137_V1.9741.00
91_G96_E1.9701.00
36_H85_E1.9691.00
100_Y104_A1.8901.00
74_T86_R1.8821.00
129_E133_R1.8641.00
36_H106_C1.8531.00
89_R96_E1.7981.00
101_A109_I1.7661.00
9_V24_A1.7591.00
113_T143_S1.7571.00
36_H100_Y1.7341.00
36_H104_A1.7041.00
38_L100_Y1.7031.00
10_P111_M1.6951.00
40_V96_E1.6621.00
10_P97_I1.6311.00
74_T78_N1.6241.00
22_A76_A1.6021.00
6_R107_D1.5151.00
96_E99_T1.4701.00
27_L31_H1.4531.00
98_V134_S1.4201.00
67_T71_D1.4101.00
130_K134_S1.4021.00
109_I135_S1.3881.00
63_S67_T1.3631.00
24_A28_A1.3591.00
34_T83_A1.3411.00
39_Y66_G1.3231.00
18_Q76_A1.3031.00
33_A107_D1.3031.00
89_R100_Y1.3001.00
9_V21_V1.2931.00
101_A136_S1.2891.00
109_I131_V1.2221.00
38_L89_R1.2201.00
69_A73_V1.1761.00
71_D74_T1.1741.00
93_P127_V1.1581.00
62_L65_E1.1431.00
40_V93_P1.1121.00
135_S139_V1.1051.00
66_G69_A1.1001.00
119_I123_L1.0791.00
73_V77_A1.0751.00
101_A137_V1.0711.00
66_G70_L1.0711.00
11_T73_V1.0631.00
23_H142_V1.0531.00
23_H27_L1.0381.00
71_D75_A1.0241.00
59_S63_S1.0131.00
64_S68_S1.0091.00
101_A106_C1.0091.00
111_M128_T0.9911.00
29_V80_R0.9911.00
6_R106_C0.9801.00
7_I108_L0.9781.00
121_R129_E0.9691.00
17_S20_A0.9681.00
98_V101_A0.9641.00
24_A110_V0.9631.00
113_T141_T0.9591.00
13_G39_Y0.9571.00
76_A79_D0.9551.00
132_V141_T0.9541.00
38_L97_I0.9471.00
18_Q72_T0.9401.00
73_V76_A0.9401.00
21_V37_A0.9271.00
71_D86_R0.9231.00
100_Y106_C0.9221.00
69_A72_T0.9181.00
37_A84_T0.9071.00
26_D30_E0.9061.00
6_R104_A0.9061.00
72_T76_A0.9041.00
128_T141_T0.8981.00
87_E104_A0.8931.00
41_V90_D0.8861.00
25_V82_V0.8781.00
23_H26_D0.8771.00
23_H138_P0.8721.00
65_E69_A0.8651.00
31_H107_D0.8591.00
21_V73_V0.8561.00
28_A35_V0.8431.00
66_G88_L0.8421.00
60_A64_S0.8411.00
11_T37_A0.8381.00
70_L86_R0.8351.00
116_R120_D0.8201.00
25_V80_R0.8191.00
8_L38_L0.8121.00
41_V88_L0.8111.00
113_T128_T0.8091.00
18_Q22_A0.7941.00
11_T20_A0.7941.00
24_A35_V0.7921.00
25_V77_A0.7921.00
8_L109_I0.7921.00
92_N95_M0.7871.00
14_S17_S0.7851.00
11_T21_V0.7831.00
118_G121_R0.7761.00
10_P112_G0.7741.00
19_D22_A0.7701.00
28_A31_H0.7661.00
98_V131_V0.7631.00
54_S57_S0.7591.00
56_E60_A0.7561.00
21_V25_V0.7521.00
75_A79_D0.7371.00
62_L66_G0.7321.00
98_V135_S0.7291.00
110_V140_L0.7291.00
11_T18_Q0.7281.00
29_V81_G0.7251.00
65_E68_S0.7231.00
119_I122_L0.7201.00
57_S60_A0.7201.00
39_Y69_A0.7111.00
75_A78_N0.7071.00
9_V35_V0.7021.00
28_A33_A0.7001.00
8_L100_Y0.6971.00
118_G122_L0.6961.00
37_A77_A0.6911.00
72_T75_A0.6851.00
26_D29_V0.6771.00
115_G124_L0.6691.00
51_M54_S0.6671.00
37_A73_V0.6641.00
96_E100_Y0.6631.00
97_I131_V0.6601.00
27_L30_E0.6591.00
64_S67_T0.6501.00
105_G137_V0.6461.00
111_M141_T0.6451.00
94_A127_V0.6431.00
11_T17_S0.6351.00
7_I28_A0.6341.00
61_M64_S0.6321.00
41_V66_G0.6321.00
5_E107_D0.6311.00
14_S115_G0.6311.00
68_S72_T0.6301.00
25_V29_V0.6271.00
52_D55_W0.6241.00
74_T77_A0.6241.00
61_M65_E0.6151.00
77_A84_T0.6121.00
5_E33_A0.6111.00
38_L96_E0.6051.00
112_G142_V0.6031.00
51_M55_W0.6001.00
95_M99_T0.5941.00
110_V142_V0.5941.00
94_A131_V0.5941.00
13_G69_A0.5921.00
60_A63_S0.5871.00
57_S61_M0.5831.00
94_A98_V0.5781.00
47_A50_P0.5711.00
16_A19_D0.5641.00
9_V20_A0.5581.00
15_N18_Q0.5561.00
114_H128_T0.5541.00
124_L128_T0.5541.00
55_W58_V0.5491.00
131_V139_V0.5471.00
91_G99_T0.5441.00
59_S90_D0.5431.00
70_L74_T0.5421.00
70_L88_L0.5401.00
67_T86_R0.5351.00
98_V130_K0.5331.00
7_I110_V0.5331.00
13_G73_V0.5321.00
6_R33_A0.5311.00
132_V139_V0.5181.00
63_S90_D0.5151.00
43_T90_D0.5131.00
68_S71_D0.5121.00
74_T84_T0.5101.00
24_A33_A0.5101.00
94_A134_S0.5081.00
20_A110_V0.5071.00
53_S57_S0.5051.00
115_G125_G0.5011.00
27_L110_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
5ahwA 4 0.9796 99.9 0.138 Contact Map
4wnyA 2 0.8776 99.9 0.148 Contact Map
1mjhA 2 0.966 99.9 0.155 Contact Map
2dumA 2 0.9592 99.9 0.159 Contact Map
2gm3A 2 0.8776 99.9 0.162 Contact Map
3loqA 1 0.9592 99.9 0.168 Contact Map
3s3tA 4 0.9728 99.9 0.17 Contact Map
3tnjA 2 0.8639 99.9 0.173 Contact Map
3hgmA 2 0.9524 99.9 0.18 Contact Map
1tq8A 4 0.8503 99.9 0.185 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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