GREMLIN Database
Q9HPP4 - Uncharacterized protein
UniProt: Q9HPP4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 409 (364)
Sequences: 1294 (926)
Seq/√Len: 48.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
19_V80_R3.8551.00
118_S136_A3.7691.00
162_L212_M3.6811.00
29_Q32_R3.5301.00
65_A156_V3.4691.00
33_N251_D3.3901.00
267_R271_R3.2321.00
111_D115_L3.2121.00
22_L81_A3.0721.00
265_T268_V2.9691.00
85_L88_I2.9581.00
63_D80_R2.8921.00
25_T124_V2.8391.00
32_R52_F2.8111.00
61_L156_V2.7931.00
67_D76_A2.7251.00
8_S46_S2.5391.00
212_M217_Y2.5091.00
232_A269_A2.4851.00
180_R219_H2.4411.00
271_R276_D2.3921.00
133_A137_A2.3461.00
62_A83_A2.3181.00
120_Q124_V2.3051.00
40_V222_A2.2681.00
212_M216_V2.2421.00
62_A79_V2.2071.00
318_D321_V2.2021.00
135_I139_V2.1601.00
91_G97_V2.1531.00
318_D323_A2.1461.00
136_A139_V2.1411.00
185_L194_L2.0000.99
122_A126_A1.9050.99
19_V59_Y1.8770.99
5_I45_P1.8590.99
120_Q125_L1.8180.99
93_F256_V1.8160.99
316_E321_V1.8100.99
85_L117_A1.7980.99
25_T28_L1.7970.99
275_R279_K1.7770.99
90_H110_D1.7360.99
180_R275_R1.7070.98
121_V125_L1.7040.98
317_R321_V1.6840.98
321_V324_P1.6430.98
132_P136_A1.6150.98
15_V20_A1.6140.98
59_Y80_R1.5980.97
86_H157_D1.5950.97
169_T216_V1.5950.97
21_A127_D1.5930.97
135_I138_L1.5880.97
42_L225_S1.5870.97
225_S277_L1.5870.97
26_P120_Q1.5870.97
114_D140_A1.5760.97
266_S269_A1.5730.97
235_T264_A1.5640.97
3_T20_A1.5630.97
11_D179_G1.5630.97
121_V124_V1.5500.97
24_D32_R1.5430.97
194_L202_A1.5420.97
318_D324_P1.5380.97
95_H157_D1.5300.97
10_H163_V1.5290.97
309_A313_G1.5240.97
198_N201_S1.5190.97
316_E323_A1.5060.96
162_L208_A1.4970.96
75_R143_G1.4910.96
305_E308_I1.4830.96
62_A149_L1.4810.96
5_I15_V1.4800.96
79_V150_V1.4760.96
23_L28_L1.4750.96
66_L80_R1.4710.96
232_A259_L1.4700.96
228_M277_L1.4650.96
345_L351_L1.4400.95
126_A129_D1.4350.95
6_K12_H1.4330.95
297_D301_V1.4320.95
65_A185_L1.4230.95
87_D157_D1.4170.95
320_I324_P1.4140.95
86_H109_H1.4130.95
228_M278_Y1.4080.95
155_D158_R1.4060.95
243_T246_A1.3950.94
306_R310_A1.3950.94
163_V178_H1.3920.94
8_S167_H1.3920.94
58_V156_V1.3860.94
79_V146_L1.3800.94
223_R322_D1.3760.94
110_D157_D1.3740.94
116_V248_R1.3650.94
9_V167_H1.3590.94
220_H280_R1.3490.93
109_H157_D1.3420.93
271_R278_Y1.3400.93
58_V83_A1.3240.93
51_R54_H1.3220.93
146_L150_V1.3130.92
283_W366_G1.3110.92
329_M332_S1.3090.92
90_H109_H1.3040.92
219_H275_R1.2980.92
41_S50_T1.2950.92
345_L349_S1.2940.92
171_V212_M1.2840.91
188_I193_V1.2770.91
9_V13_I1.2680.91
22_L85_L1.2570.91
305_E309_A1.2560.91
130_I134_E1.2530.90
173_Y212_M1.2520.90
48_N53_E1.2430.90
6_K210_A1.2420.90
60_H63_D1.2350.90
301_V304_F1.2150.89
316_E320_I1.2120.89
135_I141_G1.2120.89
60_H64_R1.2070.89
171_V174_G1.2010.88
313_G316_E1.2000.88
357_T360_R1.1990.88
221_V275_R1.1920.88
228_M232_A1.1710.87
300_T304_F1.1680.87
68_H182_I1.1660.87
69_L92_P1.1590.87
32_R42_L1.1560.86
235_T239_T1.1540.86
134_E143_G1.1400.86
126_A130_I1.1390.86
176_I206_L1.1300.85
298_H301_V1.1300.85
50_T88_I1.1290.85
298_H302_R1.1260.85
88_I117_A1.1220.85
51_R57_G1.1180.85
314_V321_V1.1140.84
302_R306_R1.1090.84
86_H110_D1.1060.84
352_V355_L1.1050.84
225_S268_V1.1000.84
89_G94_S1.1000.84
270_A274_E1.0940.83
265_T269_A1.0930.83
123_S127_D1.0920.83
246_A249_R1.0910.83
320_I323_A1.0890.83
310_A313_G1.0880.83
317_R320_I1.0870.83
95_H110_D1.0860.83
29_Q52_F1.0810.82
316_E319_V1.0780.82
270_A276_D1.0730.82
94_S158_R1.0700.82
110_D113_H1.0700.82
158_R206_L1.0640.81
269_A273_F1.0640.81
131_Q139_V1.0620.81
29_Q93_F1.0550.81
16_T19_V1.0540.81
316_E324_P1.0500.81
208_A212_M1.0470.80
350_T359_Q1.0420.80
64_R179_G1.0360.80
304_F311_D1.0340.80
224_I278_Y1.0320.79
132_P135_I1.0300.79
37_L169_T1.0300.79
158_R209_R1.0270.79
24_D29_Q1.0270.79
95_H109_H1.0240.79
61_L178_H1.0230.79
221_V279_K1.0220.79
38_G155_D1.0220.79
303_G308_I1.0170.78
15_V19_V1.0170.78
87_D109_H1.0150.78
133_A270_A1.0140.78
38_G94_S1.0130.78
232_A268_V1.0120.78
67_D74_Q1.0090.78
213_N218_S1.0090.78
162_L216_V1.0040.78
266_S273_F1.0040.78
87_D95_H1.0030.77
126_A132_P0.9950.77
347_E353_T0.9940.77
4_T12_H0.9920.77
165_D217_Y0.9910.77
47_A169_T0.9890.76
266_S270_A0.9860.76
7_D10_H0.9860.76
341_E347_E0.9850.76
196_A338_V0.9850.76
68_H183_R0.9830.76
309_A321_V0.9820.76
9_V119_G0.9810.76
54_H57_G0.9770.76
38_G226_K0.9760.75
131_Q134_E0.9700.75
364_R368_Y0.9680.75
300_T303_G0.9580.74
163_V167_H0.9540.74
134_E138_L0.9530.74
36_Q49_H0.9460.73
52_F180_R0.9450.73
184_G198_N0.9400.73
343_R348_Q0.9380.73
96_N222_A0.9260.72
8_S168_H0.9250.71
24_D275_R0.9200.71
24_D219_H0.9190.71
8_S170_G0.9150.71
299_D304_F0.9120.70
159_M176_I0.9100.70
88_I347_E0.9100.70
50_T311_D0.9020.70
46_S168_H0.9010.69
118_S133_A0.9000.69
15_V56_L0.8970.69
91_G250_M0.8870.68
91_G247_L0.8860.68
147_A150_V0.8860.68
319_V322_D0.8850.68
158_R207_L0.8830.68
364_R367_V0.8830.68
228_M268_V0.8830.68
53_E168_H0.8820.68
313_G319_V0.8810.68
72_T143_G0.8810.68
94_S226_K0.8780.67
349_S353_T0.8740.67
119_G125_L0.8700.67
43_V79_V0.8700.67
20_A24_D0.8660.66
86_H95_H0.8660.66
174_G212_M0.8620.66
299_D303_G0.8590.66
299_D310_A0.8570.66
174_G203_E0.8570.66
29_Q219_H0.8570.66
62_A156_V0.8550.65
306_R309_A0.8540.65
78_R134_E0.8540.65
72_T75_R0.8500.65
49_H165_D0.8480.65
214_P251_D0.8470.65
103_R234_E0.8430.64
142_D145_P0.8420.64
203_E212_M0.8420.64
53_E180_R0.8410.64
315_P334_T0.8390.64
361_E364_R0.8380.64
344_R347_E0.8380.64
98_E203_E0.8350.64
14_E183_R0.8350.64
5_I9_V0.8340.63
167_H213_N0.8340.63
279_K282_V0.8320.63
5_I23_L0.8320.63
27_P83_A0.8310.63
162_L166_A0.8300.63
254_D258_A0.8280.63
6_K44_Y0.8210.62
74_Q134_E0.8190.62
110_D161_Y0.8170.62
100_V116_V0.8160.62
207_L211_L0.8160.62
301_V306_R0.8140.62
90_H157_D0.8130.61
152_G185_L0.8120.61
94_S209_R0.8120.61
19_V63_D0.8110.61
294_V298_H0.8090.61
46_S195_G0.8060.61
64_R67_D0.8050.61
43_V112_V0.8040.61
86_H90_H0.8020.60
233_A319_V0.8010.60
309_A314_V0.7980.60
90_H161_Y0.7940.60
33_N274_E0.7940.60
154_L176_I0.7920.59
365_L369_T0.7920.59
326_E331_E0.7910.59
124_V128_H0.7890.59
123_S126_A0.7840.59
39_T229_L0.7820.58
338_V343_R0.7810.58
173_Y210_A0.7810.58
296_A303_G0.7800.58
31_L36_Q0.7790.58
317_R323_A0.7760.58
231_R234_E0.7730.58
98_E207_L0.7700.57
39_T226_K0.7700.57
276_D279_K0.7680.57
23_L26_P0.7680.57
8_S13_I0.7650.57
339_N351_L0.7650.57
308_I311_D0.7640.57
131_Q141_G0.7620.56
255_L272_L0.7610.56
233_A247_L0.7600.56
162_L171_V0.7570.56
40_V44_Y0.7550.56
315_P319_V0.7480.55
266_S279_K0.7470.55
355_L358_A0.7460.55
125_L128_H0.7450.55
150_V175_T0.7440.55
360_R365_L0.7390.54
332_S336_V0.7340.54
130_I135_I0.7340.54
306_R313_G0.7330.54
121_V126_A0.7310.53
28_L186_T0.7290.53
112_V247_L0.7290.53
127_D270_A0.7280.53
154_L205_L0.7250.53
56_L202_A0.7250.53
3_T11_D0.7250.53
200_Q215_T0.7240.53
19_V81_A0.7230.53
9_V46_S0.7220.52
87_D110_D0.7220.52
95_H161_Y0.7210.52
186_T193_V0.7190.52
22_L121_V0.7190.52
45_P48_N0.7180.52
172_P175_T0.7180.52
305_E310_A0.7170.52
190_G234_E0.7170.52
180_R352_V0.7160.52
168_H222_A0.7150.52
151_A155_D0.7100.51
149_L193_V0.7100.51
144_E291_D0.7080.51
308_I317_R0.7060.51
311_D318_D0.7030.51
37_L47_A0.7020.50
131_Q135_I0.6990.50
315_P321_V0.6970.50
269_A278_Y0.6940.50
319_V324_P0.6940.50
297_D304_F0.6920.49
194_L198_N0.6910.49
58_V154_L0.6900.49
98_E345_L0.6890.49
66_L79_V0.6870.49
326_E330_P0.6870.49
52_F219_H0.6860.49
200_Q210_A0.6860.49
180_R221_V0.6850.49
31_L55_S0.6850.49
315_P323_A0.6820.48
45_P53_E0.6800.48
180_R216_V0.6790.48
153_E158_R0.6780.48
134_E139_V0.6740.48
88_I113_H0.6730.48
43_V47_A0.6720.47
299_D306_R0.6710.47
38_G161_Y0.6700.47
197_G219_H0.6690.47
68_H178_H0.6630.47
265_T273_F0.6600.46
169_T204_S0.6600.46
263_D321_V0.6590.46
152_G206_L0.6590.46
119_G248_R0.6590.46
338_V341_E0.6570.46
90_H95_H0.6570.46
132_P139_V0.6560.46
292_D299_D0.6560.46
297_D300_T0.6560.46
141_G151_A0.6530.46
334_T338_V0.6520.45
236_L262_H0.6520.45
38_G222_A0.6510.45
356_Q361_E0.6500.45
92_P256_V0.6490.45
43_V219_H0.6480.45
116_V244_A0.6460.45
306_R311_D0.6440.45
130_I139_V0.6440.45
224_I277_L0.6440.45
301_V305_E0.6400.44
267_R276_D0.6380.44
14_E224_I0.6370.44
203_E207_L0.6340.44
237_L240_T0.6340.44
195_G280_R0.6340.44
96_N226_K0.6330.44
159_M183_R0.6290.43
97_V156_V0.6280.43
260_R273_F0.6280.43
172_P181_L0.6280.43
101_I247_L0.6270.43
12_H56_L0.6270.43
91_G217_Y0.6270.43
78_R82_A0.6270.43
232_A272_L0.6250.43
37_L202_A0.6240.43
36_Q165_D0.6240.43
150_V180_R0.6230.43
330_P360_R0.6230.43
12_H255_L0.6210.42
10_H209_R0.6200.42
111_D140_A0.6160.42
112_V222_A0.6160.42
309_A319_V0.6160.42
222_A271_R0.6150.42
201_S215_T0.6140.42
269_A276_D0.6140.42
88_I353_T0.6130.42
46_S252_D0.6110.41
19_V156_V0.6090.41
33_N253_H0.6090.41
232_A265_T0.6080.41
268_V285_E0.6070.41
235_T238_A0.6070.41
151_A158_R0.6060.41
366_G369_T0.6060.41
200_Q214_P0.6040.41
173_Y208_A0.6040.41
288_D314_V0.6030.41
24_D279_K0.6020.40
169_T176_I0.5980.40
228_M265_T0.5970.40
4_T16_T0.5930.40
249_R260_R0.5900.39
295_G300_T0.5890.39
136_A197_G0.5880.39
66_L76_A0.5870.39
296_A300_T0.5870.39
360_R363_W0.5860.39
208_A356_Q0.5810.38
35_A252_D0.5800.38
24_D65_A0.5790.38
350_T355_L0.5790.38
272_L275_R0.5780.38
137_A147_A0.5770.38
314_V318_D0.5770.38
159_M205_L0.5770.38
17_G23_L0.5770.38
26_P274_E0.5760.38
44_Y225_S0.5750.38
159_M163_V0.5740.38
94_S155_D0.5740.38
10_H32_R0.5730.38
162_L173_Y0.5730.38
90_H165_D0.5720.38
6_K166_A0.5700.37
101_I278_Y0.5700.37
161_Y216_V0.5690.37
171_V198_N0.5680.37
96_N156_V0.5680.37
45_P49_H0.5650.37
180_R198_N0.5620.37
79_V181_L0.5620.37
76_A80_R0.5610.37
26_P245_P0.5610.37
205_L247_L0.5600.36
155_D251_D0.5570.36
96_N174_G0.5560.36
367_V370_P0.5560.36
117_A251_D0.5550.36
23_L52_F0.5550.36
224_I228_M0.5540.36
8_S12_H0.5540.36
54_H87_D0.5530.36
303_G311_D0.5520.36
268_V278_Y0.5520.36
290_D342_V0.5520.36
109_H113_H0.5500.36
307_A312_A0.5480.35
210_A214_P0.5470.35
171_V208_A0.5470.35
59_Y220_H0.5460.35
358_A365_L0.5460.35
121_V241_D0.5460.35
197_G218_S0.5450.35
110_D151_A0.5450.35
44_Y219_H0.5450.35
67_D300_T0.5440.35
291_D328_S0.5440.35
36_Q54_H0.5440.35
266_S272_L0.5430.35
189_D253_H0.5420.35
35_A117_A0.5400.35
135_I316_E0.5360.34
91_G156_V0.5360.34
205_L220_H0.5350.34
312_A316_E0.5340.34
180_R184_G0.5320.34
158_R205_L0.5310.34
61_L65_A0.5310.34
293_L297_D0.5310.34
15_V55_S0.5310.34
113_H236_L0.5290.34
4_T183_R0.5290.34
294_V297_D0.5290.34
121_V131_Q0.5290.34
305_E313_G0.5280.34
54_H86_H0.5270.33
152_G155_D0.5270.33
174_G198_N0.5250.33
241_D249_R0.5250.33
222_A226_K0.5230.33
337_L342_V0.5210.33
298_H307_A0.5180.33
198_N212_M0.5180.33
93_F287_G0.5170.33
74_Q131_Q0.5170.33
55_S80_R0.5150.32
127_D304_F0.5150.32
299_D305_E0.5140.32
127_D242_V0.5130.32
65_A149_L0.5120.32
89_G158_R0.5120.32
71_I75_R0.5100.32
276_D317_R0.5100.32
303_G319_V0.5090.32
326_E329_M0.5080.32
171_V216_V0.5070.32
43_V222_A0.5060.32
23_L216_V0.5060.32
110_D158_R0.5050.31
211_L215_T0.5040.31
309_A317_R0.5040.31
325_S328_S0.5030.31
109_H161_Y0.5010.31
18_V77_T0.5010.31
233_A254_D0.5010.31
185_L198_N0.5000.31
228_M234_E0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4mz7A 4 0.978 100 0.276 Contact Map
4lrlA 4 0.9438 100 0.317 Contact Map
2hekA 4 0.8778 100 0.322 Contact Map
2q14A 4 0.8655 100 0.361 Contact Map
3bg2A 4 0.6357 100 0.741 Contact Map
2pgsA 4 0.6308 100 0.747 Contact Map
2dqbA 4 0.6528 100 0.748 Contact Map
4x9eA 4 0.6553 100 0.754 Contact Map
3gw7A 2 0.4694 98.7 0.908 Contact Map
2pq7A 2 0.4181 98.6 0.911 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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