GREMLIN Database
Q9HPP3 - Uncharacterized protein
UniProt: Q9HPP3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 281 (239)
Sequences: 123 (94)
Seq/√Len: 6.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
62_T238_T5.1390.99
236_G240_V3.8650.93
200_L215_T3.3000.85
34_G37_I2.8100.74
113_G170_Y2.7690.72
35_D50_A2.5350.65
15_A154_F2.4920.64
172_A198_A2.4440.62
145_V211_L2.4310.62
195_A225_T2.3060.57
14_V41_P2.2500.56
16_V19_C2.2440.55
30_G226_T2.2140.54
208_V232_F2.1960.54
51_H206_G2.1690.53
16_V20_A2.1570.52
37_I170_Y2.1110.51
234_D238_T2.0980.50
127_V249_A1.9690.45
41_P170_Y1.8580.42
196_A213_S1.8320.41
61_Y226_T1.8110.40
57_D60_S1.7600.38
37_I47_V1.7580.38
12_A16_V1.7480.38
8_L16_V1.7420.38
68_A148_F1.7040.36
216_T244_D1.6980.36
148_F213_S1.6690.35
215_T226_T1.6680.35
109_T200_L1.6410.34
48_V232_F1.6350.34
145_V208_V1.6220.34
60_S238_T1.6200.34
10_V164_G1.6150.33
37_I50_A1.5920.33
61_Y200_L1.5920.33
61_Y215_T1.5910.33
108_Y170_Y1.5880.33
65_S202_I1.5790.32
151_L196_A1.5610.32
8_L235_I1.5380.31
63_M68_A1.5290.31
21_G233_S1.5270.31
8_L14_V1.5260.31
36_Q44_T1.5200.31
43_D89_A1.5190.30
20_A216_T1.5180.30
36_Q50_A1.5180.30
7_A14_V1.5140.30
85_R231_T1.5000.30
35_D170_Y1.4940.30
74_S112_N1.4850.29
8_L17_A1.4740.29
154_F198_A1.4660.29
61_Y142_S1.4510.28
71_L169_V1.4360.28
39_Q248_D1.4240.28
154_F200_L1.4190.28
197_A248_D1.3890.27
36_Q41_P1.3700.26
9_L26_A1.3670.26
36_Q47_V1.3550.26
168_A232_F1.3510.26
95_L173_D1.3510.26
181_S216_T1.3390.25
86_G164_G1.3340.25
47_V202_I1.3280.25
73_N124_R1.3270.25
53_S96_R1.3120.25
235_I238_T1.3010.24
158_G161_T1.2950.24
52_A126_Q1.2930.24
84_V164_G1.2720.24
169_V173_D1.2720.24
34_G163_N1.2540.23
73_N179_N1.2430.23
11_V131_S1.2370.23
22_G62_T1.2350.23
169_V229_N1.2270.22
42_L226_T1.2080.22
93_L182_S1.2010.22
164_G241_T1.2000.22
48_V198_A1.1980.22
123_N222_R1.1930.22
211_L241_T1.1720.21
66_T228_V1.1680.21
112_N168_A1.1610.21
8_L229_N1.1590.21
163_N228_V1.1580.21
146_R211_L1.1470.20
52_A234_D1.1400.20
169_V200_L1.1390.20
56_T86_G1.1360.20
11_V218_A1.1340.20
115_A242_Q1.1340.20
12_A54_A1.1310.20
15_A21_G1.1280.20
55_L127_V1.1220.20
145_V216_T1.1170.20
162_E205_D1.1130.20
45_G198_A1.1120.20
216_T223_S1.1080.20
148_F232_F1.1040.19
41_P180_T1.1020.19
42_L246_A1.0980.19
36_Q168_A1.0950.19
200_L208_V1.0940.19
61_Y239_E1.0890.19
15_A104_T1.0890.19
12_A52_A1.0880.19
57_D207_V1.0880.19
19_C197_A1.0800.19
71_L227_A1.0780.19
145_V232_F1.0720.19
83_V133_R1.0700.19
15_A79_E1.0690.19
117_E229_N1.0680.19
70_S194_E1.0590.18
100_P229_N1.0520.18
114_T199_T1.0490.18
70_S232_F1.0430.18
227_A233_S1.0420.18
100_P244_D1.0410.18
168_A200_L1.0400.18
16_V207_V1.0380.18
24_A240_V1.0340.18
88_A116_Y1.0310.18
169_V201_H1.0260.18
62_T236_G1.0140.18
8_L253_A1.0140.18
28_D207_V1.0120.17
230_Y233_S1.0080.17
217_F224_Q1.0070.17
37_I208_V1.0040.17
34_G202_I1.0040.17
15_A247_S1.0040.17
14_V211_L0.9890.17
42_L151_L0.9840.17
14_V123_N0.9700.17
36_Q202_I0.9660.17
34_G168_A0.9620.16
231_T246_A0.9600.16
67_V96_R0.9590.16
7_A10_V0.9570.16
213_S232_F0.9570.16
10_V236_G0.9570.16
61_Y251_T0.9540.16
55_L174_G0.9470.16
49_D175_V0.9460.16
69_Q110_D0.9400.16
198_A211_L0.9340.16
79_E177_D0.9330.16
196_A207_V0.9330.16
90_S240_V0.9290.16
160_T203_R0.9260.16
14_V249_A0.9210.16
98_Q195_A0.9160.16
156_Y207_V0.9140.16
57_D87_N0.9120.16
115_A208_V0.9120.16
229_N232_F0.9100.15
30_G35_D0.9040.15
56_T226_T0.8990.15
35_D58_A0.8950.15
113_G244_D0.8950.15
162_E209_T0.8930.15
25_P114_T0.8930.15
38_Y170_Y0.8910.15
207_V232_F0.8810.15
167_V239_E0.8810.15
54_A122_G0.8750.15
11_V21_G0.8690.15
40_T244_D0.8670.15
44_T221_N0.8560.15
206_G243_P0.8560.15
34_G114_T0.8530.14
8_L218_A0.8500.14
142_S145_V0.8490.14
165_D244_D0.8490.14
40_T170_Y0.8480.14
85_R130_A0.8390.14
26_A221_N0.8380.14
12_A45_G0.8340.14
117_E128_R0.8310.14
68_A92_A0.8230.14
167_V209_T0.8220.14
176_A202_I0.8200.14
14_V72_A0.8200.14
127_V181_S0.8140.14
203_R209_T0.8100.14
105_V151_L0.8100.14
7_A229_N0.8080.14
83_V135_P0.8070.14
41_P249_A0.8040.14
149_I213_S0.8030.14
17_A21_G0.8010.14
127_V178_L0.8010.14
200_L232_F0.7970.13
10_V195_A0.7970.13
134_A208_V0.7960.13
149_I202_I0.7860.13
49_D202_I0.7840.13
34_G61_Y0.7830.13
11_V136_T0.7750.13
178_L248_D0.7730.13
98_Q169_V0.7720.13
60_S235_I0.7650.13
48_V230_Y0.7520.13
215_T232_F0.7510.13
35_D122_G0.7510.13
92_A224_Q0.7490.13
160_T201_H0.7460.13
8_L192_S0.7410.13
16_V103_Q0.7330.12
62_T246_A0.7330.12
19_C199_T0.7280.12
98_Q194_E0.7260.12
55_L130_A0.7240.12
92_A112_N0.7220.12
32_S156_Y0.7200.12
18_G243_P0.7160.12
129_D134_A0.7140.12
106_A233_S0.7110.12
13_L163_N0.7100.12
32_S230_Y0.7090.12
73_N157_T0.7090.12
96_R199_T0.7080.12
16_V237_S0.7070.12
116_Y159_T0.7030.12
14_V163_N0.7010.12
155_T212_Q0.7010.12
88_A218_A0.6980.12
71_L160_T0.6980.12
79_E98_Q0.6970.12
70_S179_N0.6960.12
160_T171_E0.6890.12
35_D110_D0.6880.12
218_A223_S0.6880.12
72_A241_T0.6860.12
54_A173_D0.6820.12
176_A196_A0.6820.12
37_I239_E0.6820.12
11_V24_A0.6760.12
37_I213_S0.6750.12
70_S173_D0.6750.12
32_S123_N0.6750.12
225_T246_A0.6720.12
10_V22_G0.6710.12
132_G233_S0.6710.12
152_F207_V0.6710.12
161_T237_S0.6700.12
86_G241_T0.6690.11
144_I240_V0.6680.11
60_S231_T0.6660.11
13_L19_C0.6660.11
106_A135_P0.6660.11
148_F152_F0.6640.11
73_N77_R0.6640.11
122_G242_Q0.6640.11
9_L202_I0.6610.11
123_N220_Q0.6580.11
221_N254_T0.6580.11
248_D252_T0.6580.11
13_L43_D0.6570.11
89_A231_T0.6550.11
94_F231_T0.6530.11
206_G245_W0.6520.11
20_A73_N0.6510.11
42_L200_L0.6500.11
51_H208_V0.6490.11
201_H227_A0.6450.11
69_Q155_T0.6450.11
56_T240_V0.6440.11
109_T115_A0.6440.11
47_V50_A0.6430.11
19_C207_V0.6410.11
172_A199_T0.6370.11
104_T128_R0.6360.11
89_A101_R0.6350.11
44_T168_A0.6320.11
210_S226_T0.6280.11
135_P157_T0.6280.11
205_D235_I0.6270.11
146_R214_N0.6200.11
15_A43_D0.6170.11
38_Y112_N0.6140.11
148_F200_L0.6140.11
107_V173_D0.6140.11
10_V76_Q0.6110.11
241_T251_T0.6090.11
214_N227_A0.6090.11
39_Q247_S0.6060.11
10_V142_S0.6040.11
221_N224_Q0.6040.11
123_N204_D0.6030.11
29_D251_T0.6010.11
5_L147_P0.5970.10
91_G102_G0.5960.10
69_Q249_A0.5960.10
46_T68_A0.5950.10
151_L166_T0.5930.10
210_S233_S0.5920.10
57_D164_G0.5910.10
152_F161_T0.5880.10
42_L180_T0.5840.10
6_A15_A0.5800.10
130_A248_D0.5800.10
142_S169_V0.5770.10
49_D254_T0.5770.10
89_A197_A0.5720.10
36_Q156_Y0.5710.10
16_V94_F0.5660.10
181_S246_A0.5660.10
17_A205_D0.5660.10
37_I196_A0.5640.10
41_P202_I0.5630.10
8_L173_D0.5600.10
198_A228_V0.5580.10
46_T147_P0.5560.10
179_N229_N0.5540.10
27_T40_T0.5530.10
60_S209_T0.5520.10
98_Q241_T0.5520.10
74_S110_D0.5520.10
11_V135_P0.5510.10
114_T176_A0.5480.10
17_A20_A0.5460.10
45_G74_S0.5450.10
33_S125_S0.5450.10
55_L113_G0.5440.10
31_A35_D0.5410.10
21_G197_A0.5380.10
110_D131_S0.5360.10
51_H226_T0.5350.10
92_A151_L0.5350.10
62_T154_F0.5320.10
180_T208_V0.5310.10
166_T209_T0.5300.10
5_L174_G0.5300.10
117_E232_F0.5250.10
88_A221_N0.5240.10
17_A253_A0.5230.10
36_Q170_Y0.5220.10
48_V235_I0.5190.09
66_T203_R0.5180.09
172_A223_S0.5180.09
63_M195_A0.5150.09
37_I125_S0.5150.09
127_V163_N0.5130.09
9_L82_G0.5090.09
162_E196_A0.5070.09
53_S143_S0.5070.09
61_Y193_V0.5050.09
69_Q74_S0.5030.09
56_T241_T0.5030.09
73_N143_S0.5010.09
114_T223_S0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qa8A 1 0.6868 97.7 0.877 Contact Map
3mh9C 1 0.7153 97.5 0.881 Contact Map
2byoA 1 0.6406 96.7 0.895 Contact Map
3zbiC 1 0.0996 44 0.947 Contact Map
4lm8A 1 0.4377 27 0.953 Contact Map
4n4rB 1 0.4591 19.7 0.955 Contact Map
3pmqA 1 0.5516 16.6 0.957 Contact Map
4lmhA 3 0.363 11.4 0.96 Contact Map
3ucpA 1 0.7367 8.7 0.962 Contact Map
2yzyA 1 0.5658 4.4 0.967 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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