GREMLIN Database
SUCC - Succinyl-CoA ligase [ADP-forming] subunit beta
UniProt: Q9HPP1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 382 (375)
Sequences: 2749 (1503)
Seq/√Len: 77.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
352_E356_D5.7351.00
325_N353_I5.0721.00
21_E92_E4.2321.00
305_S372_A3.9321.00
127_S131_E3.8101.00
178_D182_D3.2261.00
269_D274_Q3.1951.00
149_A174_Q3.1531.00
23_A37_A3.1391.00
23_A34_V2.9991.00
32_V69_R2.8361.00
233_L246_R2.8291.00
171_K175_G2.6691.00
15_A182_D2.6421.00
349_E352_E2.6181.00
75_I78_M2.5221.00
292_N295_D2.4591.00
168_D200_D2.3901.00
97_T197_S2.3801.00
132_A135_D2.3561.00
95_D197_S2.3471.00
26_T30_E2.3411.00
62_A71_A2.3091.00
18_P172_I2.2711.00
63_E67_E2.2701.00
26_T87_R2.2051.00
64_N67_E2.1851.00
117_V155_A2.1621.00
41_P93_A2.1511.00
29_D69_R2.1211.00
124_D127_S2.1111.00
225_E230_E2.0911.00
307_V368_A2.0881.00
9_K91_E2.0821.00
120_R135_D2.0551.00
14_D183_S2.0491.00
17_I203_A2.0301.00
102_V173_V2.0251.00
100_L195_V2.0091.00
11_V179_L1.9681.00
139_E151_Q1.9381.00
287_A326_S1.9211.00
3_L210_L1.9101.00
71_A74_S1.8961.00
291_A330_Q1.8821.00
32_V36_D1.8711.00
31_A35_A1.8391.00
346_N349_E1.8271.00
287_A322_K1.8251.00
12_F206_A1.7991.00
32_V68_A1.7971.00
139_E154_N1.7891.00
13_A21_E1.7881.00
41_P63_E1.7881.00
179_L183_S1.7811.00
137_V158_D1.7611.00
10_E14_D1.7541.00
157_Y166_A1.7371.00
371_R374_E1.7251.00
115_V173_V1.7241.00
240_Y292_N1.7151.00
322_K326_S1.7111.00
8_A206_A1.6951.00
25_A35_A1.6871.00
236_K239_E1.6601.00
370_Q374_E1.6581.00
367_G371_R1.6541.00
33_E36_D1.6381.00
273_G373_V1.6271.00
12_F179_L1.6211.00
25_A31_A1.6171.00
72_A88_V1.6151.00
69_R73_E1.6101.00
86_D228_A1.6091.00
33_E37_A1.5911.00
36_D65_T1.5871.00
150_Y153_R1.5770.99
65_T68_A1.5540.99
22_S89_L1.5490.99
95_D198_E1.5470.99
210_L221_F1.5240.99
315_T319_E1.5230.99
271_Y370_Q1.5070.99
43_A61_L1.5020.99
364_T367_G1.4990.99
30_E33_E1.4910.99
255_G261_V1.4880.99
271_Y366_E1.4880.99
142_D146_G1.4870.99
25_A30_E1.4710.99
152_A156_V1.4700.99
28_V32_V1.4690.99
343_A347_A1.4630.99
322_K353_I1.4620.99
236_K292_N1.4510.99
70_E74_S1.4500.99
67_E70_E1.4370.99
185_A188_V1.4350.99
44_V88_V1.4320.99
305_S376_A1.4290.99
31_A68_A1.4240.99
319_E322_K1.4130.99
55_K124_D1.4110.99
120_R132_A1.4020.99
372_A376_A1.3930.99
235_A239_E1.3850.99
60_K74_S1.3700.99
13_A19_T1.3480.98
42_V68_A1.3470.98
104_V113_P1.3350.98
165_V199_R1.3300.98
147_L152_A1.3210.98
349_E353_I1.3040.98
153_R157_Y1.2990.98
164_D167_G1.2980.98
351_R363_E1.2920.98
339_V372_A1.2910.98
332_D335_P1.2900.98
254_I297_V1.2870.98
76_L88_V1.2860.98
362_E367_G1.2850.98
14_D220_A1.2840.98
32_V66_A1.2730.98
25_A34_V1.2610.97
106_M180_W1.2490.97
295_D330_Q1.2360.97
96_F194_M1.2330.97
94_V204_A1.2310.97
35_A42_V1.2220.97
115_V141_V1.2200.97
308_F324_I1.2160.97
117_V159_A1.2100.97
79_D84_T1.2020.97
4_H49_H1.1830.96
102_V117_V1.1820.96
322_K349_E1.1650.96
56_A75_I1.1610.96
71_A75_I1.1570.96
188_V208_M1.1540.96
273_G372_A1.1520.96
183_S220_A1.1510.96
288_D292_N1.1480.96
74_S78_M1.1480.96
15_A183_S1.1470.96
366_E370_Q1.1450.96
28_V31_A1.1440.96
57_G60_K1.1440.96
28_V68_A1.1430.96
115_V155_A1.1420.96
149_A153_R1.1390.95
148_Q151_Q1.1370.95
352_E355_N1.1360.95
227_D235_A1.1170.95
27_S30_E1.1110.95
152_A170_A1.1110.95
116_M136_I1.1070.95
44_V71_A1.1050.95
324_I340_V1.1040.95
112_A143_P1.1040.95
187_E209_K1.1000.94
94_V194_M1.0970.94
129_A133_P1.0970.94
2_K209_K1.0930.94
175_G178_D1.0920.94
98_N195_V1.0850.94
360_T375_Y1.0790.94
169_V173_V1.0710.94
103_G116_M1.0650.93
60_K71_A1.0610.93
316_R345_T1.0600.93
20_P91_E1.0580.93
347_A351_R1.0510.93
27_S31_A1.0480.93
28_V65_T1.0480.93
62_A68_A1.0440.93
44_V90_V1.0430.93
70_E73_E1.0310.92
55_K123_V1.0260.92
196_T200_D1.0240.92
234_E237_A1.0190.92
29_D32_V1.0180.92
10_E13_A1.0140.92
185_A208_M1.0140.92
12_F17_I1.0080.91
17_I175_G1.0080.91
362_E371_R1.0080.91
250_N304_D1.0060.91
66_A70_E1.0020.91
184_D217_R1.0010.91
20_P94_V1.0010.91
28_V73_E0.9960.91
35_A65_T0.9930.91
32_V65_T0.9910.91
326_S330_Q0.9890.91
51_G54_G0.9840.90
315_T347_A0.9770.90
41_P61_L0.9760.90
128_V132_A0.9730.90
50_V81_K0.9680.90
179_L188_V0.9650.90
183_S218_Q0.9640.90
110_E140_H0.9620.89
236_K299_S0.9580.89
29_D33_E0.9550.89
31_A90_V0.9530.89
56_A78_M0.9510.89
20_P92_E0.9500.89
60_K75_I0.9470.89
148_Q153_R0.9460.89
154_N158_D0.9460.89
226_E229_A0.9450.89
248_D302_N0.9410.88
104_V180_W0.9410.88
65_T69_R0.9380.88
183_S221_F0.9380.88
24_L88_V0.9350.88
94_V202_V0.9310.88
151_Q154_N0.9310.88
267_L271_Y0.9270.88
153_R166_A0.9240.87
93_A204_A0.9220.87
326_S329_E0.9180.87
28_V88_V0.9150.87
4_H226_E0.9120.87
166_A170_A0.9000.86
10_E224_M0.8960.86
291_A295_D0.8950.86
34_V37_A0.8930.86
231_D246_R0.8930.86
25_A32_V0.8840.85
285_A315_T0.8830.85
92_E200_D0.8790.85
329_E358_L0.8780.85
219_P223_D0.8780.85
139_E158_D0.8750.84
196_T202_V0.8740.84
11_V208_M0.8740.84
150_Y154_N0.8740.84
141_V146_G0.8740.84
41_P92_E0.8730.84
365_L369_V0.8720.84
84_T229_A0.8710.84
24_L87_R0.8680.84
114_V138_R0.8670.84
39_D42_V0.8640.84
147_L173_V0.8630.84
305_S339_V0.8620.84
141_V177_Y0.8610.83
315_T320_V0.8610.83
25_A90_V0.8550.83
21_E37_A0.8540.83
119_E135_D0.8440.82
16_G175_G0.8420.82
91_E204_A0.8390.82
253_I261_V0.8370.82
22_S91_E0.8260.81
323_G327_A0.8220.81
165_V168_D0.8210.80
188_V206_A0.8190.80
17_I20_P0.8170.80
145_F151_Q0.8170.80
300_D303_V0.8170.80
251_T373_V0.8160.80
241_G289_R0.8090.79
232_D236_K0.8050.79
246_R302_N0.8010.79
35_A68_A0.7990.79
117_V169_V0.7970.78
215_L222_A0.7950.78
67_E71_A0.7940.78
195_V201_V0.7940.78
152_A174_Q0.7930.78
281_I320_V0.7920.78
114_V140_H0.7900.78
103_G114_V0.7830.77
63_E93_A0.7810.77
149_A170_A0.7810.77
12_F188_V0.7810.77
44_V68_A0.7780.77
1_M215_L0.7760.77
97_T199_R0.7750.77
113_P180_W0.7740.76
28_V35_A0.7730.76
373_V376_A0.7720.76
316_R349_E0.7710.76
167_G170_A0.7670.76
253_I268_V0.7640.75
161_I195_V0.7610.75
365_L368_A0.7600.75
120_R123_V0.7590.75
194_M204_A0.7590.75
165_V195_V0.7590.75
289_R315_T0.7550.75
287_A319_E0.7550.75
1_M222_A0.7520.74
110_E114_V0.7510.74
319_E347_A0.7480.74
236_K240_Y0.7460.74
91_E94_V0.7450.74
9_K89_L0.7410.73
17_I179_L0.7390.73
122_G191_N0.7370.73
155_A158_D0.7360.73
316_R319_E0.7340.73
250_N273_G0.7330.72
156_V169_V0.7330.72
251_T273_G0.7310.72
48_V80_L0.7300.72
100_L161_I0.7290.72
99_E122_G0.7280.72
171_K174_Q0.7270.72
258_A278_F0.7230.71
3_L208_M0.7230.71
324_I354_L0.7220.71
289_R293_A0.7210.71
172_I193_V0.7170.71
68_A72_A0.7170.71
156_V166_A0.7140.70
362_E375_Y0.7130.70
287_A330_Q0.7130.70
328_L359_V0.7090.70
122_G205_D0.7080.70
281_I285_A0.7040.69
320_V342_L0.7030.69
145_F150_Y0.7030.69
294_L308_F0.7030.69
220_A223_D0.6990.69
289_R319_E0.6980.69
58_G80_L0.6980.69
123_V132_A0.6950.68
124_D128_V0.6930.68
1_M8_A0.6920.68
150_Y167_G0.6900.68
103_G188_V0.6880.68
256_N280_D0.6880.68
48_V85_V0.6870.67
46_A85_V0.6870.67
50_V255_G0.6840.67
51_G207_V0.6840.67
3_L7_Q0.6830.67
12_F172_I0.6800.67
35_A90_V0.6790.67
147_L151_Q0.6780.66
150_Y157_Y0.6780.66
355_N363_E0.6770.66
348_A352_E0.6770.66
351_R355_N0.6760.66
230_E238_N0.6760.66
119_E160_G0.6760.66
245_V250_N0.6740.66
122_G126_E0.6710.66
3_L8_A0.6710.66
219_P222_A0.6700.66
132_A138_R0.6700.66
61_L93_A0.6690.65
102_V193_V0.6680.65
46_A75_I0.6670.65
142_D152_A0.6640.65
32_V35_A0.6640.65
42_V62_A0.6630.65
315_T342_L0.6620.65
126_E191_N0.6620.65
235_A238_N0.6600.64
7_Q49_H0.6590.64
334_I338_V0.6580.64
290_V323_G0.6570.64
313_G341_R0.6510.63
334_I347_A0.6510.63
153_R156_V0.6510.63
15_A178_D0.6480.63
72_A76_L0.6470.63
50_V56_A0.6460.63
256_N260_L0.6450.63
371_R375_Y0.6430.62
313_G317_G0.6400.62
13_A91_E0.6390.62
97_T196_T0.6390.62
12_F208_M0.6380.62
265_L275_P0.6380.62
196_T199_R0.6380.62
248_D274_Q0.6370.62
318_D346_N0.6360.62
354_L361_V0.6360.62
237_A241_G0.6360.62
170_A174_Q0.6350.61
20_P202_V0.6350.61
251_T320_V0.6340.61
29_D73_E0.6310.61
308_F320_V0.6270.60
169_V201_V0.6260.60
174_Q178_D0.6260.60
258_A262_M0.6250.60
84_T201_V0.6250.60
104_V115_V0.6250.60
46_A78_M0.6240.60
18_P200_D0.6230.60
229_A235_A0.6230.60
168_D201_V0.6230.60
246_R300_D0.6210.60
106_M186_T0.6200.60
314_I317_G0.6200.60
101_Y257_G0.6190.59
160_G163_Q0.6170.59
9_K13_A0.6170.59
152_A173_V0.6160.59
146_G177_Y0.6160.59
230_E235_A0.6150.59
12_F190_I0.6140.59
227_D239_E0.6120.59
61_L67_E0.6120.59
77_G80_L0.6110.58
115_V147_L0.6100.58
50_V207_V0.6100.58
262_M311_F0.6090.58
15_A179_L0.6090.58
244_Y296_M0.6070.58
75_I89_L0.6040.58
165_V201_V0.6040.58
324_I327_A0.6040.58
31_A39_D0.6030.57
148_Q157_Y0.6010.57
119_E128_V0.6010.57
61_L66_A0.6000.57
339_V375_Y0.5990.57
48_V58_G0.5990.57
107_D114_V0.5960.57
362_E369_V0.5960.57
25_A28_V0.5950.56
347_A367_G0.5940.56
280_D314_I0.5930.56
317_G340_V0.5930.56
97_T194_M0.5900.56
104_V173_V0.5900.56
271_Y293_A0.5890.56
20_P204_A0.5890.56
328_L360_T0.5880.56
103_G124_D0.5880.56
61_L197_S0.5870.55
186_T209_K0.5870.55
96_F204_A0.5840.55
103_G254_I0.5830.55
62_A67_E0.5810.55
185_A210_L0.5810.55
8_A208_M0.5750.54
147_L200_D0.5740.54
25_A69_R0.5740.54
112_A140_H0.5740.54
60_K78_M0.5720.54
33_E38_L0.5700.53
209_K212_E0.5700.53
128_V133_P0.5700.53
287_A291_A0.5690.53
112_A142_D0.5690.53
262_M278_F0.5690.53
129_A134_E0.5660.53
328_L332_D0.5660.53
108_R313_G0.5650.53
225_E238_N0.5650.53
176_V188_V0.5650.53
347_A362_E0.5640.53
41_P95_D0.5640.53
225_E235_A0.5630.52
119_E132_A0.5630.52
163_Q166_A0.5620.52
294_L306_V0.5620.52
42_V90_V0.5620.52
27_S72_A0.5620.52
286_K289_R0.5620.52
5_E9_K0.5610.52
315_T357_D0.5610.52
251_T347_A0.5600.52
175_G222_A0.5590.52
35_A72_A0.5590.52
4_H7_Q0.5590.52
179_L222_A0.5580.52
147_L374_E0.5560.52
55_K127_S0.5560.52
232_D235_A0.5560.52
184_D214_A0.5560.52
320_V328_L0.5540.51
28_V245_V0.5530.51
245_V258_A0.5520.51
104_V177_Y0.5520.51
211_D259_G0.5520.51
307_V365_L0.5500.51
156_V173_V0.5500.51
226_E230_E0.5500.51
116_M138_R0.5490.51
36_D66_A0.5490.51
20_P89_L0.5480.51
348_A351_R0.5480.51
256_N264_T0.5480.51
251_T287_A0.5480.51
28_V72_A0.5460.50
3_L89_L0.5460.50
244_Y247_L0.5420.50
45_K192_P0.5410.50
153_R170_A0.5400.49
234_E242_F0.5400.49
325_N357_D0.5390.49
56_A60_K0.5360.49
254_I294_L0.5350.49
182_D220_A0.5330.49
280_D313_G0.5330.49
45_K53_R0.5320.48
280_D283_G0.5320.48
52_G55_K0.5310.48
279_L282_G0.5310.48
125_I311_F0.5300.48
56_A80_L0.5300.48
278_F285_A0.5300.48
362_E365_L0.5300.48
297_V303_V0.5290.48
46_A58_G0.5280.48
8_A18_P0.5270.48
151_Q157_Y0.5270.48
54_G123_V0.5260.48
103_G177_Y0.5250.48
9_K22_S0.5250.48
256_N309_N0.5250.48
27_S69_R0.5240.47
64_N73_E0.5230.47
102_V155_A0.5220.47
243_D251_T0.5220.47
1_M49_H0.5210.47
156_V163_Q0.5200.47
113_P268_V0.5180.47
210_L218_Q0.5170.47
238_N245_V0.5170.47
324_I328_L0.5160.46
133_P136_I0.5160.46
258_A279_L0.5150.46
349_E356_D0.5140.46
309_N317_G0.5140.46
285_A316_R0.5120.46
21_E38_L0.5110.46
93_A96_F0.5110.46
11_V327_A0.5110.46
3_L48_V0.5110.46
172_I201_V0.5100.46
261_V265_L0.5100.46
121_G205_D0.5100.46
311_F314_I0.5100.46
91_E161_I0.5090.46
151_Q158_D0.5090.46
309_N313_G0.5080.45
75_I298_F0.5080.45
253_I315_T0.5080.45
326_S349_E0.5070.45
264_T278_F0.5060.45
103_G113_P0.5050.45
31_A65_T0.5040.45
195_V199_R0.5040.45
12_F18_P0.5040.45
229_A237_A0.5040.45
50_V58_G0.5040.45
156_V159_A0.5030.45
33_E70_E0.5020.45
162_E165_V0.5010.45
119_E159_A0.5010.45
359_V370_Q0.5000.44
112_A144_S0.5000.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pffA 2 0.9764 100 0.173 Contact Map
2nu8B 2 0.9895 100 0.274 Contact Map
3mwdA 2 0.9764 100 0.276 Contact Map
2fp4B 1 0.9843 100 0.284 Contact Map
3ufxB 2 0.9895 100 0.308 Contact Map
1wr2A 1 0.5497 100 0.67 Contact Map
2csuA 2 0.9162 100 0.743 Contact Map
3dmyA 2 0.5105 99.7 0.826 Contact Map
3mwdB 1 0.6335 99.7 0.839 Contact Map
2fp4A 1 0.6623 99.6 0.848 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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