GREMLIN Database
Q9HPP0 - Succinyl-CoA ligase [ADP-forming] subunit alpha
UniProt: Q9HPP0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 289 (273)
Sequences: 4834 (2843)
Seq/√Len: 172.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
147_N202_E5.1321.00
260_A274_V3.4661.00
56_T59_Q3.3451.00
55_D59_Q2.9741.00
118_R185_G2.9231.00
86_L115_V2.8141.00
83_F111_R2.7321.00
264_I274_V2.5821.00
58_N84_E2.4961.00
149_G173_T2.4641.00
93_V117_T2.4151.00
83_F107_K2.3981.00
267_L272_V2.3381.00
173_T201_T2.3051.00
263_K267_L2.2941.00
60_A66_A2.2861.00
101_P105_M2.2071.00
82_V93_V2.2011.00
73_V81_A2.1651.00
47_E50_G2.1531.00
275_G284_D2.1201.00
232_G267_L2.0281.00
58_N87_D2.0241.00
186_T191_A1.9951.00
158_T175_A1.9781.00
38_G64_E1.9541.00
69_S85_A1.9521.00
85_A90_L1.9511.00
198_D201_T1.8961.00
19_G22_K1.8921.00
204_V226_M1.8701.00
79_A107_K1.8661.00
83_F87_D1.8491.00
73_V77_F1.8391.00
163_D167_A1.8261.00
106_A110_K1.8231.00
196_E227_D1.7861.00
80_D84_E1.7801.00
95_A108_V1.7741.00
149_G201_T1.7741.00
86_L117_T1.7721.00
221_Y272_V1.7581.00
42_G60_A1.7481.00
176_I191_A1.7391.00
18_G45_G1.7341.00
205_V281_V1.7111.00
129_T132_E1.6931.00
45_G53_V1.6831.00
83_F114_E1.6621.00
14_Q69_S1.6111.00
205_V285_I1.5861.00
232_G272_V1.5821.00
148_V203_A1.5771.00
206_M232_G1.5651.00
112_L119_L1.5651.00
57_V85_A1.5481.00
204_V224_E1.5201.00
220_A224_E1.5101.00
203_A285_I1.5001.00
221_Y230_V1.4881.00
69_S90_L1.4841.00
110_K114_E1.4301.00
192_L204_V1.4231.00
71_V81_A1.4151.00
149_G195_F1.4121.00
168_R286_E1.4081.00
86_L111_R1.4011.00
103_Q107_K1.3971.00
146_G171_G1.3961.00
67_D91_D1.3811.00
41_P51_V1.3741.00
124_C177_G1.3651.00
65_N88_T1.3391.00
78_A95_A1.3331.00
40_V54_Y1.3281.00
7_D132_E1.3211.00
95_A119_L1.3171.00
78_A100_I1.3141.00
26_E30_E1.2961.00
188_F208_G1.2811.00
13_V35_V1.2791.00
80_D83_F1.2761.00
213_E217_A1.2551.00
60_A64_E1.2531.00
68_A135_L1.2531.00
150_L172_Q1.2481.00
196_E224_E1.2431.00
148_V285_I1.2401.00
16_I25_A1.2331.00
11_V134_K1.2321.00
12_V37_A1.2311.00
266_A270_A1.2251.00
231_A275_G1.2241.00
237_R276_D1.2211.00
120_L191_A1.2151.00
151_V191_A1.2091.00
48_V53_V1.2071.00
82_V111_R1.2041.00
25_A49_A1.1981.00
118_R186_T1.1941.00
27_Q96_I1.1901.00
120_L127_I1.1901.00
103_Q106_A1.1781.00
13_V28_M1.1741.00
265_S269_D1.1741.00
22_K25_A1.1541.00
29_I32_G1.1431.00
176_I195_F1.1411.00
57_V88_T1.1361.00
109_Y112_L1.1361.00
54_Y61_V1.1341.00
210_I250_A1.1311.00
174_T195_F1.1301.00
260_A264_I1.1181.00
193_E197_A1.1111.00
276_D280_E1.1041.00
196_E226_M1.1021.00
157_L278_P1.0921.00
109_Y182_P1.0911.00
111_R115_V1.0911.00
16_I48_V1.0911.00
46_Q55_D1.0901.00
28_M51_V1.0881.00
82_V108_V1.0871.00
25_A29_I1.0791.00
213_E216_E1.0761.00
193_E216_E1.0741.00
60_A65_N1.0681.00
94_V127_I1.0510.99
181_D212_G1.0490.99
129_T174_T1.0420.99
56_T84_E1.0410.99
193_E223_D1.0390.99
109_Y113_S1.0370.99
197_A223_D1.0360.99
174_T201_T1.0330.99
264_I268_N1.0280.99
75_P97_T1.0270.99
145_A200_E1.0230.99
273_P284_D1.0120.99
82_V117_T0.9980.99
209_E247_H0.9960.99
261_D265_S0.9840.99
189_I220_A0.9820.99
110_K113_S0.9760.99
68_A94_V0.9720.99
14_Q57_V0.9700.99
218_A266_A0.9680.99
107_K110_K0.9660.99
196_E223_D0.9650.99
31_Y39_A0.9640.99
81_A84_E0.9520.99
10_R38_G0.9520.99
74_P77_F0.9480.99
211_G263_K0.9440.99
277_T280_E0.9400.99
230_V272_V0.9390.99
217_A221_Y0.9350.99
172_Q175_A0.9300.99
42_G55_D0.9300.99
131_G145_A0.9240.99
79_A108_V0.9210.99
46_Q53_V0.9210.99
181_D188_F0.9190.99
151_V178_I0.9190.99
105_M180_G0.9120.99
152_S158_T0.9120.99
18_G49_A0.9110.99
12_V66_A0.9100.99
151_V195_F0.9090.99
162_V175_A0.9090.99
40_V60_A0.9060.98
208_G232_G0.9030.98
131_G200_E0.9000.98
246_G250_A0.8950.98
40_V64_E0.8940.98
87_D115_V0.8910.98
104_D108_V0.8910.98
92_L118_R0.8860.98
23_F138_L0.8840.98
190_D216_E0.8780.98
58_N88_T0.8770.98
29_I49_A0.8740.98
27_Q30_E0.8720.98
99_G102_S0.8700.98
130_P173_T0.8700.98
18_G47_E0.8700.98
16_I22_K0.8680.98
83_F115_V0.8620.98
41_P54_Y0.8580.98
83_F86_L0.8570.98
68_A136_G0.8570.98
165_L172_Q0.8560.98
61_V66_A0.8560.98
188_F206_M0.8540.98
125_P159_Y0.8530.98
222_I272_V0.8510.98
71_V78_A0.8490.98
86_L108_V0.8490.98
120_L186_T0.8460.98
22_K48_V0.8420.98
125_P156_T0.8300.97
231_A284_D0.8270.97
5_V92_L0.8260.97
150_L165_L0.8210.97
149_G174_T0.8180.97
246_G251_I0.8130.97
144_E166_T0.8120.97
95_A112_L0.8110.97
11_V33_T0.8100.97
187_D190_D0.8100.97
205_V231_A0.8060.97
151_V206_M0.8060.97
79_A104_D0.8020.97
60_A88_T0.8000.97
6_D176_I0.7990.97
47_E51_V0.7980.97
37_A51_V0.7960.97
268_N276_D0.7950.97
54_Y64_E0.7920.96
77_F81_A0.7910.96
265_S268_N0.7890.96
14_Q81_A0.7880.96
89_P115_V0.7870.96
244_R248_A0.7860.96
192_L206_M0.7840.96
86_L93_V0.7810.96
28_M41_P0.7800.96
61_V64_E0.7780.96
234_I260_A0.7780.96
192_L196_E0.7690.96
93_V112_L0.7690.96
39_A51_V0.7610.96
11_V31_Y0.7600.96
112_L116_D0.7580.95
10_R67_D0.7560.95
92_L120_L0.7540.95
168_R283_D0.7530.95
19_G25_A0.7530.95
12_V41_P0.7520.95
237_R260_A0.7510.95
79_A86_L0.7420.95
143_F162_V0.7420.95
35_V38_G0.7420.95
79_A83_F0.7390.95
247_H250_A0.7390.95
61_V88_T0.7380.95
68_A92_L0.7370.95
41_P53_V0.7340.95
243_K247_H0.7320.95
192_L220_A0.7300.94
191_A195_F0.7300.94
241_P244_R0.7290.94
28_M70_V0.7280.94
84_E87_D0.7230.94
100_I180_G0.7230.94
64_E88_T0.7160.94
14_Q85_A0.7160.94
18_G48_V0.7160.94
72_L96_I0.7140.94
164_S282_A0.7140.94
44_G55_D0.7110.94
6_D132_E0.7090.94
174_T194_L0.7010.93
280_E283_D0.7010.93
196_E225_H0.7000.93
79_A111_R0.6980.93
203_A231_A0.6960.93
98_E248_A0.6960.93
107_K111_R0.6910.93
165_L282_A0.6900.93
150_L162_V0.6870.93
97_T124_C0.6870.93
28_M39_A0.6860.92
196_E220_A0.6860.92
186_T194_L0.6830.92
91_D117_T0.6820.92
193_E220_A0.6820.92
89_P117_T0.6800.92
244_R250_A0.6800.92
189_I216_E0.6800.92
100_I104_D0.6770.92
215_E219_A0.6740.92
152_S207_C0.6710.92
123_N180_G0.6700.92
27_Q70_V0.6700.92
105_M109_Y0.6690.91
98_E156_T0.6650.91
178_I181_D0.6630.91
105_M182_P0.6590.91
16_I51_V0.6570.91
16_I24_H0.6560.91
47_E52_P0.6560.91
102_S180_G0.6550.91
244_R247_H0.6540.91
219_A222_I0.6530.91
75_P100_I0.6520.90
262_S266_A0.6490.90
275_G281_V0.6480.90
86_L89_P0.6480.90
113_S116_D0.6460.90
84_E88_T0.6450.90
48_V51_V0.6410.90
166_T172_Q0.6410.90
75_P79_A0.6400.90
41_P52_P0.6390.90
86_L112_L0.6360.89
237_R264_I0.6340.89
239_A242_G0.6340.89
155_G209_E0.6290.89
111_R114_E0.6270.89
75_P99_G0.6260.89
65_N90_L0.6190.88
193_E196_E0.6160.88
7_D131_G0.6140.88
102_S105_M0.6100.87
69_S93_V0.6090.87
108_V112_L0.6070.87
210_I249_G0.6070.87
21_G26_E0.6030.87
121_G179_G0.6000.86
13_V25_A0.5990.86
9_T68_A0.5990.86
13_V41_P0.5990.86
11_V35_V0.5980.86
234_I274_V0.5930.86
40_V55_D0.5910.86
201_T204_V0.5910.86
104_D107_K0.5890.85
223_D269_D0.5880.85
16_I49_A0.5870.85
187_D213_E0.5850.85
36_V133_A0.5840.85
130_P133_A0.5840.85
118_R194_L0.5840.85
16_I41_P0.5830.85
211_G217_A0.5830.85
66_A89_P0.5830.85
91_D118_R0.5820.85
46_Q52_P0.5810.85
247_H251_I0.5790.84
206_M230_V0.5780.84
7_D129_T0.5780.84
57_V69_S0.5770.84
40_V44_G0.5760.84
150_L161_V0.5750.84
74_P155_G0.5740.84
113_S185_G0.5730.84
195_F204_V0.5710.84
12_V42_G0.5690.83
193_E226_M0.5670.83
23_F72_L0.5670.83
178_I191_A0.5660.83
244_R249_G0.5650.83
221_Y226_M0.5650.83
123_N247_H0.5570.82
40_V61_V0.5550.82
11_V67_D0.5550.82
243_K248_A0.5540.82
254_G261_D0.5540.82
10_R40_V0.5540.82
74_P97_T0.5500.81
82_V119_L0.5500.81
149_G229_P0.5480.81
114_E117_T0.5460.81
29_I51_V0.5450.81
151_V188_F0.5450.81
5_V127_I0.5440.81
78_A97_T0.5400.80
17_T24_H0.5400.80
28_M35_V0.5390.80
12_V69_S0.5390.80
65_N89_P0.5390.80
207_C235_A0.5380.80
223_D226_M0.5370.80
244_R253_S0.5370.80
195_F201_T0.5370.80
86_L114_E0.5350.80
112_L115_V0.5350.80
100_I105_M0.5330.79
243_K246_G0.5320.79
128_I137_I0.5320.79
127_I134_K0.5300.79
196_E221_Y0.5290.79
40_V66_A0.5290.79
90_L117_T0.5280.79
106_A109_Y0.5260.78
124_C152_S0.5250.78
66_A90_L0.5250.78
193_E225_H0.5250.78
216_E219_A0.5240.78
158_T177_G0.5240.78
249_G252_V0.5230.78
13_V31_Y0.5230.78
246_G249_G0.5220.78
210_I253_S0.5220.78
231_A285_I0.5160.77
263_K274_V0.5160.77
165_L285_I0.5150.77
77_F80_D0.5150.77
61_V65_N0.5140.77
214_D217_A0.5120.77
155_G249_G0.5120.77
40_V43_K0.5120.77
173_T228_T0.5070.76
6_D174_T0.5060.76
105_M112_L0.5010.75
76_A104_D0.5000.75
243_K249_G0.5000.75
45_G49_A0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2csuA 2 0.91 100 0.195 Contact Map
3pffA 2 0.9135 100 0.215 Contact Map
3mwdB 1 0.9273 100 0.262 Contact Map
2fp4A 1 0.9827 100 0.301 Contact Map
2nu8A 1 0.9792 100 0.32 Contact Map
2yv1A 1 0.91 100 0.32 Contact Map
1oi7A 1 0.9204 100 0.336 Contact Map
2yv2A 1 0.91 100 0.348 Contact Map
3dmyA 2 0.7197 100 0.361 Contact Map
3ff4A 1 0.4152 99.9 0.713 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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