Q9HPP0 - HALSA - GREMLIN Contacts

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Q9HPP0 - Succinyl-CoA ligase [ADP-forming] subunit alpha

UniProt:	Q9HPP0	Sequences: MSILVDDDTRVVVQGITGGEGKFHAEQMIEYGTNVVAGAVPGKGGQEVAGVPVYDTVNQAVVAENADASVVLVPPAFAADAVFEALDTPLDLVVAITEGIPSQDMAKVYKRLSEVDTRLLGPNCPGIITPGEAKLGILPGNIFEAGNVGLVSRSGTLTYQVVDSLTARGVGQTTAIGIGGDPIIGTDFIDALELFEADPETEAVVMCGEIGGEDEEAAAAYIDEHMDTPVAGFIAGRTAPPGKRMGHAGAIVSGSGTGTADSKISALNDAGVPVGDTPEEVADDIEELL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	289 (273)
Sequences:	4834 (2843)
Seq/√Len:	172.1

ECOLI - SUCD PKA FDRA YAHF
BACSU - SUCD
HALSA - Q9HPP0
SULSO - Q97XD9 Q97VX2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
147_N	202_E	5.132	1.00
260_A	274_V	3.466	1.00
56_T	59_Q	3.345	1.00
55_D	59_Q	2.974	1.00
118_R	185_G	2.923	1.00
86_L	115_V	2.814	1.00
83_F	111_R	2.732	1.00
264_I	274_V	2.582	1.00
58_N	84_E	2.496	1.00
149_G	173_T	2.464	1.00
93_V	117_T	2.415	1.00
83_F	107_K	2.398	1.00
267_L	272_V	2.338	1.00
173_T	201_T	2.305	1.00
263_K	267_L	2.294	1.00
60_A	66_A	2.286	1.00
101_P	105_M	2.207	1.00
82_V	93_V	2.201	1.00
73_V	81_A	2.165	1.00
47_E	50_G	2.153	1.00
275_G	284_D	2.120	1.00
232_G	267_L	2.028	1.00
58_N	87_D	2.024	1.00
186_T	191_A	1.995	1.00
158_T	175_A	1.978	1.00
38_G	64_E	1.954	1.00
69_S	85_A	1.952	1.00
85_A	90_L	1.951	1.00
198_D	201_T	1.896	1.00
19_G	22_K	1.892	1.00
204_V	226_M	1.870	1.00
79_A	107_K	1.866	1.00
83_F	87_D	1.849	1.00
73_V	77_F	1.839	1.00
163_D	167_A	1.826	1.00
106_A	110_K	1.823	1.00
196_E	227_D	1.786	1.00
80_D	84_E	1.780	1.00
95_A	108_V	1.774	1.00
149_G	201_T	1.774	1.00
86_L	117_T	1.772	1.00
221_Y	272_V	1.758	1.00
42_G	60_A	1.748	1.00
176_I	191_A	1.739	1.00
18_G	45_G	1.734	1.00
205_V	281_V	1.711	1.00
129_T	132_E	1.693	1.00
45_G	53_V	1.683	1.00
83_F	114_E	1.662	1.00
14_Q	69_S	1.611	1.00
205_V	285_I	1.586	1.00
232_G	272_V	1.582	1.00
148_V	203_A	1.577	1.00
206_M	232_G	1.565	1.00
112_L	119_L	1.565	1.00
57_V	85_A	1.548	1.00
204_V	224_E	1.520	1.00
220_A	224_E	1.510	1.00
203_A	285_I	1.500	1.00
221_Y	230_V	1.488	1.00
69_S	90_L	1.484	1.00
110_K	114_E	1.430	1.00
192_L	204_V	1.423	1.00
71_V	81_A	1.415	1.00
149_G	195_F	1.412	1.00
168_R	286_E	1.408	1.00
86_L	111_R	1.401	1.00
103_Q	107_K	1.397	1.00
146_G	171_G	1.396	1.00
67_D	91_D	1.381	1.00
41_P	51_V	1.374	1.00
124_C	177_G	1.365	1.00
65_N	88_T	1.339	1.00
78_A	95_A	1.333	1.00
40_V	54_Y	1.328	1.00
7_D	132_E	1.321	1.00
95_A	119_L	1.317	1.00
78_A	100_I	1.314	1.00
26_E	30_E	1.296	1.00
188_F	208_G	1.281	1.00
13_V	35_V	1.279	1.00
80_D	83_F	1.276	1.00
213_E	217_A	1.255	1.00
60_A	64_E	1.253	1.00
68_A	135_L	1.253	1.00
150_L	172_Q	1.248	1.00
196_E	224_E	1.243	1.00
148_V	285_I	1.240	1.00
16_I	25_A	1.233	1.00
11_V	134_K	1.232	1.00
12_V	37_A	1.231	1.00
266_A	270_A	1.225	1.00
231_A	275_G	1.224	1.00
237_R	276_D	1.221	1.00
120_L	191_A	1.215	1.00
151_V	191_A	1.209	1.00
48_V	53_V	1.207	1.00
82_V	111_R	1.204	1.00
25_A	49_A	1.198	1.00
118_R	186_T	1.194	1.00
27_Q	96_I	1.190	1.00
120_L	127_I	1.190	1.00
103_Q	106_A	1.178	1.00
13_V	28_M	1.174	1.00
265_S	269_D	1.174	1.00
22_K	25_A	1.154	1.00
29_I	32_G	1.143	1.00
176_I	195_F	1.141	1.00
57_V	88_T	1.136	1.00
109_Y	112_L	1.136	1.00
54_Y	61_V	1.134	1.00
210_I	250_A	1.131	1.00
174_T	195_F	1.130	1.00
260_A	264_I	1.118	1.00
193_E	197_A	1.111	1.00
276_D	280_E	1.104	1.00
196_E	226_M	1.102	1.00
157_L	278_P	1.092	1.00
109_Y	182_P	1.091	1.00
111_R	115_V	1.091	1.00
16_I	48_V	1.091	1.00
46_Q	55_D	1.090	1.00
28_M	51_V	1.088	1.00
82_V	108_V	1.087	1.00
25_A	29_I	1.079	1.00
213_E	216_E	1.076	1.00
193_E	216_E	1.074	1.00
60_A	65_N	1.068	1.00
94_V	127_I	1.051	0.99
181_D	212_G	1.049	0.99
129_T	174_T	1.042	0.99
56_T	84_E	1.041	0.99
193_E	223_D	1.039	0.99
109_Y	113_S	1.037	0.99
197_A	223_D	1.036	0.99
174_T	201_T	1.033	0.99
264_I	268_N	1.028	0.99
75_P	97_T	1.027	0.99
145_A	200_E	1.023	0.99
273_P	284_D	1.012	0.99
82_V	117_T	0.998	0.99
209_E	247_H	0.996	0.99
261_D	265_S	0.984	0.99
189_I	220_A	0.982	0.99
110_K	113_S	0.976	0.99
68_A	94_V	0.972	0.99
14_Q	57_V	0.970	0.99
218_A	266_A	0.968	0.99
107_K	110_K	0.966	0.99
196_E	223_D	0.965	0.99
31_Y	39_A	0.964	0.99
81_A	84_E	0.952	0.99
10_R	38_G	0.952	0.99
74_P	77_F	0.948	0.99
211_G	263_K	0.944	0.99
277_T	280_E	0.940	0.99
230_V	272_V	0.939	0.99
217_A	221_Y	0.935	0.99
172_Q	175_A	0.930	0.99
42_G	55_D	0.930	0.99
131_G	145_A	0.924	0.99
79_A	108_V	0.921	0.99
46_Q	53_V	0.921	0.99
181_D	188_F	0.919	0.99
151_V	178_I	0.919	0.99
105_M	180_G	0.912	0.99
152_S	158_T	0.912	0.99
18_G	49_A	0.911	0.99
12_V	66_A	0.910	0.99
151_V	195_F	0.909	0.99
162_V	175_A	0.909	0.99
40_V	60_A	0.906	0.98
208_G	232_G	0.903	0.98
131_G	200_E	0.900	0.98
246_G	250_A	0.895	0.98
40_V	64_E	0.894	0.98
87_D	115_V	0.891	0.98
104_D	108_V	0.891	0.98
92_L	118_R	0.886	0.98
23_F	138_L	0.884	0.98
190_D	216_E	0.878	0.98
58_N	88_T	0.877	0.98
29_I	49_A	0.874	0.98
27_Q	30_E	0.872	0.98
99_G	102_S	0.870	0.98
130_P	173_T	0.870	0.98
18_G	47_E	0.870	0.98
16_I	22_K	0.868	0.98
83_F	115_V	0.862	0.98
41_P	54_Y	0.858	0.98
83_F	86_L	0.857	0.98
68_A	136_G	0.857	0.98
165_L	172_Q	0.856	0.98
61_V	66_A	0.856	0.98
188_F	206_M	0.854	0.98
125_P	159_Y	0.853	0.98
222_I	272_V	0.851	0.98
71_V	78_A	0.849	0.98
86_L	108_V	0.849	0.98
120_L	186_T	0.846	0.98
22_K	48_V	0.842	0.98
125_P	156_T	0.830	0.97
231_A	284_D	0.827	0.97
5_V	92_L	0.826	0.97
150_L	165_L	0.821	0.97
149_G	174_T	0.818	0.97
246_G	251_I	0.813	0.97
144_E	166_T	0.812	0.97
95_A	112_L	0.811	0.97
11_V	33_T	0.810	0.97
187_D	190_D	0.810	0.97
205_V	231_A	0.806	0.97
151_V	206_M	0.806	0.97
79_A	104_D	0.802	0.97
60_A	88_T	0.800	0.97
6_D	176_I	0.799	0.97
47_E	51_V	0.798	0.97
37_A	51_V	0.796	0.97
268_N	276_D	0.795	0.97
54_Y	64_E	0.792	0.96
77_F	81_A	0.791	0.96
265_S	268_N	0.789	0.96
14_Q	81_A	0.788	0.96
89_P	115_V	0.787	0.96
244_R	248_A	0.786	0.96
192_L	206_M	0.784	0.96
86_L	93_V	0.781	0.96
28_M	41_P	0.780	0.96
61_V	64_E	0.778	0.96
234_I	260_A	0.778	0.96
192_L	196_E	0.769	0.96
93_V	112_L	0.769	0.96
39_A	51_V	0.761	0.96
11_V	31_Y	0.760	0.96
112_L	116_D	0.758	0.95
10_R	67_D	0.756	0.95
92_L	120_L	0.754	0.95
168_R	283_D	0.753	0.95
19_G	25_A	0.753	0.95
12_V	41_P	0.752	0.95
237_R	260_A	0.751	0.95
79_A	86_L	0.742	0.95
143_F	162_V	0.742	0.95
35_V	38_G	0.742	0.95
79_A	83_F	0.739	0.95
247_H	250_A	0.739	0.95
61_V	88_T	0.738	0.95
68_A	92_L	0.737	0.95
41_P	53_V	0.734	0.95
243_K	247_H	0.732	0.95
192_L	220_A	0.730	0.94
191_A	195_F	0.730	0.94
241_P	244_R	0.729	0.94
28_M	70_V	0.728	0.94
84_E	87_D	0.723	0.94
100_I	180_G	0.723	0.94
64_E	88_T	0.716	0.94
14_Q	85_A	0.716	0.94
18_G	48_V	0.716	0.94
72_L	96_I	0.714	0.94
164_S	282_A	0.714	0.94
44_G	55_D	0.711	0.94
6_D	132_E	0.709	0.94
174_T	194_L	0.701	0.93
280_E	283_D	0.701	0.93
196_E	225_H	0.700	0.93
79_A	111_R	0.698	0.93
203_A	231_A	0.696	0.93
98_E	248_A	0.696	0.93
107_K	111_R	0.691	0.93
165_L	282_A	0.690	0.93
150_L	162_V	0.687	0.93
97_T	124_C	0.687	0.93
28_M	39_A	0.686	0.92
196_E	220_A	0.686	0.92
186_T	194_L	0.683	0.92
91_D	117_T	0.682	0.92
193_E	220_A	0.682	0.92
89_P	117_T	0.680	0.92
244_R	250_A	0.680	0.92
189_I	216_E	0.680	0.92
100_I	104_D	0.677	0.92
215_E	219_A	0.674	0.92
152_S	207_C	0.671	0.92
123_N	180_G	0.670	0.92
27_Q	70_V	0.670	0.92
105_M	109_Y	0.669	0.91
98_E	156_T	0.665	0.91
178_I	181_D	0.663	0.91
105_M	182_P	0.659	0.91
16_I	51_V	0.657	0.91
16_I	24_H	0.656	0.91
47_E	52_P	0.656	0.91
102_S	180_G	0.655	0.91
244_R	247_H	0.654	0.91
219_A	222_I	0.653	0.91
75_P	100_I	0.652	0.90
262_S	266_A	0.649	0.90
275_G	281_V	0.648	0.90
86_L	89_P	0.648	0.90
113_S	116_D	0.646	0.90
84_E	88_T	0.645	0.90
48_V	51_V	0.641	0.90
166_T	172_Q	0.641	0.90
75_P	79_A	0.640	0.90
41_P	52_P	0.639	0.90
86_L	112_L	0.636	0.89
237_R	264_I	0.634	0.89
239_A	242_G	0.634	0.89
155_G	209_E	0.629	0.89
111_R	114_E	0.627	0.89
75_P	99_G	0.626	0.89
65_N	90_L	0.619	0.88
193_E	196_E	0.616	0.88
7_D	131_G	0.614	0.88
102_S	105_M	0.610	0.87
69_S	93_V	0.609	0.87
108_V	112_L	0.607	0.87
210_I	249_G	0.607	0.87
21_G	26_E	0.603	0.87
121_G	179_G	0.600	0.86
13_V	25_A	0.599	0.86
9_T	68_A	0.599	0.86
13_V	41_P	0.599	0.86
11_V	35_V	0.598	0.86
234_I	274_V	0.593	0.86
40_V	55_D	0.591	0.86
201_T	204_V	0.591	0.86
104_D	107_K	0.589	0.85
223_D	269_D	0.588	0.85
16_I	49_A	0.587	0.85
187_D	213_E	0.585	0.85
36_V	133_A	0.584	0.85
130_P	133_A	0.584	0.85
118_R	194_L	0.584	0.85
16_I	41_P	0.583	0.85
211_G	217_A	0.583	0.85
66_A	89_P	0.583	0.85
91_D	118_R	0.582	0.85
46_Q	52_P	0.581	0.85
247_H	251_I	0.579	0.84
206_M	230_V	0.578	0.84
7_D	129_T	0.578	0.84
57_V	69_S	0.577	0.84
40_V	44_G	0.576	0.84
150_L	161_V	0.575	0.84
74_P	155_G	0.574	0.84
113_S	185_G	0.573	0.84
195_F	204_V	0.571	0.84
12_V	42_G	0.569	0.83
193_E	226_M	0.567	0.83
23_F	72_L	0.567	0.83
178_I	191_A	0.566	0.83
244_R	249_G	0.565	0.83
221_Y	226_M	0.565	0.83
123_N	247_H	0.557	0.82
40_V	61_V	0.555	0.82
11_V	67_D	0.555	0.82
243_K	248_A	0.554	0.82
254_G	261_D	0.554	0.82
10_R	40_V	0.554	0.82
74_P	97_T	0.550	0.81
82_V	119_L	0.550	0.81
149_G	229_P	0.548	0.81
114_E	117_T	0.546	0.81
29_I	51_V	0.545	0.81
151_V	188_F	0.545	0.81
5_V	127_I	0.544	0.81
78_A	97_T	0.540	0.80
17_T	24_H	0.540	0.80
28_M	35_V	0.539	0.80
12_V	69_S	0.539	0.80
65_N	89_P	0.539	0.80
207_C	235_A	0.538	0.80
223_D	226_M	0.537	0.80
244_R	253_S	0.537	0.80
195_F	201_T	0.537	0.80
86_L	114_E	0.535	0.80
112_L	115_V	0.535	0.80
100_I	105_M	0.533	0.79
243_K	246_G	0.532	0.79
128_I	137_I	0.532	0.79
127_I	134_K	0.530	0.79
196_E	221_Y	0.529	0.79
40_V	66_A	0.529	0.79
90_L	117_T	0.528	0.79
106_A	109_Y	0.526	0.78
124_C	152_S	0.525	0.78
66_A	90_L	0.525	0.78
193_E	225_H	0.525	0.78
216_E	219_A	0.524	0.78
158_T	177_G	0.524	0.78
249_G	252_V	0.523	0.78
13_V	31_Y	0.523	0.78
246_G	249_G	0.522	0.78
210_I	253_S	0.522	0.78
231_A	285_I	0.516	0.77
263_K	274_V	0.516	0.77
165_L	285_I	0.515	0.77
77_F	80_D	0.515	0.77
61_V	65_N	0.514	0.77
214_D	217_A	0.512	0.77
155_G	249_G	0.512	0.77
40_V	43_K	0.512	0.77
173_T	228_T	0.507	0.76
6_D	174_T	0.506	0.76
105_M	112_L	0.501	0.75
76_A	104_D	0.500	0.75
243_K	249_G	0.500	0.75
45_G	49_A	0.500	0.75

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2csuA	2	0.91	100	0.195	Contact Map
3pffA	2	0.9135	100	0.215	Contact Map
3mwdB	1	0.9273	100	0.262	Contact Map
2fp4A	1	0.9827	100	0.301	Contact Map
2nu8A	1	0.9792	100	0.32	Contact Map
2yv1A	1	0.91	100	0.32	Contact Map
1oi7A	1	0.9204	100	0.336	Contact Map
2yv2A	1	0.91	100	0.348	Contact Map
3dmyA	2	0.7197	100	0.361	Contact Map
3ff4A	1	0.4152	99.9	0.713	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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