GREMLIN Database
Q9HPN9 - CTAG modification methylase
UniProt: Q9HPN9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 348 (287)
Sequences: 1547 (1455)
Seq/√Len: 85.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
88_V109_V4.7111.00
110_T158_F3.3941.00
240_G266_F3.2571.00
244_V248_V2.9881.00
268_D272_A2.9291.00
129_P132_S2.8611.00
152_H189_D2.8431.00
125_L152_H2.8221.00
63_D67_A2.8051.00
129_P133_A2.7261.00
24_D83_G2.6451.00
120_P123_G2.5771.00
90_V105_N2.4711.00
268_D271_T2.4341.00
243_S255_G2.4301.00
247_A253_S2.4181.00
123_G154_H2.3731.00
227_V230_D2.3581.00
8_V266_F2.2861.00
275_E279_A2.2731.00
126_W214_P2.1651.00
237_W243_S2.1611.00
19_A78_R2.0861.00
124_V157_V2.0701.00
127_R151_E2.0481.00
237_W266_F2.0431.00
237_W255_G2.0271.00
128_K153_E1.9911.00
191_W221_L1.9831.00
95_R106_H1.9491.00
130_T133_A1.9121.00
8_V237_W1.9001.00
181_E184_N1.8861.00
240_G255_G1.8691.00
155_L217_L1.8681.00
58_G64_R1.7971.00
219_Y248_V1.7661.00
106_H120_P1.7361.00
127_R192_T1.7161.00
21_D81_R1.6911.00
181_E186_W1.6581.00
302_Y306_N1.6511.00
69_L108_R1.6421.00
159_R162_E1.6301.00
178_Y181_E1.6221.00
8_V263_V1.6021.00
177_A180_W1.5911.00
124_V191_W1.5821.00
291_F295_T1.5581.00
130_T199_Q1.5561.00
226_S230_D1.5531.00
133_A149_T1.5471.00
124_V148_V1.5381.00
5_T252_N1.5211.00
126_W155_L1.5181.00
177_A181_E1.5071.00
191_W220_R1.4870.99
243_S270_I1.4800.99
27_V89_N1.4770.99
215_F245_A1.4700.99
177_A182_E1.4530.99
87_V225_Y1.4530.99
106_H110_T1.4400.99
86_A109_V1.4250.99
127_R130_T1.4210.99
214_P217_L1.4130.99
131_N151_E1.4040.99
24_D230_D1.4000.99
152_H190_V1.3910.99
32_Y89_N1.3870.99
263_V266_F1.3820.99
177_A186_W1.3740.99
218_P221_L1.3690.99
133_A151_E1.3590.99
177_A185_D1.3490.99
301_G305_V1.3450.99
176_A179_F1.3450.99
292_V295_T1.3410.99
203_E206_L1.3330.99
219_Y223_N1.3320.99
128_K132_S1.3190.99
298_D301_G1.3110.99
125_L190_V1.3080.99
95_R123_G1.3020.99
204_P208_E1.2990.99
96_S110_T1.2910.98
215_F244_V1.2860.98
128_K131_N1.2820.98
302_Y307_Y1.2820.98
76_V235_P1.2780.98
62_H94_T1.2680.98
127_R132_S1.2640.98
104_D107_A1.2570.98
194_L199_Q1.2570.98
96_S106_H1.2510.98
132_S149_T1.2480.98
302_Y305_V1.2410.98
284_R288_H1.2410.98
175_E179_F1.2370.98
285_L288_H1.2350.98
188_S194_L1.2190.98
130_T134_A1.2130.98
24_D81_R1.2070.98
26_V80_L1.2070.98
298_D305_V1.1990.98
219_Y249_A1.1990.98
179_F183_R1.1920.97
151_E188_S1.1880.97
203_E208_E1.1810.97
126_W130_T1.1730.97
132_S151_E1.1700.97
122_P148_V1.1650.97
196_G199_Q1.1600.97
177_A183_R1.1600.97
135_K189_D1.1550.97
128_K133_A1.1420.97
33_P94_T1.1400.97
182_E186_W1.1350.97
283_D286_A1.1320.96
126_W153_E1.1300.96
182_E185_D1.1290.96
155_L221_L1.1280.96
218_P241_T1.1170.96
284_R287_A1.1150.96
194_L198_R1.1080.96
226_S251_R1.1080.96
282_A285_L1.1040.96
180_W186_W1.0940.96
134_A149_T1.0880.96
23_V231_T1.0850.96
228_Y250_G1.0820.95
128_K134_A1.0810.95
261_E264_A1.0730.95
147_Y159_R1.0660.95
136_F151_E1.0640.95
290_A293_A1.0630.95
298_D302_Y1.0630.95
75_E78_R1.0630.95
195_N199_Q1.0490.95
276_L280_V1.0430.94
131_N149_T1.0430.94
136_F146_A1.0410.94
274_P290_A1.0410.94
231_T252_N1.0400.94
124_V220_R1.0290.94
120_P158_F1.0290.94
178_Y182_E1.0270.94
121_L159_R1.0250.94
194_L197_A1.0220.94
135_K149_T1.0180.94
179_F185_D1.0120.94
33_P62_H1.0040.93
175_E185_D1.0030.93
293_A296_D1.0000.93
129_P135_K0.9970.93
150_L189_D0.9940.93
176_A181_E0.9890.93
289_R293_A0.9860.93
126_W212_A0.9860.93
90_V95_R0.9850.93
26_V76_V0.9750.92
136_F149_T0.9740.92
299_A303_D0.9730.92
124_V221_L0.9690.92
130_T194_L0.9690.92
175_E182_E0.9590.92
130_T151_E0.9580.92
291_F294_E0.9550.91
124_V155_L0.9500.91
282_A287_A0.9450.91
128_K150_L0.9420.91
129_P151_E0.9330.90
299_A304_A0.9300.90
203_E212_A0.9270.90
180_W183_R0.9200.90
179_F186_W0.9180.90
289_R292_V0.9100.89
127_R190_V0.9060.89
127_R131_N0.9040.89
300_L303_D0.8970.89
79_V233_L0.8920.88
136_F147_Y0.8900.88
311_V315_Q0.8880.88
299_A302_Y0.8880.88
175_E180_W0.8870.88
130_T201_L0.8840.88
282_A286_A0.8830.88
290_A295_T0.8800.88
92_D123_G0.8760.87
179_F182_E0.8760.87
175_E178_Y0.8740.87
178_Y186_W0.8720.87
148_V187_F0.8720.87
33_P47_P0.8700.87
87_V157_V0.8700.87
220_R223_N0.8670.87
147_Y162_E0.8670.87
204_P207_R0.8630.87
134_A151_E0.8590.86
129_P150_L0.8590.86
34_M94_T0.8570.86
129_P149_T0.8560.86
192_T196_G0.8550.86
181_E185_D0.8530.86
166_F169_G0.8520.86
302_Y309_V0.8510.86
281_A284_R0.8490.86
281_A288_H0.8450.85
128_K151_E0.8430.85
303_D306_N0.8400.85
209_R212_A0.8390.85
25_L221_L0.8360.85
312_R315_Q0.8360.85
95_R156_L0.8340.85
73_W86_A0.8310.85
292_V297_D0.8290.84
291_F297_D0.8280.84
34_M47_P0.8250.84
80_L84_G0.8240.84
92_D95_R0.8230.84
297_D302_Y0.8200.84
298_D304_A0.8180.84
125_L150_L0.8150.83
237_W263_V0.8140.83
297_D301_G0.8130.83
314_N317_R0.8120.83
191_W197_A0.8090.83
19_A75_E0.7990.82
267_A271_T0.7980.82
303_D308_D0.7970.82
261_E267_A0.7960.82
297_D305_V0.7930.82
126_W129_P0.7880.81
51_A57_A0.7820.81
188_S199_Q0.7810.81
8_V270_I0.7800.81
126_W133_A0.7790.80
132_S147_Y0.7690.80
106_H123_G0.7690.80
49_I60_R0.7680.80
169_G172_R0.7650.79
106_H158_F0.7640.79
122_P147_Y0.7610.79
133_A188_S0.7610.79
168_P171_D0.7610.79
20_A51_A0.7550.78
255_G266_F0.7550.78
276_L281_A0.7540.78
208_E212_A0.7530.78
46_D50_G0.7520.78
167_E170_A0.7520.78
313_T316_E0.7480.78
109_V158_F0.7480.78
203_E209_R0.7460.78
208_E211_A0.7420.77
122_P189_D0.7360.77
190_V197_A0.7350.76
291_F296_D0.7340.76
300_L306_N0.7290.76
248_V280_V0.7290.76
129_P136_F0.7290.76
266_F270_I0.7240.75
136_F148_V0.7240.75
297_D303_D0.7230.75
180_W185_D0.7230.75
263_V267_A0.7230.75
305_V309_V0.7230.75
259_D262_V0.7220.75
32_Y153_E0.7220.75
148_V224_M0.7210.75
66_H74_R0.7180.75
247_A274_P0.7130.74
131_N134_A0.7130.74
37_M47_P0.7070.74
188_S191_W0.7050.73
290_A297_D0.7030.73
132_S135_K0.7030.73
149_T152_H0.7020.73
132_S136_F0.6900.72
312_R316_E0.6880.72
15_D19_A0.6870.72
306_N309_V0.6840.71
288_H291_F0.6780.71
130_T153_E0.6740.70
173_R177_A0.6720.70
87_V224_M0.6720.70
215_F248_V0.6710.70
273_T277_S0.6700.70
225_Y230_D0.6660.69
70_A74_R0.6650.69
131_N135_K0.6630.69
125_L151_E0.6580.68
289_R294_E0.6560.68
128_K194_L0.6550.68
159_R164_R0.6540.68
129_P134_A0.6530.68
293_A305_V0.6510.67
61_A64_R0.6510.67
133_A147_Y0.6490.67
58_G61_A0.6480.67
190_V195_N0.6470.67
6_H14_R0.6430.66
168_P172_R0.6430.66
5_T8_V0.6420.66
148_V189_D0.6420.66
237_W240_G0.6400.66
132_S197_A0.6390.66
29_S213_F0.6370.66
96_S107_A0.6350.66
10_V64_R0.6330.65
132_S214_P0.6300.65
307_Y313_T0.6290.65
173_R176_A0.6270.65
47_P94_T0.6260.64
290_A294_E0.6260.64
130_T196_G0.6240.64
308_D311_V0.6230.64
9_A256_V0.6220.64
165_G168_P0.6210.64
130_T135_K0.6210.64
131_N220_R0.6210.64
130_T198_R0.6190.64
194_L201_L0.6180.63
167_E171_D0.6180.63
281_A286_A0.6150.63
189_D198_R0.6150.63
293_A307_Y0.6140.63
10_V263_V0.6130.63
189_D192_T0.6130.63
8_V253_S0.6110.63
125_L154_H0.6090.62
190_V194_L0.6080.62
149_T189_D0.6060.62
173_R179_F0.6060.62
134_A147_Y0.6050.62
246_A250_G0.6050.62
189_D199_Q0.6030.62
264_A267_A0.6010.61
281_A287_A0.6010.61
135_K151_E0.6000.61
270_I273_T0.5990.61
125_L128_K0.5970.61
205_G212_A0.5970.61
34_M62_H0.5950.61
286_A289_R0.5950.61
38_W60_R0.5940.60
134_A146_A0.5920.60
146_A149_T0.5920.60
47_P62_H0.5910.60
7_R20_A0.5910.60
162_E165_G0.5880.60
28_T235_P0.5880.60
155_L214_P0.5850.59
35_I38_W0.5840.59
11_G14_R0.5840.59
203_E210_S0.5830.59
174_Y177_A0.5820.59
61_A68_V0.5810.59
178_Y185_D0.5810.59
164_R167_E0.5770.58
204_P212_A0.5760.58
263_V268_D0.5760.58
122_P149_T0.5740.58
60_R64_R0.5740.58
149_T188_S0.5740.58
299_A309_V0.5740.58
203_E207_R0.5720.58
294_E297_D0.5710.57
129_P147_Y0.5680.57
309_V313_T0.5670.57
12_D70_A0.5650.57
207_R211_A0.5650.57
192_T195_N0.5640.56
135_K147_Y0.5630.56
51_A63_D0.5600.56
126_W211_A0.5600.56
133_A211_A0.5590.56
300_L305_V0.5590.56
197_A220_R0.5580.56
183_R186_W0.5580.56
243_S253_S0.5570.56
166_F172_R0.5570.56
132_S188_S0.5550.55
246_A255_G0.5540.55
128_K135_K0.5530.55
255_G270_I0.5530.55
300_L312_R0.5520.55
114_A119_D0.5510.55
306_N313_T0.5500.55
130_T147_Y0.5490.54
198_R201_L0.5480.54
46_D51_A0.5440.54
283_D288_H0.5430.54
130_T195_N0.5390.53
135_K188_S0.5380.53
191_W196_G0.5370.53
131_N198_R0.5340.52
17_P75_E0.5340.52
189_D197_A0.5330.52
205_G208_E0.5320.52
131_N214_P0.5310.52
166_F170_A0.5310.52
130_T149_T0.5310.52
226_S232_V0.5300.52
222_I231_T0.5290.52
285_L289_R0.5280.52
131_N211_A0.5270.52
126_W217_L0.5240.51
299_A308_D0.5240.51
303_D309_V0.5230.51
299_A306_N0.5210.51
119_D159_R0.5210.51
131_N147_Y0.5210.51
132_S211_A0.5210.51
197_A201_L0.5200.51
304_A308_D0.5150.50
127_R188_S0.5110.49
128_K188_S0.5090.49
35_I62_H0.5080.49
241_T247_A0.5080.49
126_W197_A0.5080.49
21_D82_P0.5070.49
52_A63_D0.5060.49
128_K155_L0.5060.49
272_A275_E0.5040.48
77_K86_A0.5040.48
124_V168_P0.5030.48
125_L146_A0.5030.48
127_R134_A0.5020.48
280_V283_D0.5000.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4zcfA 2 0.8793 100 0.359 Contact Map
1eg2A 2 0.7328 100 0.445 Contact Map
1booA 1 0.7644 100 0.465 Contact Map
1g60A 2 0.6322 100 0.483 Contact Map
2zigA 2 0.6925 100 0.492 Contact Map
3v97A 1 0.3161 97.9 0.905 Contact Map
3lpmA 2 0.3707 97.6 0.91 Contact Map
2yxlA 1 0.3764 97.6 0.911 Contact Map
2b3tA 1 0.3477 97.5 0.913 Contact Map
4krgA 1 0.8362 97.4 0.914 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.01 seconds.