GREMLIN Database
Q9HPN7 - Uncharacterized protein
UniProt: Q9HPN7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 163 (153)
Sequences: 2469 (1672)
Seq/√Len: 135.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
20_L109_C4.1141.00
116_A136_L3.7871.00
7_A121_D2.9771.00
12_E115_R2.7721.00
23_A104_Q2.6851.00
28_R36_D2.4341.00
27_I102_L2.4291.00
67_A71_T2.4211.00
24_V39_L2.3961.00
7_A118_A2.3391.00
30_T97_E2.3171.00
23_A108_V2.2941.00
11_I14_Y2.1941.00
38_W76_W2.1541.00
45_H135_Y2.0321.00
24_V143_L2.0201.00
38_W142_A1.9871.00
5_S121_D1.9311.00
16_T115_R1.9211.00
67_A131_T1.9031.00
97_E101_A1.8581.00
149_L153_V1.8451.00
142_A146_F1.8391.00
45_H69_H1.8021.00
12_E16_T1.7301.00
108_V111_R1.7221.00
72_H76_W1.6981.00
99_G151_N1.6971.00
38_W80_C1.6851.00
7_A117_V1.6191.00
47_H50_Q1.6191.00
83_R153_V1.6101.00
52_D129_N1.6041.00
76_W79_H1.5681.00
105_A143_L1.5521.00
80_C142_A1.5361.00
23_A105_A1.5231.00
71_T75_K1.5001.00
102_L150_A1.4461.00
115_R118_A1.4141.00
19_E111_R1.3821.00
81_E145_V1.3721.00
4_V8_S1.3711.00
53_F116_A1.3561.00
70_V131_T1.3451.00
21_N47_H1.3271.00
35_L150_A1.3121.00
8_S126_D1.2891.00
26_A101_A1.2761.00
26_A104_Q1.2701.00
30_T101_A1.2651.00
96_S154_A1.2651.00
84_L145_V1.2561.00
35_L146_F1.2501.00
119_L126_D1.2501.00
22_A107_A1.2481.00
41_E72_H1.2281.00
65_I69_H1.1890.99
80_C149_L1.1850.99
151_N158_E1.1360.99
14_Y53_F1.1310.99
29_P97_E1.1290.99
67_A134_A1.1160.99
34_D79_H1.1120.99
96_S151_N1.0980.99
23_A101_A1.0970.99
101_A104_Q1.0940.99
27_I105_A1.0940.99
27_I150_A1.0770.99
5_S8_S1.0760.99
77_I145_V1.0640.99
76_W142_A1.0520.99
29_P100_A1.0420.99
98_A150_A1.0330.99
13_A116_A1.0260.99
74_E78_D1.0250.98
52_D64_Q1.0160.98
120_Q133_V1.0160.98
45_H72_H0.9870.98
12_E118_A0.9670.98
42_A135_Y0.9590.98
29_P101_A0.9550.98
36_D40_R0.9510.98
34_D153_V0.9490.98
28_R40_R0.9460.97
131_T134_A0.9440.97
16_T111_R0.9410.97
85_D152_D0.9370.97
116_A132_A0.9360.97
44_N48_V0.9270.97
49_V132_A0.9160.97
23_A27_I0.9150.97
21_N50_Q0.9150.97
33_A37_A0.9010.97
90_F144_F0.8820.96
21_N43_Q0.8790.96
95_G151_N0.8630.96
18_D106_R0.8570.95
70_V134_A0.8560.95
17_V46_L0.8500.95
38_W79_H0.8490.95
118_A122_H0.8490.95
25_G43_Q0.8490.95
66_T69_H0.8450.95
10_R126_D0.8440.95
41_E45_H0.8200.94
9_P115_R0.8190.94
79_H83_R0.8140.94
120_Q128_V0.8110.94
68_E71_T0.8030.94
141_D148_R0.8000.93
4_V11_I0.7920.93
10_R14_Y0.7920.93
16_T112_A0.7860.93
80_C146_F0.7810.93
152_D157_H0.7810.93
17_V49_V0.7770.92
9_P122_H0.7730.92
112_A136_L0.7730.92
39_L102_L0.7660.92
76_W80_C0.7650.92
104_Q108_V0.7590.92
59_E62_D0.7580.92
51_A55_N0.7580.92
109_C143_L0.7580.92
38_W72_H0.7520.91
74_E77_I0.7480.91
41_E76_W0.7420.91
14_Y78_D0.7410.91
8_S122_H0.7410.91
120_Q127_A0.7390.90
99_G158_E0.7380.90
91_I147_A0.7330.90
84_L87_L0.7200.89
26_A97_E0.7110.89
81_E84_L0.7100.89
26_A30_T0.7100.89
32_I153_V0.7070.88
101_A105_A0.7060.88
16_T108_V0.6960.88
94_G100_A0.6930.87
129_N132_A0.6900.87
116_A133_V0.6840.87
83_R149_L0.6840.87
27_I101_A0.6790.86
20_L105_A0.6790.86
91_I144_F0.6780.86
92_L95_G0.6750.86
75_K79_H0.6720.86
15_G18_D0.6710.86
96_S156_V0.6640.85
42_A139_L0.6640.85
93_P106_R0.6540.84
35_L149_L0.6530.84
13_A115_R0.6510.84
117_V133_V0.6500.84
102_L146_F0.6420.83
14_Y107_A0.6420.83
117_V120_Q0.6380.83
21_N95_G0.6360.83
50_Q95_G0.6230.81
84_L89_S0.6190.81
57_E60_P0.6180.81
96_S99_G0.6170.81
35_L80_C0.6170.81
138_R141_D0.6080.80
79_H82_A0.5970.78
78_D141_D0.5970.78
13_A17_V0.5970.78
13_A119_L0.5970.78
52_D63_P0.5940.78
22_A26_A0.5930.78
19_E108_V0.5930.78
25_G50_Q0.5920.78
99_G147_A0.5920.78
103_H147_A0.5870.77
5_S117_V0.5850.77
32_I150_A0.5820.77
43_Q50_Q0.5790.76
21_N93_P0.5790.76
87_L144_F0.5760.76
17_V112_A0.5750.76
152_D156_V0.5750.76
40_R44_N0.5740.76
94_G156_V0.5740.76
16_T114_R0.5710.75
4_V10_R0.5700.75
9_P118_A0.5690.75
98_A101_A0.5680.75
17_V136_L0.5680.75
6_K15_G0.5640.74
109_C139_L0.5640.74
20_L23_A0.5630.74
42_A80_C0.5620.74
144_F151_N0.5590.74
22_A147_A0.5530.73
26_A29_P0.5520.73
96_S158_E0.5430.72
41_E82_A0.5420.72
20_L27_I0.5390.71
34_D83_R0.5390.71
65_I131_T0.5390.71
66_T72_H0.5370.71
93_P103_H0.5340.70
18_D147_A0.5340.70
119_L128_V0.5330.70
130_D134_A0.5330.70
17_V116_A0.5310.70
8_S62_D0.5300.70
18_D22_A0.5300.70
51_A89_S0.5290.70
15_G133_V0.5250.69
9_P13_A0.5220.69
44_N47_H0.5220.69
72_H75_K0.5210.69
63_P66_T0.5200.68
32_I154_A0.5180.68
69_H72_H0.5150.68
95_G144_F0.5140.68
91_I148_R0.5130.67
112_A119_L0.5110.67
119_L127_A0.5090.67
20_L108_V0.5080.67
67_A70_V0.5060.66
10_R53_F0.5040.66
31_D134_A0.5040.66
85_D88_E0.5030.66
44_N63_P0.5010.66
17_V53_F0.5000.65
20_L24_V0.5000.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2nt8A 3 0.9816 100 0.101 Contact Map
3ci3A 3 0.9816 100 0.106 Contact Map
2idxA 3 0.9816 100 0.109 Contact Map
2ah6A 3 0.9693 100 0.11 Contact Map
2zhyA 3 0.9387 100 0.11 Contact Map
1rtyA 3 0.9448 100 0.113 Contact Map
3ke4A 3 0.9693 100 0.113 Contact Map
1nogA 4 0.908 100 0.117 Contact Map
1wy1A 3 0.8957 100 0.123 Contact Map
2g2dA 3 0.9387 100 0.128 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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