Q9HPN7 - HALSA - GREMLIN Contacts

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Q9HPN7 - Uncharacterized protein

UniProt:	Q9HPN7	Sequences: MDRVSKASPRIEAYGTVDELNAAVGAIRPTDIADLDAWLREAQNHLHVVQADFANPEPEPDDPQITAEHVTHVEKWIDHCEARLDPLESFILPGGSEAGAALHQARAVCRRAERRAVALQDHEPDDAVNDTAVAYLNRLSDALFVFARLANDVAGVHEESPSY	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	163 (153)
Sequences:	2469 (1672)
Seq/√Len:	135.2

BACSU - PDUO
HALSA - Q9HPN7
SULSO - Q7LXT1 Q980D7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
20_L	109_C	4.114	1.00
116_A	136_L	3.787	1.00
7_A	121_D	2.977	1.00
12_E	115_R	2.772	1.00
23_A	104_Q	2.685	1.00
28_R	36_D	2.434	1.00
27_I	102_L	2.429	1.00
67_A	71_T	2.421	1.00
24_V	39_L	2.396	1.00
7_A	118_A	2.339	1.00
30_T	97_E	2.317	1.00
23_A	108_V	2.294	1.00
11_I	14_Y	2.194	1.00
38_W	76_W	2.154	1.00
45_H	135_Y	2.032	1.00
24_V	143_L	2.020	1.00
38_W	142_A	1.987	1.00
5_S	121_D	1.931	1.00
16_T	115_R	1.921	1.00
67_A	131_T	1.903	1.00
97_E	101_A	1.858	1.00
149_L	153_V	1.845	1.00
142_A	146_F	1.839	1.00
45_H	69_H	1.802	1.00
12_E	16_T	1.730	1.00
108_V	111_R	1.722	1.00
72_H	76_W	1.698	1.00
99_G	151_N	1.697	1.00
38_W	80_C	1.685	1.00
7_A	117_V	1.619	1.00
47_H	50_Q	1.619	1.00
83_R	153_V	1.610	1.00
52_D	129_N	1.604	1.00
76_W	79_H	1.568	1.00
105_A	143_L	1.552	1.00
80_C	142_A	1.536	1.00
23_A	105_A	1.523	1.00
71_T	75_K	1.500	1.00
102_L	150_A	1.446	1.00
115_R	118_A	1.414	1.00
19_E	111_R	1.382	1.00
81_E	145_V	1.372	1.00
4_V	8_S	1.371	1.00
53_F	116_A	1.356	1.00
70_V	131_T	1.345	1.00
21_N	47_H	1.327	1.00
35_L	150_A	1.312	1.00
8_S	126_D	1.289	1.00
26_A	101_A	1.276	1.00
26_A	104_Q	1.270	1.00
30_T	101_A	1.265	1.00
96_S	154_A	1.265	1.00
84_L	145_V	1.256	1.00
35_L	146_F	1.250	1.00
119_L	126_D	1.250	1.00
22_A	107_A	1.248	1.00
41_E	72_H	1.228	1.00
65_I	69_H	1.189	0.99
80_C	149_L	1.185	0.99
151_N	158_E	1.136	0.99
14_Y	53_F	1.131	0.99
29_P	97_E	1.129	0.99
67_A	134_A	1.116	0.99
34_D	79_H	1.112	0.99
96_S	151_N	1.098	0.99
23_A	101_A	1.097	0.99
101_A	104_Q	1.094	0.99
27_I	105_A	1.094	0.99
27_I	150_A	1.077	0.99
5_S	8_S	1.076	0.99
77_I	145_V	1.064	0.99
76_W	142_A	1.052	0.99
29_P	100_A	1.042	0.99
98_A	150_A	1.033	0.99
13_A	116_A	1.026	0.99
74_E	78_D	1.025	0.98
52_D	64_Q	1.016	0.98
120_Q	133_V	1.016	0.98
45_H	72_H	0.987	0.98
12_E	118_A	0.967	0.98
42_A	135_Y	0.959	0.98
29_P	101_A	0.955	0.98
36_D	40_R	0.951	0.98
34_D	153_V	0.949	0.98
28_R	40_R	0.946	0.97
131_T	134_A	0.944	0.97
16_T	111_R	0.941	0.97
85_D	152_D	0.937	0.97
116_A	132_A	0.936	0.97
44_N	48_V	0.927	0.97
49_V	132_A	0.916	0.97
23_A	27_I	0.915	0.97
21_N	50_Q	0.915	0.97
33_A	37_A	0.901	0.97
90_F	144_F	0.882	0.96
21_N	43_Q	0.879	0.96
95_G	151_N	0.863	0.96
18_D	106_R	0.857	0.95
70_V	134_A	0.856	0.95
17_V	46_L	0.850	0.95
38_W	79_H	0.849	0.95
118_A	122_H	0.849	0.95
25_G	43_Q	0.849	0.95
66_T	69_H	0.845	0.95
10_R	126_D	0.844	0.95
41_E	45_H	0.820	0.94
9_P	115_R	0.819	0.94
79_H	83_R	0.814	0.94
120_Q	128_V	0.811	0.94
68_E	71_T	0.803	0.94
141_D	148_R	0.800	0.93
4_V	11_I	0.792	0.93
10_R	14_Y	0.792	0.93
16_T	112_A	0.786	0.93
80_C	146_F	0.781	0.93
152_D	157_H	0.781	0.93
17_V	49_V	0.777	0.92
9_P	122_H	0.773	0.92
112_A	136_L	0.773	0.92
39_L	102_L	0.766	0.92
76_W	80_C	0.765	0.92
104_Q	108_V	0.759	0.92
59_E	62_D	0.758	0.92
51_A	55_N	0.758	0.92
109_C	143_L	0.758	0.92
38_W	72_H	0.752	0.91
74_E	77_I	0.748	0.91
41_E	76_W	0.742	0.91
14_Y	78_D	0.741	0.91
8_S	122_H	0.741	0.91
120_Q	127_A	0.739	0.90
99_G	158_E	0.738	0.90
91_I	147_A	0.733	0.90
84_L	87_L	0.720	0.89
26_A	97_E	0.711	0.89
81_E	84_L	0.710	0.89
26_A	30_T	0.710	0.89
32_I	153_V	0.707	0.88
101_A	105_A	0.706	0.88
16_T	108_V	0.696	0.88
94_G	100_A	0.693	0.87
129_N	132_A	0.690	0.87
116_A	133_V	0.684	0.87
83_R	149_L	0.684	0.87
27_I	101_A	0.679	0.86
20_L	105_A	0.679	0.86
91_I	144_F	0.678	0.86
92_L	95_G	0.675	0.86
75_K	79_H	0.672	0.86
15_G	18_D	0.671	0.86
96_S	156_V	0.664	0.85
42_A	139_L	0.664	0.85
93_P	106_R	0.654	0.84
35_L	149_L	0.653	0.84
13_A	115_R	0.651	0.84
117_V	133_V	0.650	0.84
102_L	146_F	0.642	0.83
14_Y	107_A	0.642	0.83
117_V	120_Q	0.638	0.83
21_N	95_G	0.636	0.83
50_Q	95_G	0.623	0.81
84_L	89_S	0.619	0.81
57_E	60_P	0.618	0.81
96_S	99_G	0.617	0.81
35_L	80_C	0.617	0.81
138_R	141_D	0.608	0.80
79_H	82_A	0.597	0.78
78_D	141_D	0.597	0.78
13_A	17_V	0.597	0.78
13_A	119_L	0.597	0.78
52_D	63_P	0.594	0.78
22_A	26_A	0.593	0.78
19_E	108_V	0.593	0.78
25_G	50_Q	0.592	0.78
99_G	147_A	0.592	0.78
103_H	147_A	0.587	0.77
5_S	117_V	0.585	0.77
32_I	150_A	0.582	0.77
43_Q	50_Q	0.579	0.76
21_N	93_P	0.579	0.76
87_L	144_F	0.576	0.76
17_V	112_A	0.575	0.76
152_D	156_V	0.575	0.76
40_R	44_N	0.574	0.76
94_G	156_V	0.574	0.76
16_T	114_R	0.571	0.75
4_V	10_R	0.570	0.75
9_P	118_A	0.569	0.75
98_A	101_A	0.568	0.75
17_V	136_L	0.568	0.75
6_K	15_G	0.564	0.74
109_C	139_L	0.564	0.74
20_L	23_A	0.563	0.74
42_A	80_C	0.562	0.74
144_F	151_N	0.559	0.74
22_A	147_A	0.553	0.73
26_A	29_P	0.552	0.73
96_S	158_E	0.543	0.72
41_E	82_A	0.542	0.72
20_L	27_I	0.539	0.71
34_D	83_R	0.539	0.71
65_I	131_T	0.539	0.71
66_T	72_H	0.537	0.71
93_P	103_H	0.534	0.70
18_D	147_A	0.534	0.70
119_L	128_V	0.533	0.70
130_D	134_A	0.533	0.70
17_V	116_A	0.531	0.70
8_S	62_D	0.530	0.70
18_D	22_A	0.530	0.70
51_A	89_S	0.529	0.70
15_G	133_V	0.525	0.69
9_P	13_A	0.522	0.69
44_N	47_H	0.522	0.69
72_H	75_K	0.521	0.69
63_P	66_T	0.520	0.68
32_I	154_A	0.518	0.68
69_H	72_H	0.515	0.68
95_G	144_F	0.514	0.68
91_I	148_R	0.513	0.67
112_A	119_L	0.511	0.67
119_L	127_A	0.509	0.67
20_L	108_V	0.508	0.67
67_A	70_V	0.506	0.66
10_R	53_F	0.504	0.66
31_D	134_A	0.504	0.66
85_D	88_E	0.503	0.66
44_N	63_P	0.501	0.66
17_V	53_F	0.500	0.65
20_L	24_V	0.500	0.65

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2nt8A	3	0.9816	100	0.101	Contact Map
3ci3A	3	0.9816	100	0.106	Contact Map
2idxA	3	0.9816	100	0.109	Contact Map
2ah6A	3	0.9693	100	0.11	Contact Map
2zhyA	3	0.9387	100	0.11	Contact Map
1rtyA	3	0.9448	100	0.113	Contact Map
3ke4A	3	0.9693	100	0.113	Contact Map
1nogA	4	0.908	100	0.117	Contact Map
1wy1A	3	0.8957	100	0.123	Contact Map
2g2dA	3	0.9387	100	0.128	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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