GREMLIN Database
Q9HPN6 - Uncharacterized protein
UniProt: Q9HPN6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 79 (76)
Sequences: 416 (218)
Seq/√Len: 25.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
3_L55_L3.6831.00
20_T75_A3.5821.00
47_S65_A2.9491.00
73_Y77_T2.6240.99
4_T31_V2.4400.99
7_A34_D2.4370.99
16_S68_Q2.3550.98
43_V54_V2.1650.97
7_A30_T2.1430.97
13_D66_D1.7960.91
4_T58_D1.7890.91
21_L28_H1.7600.90
46_A63_V1.6550.87
7_A14_C1.5630.84
54_V63_V1.3980.77
14_C32_H1.3610.75
40_R66_D1.3460.74
69_R72_T1.3200.72
27_D37_H1.3140.72
74_A78_L1.3020.71
20_T71_Q1.2860.70
24_D78_L1.2680.69
4_T42_A1.2660.69
4_T56_V1.2520.68
40_R67_S1.2410.67
10_G49_Q1.2390.67
6_Y14_C1.2000.65
41_N71_Q1.1890.64
11_C65_A1.1220.59
13_D67_S1.0650.55
6_Y34_D1.0570.55
50_R65_A1.0460.54
4_T29_E1.0160.52
30_T34_D0.9910.50
26_I74_A0.9600.48
9_D32_H0.9510.47
41_N45_R0.9410.46
8_L11_C0.9380.46
21_L30_T0.9180.45
16_S23_A0.9180.45
34_D37_H0.9130.44
10_G31_V0.8950.43
56_V61_G0.8890.43
46_A56_V0.8820.42
12_P33_V0.8810.42
41_N52_V0.8790.42
56_V72_T0.8710.41
62_V73_Y0.8620.41
7_A28_H0.8590.41
68_Q76_V0.8470.40
62_V76_V0.8450.40
7_A18_I0.8440.40
15_E35_A0.8330.39
3_L29_E0.8220.38
72_T77_T0.8210.38
22_A25_D0.8210.38
13_D40_R0.8040.37
14_C30_T0.7930.36
15_E19_D0.7840.35
43_V52_V0.7710.35
13_D35_A0.7610.34
25_D32_H0.7580.34
29_E43_V0.7550.34
8_L37_H0.7550.34
57_D78_L0.7530.33
33_V43_V0.7500.33
9_D19_D0.7460.33
8_L35_A0.7380.32
61_G72_T0.7360.32
42_A45_R0.7310.32
6_Y31_V0.7180.31
7_A32_H0.7100.31
8_L12_P0.7070.31
56_V77_T0.6950.30
49_Q65_A0.6940.30
35_A59_D0.6930.30
21_L39_A0.6790.29
38_S41_N0.6690.28
51_S65_A0.6690.28
15_E32_H0.6650.28
11_C27_D0.6640.28
10_G16_S0.6620.28
44_K49_Q0.6530.27
9_D74_A0.6400.27
31_V42_A0.6400.27
9_D59_D0.6320.26
11_C14_C0.6310.26
38_S50_R0.6220.26
38_S45_R0.6200.25
25_D75_A0.6180.25
56_V63_V0.6170.25
42_A46_A0.6110.25
71_Q74_A0.6090.25
13_D33_V0.6070.25
51_S54_V0.6060.25
45_R77_T0.6000.24
19_D32_H0.5930.24
7_A15_E0.5720.23
45_R64_M0.5670.23
5_L55_L0.5650.23
24_D27_D0.5590.22
40_R43_V0.5580.22
15_E18_I0.5550.22
54_V65_A0.5540.22
21_L55_L0.5500.22
10_G22_A0.5490.22
6_Y50_R0.5480.22
41_N56_V0.5390.21
18_I32_H0.5350.21
43_V47_S0.5310.21
56_V65_A0.5200.20
12_P67_S0.5190.20
21_L42_A0.5070.20
26_I29_E0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4kh7A 2 1 99.4 0.575 Contact Map
3wywA 2 0.9747 99.4 0.583 Contact Map
4igjA 2 0.9241 99.4 0.587 Contact Map
4ielA 2 0.9747 99.4 0.588 Contact Map
4mpgA 2 0.9747 99.4 0.589 Contact Map
3vk9A 2 0.9747 99.4 0.589 Contact Map
3m0fA 2 0.9494 99.4 0.59 Contact Map
3nivA 2 0.7722 99.4 0.59 Contact Map
1gnwA 2 0.962 99.4 0.592 Contact Map
4agsA 3 1 99.4 0.592 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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