GREMLIN Database
Q9HPN5 - Uncharacterized protein
UniProt: Q9HPN5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 270 (255)
Sequences: 122 (97)
Seq/√Len: 6.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
115_I144_A7.1351.00
153_D182_G5.9491.00
153_D183_S4.0500.94
153_D181_G3.6280.90
80_D159_F3.3800.86
212_V242_V3.1840.82
191_V212_V2.9730.78
46_V172_V2.9190.76
171_T240_L2.5810.66
48_A175_T2.2800.56
46_V91_T2.2740.56
35_V157_A2.2400.55
175_T242_V2.2320.55
142_A206_V2.2120.54
74_V264_V2.1490.52
143_V178_V2.1410.51
39_E99_S2.1340.51
173_L235_R1.9620.45
82_L208_A1.9230.44
80_D252_T1.8920.42
142_A191_V1.8800.42
129_V241_L1.8580.41
12_V165_Y1.8490.41
191_V242_V1.8370.41
20_T237_L1.8060.40
24_I201_V1.7990.39
22_Y53_D1.7990.39
67_H148_A1.7690.38
152_Q214_D1.7500.38
139_S196_A1.7380.37
202_A221_I1.7360.37
115_I213_R1.7350.37
115_I150_A1.7150.36
155_G178_V1.6150.33
17_R39_E1.6090.33
95_Y99_S1.5790.32
191_V211_A1.5770.32
182_G187_P1.5730.32
113_A150_A1.5590.31
178_V210_V1.5400.31
153_D184_G1.5230.30
92_F244_T1.5060.30
195_L240_L1.4920.29
21_R201_V1.4720.29
182_G186_L1.4710.29
116_D149_A1.4280.28
23_Q140_A1.4200.27
23_Q37_Q1.4190.27
156_T178_V1.4050.27
86_T163_L1.3760.26
175_T203_A1.3650.26
192_T216_G1.3610.26
179_Q228_A1.3540.26
92_F266_G1.3420.25
190_A218_E1.3310.25
114_D166_E1.3220.25
114_D151_G1.3170.25
159_F256_R1.3090.24
122_S253_D1.3070.24
21_R46_V1.3070.24
16_K20_T1.3040.24
227_S254_P1.2900.24
73_E165_Y1.2850.24
102_E241_L1.2840.24
35_V99_S1.2830.24
40_I232_A1.2760.23
90_R239_V1.2740.23
175_T201_V1.2600.23
116_D172_V1.2520.23
172_V243_V1.2500.23
116_D120_R1.2470.23
30_E95_Y1.2430.23
81_W207_E1.2410.23
12_V223_F1.2350.22
27_E52_S1.2310.22
37_Q52_S1.2120.22
46_V64_A1.2110.22
12_V155_G1.2100.22
148_A154_V1.2020.22
103_E215_A1.1930.21
152_Q217_S1.1910.21
28_I242_V1.1810.21
18_N202_A1.1800.21
24_I208_A1.1750.21
115_I151_G1.1740.21
18_N259_N1.1730.21
22_Y86_T1.1720.21
130_M157_A1.1710.21
90_R94_E1.1610.21
41_A183_S1.1610.21
21_R175_T1.1610.21
172_V228_A1.1570.21
64_A179_Q1.1570.21
101_L264_V1.1500.20
153_D187_P1.1480.20
51_V203_A1.1470.20
24_I173_L1.1400.20
110_V196_A1.1390.20
126_H242_V1.1370.20
164_D217_S1.1330.20
120_R150_A1.1330.20
56_G97_S1.1320.20
55_L243_V1.1300.20
30_E249_S1.1280.20
260_L266_G1.1240.20
50_A81_W1.1220.20
83_I155_G1.1210.20
149_A166_E1.1180.20
116_D166_E1.1170.20
144_A147_G1.1160.20
203_A242_V1.1140.20
251_H264_V1.1120.20
109_A232_A1.1040.19
37_Q53_D1.1000.19
261_G264_V1.0950.19
185_A217_S1.0950.19
79_V156_T1.0930.19
24_I182_G1.0850.19
117_D147_G1.0840.19
83_I125_M1.0840.19
137_D224_G1.0830.19
212_V266_G1.0820.19
107_D140_A1.0780.19
213_R265_V1.0770.19
33_P72_Y1.0690.19
32_Q68_G1.0620.18
203_A213_R1.0590.18
64_A244_T1.0510.18
40_I110_V1.0390.18
210_V235_R1.0340.18
44_I206_V1.0270.18
107_D163_L1.0180.18
183_S186_L1.0120.17
56_G228_A1.0070.17
22_Y37_Q1.0070.17
122_S138_G1.0020.17
114_D150_A0.9960.17
202_A220_D0.9940.17
211_A215_A0.9850.17
77_E160_D0.9790.17
147_G250_E0.9780.17
123_L156_T0.9780.17
71_R77_E0.9750.17
130_M162_M0.9660.16
45_G223_F0.9640.16
24_I183_S0.9550.16
202_A222_R0.9530.16
192_T213_R0.9520.16
91_T129_V0.9520.16
92_F218_E0.9490.16
175_T259_N0.9420.16
40_I156_T0.9360.16
143_V159_F0.9320.16
89_L132_A0.9310.16
152_Q184_G0.9310.16
73_E89_L0.9290.16
110_V248_L0.9220.16
23_Q92_F0.9220.16
166_E197_A0.9180.16
83_I246_D0.9150.16
217_S240_L0.9110.15
164_D211_A0.9100.15
133_T150_A0.9040.15
18_N82_L0.9030.15
213_R218_E0.9030.15
130_M163_L0.9000.15
114_D149_A0.9000.15
70_G222_R0.8990.15
32_Q39_E0.8950.15
50_A72_Y0.8940.15
29_A50_A0.8940.15
28_I65_R0.8940.15
154_V164_D0.8870.15
167_P235_R0.8860.15
62_G166_E0.8850.15
189_D240_L0.8730.15
66_K123_L0.8690.15
120_R194_R0.8650.15
23_Q260_L0.8620.15
120_R198_H0.8620.15
208_A217_S0.8600.15
186_L189_D0.8530.14
193_A266_G0.8520.14
59_V76_K0.8520.14
85_Q260_L0.8510.14
13_L211_A0.8440.14
22_Y55_L0.8440.14
188_D238_S0.8430.14
118_G161_G0.8420.14
206_V242_V0.8320.14
116_D218_E0.8320.14
202_A229_V0.8310.14
162_M200_I0.8270.14
63_H240_L0.8240.14
18_N222_R0.8240.14
48_A170_V0.8210.14
109_A176_P0.8190.14
169_E196_A0.8150.14
107_D159_F0.8080.14
106_V257_E0.8060.14
78_G236_G0.8050.14
49_Q236_G0.8050.14
49_Q78_G0.8050.14
80_D256_R0.8040.14
33_P68_G0.8030.14
73_E86_T0.7920.13
13_L207_E0.7910.13
79_V96_V0.7890.13
127_D257_E0.7870.13
124_S158_E0.7850.13
73_E156_T0.7810.13
16_K32_Q0.7810.13
28_I162_M0.7810.13
43_E252_T0.7780.13
15_S23_Q0.7770.13
196_A216_G0.7700.13
187_P231_A0.7680.13
80_D223_F0.7680.13
20_T51_V0.7670.13
184_G191_V0.7670.13
113_A193_A0.7670.13
81_W108_T0.7650.13
130_M172_V0.7630.13
230_P261_G0.7620.13
33_P37_Q0.7610.13
29_A79_V0.7610.13
209_L213_R0.7600.13
22_Y33_P0.7600.13
132_A201_V0.7560.13
130_M266_G0.7540.13
170_V260_L0.7530.13
27_E227_S0.7470.13
18_N89_L0.7450.13
127_D237_L0.7440.13
35_V74_V0.7440.13
63_H192_T0.7360.12
118_G220_D0.7310.12
37_Q72_Y0.7290.12
98_E164_D0.7290.12
133_T197_A0.7280.12
116_D126_H0.7260.12
54_Y246_D0.7230.12
53_D86_T0.7200.12
64_A215_A0.7190.12
99_S104_V0.7150.12
63_H211_A0.7130.12
51_V204_A0.7120.12
189_D247_R0.7090.12
114_D213_R0.7040.12
148_A233_A0.7010.12
223_F232_A0.7010.12
33_P50_A0.7010.12
172_V186_L0.7000.12
17_R32_Q0.6980.12
117_D214_D0.6970.12
135_G261_G0.6960.12
31_R35_V0.6930.12
119_E192_T0.6900.12
98_E221_I0.6870.12
138_G193_A0.6860.12
24_I153_D0.6860.12
50_A79_V0.6860.12
52_S111_A0.6840.12
90_R98_E0.6830.12
207_E231_A0.6790.12
137_D144_A0.6780.12
89_L156_T0.6780.12
37_Q68_G0.6760.12
86_T248_L0.6760.12
74_V207_E0.6740.12
173_L177_V0.6690.11
46_V140_A0.6680.11
199_D237_L0.6670.11
113_A200_I0.6650.11
14_R117_D0.6600.11
68_G125_M0.6590.11
52_S72_Y0.6580.11
107_D256_R0.6550.11
131_H188_D0.6500.11
48_A207_E0.6490.11
21_R26_V0.6480.11
160_D172_V0.6430.11
86_T96_V0.6430.11
132_A168_G0.6420.11
86_T142_A0.6420.11
119_E137_D0.6390.11
120_R169_E0.6380.11
224_G230_P0.6380.11
142_A248_L0.6370.11
169_E227_S0.6310.11
113_A149_A0.6280.11
158_E241_L0.6280.11
149_A196_A0.6240.11
241_L251_H0.6240.11
254_P266_G0.6200.11
110_V131_H0.6180.11
216_G224_G0.6160.11
133_T175_T0.6160.11
56_G131_H0.6150.11
37_Q41_A0.6070.11
50_A128_G0.6070.11
150_A187_P0.6060.11
68_G96_V0.6030.11
88_D141_T0.6030.11
166_E196_A0.6020.11
112_D126_H0.6010.10
59_V254_P0.5990.10
54_Y83_I0.5990.10
67_H73_E0.5980.10
140_A163_L0.5970.10
21_R57_D0.5930.10
51_V140_A0.5930.10
116_D147_G0.5900.10
19_A39_E0.5890.10
49_Q205_G0.5860.10
78_G205_G0.5860.10
205_G236_G0.5860.10
63_H149_A0.5840.10
40_I102_E0.5830.10
65_R73_E0.5800.10
24_I137_D0.5790.10
41_A45_G0.5780.10
92_F247_R0.5750.10
14_R265_V0.5740.10
131_H256_R0.5740.10
15_S18_N0.5730.10
75_T236_G0.5730.10
75_T78_G0.5730.10
49_Q75_T0.5730.10
109_A161_G0.5720.10
127_D211_A0.5710.10
36_S247_R0.5700.10
82_L139_S0.5700.10
70_G73_E0.5690.10
37_Q96_V0.5690.10
12_V102_E0.5660.10
110_V177_V0.5660.10
178_V219_P0.5650.10
93_V243_V0.5650.10
46_V251_H0.5640.10
12_V122_S0.5610.10
83_I129_V0.5610.10
54_Y155_G0.5570.10
153_D186_L0.5540.10
133_T188_D0.5530.10
65_R158_E0.5520.10
80_D143_V0.5470.10
88_D224_G0.5440.10
77_E188_D0.5440.10
16_K29_A0.5420.10
191_V217_S0.5400.10
186_L231_A0.5390.10
139_S203_A0.5380.10
165_Y180_D0.5380.10
33_P111_A0.5360.10
100_V210_V0.5350.10
224_G235_R0.5350.10
163_L262_Y0.5270.10
30_E152_Q0.5260.10
120_R147_G0.5250.10
169_E214_D0.5250.10
21_R255_L0.5230.09
60_E143_V0.5170.09
28_I172_V0.5170.09
22_Y92_F0.5170.09
133_T144_A0.5160.09
171_T186_L0.5160.09
150_A189_D0.5140.09
141_T157_A0.5130.09
65_R208_A0.5120.09
168_G238_S0.5110.09
32_Q45_G0.5100.09
78_G128_G0.5100.09
128_G236_G0.5100.09
49_Q128_G0.5100.09
202_A232_A0.5050.09
98_E199_D0.5040.09
110_V175_T0.5010.09
244_T251_H0.5010.09
17_R70_G0.5010.09
116_D208_A0.5010.09
41_A52_S0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3f6oA 2 0.3481 99.1 0.879 Contact Map
4hw0A 2 0.337 99 0.883 Contact Map
2zkzA 2 0.3111 99 0.884 Contact Map
2oqgA 4 0.3926 99 0.885 Contact Map
3df8A 2 0.3593 98.9 0.887 Contact Map
4k2eA 2 0.3333 98.9 0.889 Contact Map
1u2wA 2 0.3444 98.8 0.89 Contact Map
3cuoA 2 0.3333 98.8 0.891 Contact Map
3f6vA 2 0.3444 98.8 0.891 Contact Map
1ub9A 2 0.3407 98.8 0.892 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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