GREMLIN Database
CBIT - Probable cobalt-precorrin-6B C(15)-methyltransferase (decarboxylating)
UniProt: Q9HPN4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 187 (171)
Sequences: 1917 (1297)
Seq/√Len: 99.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
23_V126_N5.2591.00
18_E156_H3.3711.00
40_S69_T3.1631.00
40_S58_A3.1531.00
87_A92_E2.9771.00
34_H57_T2.9161.00
100_L115_A2.8661.00
112_L139_A2.7181.00
131_E164_T2.4881.00
22_V152_F2.2481.00
127_V132_V2.2231.00
61_R88_E2.1851.00
35_F49_A2.1321.00
36_V97_A2.1151.00
66_L84_L2.0061.00
63_A86_N1.9721.00
9_D71_K1.9461.00
40_S46_T1.8771.00
158_Y167_D1.8511.00
73_L82_V1.8451.00
29_L49_A1.8301.00
125_M136_A1.8061.00
14_P42_T1.7541.00
67_E71_K1.7521.00
17_P26_K1.7481.00
71_K74_A1.6901.00
50_A82_V1.6801.00
34_H55_R1.6731.00
109_D142_D1.6701.00
33_D99_A1.6621.00
96_D118_T1.6521.00
66_L86_N1.6501.00
40_S60_E1.6491.00
38_V89_A1.6251.00
126_N174_M1.5831.00
165_S170_N1.5751.00
58_A69_T1.5371.00
70_R74_A1.5111.00
70_R86_N1.5031.00
123_I177_G1.4991.00
59_L92_E1.4941.00
45_V101_F1.4941.00
55_R83_E1.4691.00
18_E26_K1.4611.00
106_R132_V1.4531.00
30_T33_D1.4321.00
139_A143_R1.4061.00
46_T82_V1.3690.99
99_A122_R1.3140.99
61_R106_R1.3120.99
116_A177_G1.2950.99
9_D68_T1.2880.99
166_F173_Y1.2830.99
90_P93_L1.2830.99
114_H118_T1.2750.99
129_R163_A1.2530.99
115_A121_D1.2510.99
38_V59_L1.2390.99
160_L170_N1.2280.99
42_T68_T1.2030.99
23_V174_M1.2030.99
155_S171_P1.2020.99
138_Q142_D1.1820.98
157_G166_F1.1800.98
121_D179_A1.1760.98
157_G164_T1.1750.98
69_T84_L1.1680.98
57_T95_A1.1370.98
46_T56_V1.1330.98
167_D170_N1.1280.98
38_V115_A1.1030.97
60_E69_T1.0960.97
156_H169_E1.0930.97
50_A80_D1.0840.97
50_A56_V1.0710.97
133_A173_Y1.0570.97
27_L35_F1.0490.96
29_L53_A1.0470.96
110_A113_D1.0440.96
67_E70_R1.0420.96
29_L35_F1.0310.96
106_R125_M1.0310.96
140_F177_G1.0190.96
47_I76_N1.0140.96
26_K148_E1.0120.96
149_V157_G1.0010.95
102_I125_M0.9990.95
73_L78_L0.9940.95
66_L70_R0.9940.95
22_V154_V0.9930.95
111_V115_A0.9670.94
73_L84_L0.9650.94
18_E22_V0.9630.94
17_P25_S0.9550.94
34_H95_A0.9480.94
122_R176_V0.9470.94
113_D143_R0.9340.93
88_E91_A0.9300.93
107_N110_A0.9230.93
97_A100_L0.9130.93
26_K174_M0.9100.92
116_A179_A0.9060.92
21_A25_S0.9050.92
70_R73_L0.9010.92
38_V90_P0.8970.92
27_L101_F0.8930.92
35_F53_A0.8920.92
22_V25_S0.8840.91
109_D138_Q0.8840.91
134_G138_Q0.8810.91
138_Q141_R0.8730.91
131_E163_A0.8720.91
10_A14_P0.8690.91
7_P51_R0.8630.90
136_A175_L0.8530.90
93_L114_H0.8510.90
125_M132_V0.8380.89
23_V101_F0.8330.89
63_A67_E0.8260.88
124_V174_M0.8220.88
14_P44_A0.8200.88
151_Q173_Y0.8090.87
107_N163_A0.7970.86
60_E65_R0.7950.86
65_R68_T0.7930.86
109_D135_A0.7910.86
155_S168_S0.7910.86
22_V26_K0.7900.86
40_S84_L0.7870.86
57_T85_R0.7840.85
113_D117_E0.7800.85
105_S108_Y0.7740.85
9_D14_P0.7690.84
114_H117_E0.7660.84
128_S167_D0.7610.84
87_A91_A0.7580.83
59_L89_A0.7480.83
112_L123_I0.7470.83
18_E154_V0.7380.82
11_K64_D0.7290.81
27_L45_V0.7260.81
125_M140_F0.7250.81
36_V100_L0.7240.81
116_A139_A0.7180.80
79_A82_V0.7110.79
96_D119_G0.7020.79
58_A82_V0.6990.78
78_L82_V0.6980.78
14_P68_T0.6960.78
113_D142_D0.6930.78
151_Q155_S0.6920.78
22_V126_N0.6900.77
44_A68_T0.6900.77
6_L10_A0.6870.77
12_A65_R0.6820.77
27_L122_R0.6810.76
151_Q154_V0.6810.76
39_G104_G0.6810.76
12_A68_T0.6770.76
132_V163_A0.6760.76
150_V154_V0.6750.76
32_D53_A0.6740.76
13_G68_T0.6740.76
69_T73_L0.6740.76
112_L143_R0.6730.76
135_A139_A0.6700.75
133_A166_F0.6690.75
135_A138_Q0.6680.75
46_T69_T0.6660.75
23_V173_Y0.6620.74
28_A33_D0.6600.74
36_V95_A0.6600.74
70_R84_L0.6590.74
29_L33_D0.6580.74
127_V175_L0.6560.74
33_D53_A0.6480.73
70_R83_E0.6480.73
26_K176_V0.6470.73
59_L93_L0.6460.73
150_V176_V0.6450.72
71_K75_A0.6440.72
11_K62_K0.6430.72
108_Y132_V0.6410.72
59_L87_A0.6390.72
19_V126_N0.6390.72
133_A149_V0.6380.72
46_T76_N0.6310.71
17_P169_E0.6310.71
18_E150_V0.6140.69
19_V172_V0.6130.69
9_D42_T0.6030.67
62_K65_R0.6020.67
91_A94_P0.6020.67
55_R95_A0.6000.67
45_V49_A0.6000.67
141_R159_E0.6000.67
67_E86_N0.5960.66
51_R76_N0.5950.66
14_P65_R0.5950.66
20_R72_N0.5940.66
110_A114_H0.5930.66
108_Y136_A0.5920.66
140_F164_T0.5870.65
68_T73_L0.5870.65
134_G137_T0.5860.65
15_T39_G0.5860.65
44_A47_I0.5850.65
152_F174_M0.5780.64
122_R178_S0.5760.64
133_A165_S0.5750.64
34_H97_A0.5730.63
113_D139_A0.5730.63
160_L163_A0.5710.63
88_E107_N0.5700.63
17_P150_V0.5690.63
28_A178_S0.5650.62
37_E46_T0.5650.62
106_R127_V0.5630.62
42_T65_R0.5600.62
74_A162_G0.5600.62
148_E176_V0.5580.61
29_L99_A0.5580.61
85_R92_E0.5570.61
168_S171_P0.5560.61
28_A122_R0.5530.61
10_A42_T0.5500.60
57_T118_T0.5490.60
160_L165_S0.5430.59
128_S166_F0.5410.59
85_R90_P0.5400.59
151_Q166_F0.5390.59
88_E92_E0.5330.58
28_A176_V0.5330.58
7_P30_T0.5310.58
26_K150_V0.5300.58
52_D138_Q0.5290.57
65_R84_L0.5260.57
84_L124_V0.5250.57
128_S175_L0.5250.57
7_P10_A0.5230.57
84_L148_E0.5220.56
133_A175_L0.5200.56
136_A177_G0.5190.56
90_P110_A0.5170.56
144_D147_T0.5170.56
27_L99_A0.5130.55
114_H152_F0.5120.55
13_G65_R0.5110.55
83_E86_N0.5070.54
17_P54_G0.5070.54
46_T50_A0.5060.54
13_G161_A0.5060.54
10_A40_S0.5030.54
37_E49_A0.5010.53
106_R172_V0.5000.53
33_D98_D0.5000.53
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2yxdA 4 0.9465 99.9 0.608 Contact Map
3hm2A 3 0.8877 99.9 0.62 Contact Map
3e05A 4 0.9626 99.9 0.625 Contact Map
1l3iA 5 0.9572 99.9 0.64 Contact Map
3njrA 4 0.9305 99.9 0.651 Contact Map
3gnlA 1 0.9144 99.8 0.719 Contact Map
1o54A 4 0.9733 99.7 0.729 Contact Map
3lecA 2 0.9305 99.7 0.732 Contact Map
3mb5A 3 0.9572 99.7 0.739 Contact Map
2pwyA 3 0.9626 99.7 0.741 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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